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  • proteins
  • I. The appeal contests the interlocutory decision of the Opposition Division of the European Patent Office dated 30 June 2009 concerning maintenance of European patent No. 0 781 329 entitled 'Overexpression of mammalian and viral proteins' in amended form. (epo.org)
  • coli
  • The techniques for overexpression in E. coli are well developed and work by increasing the number of copies of the gene or increasing the binding strength of the promoter region so assisting transcription. (wikipedia.org)
  • cardiac
  • At higher levels of Gαq overexpression, frank cardiac decompensation occurred in 3 of 6 animals with development of biventricular failure, pulmonary congestion, and death. (pnas.org)
  • We hypothesized that lowering ADMA concentrations by dimethylarginine dimethylaminohydrolase (DDAH) overexpression in the recipient might suppress GCAD and long-term immune responses in murine cardiac allografts. (ahajournals.org)
  • Expression
  • Two-fold overexpression of Gαq showed no detectable effects, whereas 4-fold overexpression resulted in increased heart weight and myocyte size along with marked increases in atrial naturietic factor (≈55-fold), β-myosin heavy chain (≈8-fold), and α-skeletal actin (≈8-fold) expression, and decreased (≈3-fold) β-adrenergic receptor-stimulated adenylyl cyclase activity. (pnas.org)
  • mice
  • Adipocyte Xbp1s overexpression drives energy mobilization and protects mice from obesity through activation of the pyrimidine biosynthesis pathway. (nih.gov)