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Cell CycleCell Cycle ProteinsCell ProliferationCell Cycle CheckpointsApoptosisCell Line, TumorCell LineImmunohistochemistryGene Expression Regulation, NeoplasticG1 PhaseRNA, MessengerGene ExpressionUp-RegulationBlotting, WesternSignal TransductionMolecular Sequence DataGene Expression RegulationS PhaseMitosisDown-RegulationReverse Transcriptase Polymerase Chain ReactionBase SequenceGene Expression ProfilingCyclinsCell DivisionPromoter Regions, GeneticTransfectionCells, CulturedMenstrual CycleG2 PhaseProtein BindingMice, TransgenicCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Tumor Markers, BiologicalRetinoblastoma ProteinMembrane ProteinsG2 Phase Cell Cycle CheckpointsCell MovementG0 PhaseCDC2 Protein KinaseG1 Phase Cell Cycle CheckpointsTumor Suppressor Protein p53Cyclin-Dependent Kinase 2Protein-Serine-Threonine KinasesCyclin D1PhosphorylationDNA ReplicationCyclin EGenes, cdcDNA DamageCyclin AInterphaseDNA-Binding ProteinsCyclin BFlow CytometryCyclin-Dependent Kinase 4Nuclear ProteinsTumor Suppressor ProteinsCDC2-CDC28 KinasesEstrous Cyclecdc25 PhosphatasesCell NucleusTranscription FactorsMutationTumor Cells, CulturedE2F Transcription FactorsHeLa CellsTime FactorsCyclin B1Saccharomyces cerevisiaeModels, BiologicalTranscription, GeneticCyclin DDNACell DifferentiationCitric Acid CycleCell SurvivalBromodeoxyuridineE2F1 Transcription FactorAmino Acid SequenceSaccharomyces cerevisiae ProteinsS Phase Cell Cycle CheckpointsProtein KinasesCyclin D3Cyclin-Dependent Kinase Inhibitor ProteinsFibroblastsAntineoplastic AgentsFungal ProteinsSchizosaccharomycesHistonesM Phase Cell Cycle CheckpointsProliferating Cell Nuclear AntigenMicrotubule-Associated ProteinsProto-Oncogene ProteinsHydroxyureaRNA, Small InterferingCyclin-Dependent Kinase Inhibitor p16Caulobacter crescentusCyclin-Dependent Kinase 6
ProgressionProteinsArrestProteinReduced cell proliferationCyclinCheckpointsDifferentiationInducesReplicationRegulationOrganismMitotic cell cyclePhenotypeMicroarrayPhosphorylationInduction of apoptosisPathwaysHematopoietic cellsRegulatorCarcinomasSquamous cell carcGenes involved in cellBiologyProliferativeMRNATranscriptionMechanismsSignificantlyPopulationsTumor suppressorMarkerCorrelatesCellular senescenceTransition2023Eukaryotic CellsPathwayCDK6TranscriptionalCarcinomaGenomicsBladder cancerPancreatic cancerImmuneMalignant CellsReceptorsPhasePathogenesisGrowthTissueIntracellularFunctionalStem cellsHuman
Progression17
  • We found that the total transcript level per cell and the expression of most individual genes correlated with progression through the cell cycle, but not with cell size. (frontiersin.org)
  • The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)
  • Seattle MCB faculty take various approaches to investigate how cells maintain proper cell cycle progression, chromosomal organization, DNA replication, transcription, DNA repair and chromosome segregation. (mcb-seattle.edu)
  • Covers principle molecular mechanisms responsible for tumor initiation and progression, with a specific emphasis on intracellular signaling, DNA repair, cell cycle checkpoints, and loss of normal tissue homeostasis. (mcb-seattle.edu)
  • It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium to exit quiescence are largely unknown. (biomedcentral.com)
  • Here, we ask whether the expression of HIV-1 genes in infected podocytes induces cyclin D 1 and phospho-pRb (Ser780) expression, hallmarks of cyclin D1-mediated G 1 → S phase progression. (biomedcentral.com)
  • In comparison to the two general alternative mechanisms utilized by known transforming viruses to promote cell-cycle progression, namely, by activating or bypassing endogenous D-type cyclins (herein, referred to as "cyclin D"), it has not been established whether HIV-1 gene products trigger either cyclin D-dependent or cyclin D-independent proliferation in non-lymphoid tissues [ 15 ]. (biomedcentral.com)
  • High expression of MRPL13 promotes cell cycle progression and proliferation of gastric cancer cells by inhibiting p53 signaling to affect long-term prognosis]. (bvsalud.org)
  • MRPL13 is highly expressed in gastric cancer and affects the long- term prognosis of the patients possibly by inhibiting p53 signaling to promote cancer cell proliferation and cell cycle progression. (bvsalud.org)
  • These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
  • Unpredictably, cell cycle progression, cell proliferation and DNA synthesis were unaffected fol lowing NDRG1 expression. (scirp.org)
  • However, the pathway downstream NDRG1, involving p21 and c8/18, regulating cell cycle progression and DNA synthesis is unfunctional. (scirp.org)
