Ovarian tumors tumor burden. Medical search. Frequent questions

A study by Potenza et al indicated that in patients with epithelial ovarian cancer, combined analysis of CA 125 and human epididymis protein 4 (HE4) is an effective indicator of success in chemotherapy. (medscape.com)
Epithelial ovarian cancer (EOC) is divided into type I and type II based on histopathological features. (spandidos-publications.com)
The most common form is epithelial ovarian cancer (EOC). (spandidos-publications.com)
While platinum chemotherapy is the cornerstone of contemporary treatment, ultimately, the majority of women with epithelial ovarian cancer (EOC) will develop chemotherapy resistance and succumb to their disease within 5 years of diagnosis (46.2% 5-year survival) [ 3 ]. (biomedcentral.com)
Surgery is the initial modality of treatment for stage I-IVA epithelial ovarian cancer. (medscape.com)
However, only a small percentage of women with epithelial ovarian cancer can be treated with surgery alone. (medscape.com)
Women with any stage of epithelial ovarian cancer should be considered for clinical trials if available. (medscape.com)

Genetic testing revealed a high loss of heterozygosity score and high tumor mutational burden (TMB). (spandidos-publications.com)
However, it remains unclear whether SETD2 dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) and tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, and little is known regarding whether this type of dysfunction acts differently in various types of cancer. (biomedcentral.com)
FoundationOne CDx also reports genomic biomarkers-such as microsatellite instability and tumor mutational burden-that can help inform the use of other targeted oncology therapies, including immunotherapies and relevant clinical trial information. (ascopost.com)
We demonstrate that RNA‐seq can be used to call mutations in genes such as PIK3CA, TP53, and ERBB2, as well as the status of molecular pathways and mutational burden, and identify potentially druggable mutations in 86.8% of tumors. (lu.se)

