Ovary to induce cancer. Medical search. Frequent questions

Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there is little consensus regarding its aetiology. (nature.com)
Polycystic ovary syndrome (PCOS) is a common reproductive disorder in women that is defined by two out of three criteria: (1) menstrual irregularity (oligo-ovulation or anovulation), (2) hyperandrogenism (clinical or biochemical) and (3) polycystic ovarian morphology 1 , 2 . (nature.com)
The drug letrozole is more effective than standard therapy in increasing live births for women with polycystic ovary syndrome. (nih.gov)
Polycystic ovary syndrome (PCOS) is a leading cause of female infertility. (nih.gov)
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. (nih.gov)
Polycystic ovary syndrome is one of the most common endocrine and metabolic gynecological disorders, of which dysfunction of ovarian granulosa cells is a key contributing factor. (nih.gov)
Polycystic ovary syndrome is a complex disorder that some women develop during their childbearing years. (centrastate.com)
An internal (transvaginal) ultrasound will enable your doctor to look at the follicles on your ovaries to determine if they are increased in number and therefore appear polycystic. (centrastate.com)
The effects of asafoetida on ovarian tissue, expression of certain genes associated with polycystic ovary syndrome (PCOS), and levels of liver, kidney, and blood cell factors after treatment in a rat model were investigated. (ecerm.org)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women that has adverse effects on childbearing. (ecerm.org)
In polycystic ovary syndrome (PCOS), the ovaries may not release an egg regularly or they may not release a healthy egg. (medlineplus.gov)
Protective effect of wuzibushen recipe on follicular development via regulating androgen receptor in polycystic ovary syndrome model rats. (amedeo.com)
Diagnostic value of anti-Mullerian hormone combined with androgen-levels in Chinese patients with polycystic ovary syndrome. (amedeo.com)
Correlation between kisspeptin and biochemical markers in obese and non-obese women with polycystic ovary syndrome. (amedeo.com)
Correlation between different endometrial preparation protocols and pregnancy outcome of frozen embryo transfer in patients with polycystic ovary syndrome: a retrospective study. (amedeo.com)
Some groups of patients, such as women with PCOS - polycystic ovary syndrome, do not respond well to clomiphene citrate. (ivf1.com)
The Pregnancy in Polycystic Ovary Syndrome (PPCOS I) study found that over 6 months time, 1 in 4 PCOS patients never had a single documented ovulation. (ivf1.com)
Learn about using metformin for the management of polycystic ovary syndrome (PCOS) after a hysterectomy. (s7ost.de)
Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects women of reproductive age. (s7ost.de)
Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases that affects 5%-10% of women of childbearing age. (jrpsjournal.com)
Polycystic ovary syndrome (PCOS) is an endocrine disease that affects 5%-10% of women of childbearing age. (jrpsjournal.com)
Physical activity may also have some benefit for women with obesity and polycystic ovary syndrome (PCOS), explains a review featured in the International Journal of Endocrinology in July 2012. (livestrong.com)