  • p53, mdm-2, p21, and mib-1 expression were not significantly associated with response to chemotherapy, time to progression, or overall survival in the whole patient population or in the docetaxel group. (lu.se)
  • Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. (bvsalud.org)
  • May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T cells. (lu.se)
  • [ 14 ] Subsequent work in our laboratory demonstrated that K17 serves as a nuclear shuttle of p27KIP1, resulting in sustained cell cycle progression. (medscape.com)
Proteins9
  • But it is not associated with cell cycle proteins. (biomedcentral.com)
  • The last model integrates then all the genes of the cell and takes into account their interactions in the productions of different proteins through a common sharing of RNA-polymerases and ribosomes, available in limited quantities. (hal.science)
  • A cells cycle is positively regulated promoting progress through the stages via the interaction of two classes of proteins found in the cytoplasm. (jove.com)
  • The mechanisms involve the proteins and DNA sequences inside cells. (wikipedia.org)
  • As these cells with limited functions are inefficient in performing body activities, they are programmed to self demolition under the presence of apoptotic signals, such as caspase proteins and Bcl-2 family regulation proteins. (wikipedia.org)
  • Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. (ox.ac.uk)
  • This volume the assembly of proteins necessary for nans is explained as a useful adjunct begins by discussing the cell wall mycelial growth. (cdc.gov)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)
Arrest16
  • Flow cytometric analysis revealed partial cell arrest in the G(1) phase at less than 5 micro L/mL and induction of apoptosis at 10 micro L/mL or more of ethanol and water extracts, with the latter exhibiting more pronounced inhibition than the former. (nih.gov)
  • It has also been demonstrated that TGF-β induced cell cycle arrest can be partially attributed to the regulatory effects of TGF-β on both the expression and activity of cyclin-dependent kinase inhibitors [CDKI] such as p21 and p27. (biomedcentral.com)
  • These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
  • Alternatively, activation of BMP signaling in HaCaT KC induces growth arrest, stimulates p27(Kip1) expression, and positively regulates p27(Kip1) promoter activity, thus further supporting a role of p27(Kip1) in mediating the effects of BMP signaling on HF size. (brad.ac.uk)
  • Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC). (pucv.cl)
  • In this study, we report that surface expression of CD26, through its associated DPPIV enzyme activity, enhanced sensitivity of Jurkat T-cell transfectants to G 2 -M arrest induced by the chemotherapeutic drug, doxorubicin. (elsevierpure.com)
  • In the present study, cell cycle analysis of HeLa cells treated with RuT7 showed S phase arrest and an increase in sub-G1 population. (ac.rs)
  • Fluorouracil induces apoptosis and cell cycle arrest in cancer cells. (ac.ir)
  • Fluorouracil induces S phase cell cycle arrest in AsPC-1 cells and reduced distribution in the G1 phase. (ac.ir)
  • Fluorouracil also caused cell cycle arrest in these cells by regulating the (p53, p21) genes. (ac.ir)
  • Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)
  • Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
  • Dmp1 is a unique tumor suppressor that activates Arf expression and thus induces p53-dependent cell cycle arrest. (eurekalert.org)
  • It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
  • We also assessed the effect of WSC on the expression of genes involved in cell cycle arrest and inflammation. (who.int)
  • However, WSC induced cell cycle arrest and cellular senescence mediated by the p53-p21 pathway. (who.int)
Protein28
  • p27 expression is reduced in pancreatic adenocarcinomas and decreased protein levels of p27 may play a role in the differentiation of pancreatic cancer. (biomedcentral.com)
  • The good understanding of gene expression requires therefore to resort to stochastic models that are able to characterise the different origins of protein production variability as well as the biological devices that potentially control it. (hal.science)
  • Yet, it has been suggested in the literature that the variations of these quantities during the cell cycle may participate to protein vari- ability. (hal.science)
  • In a model with a changing volume that follows the cell cycle, we integrate successively the protein production mechanism (transcription and translation), the random segregation of compounds at divi- sion, and the gene replication. (hal.science)