The peptide is secreted by tumor cells and found in the plasma of cancer patients from early stages. (wikipedia.org)
1993 - 1994: hPG80 is secreted by ovarian and colon cancer cells. (wikipedia.org)
Through a variety of mechanisms, all crucial for tumor growth and survival, research has demonstrated the major role that hPG80 plays in tumor initiation and progression, generally using colorectal cancer as a model. (wikipedia.org)
Maximal effort cytoreductive surgery is associated with improved outcomes in advanced high-grade serous ovarian cancer (HGSOC). (nature.com)
Fig. 1: Complete gross tumour resection is associated with improved prognosis in advanced stage high-grade serous ovarian cancer patients. (nature.com)
British Gynaecological Cancer Society (BGCS) epithelial ovarian/fallopian tube/primary peritoneal cancer guidelines: recommendations for practice. (nature.com)
Olaparib plus bevacizumab as first-line maintenance in ovarian cancer. (nature.com)
Veliparib with first-line chemotherapy and as maintenance therapy in ovarian cancer. (nature.com)
Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
Chemotherapy has been shown to enrich cancer stem cells in tumors. (aacrjournals.org)
Recently, we demonstrated that administration of chemotherapy to human bladder cancer xenografts could trigger a wound-healing response that mobilizes quiescent tumor stem cells into active proliferation. (aacrjournals.org)
Cancer antigen 125 (CA 125) is the only tumor marker recommended for clinical use in the diagnosis and management of ovarian cancer . (medscape.com)
However, owing to the lack of sensitivity and specificity, elevations in single or sequential CA 125 levels alone are not recommended for ovarian cancer screening or in the initial diagnosis of ovarian cancer. (medscape.com)
A model based on artificial intelligence is able to predict the therapy outcome (measured by volumetric reduction of tumor lesions) in 80% of ovarian cancer patients. (technologynetworks.com)
This achievement stems from a recent study published in Nature Communications , conducted on 134 high-grade ovarian cancer patients. (technologynetworks.com)
Ovarian cancer affects over five thousand women annually in Italy, adding to the thirty thousand patients who have already received a diagnosis. (technologynetworks.com)
Omental and pelvic/ovarian locations (common for ovarian cancer spread) represented the majority of disease burden initially. (technologynetworks.com)
The patient received paclitaxel and carboplatin therapy followed by a poly ADP‑ribose polymerase inhibitor as regimens for ovarian cancer and achieved complete remission. (spandidos-publications.com)
The former includes adenocarcinoma of the axillary lymph nodes, papillary serous carcinoma of the peritoneum (redefined as peritoneal cancer), squamous cell carcinoma of the cervical lymph nodes and extragonadal germ cell tumors in young men, which are derived from the middle of the body ( 4 ). (spandidos-publications.com)
In most cases, modern treatment of ovarian cancer includes radical cytoreductive surgery, followed by platinum- and paclitaxel-based systemic chemotherapy ( 5 - 7 ). (spandidos-publications.com)
The histopathology of ovarian cancer is heterogeneous, and each subtype harbors specific genetic mutations that can be used for diagnostics and targeted treatment. (spandidos-publications.com)
In the past decade, the use of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of a variety of tumors, including lung cancer, melanoma, colorectal cancer, and renal cell carcinoma [ 1 , 2 ]. (biomedcentral.com)
B7H6-specific BiTE therapy enhanced the survival of lymphoma bearing mice and decreased tumor burden of melanoma and ovarian cancer bearing mice. (bioskinrevive.com)
Oncology therapeutics designed to activate the immune system against tumors are a promising strategy for cancer treatment. (jax.org)
They were able to suppress tumor growth in lung, sarcoma, bladder, breast cancer PDX, and a breast cancer cell line when co-engrafted in CD34+ hematopoietic stem cell (HSC) humanized NSG TM mice (Wang et al. (jax.org)
Our objective was to evaluate the effect of the COX-2 inhibitor, celecoxib, on (1) proliferation and apoptosis in human ovarian cancer cell lines and primary cultures of ovarian cancer cells, and (2) inhibition of tumor growth in a genetically engineered mouse model of serous ovarian cancer under obese and non-obese conditions. (houstonmethodist.org)
Celecoxib inhibited cell proliferation in three ovarian cancer cell lines and five primary cultures of human ovarian cancer after 72 hours of exposure. (houstonmethodist.org)
Treatment with celecoxib resulted in G1 cell cycle arrest, induction of apoptosis, inhibition of cellular adhesion and invasion and reduction of expression of hTERT mRNA and COX- 2 protein in all of the ovarian cancer cell lines. (houstonmethodist.org)
Celecoxib strongly decreased the serum level of VEGF and blood vessel density in the tumors from the KpB ovarian cancer mouse model under obese and non-obese conditions. (houstonmethodist.org)
This work suggests that celecoxib may be a novel chemotherapeutic agent for ovarian cancer prevention and treatment and be potentially beneficial in both obese and non-obese women. (houstonmethodist.org)
Ovarian cancer is the leading cause of death among women with gynecologic malignancies in the United States. (biomedcentral.com)
We showed that incubation of murine ovarian cancer cells (MOSEC) with doxorubicin led to the intracellular uptake of the drug (MOSEC-dox cells) and the eventual death of the tumor cell. (biomedcentral.com)
Most patients who are diagnosed with ovarian cancer are detected at an advanced stage (III/IV), often presenting with complications associated with intraperitoneal metastasis. (biomedcentral.com)