It could also open new avenues for the treatment of menopause-induced health issues. (mirror.co.uk)
Menopause happens when the ovaries no longer release an egg every month and menstruation stops. (webmd.com)
This phase usually begins several years before menopause, when your ovaries slowly make less estrogen . (webmd.com)
Perimenopause lasts until menopause, the point at which your ovaries stop releasing eggs. (webmd.com)
Induced menopause. (webmd.com)
Surgical menopause is triggered by having both ovaries removed during an operation. (medbroadcast.com)
Chemotherapy-induced menopause is brought on by chemotherapy, usually in the course of being treated for cancer. (medbroadcast.com)
These drugs can affect the ovaries enough to begin the process but, depending on different factors, chemotherapy-induced menopause isn't always complete or permanent. (medbroadcast.com)
Radiation-induced menopause can happen while undergoing radiotherapy for cancer. (medbroadcast.com)
Hormone suppressive therapy induced menopause occurs when certain medications stop the ovaries from releasing eggs. (medbroadcast.com)
You've probably heard a lot about hormone replacement therapy (HRT), which may be used to treat the symptoms of menopause and, in some cases, to protect against osteoporosis and colorectal cancer. (medbroadcast.com)
Mice rendered follicle-depleted through treatment with 4-vinylcyclohexene diepoxide (VCD) are a model of ovary-intact menopause. (nih.gov)
I had a lower oncotype test result (under 20), but because I am premenopausal (and am ER/PR+/ HER2-) and had one positive node, it's being recommended I get lupron injections to shut ovaries down (an abruptly induced menopause with its own health implications and side effects) and go on hormone pills (I guess Tamoxifen? (cancer.org)
If you haven't gone through menopause, surgery to remove your ovaries will trigger surgically induced menopause because the body will no longer produce sufficient amounts of estrogen. (cancercenter.com)
The changes associated with menopause occur when the ovaries stop maturing eggs and secreting oestrogen and progesterone. (hsj.co.uk)
There are also a number of women that will experience a clinically induced and/or early menopause as a result of conditions such as cancer and interventions such as hysterectomy. (hsj.co.uk)
In primary ovarian insufficiency , the ovaries stop functioning before natural menopause. (medlineplus.gov)
Not beneficial for premenopausal women because the ovaries are the primary site of estrogen biosynthesis prior to menopause. (standardofcare.com)
Estrogen can raise the risk of ER-positive breast cancer, even before menopause. (hormonely.com)
There are some factors that can induce menopause. (drbinhtly.com.au)
This can lead to a condition known as chemotherapy-induced menopause or premature ovarian insufficiency. (goodnesscare.com)
When estrogen levels drop, it can induce menopause, even in women not of typical menopausal age. (goodnesscare.com)
Menopause, whether natural or induced, often leads to vaginal dryness. (goodnesscare.com)
In what is called natural menopause, symptoms start during the transitional stage when a woman's ovaries are making less and less estrogen and progesterone. (pinklotus.com)
This type of menopause is called induced and is a result of a medical procedure, such as a total hysterectomy with removal of both ovaries (called a bilateral salpingo-oophorectomy) or damage to the ovaries by drugs (e.g. chemotherapy) or radiation therapy, or from taking a medication that inhibits the effect of estrogen in your body, such as tamoxifen. (pinklotus.com)
Surgically-induced menopause due to the removal of your ovaries is permanent and immediate. (pinklotus.com)
For women undergoing chemotherapy treatment, induced menopause can be somewhat more gradual and either temporary or permanent, depending if the ovaries can recover from chemotherapy's likely cell damage. (pinklotus.com)
This means that the age for induced menopause can occur at any time after puberty. (pinklotus.com)

For example, each ovulation induces a surface trauma in the ovary. (medscape.com)
It works by blocking estrogen action, which stimulates hormones that induce ovulation. (nih.gov)
Their ovaries also make the hormones estrogen and progesterone , which control their period ( menstruation ) and the release of eggs ( ovulation ). (webmd.com)
Even if you're using a birth control method that stops ovulation , it doesn't stop your loss of follicles -- the constant process of your ovary taking them from your resting pool of eggs. (webmd.com)
If you still are having trouble conceiving, many women are able to using medications to induce ovulation or to treat ovulation disorders. (centrastate.com)
Functional Cysts - Each month, prior to ovulation, a woman's ovaries will develop the eggs destined for release inside small fluid-filled sacs called functional cysts. (womens-health.co.uk)
If you are taking ovulation-inducing drugs, such as Clomid or Serophene, this can increase the risk of developing a corpus luteum cyst. (womens-health.co.uk)
Gonadotropin therapy or the use of pulsatile gonadotropin-releasing hormone (GnRH) therapy may be required to induce ovulation in patients with infertility whose underlying pathology cannot be reversed. (medscape.com)
The gonadotropins are very efficient at inducing ovulation and have higher pregnancy rates than clomiphene citrate. (ivf1.com)
These hormones, FSH and LH, can cause the development of ovulation in women who are anovulatory or increase the number of eggs developing in the ovaries of women who already ovulate. (ivf1.com)

Women with PCOS have unusually high levels of male hormones, infrequent or irregular menstruation cycles, and oftentimes enlarged ovaries packed with fluid-filled cysts. (nih.gov)
Women with PCOS have an increased risk of developing diabetes, cardiovascular disease, high blood pressure, high cholesterol, and endometrial cancer. (centrastate.com)
You have to have cysts on your ovaries to have PCOS. (centrastate.com)
PCOS was induced by letrozole at a dose of 1 mg/kg administered orally for 3 weeks. (ecerm.org)
In animal models, letrozole is used to induce PCOS, and follicular atresia and abnormal follicular development have been observed in these models [ 4 ]. (ecerm.org)
The effects of B. dioica (30 and 60 mg/kg) root methanolic extract on PCOS-induced was evaluated after 28-day treatment. (jrpsjournal.com)