  • Therefore, in the present investigation the expression of protein within different tissue areas obtained from renal cell carcinomas, their invasion front and corresponding histologically benign renal parenchyma was determined and statistically correlated with several tumor and patient characteristics including the disease-specific long-term survival following surgical treatment. (uni-luebeck.de)
  • Moreover, the results of the present study supports the prognostic value of p27 Kip1 protein expression for patients diagnosed with renal cell carcinoma. (uni-luebeck.de)
  • Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
  • When this complex forms the CDK can phosphorylate a target protein which alters it's function and initiates the cell to advance to the next phase. (jove.com)
  • Positive regulators include two protein groups that allow cells to pass through regulatory checkpoints: cyclins and cyclin-dependent kinases (CDKs). (jove.com)
  • The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). (rcsb.org)
  • Bone morphogenetic protein signaling regulates size of hair follicles and modulates the expression of cell cycle-associated genes. (brad.ac.uk)
  • Protein expression of RPRM was evaluated in 20 tumor and non-tumor matched cases. (pucv.cl)
  • In clinical samples, RPRM gene protein expression was detected in 75% (15/20) of non-tumor adjacent mucosa, but only in 25% (5/20) of gastric tumor tissues (p = 0.001). (pucv.cl)
  • Loss of expression of RPRM gene protein product is associated with the invasive stage of GC. (pucv.cl)
  • Using flow cytofluorimetry sorting of populations of exponentially growing cells, coupled to a radioimmune assay, we have investigated the accumulation of p53 along the cell cycle in normal FR 3T3 rat cells as well as in two types of SV40-transformed derivatives, one of which only expresses the large-T protein during the G2 phase of the cell cycle. (crcm-marseille.fr)
  • HIV-1-infected podocytes showed markedly elevated cyclin D 1 mRNA and cyclin D 1 protein, the latter of which did not down-regulate during cell-cell contact or differentiation, suggesting post-transcriptional stabilization of cyclin D 1 protein levels by HIV-1. (biomedcentral.com)
  • To determine the expression of mitochondrial ribosomal protein L13 (MRPL13) in gastric cancer and its impact on long-term prognosis and explore the possible mechanism. (bvsalud.org)
  • One basic problem is how a decrease in tRNA levels, by downregulating Pol III efficiency, influences the expression pattern of protein-coding genes. (mdpi.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
  • LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
  • We recently discovered a new type of stress-responsive, protein-directed human RNA switch that regulates expression of vascular endothelial growth factor-A in human monocytic cells (Ray, PS, et al. (rochester.edu)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • Calcium-dependent signaling pathways and heat shock protein expression regulate dimorphism in Paracoccidioides brasiliensis and have broad implications for other pathogens. (cdc.gov)
  • Theories of drug development, including identification of genes for diagnostics, protein and drug interactions, models for 'knock-out' and 'knock-down' of genes, gene therapy, cancer and stem cell biology, as well as clinical assessment. (lu.se)
  • Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)
  • To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma todetermine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity. (bvsalud.org)
  • Malnutrition, both protein-energy mal- aimed to assess the use of CD95 expression nutrition (PEM) and micronutrient defi- as a marker for following up these patients ciencies, continues to be a major health during their nutritional rehabilitation and burden in developing countries. (who.int)
Reduced cell proliferation1
  • TYRO3 or AXL gene knockdown reduced cell proliferation/colony formation. (nature.com)
Cyclin11
  • Entry into the S phase in animal cells is regulated to a large extent by the cyclin E-CDK2 kinase complex. (news-medical.net)
  • We also aimed to evaluate the expression of TGF-β1 and p27 in the context of other cell cycle and proliferation markers such as cyclin D1 and Ki-67. (biomedcentral.com)
  • For instance, during G1, when one type of cyclin, named D, is synthesized and binds to a CDK, the cell transitions into S phase, as another cyclin, E, peaks and forms a complex with CDK to promote DNA replication. (jove.com)
  • Generally, levels of a given cyclin are low during most of the cell cycle but abruptly increase at the checkpoint they most contribute to (G 1 cyclins are an exception, as they are required throughout the cell cycle). (jove.com)
  • Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. (rcsb.org)