Thus, there is a critical need for alternative approaches to administer chemotherapeutic agents to control advanced stages of ovarian cancer without serious side effects. (biomedcentral.com)
In the current study, we hypothesized that local administration of doxorubicin delivered by irradiated tumor cells may reduce the dose required to treat murine ovarian cancer cells and decrease the systemic circulation of doxorubicin. (biomedcentral.com)
Patients diagnosed with high-grade serous ovarian cancer (HGSOC) who received initial debulking surgery followed by platinum-based chemotherapy can experience highly variable clinical responses. (biomedcentral.com)
Cervix cancer seemed to be a more serious burden of. (evenimente-corporate.ro)
In vitro studies showed that CHI3L1 up-regulated the expression of anti-apoptotic Mcl-1 protein and hampered paclitaxel-induced apoptosis of ovarian cancer cells. (oncotarget.com)
Chemoresistance is an obstacle in the management of ovarian cancer. (oncotarget.com)
Renal cell cancer (RCC) accounts for 2-3% of all tumor malignancies in human. (oncotarget.com)
FoundationOne CDx is a first-of-its-kind test for individuals with advanced cancer that is offered as a nationally covered benefit across all solid tumors for Medicare and Medicare Advantage beneficiaries who meet eligibility requirements. (ascopost.com)
FoundationOne CDx, an FDA-approved comprehensive genomic-profiling assay for all solid tumors, assesses genomic alterations in 324 genes known to drive cancer growth, providing potentially actionable information to help guide treatment options. (ascopost.com)
FoundationOne CDx is also FDA-approved as a broad companion diagnostic for patients with certain types of non--small cell lung cancer, melanoma, colorectal cancer, ovarian cancer, or breast cancer to identify patients who may benefit from treatment with one of 17 on-label targeted therapies, 12 of which are approved as first-line therapy for their respective indications. (ascopost.com)
Pancreatic cancer spatial transcriptomics The lethality and treatment-refractory nature of pancreatic cancer are largely mediated by collaborative interactions between cancer cells and other cell types in the tumor microenvironment, including cancer-associated fibroblasts and immune cells. (harvard.edu)
Agenus Inc. (Nasdaq: AGEN), an immuno-oncology company with a pipeline of immunological agents targeting cancer and infectious disease, today announced results from a cohort of 24 evaluable patients in an expansion of the Company's Phase 1b study of botensilimab (multifunctional CTLA-4 antibody) in combination with balstilimab (PD-1 antibody) in patients with recurrent platinum resistant/refractory ovarian cancer. (statesmanexaminer.com)
The combination of botensilimab and balstilimab in platinum-resistant ovarian cancer shows promise for a substantial improvement in efficacy compared to existing therapies, which typically only yield single-digit response rates," said Bruno Bockorny, M.D., Harvard Medical School, Beth Israel Deaconess Medical Center, and principal investigator for the study. (statesmanexaminer.com)
The remarkable efficacy and manageable tolerability profile of this combination suggest a transformative potential for ovarian cancer patients. (statesmanexaminer.com)
The ovarian cancer cohort is part of a large study evaluating the safety, efficacy, and dose optimization of botensilimab alone and in combination with balstilimab in multiple solid tumors. (statesmanexaminer.com)
A total of 24 evaluable patients with recurrent platinum resistant/refractory ovarian cancer received either 1 or 2 mg/kg botensilimab every 6 weeks and 3 mg/kg balstilimab every 2 weeks. (statesmanexaminer.com)
Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
A clinical study to evaluate of the combination of AHCC plus PLD in the treatment of ovarian cancer is being pursued. (researchgate.net)
Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel. (ucdenver.edu)
The transcriptome profiling (RNA-seq) data harmonized to fragments per kilobase million (FPKM), clinical information, and tumor mutations in patients with HNSCC were downloaded from the Cancer Genome Atlas (TCGA) database ( https://portal.gdc.cancer.gov/ ) in March 2021 ( 9 ). (frontiersin.org)
20, 2018-The T.J. Martell Foundation's 6th Annual Chic Awearness fundraising event that supports ovarian cancer research at Vanderbilt-Ingram Cancer Center will be held Monday, Sept. 24, 6:30 - 8:30 p.m. (vumc.org)
15, 2016-Fall fashions for women will be on display during the 4th Annual Chic Awearness Fashion Show promoting ovarian cancer awareness and research. (vumc.org)
The event, to be held Monday, Sept. 26, 6:30 to 8:30 p.m., will benefit the T.J. Martell Foundation, which supports ovarian cancer research at Vanderbilt-Ingram Cancer Center (VICC). (vumc.org)
Dec. 10, 2015-Combining inhibitors of the BMP signaling pathway with standard chemotherapy drugs may overcome drug resistance in ovarian cancer. (vumc.org)
All patients with stage II or higher cancer should be considered for front-line chemotherapy based on burden of disease and ability to achieve optimal primary resection. (medscape.com)
1 cm) stage III ovarian cancer after front-line surgery. (medscape.com)
Several recent studies suggest that young age is an independent predictor of poorer survival after breast cancer, even after adjustment for sociodemographic and tumor characteristics [ 7 - 14 ]. (cdc.gov)
For instance, BRAF in melanoma, ROS1, ALKr, EGFR in non-small-cell lung cancer (NSCLC), extended spectrum RAS in colon cancer, BRCA in ovarian cancer, and many other mutations are tested daily. (medscape.com)
The coverage decision for F1CDx dramatically expands on current profiling and will provide information for tumors where mutational testing is not common, such as pancreatic and prostate cancer. (medscape.com)
As a result, your cells may grow out of control, which can lead to tumors and cancer. (medlineplus.gov)