The former induces irreversible genetic alterations (tumor initiation), whereas the latter promotes tumor development by favoring the clone outgrowth of the genetically altered cells (tumor promotion) through activating cell survival and proliferation signal pathways and altering the machineries controlling cell proliferation and apoptosis. (nih.gov)
Ascorbate andα-tocopherol prevent apoptosis induced by serum removal independent of Bcl-2. (ac.ir)
Studies on DNA damage and apoptosis in rat brain induced by fluoride. (ac.ir)
We investigated the effect of tanshinone I on the induction of apoptosis in human breast cancer cells (MCF-7 and MDA-MB-231) in vitro. (spandidos-publications.com)
In addition, TUNEL assay and flow cytometry showed that tanshinone I significantly induced apoptosis in MCF-7 and MDA-MB-231 cells. (spandidos-publications.com)
In vitro assay also demonstrated that ADSC markedly attenuated CTX-induced senescence and apoptosis of granulosa cell. (biomedcentral.com)
Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family. (thermofisher.com)

Ovarian cancer develops in the ovaries, the female reproductive organs that store eggs and produce hormones. (cancercenter.com)
Work by preventing the conversion of male hormones to estrogen and on therefore suitable only for women whose ovaries are no longer producing estrogen. (standardofcare.com)
Several years ago, the Endogenous Hormones and Breast Cancer Collaborative Group set out to re-evaluate and re-analyze individual data from seven studies. (hormonely.com)
They looked for an association between hormones and breast cancer in younger women. (hormonely.com)
The production of the hormones by your ovaries to regulate your menstrual cycle, namely oestrogen and progesterone, start to decrease. (drbinhtly.com.au)
Autoimmune diseases or genetic factors can cause your ovaries to produce less than normal amounts of reproductive hormones. (drbinhtly.com.au)
In both cases, the result is that the pituitary gland produces more of the hormones needed to stimulate the ovaries. (ivf1.com)
While they effectively kill cancer cells, they can also affect normal cells, including those in the ovaries that produce hormones such as estrogen. (goodnesscare.com)
It is characterized by enlarged ovaries with small cysts, irregular menstrual cycles, and high levels of male hormones. (s7ost.de)
It is characterized by irregular menstrual periods, high levels of androgens (male hormones), and cysts in the ovaries. (s7ost.de)
Estrogen and other hormones can be naturally balanced by physical activity, reducing the risk of breast cancer and other diseases. (livestrong.com)
These sex hormones are produced by the ovaries, adrenal glands and fat cells. (livestrong.com)

Within days the number of follicles in the ovaries rose sharply, meaning more chances of eggs being released. (mirror.co.uk)
Women are born with all of their eggs , which are stored in their ovaries. (webmd.com)
Your ovaries have stopped releasing eggs and making most of their estrogen. (webmd.com)
When your ovaries prematurely stop releasing eggs, for unknown reasons, your levels of estrogen and progesterone change. (webmd.com)
The ovaries gradually stop releasing follicles (eggs), eventually ending your reproductive stage of life. (medbroadcast.com)
The ovaries no longer release eggs. (hormonely.com)
Eventually, your ovaries will stop producing eggs. (drbinhtly.com.au)
At this time, your ovaries no longer make eggs and your estrogen and progesterone levels are plummeting, signaling the end of your reproductive years. (pinklotus.com)

Chemotherapy drugs, particularly alkylating agents such as cyclophosphamide , can cause damage to the ovaries, leading to a decrease or cessation of estrogen production. (goodnesscare.com)

Traditional spay surgery (ovariohysterectomy) involves removal of the uterus and both ovaries. (dogster.com)
Surgeries such as total hysterectomy and bilateral oophorectomy that involve the removal of your uterus and both ovaries will immediately stop menstruation. (drbinhtly.com.au)

However, the development of certain types cysts have been linked to some cancers, so it's best to see your doctor if you're experiencing the symptoms of ovarian cysts. (womens-health.co.uk)
Ovarian cysts are fluid-filled sacs that develop on one or both ovaries. (cancercenter.com)
Post-menopausal women with ovarian cysts have a higher risk of cancer. (cancercenter.com)
In the ovaries, hormone imbalance promotes the formation of functional cysts. (medscape.com)