  • This was associated with disruption of cell cycle-related events, including hyperphosphorylation and inhibition of p34 cdc2 kinase activity, phosphorylation of cdc25C, and alteration in cyclin B1 expression. (elsevierpure.com)
  • We assessed cyclin D 1 and phospho-pRb (Ser780) expression in two well-characterized models of HIV-associated nephropathy pathogenesis: HIV-1 infection of cultured podocytes and HIV-1 transgenic mice (Tg26). (biomedcentral.com)
  • The selective suppression of HIV-1 transcription by the cyclin-dependent kinase inhibitor, flavopiridol, abrogated cyclin D 1 expression, underlying the requirement for HIV-1 encoded products to induce cyclin D 1 . (biomedcentral.com)
  • HIV-1 expression induces cyclin D 1 and phospho-pRb (Ser780) expression in infected podocytes, suggesting that HIV-1 activates cyclin D1-dependent cell-cycle mechanisms to promote proliferation of infected renal epithelium. (biomedcentral.com)
  • There was a statistically significant association between the expression of p27 and both cyclin D1 and the retinoblastoma gene product (pRb), corresponding to their close interactions in regulating the G1/S transition in the cell cycle. (ox.ac.uk)
  • When the combined expression of p27 and cyclin D1 was related to survival, patients with high levels of p27, regardless of their cyclin D1 status, did well, whilst those with low p27 had a poor outcome. (ox.ac.uk)
Checkpoints4
  • Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. (frontiersin.org)
  • Many more investigations have been made on cells, sorted according to size, or artificially arrested at various cell cycle checkpoints. (frontiersin.org)
  • Internal regulatory checkpoints ensure that a cell's size, energy reserves, and DNA quality and completeness are sufficient to advance through the cell cycle. (jove.com)
  • At these checkpoints, positive and negative regulators promote or inhibit a cell's continuation through the cell cycle. (jove.com)
Differentiation9
  • It has been reported that TGF-β influence different cell functions, including growth, proliferation and differentiation. (biomedcentral.com)
  • Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
  • This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
  • These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
  • T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
  • A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)
  • N. van Belzen, W. N. Dinjens, B. H. Eussen and F. T. Bosman, "Expression of Differentiation-Related Genes in Colorectal Cancer: Possible Implications for Prognosis," Histology and Histopathology, Vol. 13, No. 4, 1998, pp. 1233-1242. (scirp.org)
  • M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)
  • Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
Induces1
  • The results indicate that TCE induces changes in expression of certain important cell cycle regulation genes. (cdc.gov)
Replication6
Regulation3
  • Positive association between RPRM and p73 expression suggest that other members of the p53 gene family may participate in the regulation of RPRM expression. (pucv.cl)
  • Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
  • Acts upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. (nih.gov)
Organism1
  • The stoppage of exponential growth in cells also avoids cell growth diseases, such as tumours or cancer, from occurring in organism bodies. (wikipedia.org)
Mitotic cell cycle1
Phenotype4
  • In conclusion, we provide evidence that proinflammatory polarization of macrophages does not lead to enhanced procoagulatory function, whereas alternative polarization of macrophages leads to an increased expression of TF and increased production of TF bearing extracellular vesicles by these cells suggesting a procoagulatory phenotype of alternatively polarized macrophages. (haematologica.org)
  • 4 Upon polarization, macrophages react to the respective stimulus with the expression of a distinct phenotype. (haematologica.org)
  • During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
Microarray7
  • Microarray gene expression performed in 251 sarcomas revealed significantly higher expression of TYRO3 and GAS6 in LMS than other sarcomas. (nature.com)
  • Microarray and real-time PCR analyses of the laser-captured hair matrix cells show a strong decrease in expression of Cdk inhibitor p27(Kip1) and increased expression of selected cyclins in TG vs. WT mice. (brad.ac.uk)
  • microarray gene expression analysis was performed. (ac.rs)
  • This is the peer-reviewed version of the article: Jovanovic KK, Tanic M, Ivanovic I, Gligorijević N, Dojčinović B, Radulovic S. Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand. (ac.rs)
  • To gain further insight in the molecular mechanism of action of RuT7 on HeLa cells, a whole-transcriptome microarray gene expression analysis was performed. (ac.rs)