Roche is another firm that has seen recent success in PCR-based liquid biopsy, receiving the first US Food and Drug Administration approval for a blood-based solid tumor mutation test with its Cobas EGFR Mutation Test v2. (genomeweb.com)
MSIsensor score, HRD score, RNAseq, mutational data, and corresponding clinical data were obtained from the TCGA and MSKCC cohort for seven solid tumor types. (biomedcentral.com)
On 30 November 2017, a collaborative action between the US Food and Drug Administration (FDA) and the Centers for Medicare and Medicaid Services (CMS) announced that a 324-gene panel offered by Foundation Medicine, F1CDx, would be FDA approved and receive national coverage through CMS for any solid tumor type [ 1 ] with enrollment in an observational registry. (medscape.com)

For all patients clinicians collected clinical data, including demographic information and treatment details, as well as blood biomarkers like CA-125 and circulating tumor DNA (ctDNA). (technologynetworks.com)
To identify clinical and tumor molecular biomarkers associated with exceptional clinical response or resistance, we conducted an integrated clinical, exome, and transcriptome analysis of 41 primary tumors from LT ( n = 20) and ST ( n = 21) HGSOC patients. (biomedcentral.com)
These features are biomarkers with prognostic and predictive value, which provide a characterization of tumor phenotypes in a non-invasive manner. (evenimente-corporate.ro)
Personalized, biomarker-based therapy has been shown to be associated with clinical benefit across tumor types and biomarkers, making therapy selection ever more complex. (ascopost.com)
FoundationOne CDx offers treating physicians a single, FDA-approved comprehensive platform for all solid tumors to detect specific genomic alterations that help guide efficient, personalized treatment decisions, while reducing the time and tissue needed when testing for biomarkers one at a time. (ascopost.com)
These results add another dimension to the use of RNA‐seq as a clinical tool, where both gene expression‐ and mutation‐based biomarkers can be interrogated in real‐time within 1 week of tumor sampling. (lu.se)

Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)

Through different experimental configurations, alteration of the GAST gene or neutralization of hPG80 resulted in a decrease in the number of tumors in mice with a tumor predisposition (mutation on the APC gene). (wikipedia.org)
Younger age at diagnosis, no residual disease post debulking surgery and low CA125 levels following surgery and chemotherapy were clinical characteristics of LT. Tumors from LT survivors had increased somatic mutation burden (median 1.62 vs. 1.22 non-synonymous mutations/Mbp), frequent BRCA1/2 biallelic inactivation through mutation and loss of heterozygosity, and enrichment of activated CD4+, CD8+ T cells, and effector memory CD4+ T cells. (biomedcentral.com)
Tumor mutation burden (TMB) is the total number of mutations identified in the genome of a tumor [1] . (idtdna.com)
We also analyzed the tumor-infiltrating immune cells, immune-related gene expression, tumor mutation burden, and drug sensitivity of patients with HNSCC in the high- and low-risk groups. (frontiersin.org)