Cases were women between the ages of 30 and 84 years with the first diagnosis of epithelial ovarian cancer or borderline ovarian tumors. (medscape.com)
As FSH/FSHR has been implicated in distinct hormone-dependent cancers, including endometrial cancer, analysis of the cancer genome database from 575 human endometrial adenocarcinoma tumors revealed that a subpopulation of samples expressed FSHR. (frontiersin.org)
7,12-dimethylbenz[a]anthracene induces sertoli-leydig-cell tumors in the follicle-depleted ovaries of mice treated with 4-vinylcyclohexene diepoxide. (nih.gov)
Butadiene induced dose related increases in the incidence of lymphoma, heart hemangiosarcomas, and lung, liver, forestomach, and Harderian tumors in both male and female mice. (cdc.gov)
Female mice also had dose related increases in the incidence of mammary and ovary tumors. (cdc.gov)
The authors conclude that when based on the most sensitive site (the female mouse lung) the excess risk for cancer resulting from lifetime occupational exposure to 2ppm butadiene would be approximately 600 tumors/10,000. (cdc.gov)
A Golden Retriever study demonstrated that a dog's age at the time of neutering influenced the incidence of two orthopedic issues - hip dysplasia and cruciate ligament disease - and three forms of cancer: lymphosarcoma, hemangiosarcoma, and mast cell tumors. (dogster.com)
Hormonally Induced Reproductive Tumors: Relevance of Rodent. (nih.gov)

9. Luteinizing hormone-induced RUNX1 regulates the expression of genes in granulosa cells of rat periovulatory follicles. (nih.gov)
The term actually refers to an increased number of follicles in the ovaries that appear as fluid filled sacs during an ultrasound. (centrastate.com)

Gynecologic oncologists are trained and experienced in treating cancers of the female reproductive system. (cancercenter.com)

However, surgically removing the ovaries or testes may have unexpected consequences. (pwdfoundation.org)
Can give premenopausal women the benefit of aromatase inhibitors by causing them to become postmenopausal through the use of luteinizing homeone-releasing hormone suppressing ovarian function or surgically removing the ovaries. (standardofcare.com)

The aim of the present study was to explore the role of ferrostatin‑1 (Fer‑1), a ferroptosis inhibitor, in a cell injury model established by homocysteine (Hcy)‑induced ovarian granulosa KGN cell line and the potential underlying mechanism. (nih.gov)
In females, FSH-mediated activation of its receptor expressed in ovarian granulosa cells, induces steroidogenesis and stimulates growth of the follicle. (frontiersin.org)
6. Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary. (nih.gov)
8. Role of activin C in normal ovaries and granulosa cell tumours of mice and humans. (nih.gov)
15. The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers. (nih.gov)
18. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis. (nih.gov)
To evaluate the effects of ADSC on granulosa cells in vitro, CTX-induced senescent KGN cells were co-cultured with ADSCs, and senescent-related marker expression was investigated by immunofluorescent staining. (biomedcentral.com)

About 65% of estrogen-receptor positive breast cancers are also progesterone-receptor positive (PR-positive). (hormonely.com)
About 10-20% of breast cancers are triple-negative and don't need estrogen or progesterone to grow. (hormonely.com)
Nevertheless, the progesterone-only treatment dydrogesterone (Duphaston) taken on 10 days per month is recommended for women with cycle irregularities to reduce to the risk of endometrial cancer , which is related to high estrogen levels, reported Sandrine Pérol, MD, a gynecologist at Cochin Hospital in Paris, at the most recent French national general medicine conference. (medscape.com)
Since periods of high estrogen levels are associated with low progesterone levels, they tend to cause endometrial hyperplasia, which is a major risk factor for endometrial cancer, said Pérol. (medscape.com)
The recommended treatment for cycle irregularities and reducing the risk for endometrial cancer is progesterone administered for 10 days per month, during the second half of the cycle, said Pérol. (medscape.com)

We used the soft agar assay to evaluate the cell transformation activity of arsenite exposure and the nude mice xenograft model to determine the tumorigenesis of arsenite-induced transformed cells. (nih.gov)
In a world first, human stem cells were injected into the ovaries of mice that had suffered ovarian failure from factors unrelated to cancer treatment. (mirror.co.uk)
The present study was designed to induce ovarian neoplasia in this model by treating mice with 7,12-dimethylbenz[a]anthracene (DMBA). (nih.gov)
Notably, our data indicated that the absence of the CB1/2 receptors in mice results in a dramatic resistance to UVB-induced inflammation and a marked decrease in UVB-induced skin carcinogenesis. (aacrjournals.org)
The excess cancer risk was expressed as a function of tumor site and derived from mice to humans based on body weights raised to the three fourths power. (cdc.gov)
This study aimed to investigate the immunomodulatory effect and the underlying mechanism of HWH in cyclophosphamide (CTX)-induced immunocompromised mice. (bvsalud.org)
BALB/c mice received CTX (80 mg/kg, intraperitoneally) once a day for 3 days to induce immunodeficiency, and then they received the oral administration of HWH (80 or 240 mg/kg) or levamisole hydrochloride (LH, 40 mg/kg, positive control), respectively, once a day for 7 days. (bvsalud.org)
HWH attenuated the immune organ damage induced by CTX, increased the secretions of interleukin (IL)-6, IL-1ß, and tumor necrosis factor (TNF)-α, and promoted the recovery of goblet cells and the production of TJs (claudin-1, occludin, and ZO-1) in the colon of the immunocompromised mice. (bvsalud.org)
Our laboratory had been studying materials such as paraffin oils and solid plastics that induce the formation of plasmacytomas (PCTs) in genetically susceptible strains of mice, and the FDA moratorium rekindled our interest in exploring silicone as another possible plasmacytomagenic material. (nih.gov)
Our studies now show that injection of silicone gel into the peritonium of Balb/c mice induces plasmacytoma formation. (nih.gov)
The silicone gels have not yet produced PCTs in other strains of mice, nor have they induced PCTs when injected subcutaneously in BALB/c mice. (nih.gov)
The peritoneal connective tissues appear to be a required site for pristane- and silicone-induced PCT development in mice. (nih.gov)