  • Gene expression patterns in normal human liver cells exposed to tetrachloroethylene using microarray analysis. (cdc.gov)
  • In this study, we have investigated TCE exposure and global gene expression pattern in normal human liver cells using microarray analysis. (cdc.gov)
Phosphorylation2
Induction of apoptosis1
  • I'm-Yunity acts selectively in HL-60 leukemic cells, resulting in cell cycle restriction through the G(1)/S checkpoint and the induction of apoptosis. (nih.gov)
Pathways8
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Cell cycle and apoptosis are key pathways of multicellular homeostasis and deregulation of these pathways is associated with cancerogenesis. (oncotarget.com)
  • Intracellular signaling pathways leading from cell membrane receptors to nucleus. (mcb-seattle.edu)
  • Analysis of functional categories and signaling and biochemical pathways associated with the response of HeLa cells to treatment with RuT7 showed that it leads the cells through the intrinsic (mitochondrial) apoptotic pathway, via indirect DNA damage due to the action of reactive oxygen species, and through direct DNA binding of RuT7. (ac.rs)
  • These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement. (biomedcentral.com)
  • In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
  • Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
  • Pathways associated with cell cycle and proliferation were markedly upregulated in muscle-invasive and grade 3 cancers. (urotoday.com)
Hematopoietic cells1
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
Regulator3
  • Transforming growth factor-β [TGF-β] is such an example, being a growth stimulator in fibroblastic cells with TGF-β receptors, but a negative regulator in epithelial cells. (biomedcentral.com)
  • Background: The expression of the negative cell cycle regulator p27 Kip1 is frequently found to be deregulated in various human cancer types. (uni-luebeck.de)
  • Also our study indicated that WSC induced an increase in the transcriptional expression of matrix metalloproteinases, MMP-2 and MMP-9 and an immune response regulator, Toll Like Receptor-4. (who.int)
Carcinomas7
  • In contrast, CCNE1 and CDK6 showed elevated expression in carcinoids compared to carcinomas. (oncotarget.com)
  • Conclusion: Our analysis demonstrated that p27 Kip1 is heterogeneously expressed in renal cell carcinomas. (uni-luebeck.de)
  • We have demonstrated that the hDMP1 gene is hemizygously deleted in a significant percentage of mouse and human non-small-cell lung carcinomas, especially those which retained the intact Arf-p53 pathway," explains Dr. Inoue. (eurekalert.org)
  • Translocation-associated renal cell carcinomas (RCCs) arise from the proximal tubule epithelium, similar to conventional clear cell and papillary RCCs. (medscape.com)
  • Xp11.2 translocation-associated renal cell carcinomas are generally cortical or subcapsular, well-circumscribed lesions with yellow-tan, variegated cut surfaces. (medscape.com)
  • Xp11.2 translocation-associated renal cell carcinomas (RCCs) may have well-developed papillae, mimicking papillary RCCs. (medscape.com)
  • The nests of tumor cells in Xp11.2 translocation-associated renal cell carcinomas may become centrally discohesive, giving rise to a pseudoalveolar growth pattern. (medscape.com)
Squamous cell carc11
  • Two contiguous sections from 30 tissue specimens (10 each from oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma) were subjected to hematoxylin and eosin (H/E) staining for histopathological diagnosis and immunohistochemical (IHC) staining for demonstration of p53. (bvsalud.org)
  • Higher p53 positive cell counts were demonstrated in oral squamous cell carcinoma compared to hyperplastic and dysplastic tissues. (bvsalud.org)
  • However the quantitative analysis of p53 positive cells and their localization in oral epithelium is of importance as a marker for oral squamous cell carcinoma. (bvsalud.org)
  • Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases. (bvsalud.org)
  • early event of malignant transformation and has a predictive value for developing oral squamous cell carcinoma. (bvsalud.org)
  • preneoplastic oral lesion and oral squamous cell carcinoma. (bvsalud.org)
  • 9. Iamaroon A, Khemaleelakul U, Pongsiriwet S, Pintong J. Co-expression of p53 and Ki67 and lack of EBV expression in oral squamous cell carcinoma. (bvsalud.org)
  • Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki67. (bvsalud.org)
  • Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). (medscape.com)
  • Cervical cancer has multiple histologic subtypes, with squamous cell carcinoma (SCC) accounting for approximately 75% of cases and invasive adenocarcinoma accounting for 10% to 15% of cases. (medscape.com)