In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
The tool, named IRON (Integrated Radiogenomics for Ovarian Neoadjuvant therapy), analyzes various patient clinical features, from circulating tumor DNA in the blood (liquid biopsy) to general characteristics (age, health status, etc.), tumor markers, and disease images obtained through CT scans. (technologynetworks.com)
However, without complete long-term follow-up information to accompany patient and tumor molecular profiles, clinical and molecular factors that contribute to long-term (LT) and short-term (ST) survival in HGSOC remain elusive. (biomedcentral.com)
In this pilot study, we sought to identify clinical and molecular factors that distinguish HGSOC patients who share similar clinical characteristics and pathology at diagnosis with exceptional survival outcomes, either LT or ST, through integrated analysis of clinical features, germline variants, somatic genomic alterations, and tumor immune microenvironment. (biomedcentral.com)
Botensilimab is a novel, multifunctional CTLA-4 investigational antibody that has been designed to extend clinical benefits to "cold" tumors that have not historically responded to standard of care or investigational therapies. (statesmanexaminer.com)
The targeted therapy nirogacestat demonstrated rapid and sustained improvements for adults with progressing desmoid tumors, according to results from a phase 3 clinical trial published March 9 in The New England Journal of Medicine . (mskcc.org)
Dr. Lim's clinical interests include the treatment of benign and malignant brain tumors, with special interest in gliomas, meningiomas, metastatic tumors, and skull base tumors. (stanfordhealthcare.org)
He has successfully translated his findings from the laboratory to the clinics and has conducted and led several large national immunotherapy clinical trials for brain tumors. (stanfordhealthcare.org)
In addition to being invited world-wide to give lectures and seminars, he has given platform presentations on the topics of immunotherapy for brain tumors, neurosurgical techniques and management of brain tumors at the American Society of Clinical Oncologists, American Academy of Neurological Surgeons, Radiological Society of North America, Annual Symposium on Brain and Spine Metastases, Congress of Neurological Surgeons, and other meetings. (stanfordhealthcare.org)
Third, match rates, a prerequisite for clinical benefit, remain suboptimal for next-generation sequencing in diverse solid tumors. (medscape.com)

This phenomenon leads to a loss of sensitivity to chemotherapy partly due to an increase in the number of tumor stem cells, which typically respond to chemotherapy-induced cell death less than more differentiated cells. (aacrjournals.org)
High-grade serous ovarian carcinoma, constituting 70-80% of ovarian tumors, is particularly aggressive and frequently resistant to chemotherapy. (technologynetworks.com)
Advanced ovarian cancers are difficult to cure with the current available chemotherapy, which has many associated systemic side effects. (biomedcentral.com)

Dr. Lim is the Chair of the Department of Neurosurgery and a board-certified neurosurgeon specializing in brain tumors and trigeminal neuralgia. (stanfordhealthcare.org)
Dr. Lim is a world leader in immunotherapy for brain tumors. (stanfordhealthcare.org)

EOC can include cells of origin from both the ovarian surface epithelium and the fallopian tube ( 2 ). (spandidos-publications.com)

In another study, efficacy of a BiTE was assessed in NSG TM mice engrafted with hematological cancers known to express the intracellular tumor marker WT1, where an epitope of the tumor marker is expressed on the cell surface in the context of the MHC I molecule HLA-A2 (Dao et al. (jax.org)
For patients with positive HPV-oropharyngeal cancers, the correlation of the radiomic textural features from the tumor oxiuros nombre cientifico p16 values from the pathological sample can identify tumor specific signatures in CT imaging, an entity with favorable prognosis and a better response to chemo-radiotherapy. (evenimente-corporate.ro)
MSI is associated with colon, gastric, ovarian, skin, and a variety of other types of cancers [1] . (idtdna.com)
Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective study elucidating the transcriptomic profiles for thousands of breast cancers, we developed a RNA‐seq pipeline for detection of SNVs/indels and profiled a real‐world cohort of 3,217 breast tumors. (lu.se)
Breast cancers are now recognized as heterogeneous, based on tumor expression of receptors for estrogen (ER), progesterone (PR)-referred to jointly as hormone receptor (HR)-and human epidermal growth factor receptor 2 (HER2) [ 3 - 5 ]. (cdc.gov)
[ 1 ] This coverage decision is the culmination of widespread enthusiasm for precision oncology-heightened by the first tissue agnostic approval-the use of pembrolizumab in MSI-high solid tumors, and by reports of dramatic response in diverse cancers to a tropomyosin receptor kinase inhibitor. (medscape.com)