Results of recent studies in animals indicate an increased incidence of laryngeal cancer in hamsters and nasal cancer in rats following exposure to acetaldehyde. (cdc.gov)
Long-term inhalation studies of acetaldehyde produced laryngeal cancers in hamsters and nasal cancers in rats. (cdc.gov)
In histologic assay, metformin and B. dioica restricted the effects of testosterone in the ovaries of rats. (jrpsjournal.com)

The aim of the current study was to evaluate the impact of ADAM12 on cancer progression, prognosis, and therapeutic targets in colorectal cancer (CRC). (mdpi.com)
Bevacizumab has been used as a promising drug for metastatic colorectal cancer in combination with chemotherapeutic agents. (kjco.org)
The purpose of this study is to identify the clinical characteristics of intestinal perforation induced by bevacizumab in colorectal cancer patients. (kjco.org)
From January 2007 to June 2018, a total of 488 patients underwent chemotherapy with bevacizumab for metastatic colorectal cancer. (kjco.org)
Bevacizumab induced intestinal perforation is a lethal adverse effect in patients with colorectal cancers. (kjco.org)
It has shown promise as a clinical agent against metastatic colorectal cancer, and particularly in combination with chemotherapy [ 1 ]. (kjco.org)
In two phase 3 trials of bevacizumab in colorectal cancer, intestinal perforation was an uncommon adverse event occurring at rates of only 1.5% and 1.1%, though serious and lethal. (kjco.org)
From January 2007 to June 2018, a total of 488 patients underwent chemotherapy with bevacizumab (Avastin, Genentech, Inc., South San Francisco, CA, USA) with metastatic colorectal cancers. (kjco.org)

It can also happen when radiation or chemotherapy damages your ovaries. (webmd.com)
If the ovaries are exposed to enough radiation, they'll begin to shut down. (medbroadcast.com)
My sister diagnosed to have metatstatic breast cancer on July 2011 which undergoing surgery on Nov 2011, radiation therapy on Dec 2011 and chemotherapy as well as targeted therapy Herceptin for 18 doses with the start of tamoxifen since January this year. (cancergrace.org)
Chemotherapy and radiation therapy are common treatments for many types of cancer. (goodnesscare.com)
Likewise, radiation therapy to the pelvic area can also damage the ovaries. (goodnesscare.com)

It can be the result of surgery, like if their ovaries are removed in a hysterectomy , or damage to their ovaries, such as from chemotherapy . (webmd.com)

Patients and clinicians need to view the ovary as an important endocrine organ that helps to maintain healthy bones. (medscape.com)
Another study, which was featured in Endocrine-Related Cancer in October 2015, tried to determine how much exercise is required to lower breast cancer risk in postmenopausal women. (livestrong.com)

Pharmacologic doses of megestrol acetate not only decrease the number of hormone-dependent human breast cancer cells but also are capable of modifying and abolishing the stimulatory effects of estrogen on these cells. (nih.gov)
AIs substantially decrease the risk of breast cancer in postmenopausal women. (standardofcare.com)
Two-thirds of breast cancers have aromatase activity creating estrogens available for breast cancer cells so that aromatase inhibitors decrease circulating levels of estrogen and local estrogen production in the breast cancer. (standardofcare.com)

What is the difference between fallopian tube cancer , peritoneal cancer and ovarian cancer? (cancercenter.com)
Although these cancer types differ in origin and other factors, ovarian, fallopian tube and peritoneal cancers are often treated with the same approach and techniques. (cancercenter.com)
In some cases, the entire fallopian tube or portions thereof, the ovary and the uterus may have to be removed. (home-remedies-for-you.com)