  • [ 11-13 ] By contrast, we discovered, using laser capture microdissection and mass spectrometry, that keratin 17 (K17) could predict the overall survival of patients with cervical squamous cell carcinoma more accurately than grade, stage, or any other clinicopathologic features. (medscape.com)
Genes involved in cell1
Biology5
  • They also provide a listing of suggested courses for those interested in Gene Expression, Cell Cycle & Chromosome Biology. (mcb-seattle.edu)
  • introductory biochemistry and cell biology. (mcb-seattle.edu)
  • Assembly of gamma-tubulin ring complexes: implications for cell biology and disease. (nih.gov)
  • He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
  • Group Leader at Department of Cell and Regenerative Biology at the University of Wisconsin-Madison, School of Medicine and Public Health, USA. (igbmc.fr)
Proliferative2
  • Here, we employed single-cell gene expression profiling to describe the dynamic transition between cell proliferative states in three different cell lines using a panel consisting of 93 marker genes. (frontiersin.org)
  • We have shown that in clinical material p27 expression is associated with proliferative activity and while univariate analysis shows it to be a significant indicator of prognosis, this significance is lost in multivariate analysis when traditional prognostic factors are included in the model. (ox.ac.uk)
MRNA3
  • Materials and Methods: Sixty representative FFPE-specimens (16 TC, 13 AC, 16 LCNEC and 15 SCLC) were used for mRNA expression analysis using the NanoString technique. (oncotarget.com)
  • In this study, we examined the expressions of p33ING1, p14ARF, MDM2 and p21WAF1 mRNA in 25 advanced colorectal cancers by quantitative RT-PCR method, and compared the expression levels of p33ING1, p14ARF, p21WAF1 and MDM2 in relation to p53 status in the tumors. (nih.gov)
  • We also identified a novel mRNA processing mechanism that expands human proteome at the posttranscriptional level and regulates gene expression (Yao, P, et al. (rochester.edu)
Transcription8
  • Therefore, NPAT could be the link between cell cycle machinery and shared heightened transcription of histone genes during S phase. (news-medical.net)
  • pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
  • p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • The programmes governing the function and fate of cells are to a large extent driven by the coordinated activity of transcription factors forming complex and dynamic gene regulatory networks (GRNs). (lu.se)
  • Such heterogeneity could originate from extrinsic factors, such as cell-to-cell signalling and surrounding temperature and pressure, but also from the intrinsic noise generated by having few copies of molecules involved in transcription and translation. (lu.se)
  • p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. (lu.se)
  • Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)
  • We used a decay rate model to fit the temporal transcription profiles of regenerating HSCs and identified genes with progressively decreased or increased expression after transplantation. (lu.se)
Mechanisms6
  • Certain mechanisms are present to prevent cells from indefinite division, which is mostly done by programmed failure in DNA synthesis. (wikipedia.org)
  • Yet, the mechanisms are largely unknown whereby HIV-1 subverts the cell-cycle controls that normally maintain renal epithelial in G 0 . (biomedcentral.com)
  • During his post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic, he made contributions in understanding the translational control mechanisms regulating VEGFA (vascular endothelial growth factor-A) expression in human monocytes. (rochester.edu)
  • The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
  • This averaging effect hampered the analysis of finer regulatory mechanisms at the single-cell level, the fundamental unit for any fate decision process. (lu.se)
  • One of the major mechanisms that cells use to fix DNA is known as nucleotide excision repair (NER). (medlineplus.gov)
Significantly7
  • Between SCLC and LCNEC CDK2 , CDKN1B , CDKN2A and PNN expression was significantly different with higher expression in SCLC. (oncotarget.com)
  • Leiomyosarcoma patients with high expression of GAS6 or PROS1 present a significantly worse PFS. (nature.com)
  • Results: In univariate survival analysis, decreased expression of p27 Kip1 within tissue cores obtained from the invasion front was significantly correlated with the patients' disease-specific long-term survival (p=0.02, log rank test). (uni-luebeck.de)