These CAR-T cells were administered to NRG (NOD.Cg- Rag1 tm1Mom Il2rg tm1Wjl /SzJ JAX Stock# 007799 ) or NSG-B2m (NOD.Cg- B2m tm1Unc Prkdc scid Il2rg tm1Wjl /SzJ, JAX Stock# 010636 ) carrying U87 glioma cells, PANC-1 pancreatic tumor cells, or SK-OV-3 ovarian tumor cells after local radiation treatment (Jin et al. (jax.org)

Quantitative characteristics of the tumor derived from CT scan images of all primary and metastatic tumor sites were also obtained. (technologynetworks.com)

The usefulness of a tumor marker is in its sensitivity and specificity, as well as its influence on patient management decisions. (medscape.com)
Using mathematical models, we show that characteristics of the tumor cell hierarchy can be crucial for determining the sensitivity of tumors to drug therapy, under the assumption that stem cell enrichment is the primary basis for drug resistance. (aacrjournals.org)
Isolated EOC tumor cells obtained at surgery were investigated for their sensitivity to seven standard cytotoxic drugs and nine TKIs using a short‑term fluorescent microculture cytotoxicity assay (FMCA). (spandidos-publications.com)

Meanwhile, methods are also being advanced that extract and analyze the nucleic acids within circulating tumor cells or extracellular vesicles - isolated from blood samples with varying technologies. (genomeweb.com)

Therefore, it is thought that some TMB-H tumors are more responsive to immunotherapy though many factors, such as ethnicity, can influence response [2] . (idtdna.com)

[ 3 ] The degree of elevation has also been shown to correlate with tumor burden and International Federation of Obstetrics and Gynecologic (FIGO) pathologic stage. (medscape.com)
4] Although increasing CA 125 levels correlate with tumor recurrence after primary treatment, management of biochemical relapses remain controversial. (medscape.com)

Epithelial ovarian carcinoma (EOC) has received increasing attention in recent years because it is associated with the highest mortality rate among gynecologic malignancies [ 1 , 2 ]. (oncotarget.com)
Alimentary tract malignancies (ATM) caused nearly one-third of all tumor-related death. (biomedcentral.com)

We propose CHI3L1 as a prognostic biomarker for patients with epithelial ovarian carcinoma (EOC) and also suggest possible biological functions of CHI3L1. (oncotarget.com)

We confirmed our recommendation to frontline chemoimmuno-therapy in patients with Stage III-IV disease and/or high tumor burden. (bvsalud.org)

Major human ovarian tumor samples were from Dartmouth-Hitchcock INFIRMARY after medical procedures with educated consent. (bioskinrevive.com)

Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
Up to 80% of women with ovarian carcinoma of epithelial origin have elevated serum CA 125 levels, with the frequency of elevation correlating with the clinically detected stage. (medscape.com)
Pathological diagnosis based on a biopsy sample of the para‑aortic lymph nodes indicated that the tumor was a high‑grade serous carcinoma of possible gynecological organ origin. (spandidos-publications.com)
Head and neck squamous cell carcinoma (HNSCC) is a type of tumor that originates from the squamous epithelium of the head and neck areas, including the mucous membranes of the lips, tongue, pharynx, larynx, and others ( 1 ). (frontiersin.org)

The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
However, tumor recurrence may occur in the setting of normal CA 125 levels, and serum measurements do not replace imaging and physical examination of the patient. (medscape.com)

Currently, therapy response prediction for this type of tumor is only 50% accurate. (technologynetworks.com)