Exposure of Chinese hamster ovary cells to 100 microM BG results in enhancement in the cytotoxicity of PM (300 microM), chlorambucil (40 microM), and melphalan (10 microM) by 9-, 7-, and 18-fold, respectively. (nih.gov)
Long-term exposure of arsenite leads to human skin cancer. (nih.gov)
Treatment of cells with arsenite also induced significant activation of PI-3K and Akt, which was responsible for the anchorage-independent cell growth induced by arsenite exposure. (nih.gov)
Skin cancer is the most common type of human cancer and is associated with excessive exposure to UV solar irradiation. (aacrjournals.org)
The excess risk for cancer due to lifetime occupational exposure, 8 hours per day, 5 days a week, 50 weeks per year for 45 years, to butadiene at the proposed OSHA standard of 2ppm was estimated by fitting the bioassay data to a multistage Weibull time to tumor model and applying various mouse to human scaling factors. (cdc.gov)
Although varying the assumptions and considering other tumor sites can lower the estimated risks, the results suggest that prolonged exposure to 2ppm butadiene may present a significant cancer risk and that work related butadiene exposures should be reduced to the lowest feasible level. (cdc.gov)
Thus, maternal diet and environmental exposure might increase the risk of breast cancer by inducing permanent epigenetic changes in the fetus that alter the susceptibility to factors that can initiate breast cancer. (thehealthyskeptic.org)

Furthermore, the incidence of ovarian cancer is higher in postmenopausal women. (nih.gov)
Statistical data confirmed that as the overall survival of patients with cancer was significantly prolonged, the incidence of POF dramatically increased to 2% in women under the age of 40 [ 11 ]. (biomedcentral.com)
A study of Vizslas documented an increased incidence of some cancers in neutered dogs. (dogster.com)
The incidence of aromatase inhibitor induced musculo skeleton syndrome is higher with women with the last menstrual period within five years. (standardofcare.com)

and, therefore, the amount of gonadotropins reaching the ovary and potentially inducing cancer is reduced as well. (medscape.com)

Chemotherapeutic drugs, particularly alkylating cytotoxics such as cyclophosphamide (CTX), play an important role to induce premature ovarian failure (POF). (biomedcentral.com)

WITH LUPRON and TAMOXIFEN: I may reduce my risk of DISTANT recurrence an avg. of 2-3% over 9 years- and of course this may not factor in a nutritious, cancer-gihting diet and lifestyle changes as best as I can make them. (cancer.org)
However, I can assure you that an aromatase inhibitor, or AI, is really a cornerstone of treatment for patients with hormone receptor-positive breast cancer, particularly after they have progressed on tamoxifen, but this needs to be accompanied by ovarian ablation in premenopausal women. (cancergrace.org)
For breast cancer, hormone therapy can include drugs such as tamoxifen or aromatase inhibitors like letrozole, anastrozole, and exemestane. (goodnesscare.com)

Madelyn Butler, MD, remembers the day in 2002 when the public learned the results of the Women's Health Initiative study, which confirmed that combined estrogen plus progestin increased the risk of incident breast cancer in postmenopausal women enrolled in the randomized controlled trial. (ama-assn.org)
Treatment with aromatase inhibitors is the most commonly used form of nontoxic treatment in postmenopausal breast cancer. (northwestern.edu)
For many years, research framed estrogen-receptor positive breast cancer as a postmenopausal condition. (hormonely.com)

Women who have hysterectomies (removal of the uterus, therefore no menstrual periods) may or may not have their ovaries taken out, depending on how extensive the surgery was and why it was done. (medbroadcast.com)

[ 1 ] Because there are no good screening tests and the early disease is associated with nonspecific vague symptoms, most ovarian cancers are diagnosed at an advanced stage. (medscape.com)
Ovarian cancer is associated with high mortality due to its late onset of symptoms and lack of reliable screening methods for early detection. (nih.gov)
Ovarian cancer is a disease commonly marked by symptoms that may mimic other, less-serious conditions, such as constipation and gallbladder issues. (cancercenter.com)
Because there are no available screenings for ovarian cancer and its symptoms may be overlooked or mistaken for other maladies, the disease often isn't diagnosed until it has advanced beyond the pelvic region, when symptoms are typically more severe. (cancercenter.com)
If you are experiencing symptoms of ovarian cancer or if you have an undiagnosed pelvic mass, consider seeing a gynecologic oncologist . (cancercenter.com)
AIs can induce musculoskeletal symptoms (AIMSS). (standardofcare.com)
Replacement therapy helps regulate cycles by inducing more regular bleeding, and it also limits symptoms of high estrogen. (medscape.com)
However the symptoms occur - naturally or induced, abrupt or gradual - the question always remains the same. (pinklotus.com)

11. Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis. (nih.gov)

Over time, the cells of the uterus can become abnormal and cancer may develop. (centrastate.com)
Recently, anti-cancer activities of tanshinone IIA have been reported, which suggest that the structurally similar tanshinone I may possess similar cytotoxic effects on tumor cells. (spandidos-publications.com)
Taken together, these results reveal a potential mechanism for the anti-cancer effect of tanshinone I on human breast cancer cells, and suggest that tanshinone I may serve as an effective adjunctive reagent in the treatment of human breast cancer. (spandidos-publications.com)
I had a re-excision surgery to the left breast which affirmed all clear margins, but just a sentinel node had a small amount of cancer cells (three others were removed - they were clear). (cancer.org)
The most common type of ovarian cancer is epithelial cancer, which originates in the layer of cells that cover the ovaries and the abdominal cavity. (cancercenter.com)
Treatment for ovarian cancer typically begins with surgery to remove visible signs of cancer, as well as organs that may be affected by cancerous cells, such as the ovaries. (cancercenter.com)
After your initial surgery, called debulking, your treatment may include chemotherapy , hormone therapy and/or targeted therapy , which is designed to use drugs to attack cancer cells while reducing damage to normal cells. (cancercenter.com)
The initial surgery to remove ovarian cancer and affected tissue is a key part of your treatment because, in addition to excising visible cancer cells, it allows your doctor to determine whether the cancer has spread beyond the ovaries. (cancercenter.com)
Medical treatment uses an anti-cancer drug known as methotrexate, which acts by killing the cells of the placenta thereby inducing a miscarriage. (home-remedies-for-you.com)
Acquiring resistance to chemotherapeutic drugs made focus on new metabolites to act against cancer cells [ 11 ]. (ijpsonline.com)
That means cancer cells attach to estrogen. (hormonely.com)
Once inside cancer cells, the chemotherapy drug is released from the molecule. (nih.gov)
Olaparib is a drug that may stop cancer cells from repairing the DNA damage caused by chemotherapy. (nih.gov)
These medications block the body's ability to produce or use estrogen, a hormone that can promote the growth of certain types of breast cancer cells. (goodnesscare.com)
Tumor metabolism is a thrilling discipline that focuses on mechanisms used by cancer cells to earn crucial building blocks and energy to preserve growth and overcome resistance to various treatment modalities. (biomedcentral.com)
The so-called Warburg effect is nowadays considered a major hallmark of cancer and numerous studies have been repeatedly reporting that various metabolic pathways appear to be distinctive in individual tumour cells [ 3 , 4 ]. (biomedcentral.com)
Many of these alterations emerge as a consequence of the gain of mutations accumulated during oncogenesis, providing proliferative advantage for cancer cells in their microenvironment. (biomedcentral.com)

2. RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. (nih.gov)

Letrozole is a medication that has been widely used in women with breast cancer. (ivf1.com)

Nine patients (1.8%) were identified with intestinal perforation induced with bevacizumab. (kjco.org)
For the patients with intestinal perforation induced by bevacizumab, clinical characteristics were reviewed such as perforation sites, surgery of intestinal perforation, postoperative complication, chemotherapy cycles, and interval between chemotherapy and intestinal perforation. (kjco.org)
However, it is unknown whether the daily administration of holothurian wall hydrolysate (HWH) ameliorated intestinal dysbiosis and barrier injury induced by immunodeficiency. (bvsalud.org)

Manipulation of the cannabinoid receptors has been useful in the pain management and treatment of osteoporosis, inflammation, and cancer ( 4 ), but the mechanisms of these effects are still not fully understood. (aacrjournals.org)
Besides, my sister already got multiple bone metatasis , one of the side effect of AI may induce osteoporosis, then would it make the bone more osteopenic and therefore easier to break. (cancergrace.org)

The authors of this case-control study have found a significantly lower risk for ovarian cancer among those with tubal ligation or bilateral salpingectomy. (medscape.com)
ADAM12 overexpression was significantly associated with the cancer stage, depth of invasion, lymph node metastasis, distant metastasis, and poor survival in CRC patients. (mdpi.com)
Furthermore, both inhibition of Gαi/o signaling and siRNA knockdown of β-arrestin 1/2 significantly reduced FSH-induced lipid droplet accumulation, implying a role for a Gαi/o/β-arrestin complex in FSH functions in this cell type. (frontiersin.org)