  • Primary epidermal keratinocytes (KC) from TG mice exhibit significantly increased proliferation and decreased p27(Kip1) expression, compared with WT KC. (brad.ac.uk)
  • Furthermore, we established a BCa cell model with downregulated LAPTM5, revealing a significantly delayed growth rate in the BCa cells with knockdown of LAPTM5. (spandidos-publications.com)
  • CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)
  • High levels of K17 expression were significantly associated with decreased patient survival. (medscape.com)
Populations5
  • Most studies have been performed on large cell populations, but detailed understanding of cell dynamics and heterogeneity requires single-cell analysis. (frontiersin.org)
  • However, most of our knowledge about cell proliferation comes from studies that average data from large and mixed cell populations. (frontiersin.org)
  • While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
Tumor suppressor1
  • The aim of this study was to evaluate the epigenetic silencing of RPRM gene by promoter methylation and its tumor suppressor function in GC cell lines. (pucv.cl)
Marker1
  • Whether the expression of p27 Kip1 can be used as a prognostic marker for renal cell cancer patients still remains to be clarified. (uni-luebeck.de)
Correlates1
  • PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types. (bvsalud.org)
Cellular senescence1
  • At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
Transition2
20231
  • Cell Death Dis, 2023 Feb 10. (nih.gov)
Eukaryotic Cells1
  • This is to prevent the stopping of cell division in eukaryotic organisms, or even withdrawing from the basic reproduction procedures of eukaryotic cells. (wikipedia.org)
Pathway3
  • Growth factors do not only stimulate cell proliferation, but they may also act as growth inhibitors, depending on the cell type and the stimulatory pathway that is involved. (biomedcentral.com)
  • the effect of Fluorouracil on different stages of the cell cycle and the expression of genes involved in the internal pathway of apoptosis in the AsPC-1 cell line (human pancreatic cancer) were investigated. (ac.ir)
  • The Real-time PCR results in treated cells showed an increase in the expression of genes in the mitochondrial apoptotic pathway as well as genes effective in regulating the cell cycle. (ac.ir)
CDK61
  • Palbociclib instead primarily targeted monomeric CDK4 and CDK6 (CDK4/6) in breast tumor cells. (rcsb.org)
Transcriptional1
Carcinoma5
  • Our findings suggest that in pancreatic carcinoma, TGF-β1 expression is related to tumor growth and metastasis. (biomedcentral.com)
  • The interest in p27 expression in mammary carcinoma lies in its behaviour when examined in combination with other G1 cell cycle regulators. (ox.ac.uk)
  • Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
  • In Xp11.2 translocation-associated renal cell carcinoma (RCC), cells typically have voluminous cytoplasm, which can range from eosinophilic and granular to clear. (medscape.com)
  • In Xp11.2 translocation-associated renal cell carcinoma, tumor cells with abundant eosinophilic cytoplasm and high nuclear grade are often arranged in large nests with a delicate, intervening vascular stroma. (medscape.com)
Genomics1
  • Finally, in a return to the mycology moves into the genomics yeast growth and another, with a heat original cell wall theme, the fine era. (cdc.gov)
Bladder cancer2
  • Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity. (rochester.edu)
  • The present study contributes to a growing body of work on gene expression signatures in bladder cancer. (urotoday.com)
Pancreatic cancer2
  • Recent studies denoted that alterations in growth factors and growth factor receptors seem to influence the biologic behaviour of pancreatic cancer cells [ 2 ]. (biomedcentral.com)
  • Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer. (rochester.edu)
Immune3
  • It can influence cancer growth in various ways, such as by stimulating angiogenesis, suppressing cancer-directed immune functions, increasing the expression of adhesion molecules and extracellular matrix components [ 9 ]. (biomedcentral.com)
  • Poor glycaemic control is associated with altered blood gene expression levels of cell cycle and immune related genes. (amsterdamumc.org)
  • Macrophages are cells of the innate immune system which play numerous and vastly different functions within the body. (haematologica.org)
Malignant Cells1
  • In adenocarcinomas, K17 staining was detected in a mean of 33.9% of malignant cells. (medscape.com)
Receptors1
  • 7 In contrast, alternatively activated macrophages are characterized by increased expression of IL-10 and of scavenger receptors. (haematologica.org)
Phase6
Pathogenesis4
  • Nonetheless, several observations from in vitro and in vivo models of HIVAN pathogenesis suggest that HIV-1 expression itself may be a key pathogenic factor. (biomedcentral.com)