They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)
Thus, type I (low-grade serous G1, low-grade endometrioid G1/G2, mucinous or clear cell) tumors are associated with corresponding benign ovarian cystic neoplasms, often developing through an intermediate borderline step and have a better prognosis. (spandidos-publications.com)

Conversely, a significant increase in tumor formation was observed in mice overexpressing progastrin and treated with azoxymethane (AOM), a chemical carcinogen. (wikipedia.org)
2018). In another experiment, treatment with an antibody directed against the costimulatory molecule GITR in CD34+ HSC-engrafted NSG TM mice co-engrafted with the human melanoma cell line SK-MEL-5 suppressed tumor growth and reduced intratumoral T regulatory cell number concurrent with increased activation of CD8+ T cells, mirroring what had been observed in syngeneic model systems (Mahne et al. (jax.org)
2019). Intratumoral migration of CAR-T was increased and tumor burden was diminished in treated mice (Jin et al. (jax.org)
In the KpB mice fed a high fat diet (obese) and treated with celecoxib, tumor weight decreased by 66% when compared with control animals. (houstonmethodist.org)
Among KpB mice fed a low fat diet (non-obese), tumor weight decreased by 46% after treatment with celecoxib. (houstonmethodist.org)
In the ovarian tumors from obese and non-obese KpB mice, treatment with celecoxib as compared to control resulted in decreased proliferation, increased apoptosis and reduced COX-2 and MMP9 protein expression, as assessed by immunohistochemistry. (houstonmethodist.org)
The irradiated form of the MOSEC-dox cells were capable of treating luciferase-expressing MOSEC tumor cells (MOSEC/luc) in C57BL/6 mice as well as in athymic nude mice resulting in improved survival compared to the non drug-loaded irradiated MOSEC cells. (biomedcentral.com)
Furthermore, we showed that irradiated MOSEC-dox cells was more effective compared to an equivalent dose of doxorubicin in treating MOSEC/luc tumor-bearing mice. (biomedcentral.com)

Humanized NSG TM have also proven to be a valuable platform for assessment of anti-tumor T cell activity using both chimeric antigen receptor T cells (CAR-T) and bi-specific T cell engagers (BiTE). (jax.org)

Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
For example, co-engrafting human tumors with human immune cells into the NSG TM (NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ, JAX Stock# 005557 ) and its variant strains creates a powerful system to interrogate the immunomodulatory effects of human-specific experimental treatments in a preclinical setting. (jax.org)

Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
Tumor suppressor genes provide instructions for making proteins that control how fast your cells grow and divide to make new cells. (medlineplus.gov)

Mouse T cell lymphoma range RMA melanoma cell range B16F10 and ovarian tumor cell line Identification8 have already been referred to previously (17-19). (bioskinrevive.com)
Mouse T cell lymphoma range RMA/B7H6 melanoma cell range B16F10/B7H6 ovarian tumor cell line Identification8/B7H6 were produced by retrovirus transduction of their parental range RMA B16F10 or Identification8 cells respectively using dualtropic retroviral vectors including the human being gene Doripenem Doripenem Hydrate Hydrate relating to protocols previously referred to (17). (bioskinrevive.com)

Type II (high-grade serous G2/G3, high-grade endometrioid G3 or carcinosarcoma) tumors are highly aggressive and genetically unstable tumors that most often present at advanced stages and are responsible for the majority of EOC-associated deaths ( 3 , 4 ). (spandidos-publications.com)
The DeFi trial randomized 142 patients with desmoid tumors (or aggressive fibromatosis) to receive oral treatment with either a placebo or nirogacestat, an investigational, selective gamma-secretase inhibitor that blocks Notch pathway signaling and cell growth. (mskcc.org)

Aug. 14, 2014-Inhibition of BMP growth factor signaling reduces breast tumor burden and metastasis. (vumc.org)