These tanshinones are the major diterpenes isolated from Danshen, and show cytotoxic effects on cell lines derived from human carcinomas of the colon, ovary, lung, mouth, and breast. (spandidos-publications.com)
Researchers want to see how safe it is to give EP0057 and olaparib together and to see how well the combination treats a specific type of lung cancer called small cell lung cancer (SCLC). (nih.gov)
To test how well they treat small cell lung cancer. (nih.gov)
Adults 18 and older with small cell lung cancer. (nih.gov)
Selected compounds were primarily evaluated for their antiproliferative activities against five human tumor cell lines including lung carcinoma (A549), triple-negative breast cancer (MDA-MB-231), estrogen receptor-positive and HER2-negative breast cancer (MCF-7), as well as HeLa (cervical carcinoma)-derived (KB) and its multidrug-resistant (MDR) subline (KB-VIN). (technologynetworks.com)

Cytotoxic compounds are most promising compounds for curing cancers or tumours in a most systemic way. (ijpsonline.com)

However, the exact mechanisms of arsenite-induced human skin carcinogenesis remain to be defined. (nih.gov)
However, the receptors that mediate UV-induced skin carcinogenesis have not yet been unequivocally identified. (aacrjournals.org)
However, no direct experimental evidence has confirmed that these membrane-bound receptors are required for UV-induced skin carcinogenesis. (aacrjournals.org)

Researchers identified 13,241 women with ovarian cancer. (medscape.com)
Borderline cancer was found in 3605 women. (medscape.com)
Women unable to have children after cancer treatment could have their fertility restored with breakthrough stem cell treatment. (mirror.co.uk)
Millions of women around the world undergo cancer treatment and some of them will become infertile through ovarian failure. (mirror.co.uk)
It's not clear why some women develop ovarian cancer while others don't, but the risk of developing the disease increases with age. (cancercenter.com)
In premenopausal women, aromatase inhibitors are used in combination with an additional drug that suppresses the ovaries because aromatase inhibitor-only treatments may give rise to ovarian stimulation. (northwestern.edu)
In pre-menopausal women, aromatase inhibitors may not be very effective at blocking estrogen production because the levels of aromatase in the ovaries are high, and aromatase inhibitors are active in women who are in either natural or medically induced post menopausal state. (standardofcare.com)
Aromatase inhibitors are contraindicated in pre-menopausal women who are not undergoing ovarian suppression, because compensatory physiological responses induce ovarian estrogen production. (standardofcare.com)
And, while it's true younger women are more likely to deal with hormone-receptor negative breast cancer, ideas about ER-positive cancer-and who it affects-are changing. (hormonely.com)
First, these drugs can be used to induce an egg to develop and be released in women who are not ovulating on their own. (ivf1.com)
These effects were more noticeable in women who did not have obesity and those who engaged in high-intensity training , regardless of weight loss induced by exercise. (livestrong.com)

[ 4 ] This latter mechanism and the association between ascending infectious or inflammatory agents and ovarian cancer have led to an increased interest in the potential benefits of tubal occlusion or removal as a measure to prevent ovarian cancer. (medscape.com)
Removal of just the ovaries induces sterility and is a simpler surgery. (dogster.com)

Polymorphisms in this gene have been linked to breast and prostate cancer. (cancerindex.org)

at 5 mo, 57.1% of the VCD+DMBA+ and 14.3% of VCD+DMBA- ovaries had neoplasms. (nih.gov)
Otto Warburg in 1956 described for the first time a specific metabolic characteristic of neoplasms by demonstrating that a cancer cell, unlike an untransformed cell, relies mainly on a higher glycolytic flux without a change in oxidative phosphorylation even in the presence of oxygen [ 2 ]. (biomedcentral.com)

While cancer survival rates have increased dramatically, to date there is no effective method of preventing infertility after chemotherapy. (mirror.co.uk)

Anatomy16

Organisms5

Diseases52

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment65

Psychiatry and Psychology1

Phenomena and Processes53

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science8

Named Groups2

Health Care29

Geographicals4

Polycystic22

Menopause28

Ovulation10

PCOS6

Apoptosis7

Hormones12

Eggs8

Damage to the ovaries1

Uterus and both ovaries2

Cysts4

Tumors8

Follicles2

Reproductive1

Surgically2

Granulosa7

Progesterone5

Mice12

Rats3

Colorectal8

Radiation5

Hysterectomy1

Endocrine2

Decrease3

Fallopian tube3

Exposure7

Incidence4

Gonadotropins1

Premature1

Tamoxifen3

Postmenopausal3

Menstrual1

Symptoms8

Tumorigenesis1

Cells17

Fetal1

Letrozole1

Intestinal3

Osteoporosis2

Significantly3

Lung5

Tumours1

Carcinogenesis3

Women11

Removal2

Prostate cancer1

Neoplasms2

Infertility1