  • This volume begins by discussing the cell wall which, besides its roles in pathogenesis, is now a practical drug target. (cdc.gov)
  • The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
  • bioethanol, pathogenesis and expression of human hormones. (lu.se)
Growth11
  • Such data are only indirectly related to quantitative changes in cells at different states of division and growth. (frontiersin.org)
  • HL-60 cells incubated with various amounts (1, 3, 5, 7.5, and 10 micro l/mL) of the extracts for 1-3 days showed dose-dependent, time-dependent growth suppression and decrease in cell viability. (nih.gov)
  • Thus, the secretion of gall wasps stimulates plant cell growth and overrules homeostasis of the affected leaf area - this is similar to tumour outgrowth. (nature.com)
  • In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control. (nature.com)
  • The process also enables cells to proceed to senescence, which are further stages of cell life and growth. (wikipedia.org)
  • This is to ensure that these cells continue dividing for body growth or reproduction. (wikipedia.org)
  • We further assessed the effects of MRPL13 overexpression and knockdown on proliferation and cell cycle of gastric cancer MGC-803 and SGC-7901 cells in vitro and on subcutaneous xenograft growth in nude mice . (bvsalud.org)
  • Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
  • Importantly, Dmp1 overexpression inhibited growth of human lung cancer cells with K-ras mutation and wild-type Arf and p53. (eurekalert.org)
  • At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
  • When UV rays damage genes that control cell growth and division, cells can grow too fast and in an uncontrolled way. (medlineplus.gov)
Tissue8
  • Patients and Methods: For analysis of p27 Kip1 expression in 420 tumor nephrectomy specimens obtained from 420 consecutively included patients, tissue microarrays were used comprising 1260 tissue samples each obtained from the tumor itself, the invasive front as well as the non-malignant surrounding parenchyma. (uni-luebeck.de)
  • 0.01) as well as decreased expression of p27 Kip1 (p=0.04) within the invasion front tissue samples independently predicted the disease-specific long-term survival following surgery. (uni-luebeck.de)
  • Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. (haematologica.org)
  • In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
  • 6 In addition, these cells are present during early wound healing and proinflammatory macrophages are characterized by a pronounced ability to degrade tissue. (haematologica.org)
  • Long ncRNA expression associates with tissue-specific enhancers. (mpg.de)
  • In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
Intracellular3
  • Analysis of the intracellular accumulation of ruthenium showed 8.9 ng Ru/10(6) cells after 6 h of incubation. (ac.rs)
  • 5 Functionally, proinflammatory polarization leads to potent effector cells that kill intracellular micro-organisms and tumor cells. (haematologica.org)
  • Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)
Functional1
  • CD26, a M r 110,000 surface-bound ectopeptidase with dipeptidyl peptidase IV (DPPIV) activity, has an array of diverse functional properties, with a role in T-cell physiology and the development of certain human cancers. (elsevierpure.com)
Stem cells4
  • In some cells, such as germ cells, stem cells and white blood cells, the withdrawal process do not occur. (wikipedia.org)
  • Stem cells are characterized by their ability to undergo self-renewal to maintain stem cell reserves, and, when required, to produce new, terminally differentiated cells. (karger.com)
  • During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)
  • Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. (lu.se)
Human5
  • Different volumes of 70% ethanol and water extracts of I'm-Yunity were incubated with cultures of human promyelocytic leukemic HL-60 cells, and compared to nontreated control cells. (nih.gov)
  • Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
  • In addition, we demonstrate that the addition of exogenous soluble DPPIV enhanced sensitivity of lymphoid tumor cell lines to doxorubicin, suggesting a potentially useful clinical role for CD26/DPPIV in the treatment of selected human hematological malignancies. (elsevierpure.com)
  • Furthermore, human cDNA of NDRG1 from normal placenta was cloned into a eukaryotic expression vector and transfected into the three cancer cell lines. (scirp.org)
  • Daneshpajooh M, Bacos K, Bysani M, Bagge A, Ottosson Laakso E, Vikman P, Eliasson L, Mulder H, Ling C. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. (lu.se)