These observations led to the study of autocrine and paracrine function of hPG80 in tumor cells. (wikipedia.org)
Intriguingly, our model predicts a weaker response to therapy if there is negative feedback from differentiated tumor cells that inhibits the rate of tumor stem cell division. (aacrjournals.org)
The clinically observed relative drug resistance of EOC type I, as well as in patients previously treated, is at least partly due to mechanisms in the tumor cells. (spandidos-publications.com)
Significant evidence showed that T cells are the key effectors in immune-mediated tumor eradication. (bioskinrevive.com)
In this study we showed that an B7H6-specific BiTE directs T cells to mediate cytotoxicity and IFN-γ secretion against B7H6+ tumor cells. (bioskinrevive.com)
Major ovarian tumor cells had been cultured for just two times before useful for practical assay. (bioskinrevive.com)
CD70 CAR-T cells were modified to express receptors for IL-8 to enhance intratumoral T cell migration as expression of this chemokine is increased in tumor tissue and can be stimulated by radiation. (jax.org)
2017). Dao and colleagues demonstrated efficacy of a BiTE directed against WT1 displayed by the tumor and CD3 on human T cells. (jax.org)
In the current study, we generated an irradiated tumor cell-based drug delivery system which uses irradiated tumor cells loaded with the chemotherapeutic drug, doxorubicin. (biomedcentral.com)
Thus, the employment of drug-loaded irradiated tumor cells represents a potentially innovative approach for the delivery of chemotherapeutic drugs for the control of ovarian tumors. (biomedcentral.com)
Tumors with high TMB (TMB-H) have been shown to have more 'neo-antigens' which coat the tumor cell that leads to the identification of tumor cells by the immune system. (idtdna.com)

Diagnosis was suggestive of tumor of pancreas. (who.int)

Borderline ovarian tumors: french guidelines from the CNGOF. (bvsalud.org)
In the Early Stages (ES) of Borderline Ovarian Tumor (BOT), if surgery without risk of tumor rupture is possible, then laparoscopy with protected extraction is recommended over laparotomy (Grade C). In case of bilateral serous ES BOT treatment with a strategy to preserve fertility and/or endocrine functi. (bvsalud.org)

This small percentage includes patients with stage IA or IB (grade 1) serous, mucinous, endometrioid, and Brenner tumors. (medscape.com)

Thus, local delivery of chemotherapeutic drugs by tumor may represent a potentially innovative approach for the control of ovarian tumors. (biomedcentral.com)

High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
A TP53 genetic test usually uses a sample of your blood to look for changes in the tumor protein 53 gene, or TP53 for short. (medlineplus.gov)

During his time at Johns Hopkins, Dr. Lim built one of the largest brain tumor and trigeminal neuralgia practices and utilized the most advanced surgical technologies and techniques for his patients. (stanfordhealthcare.org)

Moreover, EOC is not a single disease, but a heterogenic group of tumors that can be classified by their genetic and histological features. (spandidos-publications.com)

Tissue from a tumor or bone marrow may sometimes be used instead. (medlineplus.gov)
For tumor tissue testing , tissue is removed during a procedure called a biopsy . (medlineplus.gov)
A provider may use a hollow needle or surgery to take a tissue sample from a tumor. (medlineplus.gov)

HNSCC is currently one of the most common malignant tumors worldwide, with morbidity and mortality accounting for 3.6 and 3.4% of all malignant tumors in 2020, respectively ( 2 ). (frontiersin.org)

Anatomy16

Organisms10

Diseases107

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes39

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care12

Epithelial ovarian cancer7

Mutational burden4

Cancer69

Solid tumor3

Biomarkers6

Germ cell t1

Mutation4

Clinical11

Chemotherapy3

Brain tumors2

Fallopian tube1

Cancers6

Pancreatic1

Metastatic1

Sensitivity3

Circulating tumor cells1

Immunotherapy1

Correlate with tumor2

Malignancies2

Biomarker1

High tumor1

Human ovarian1

Carcinoma4

Recurrence2

Type of tumor1

Benign2

Mice8

Anti-tumor1

Immune cells2

Genes2

Melanoma cell2

Aggressive2

Metastasis1

Cells11

Diagnosis1

Borderline2

Endometrioid1

Chemotherapeutic1

Protein2

Patients1

Histological1

Tissue3

20201