• Differential diagnoses include other DSD, including mixed gonadal dysgenesis and 46,XX testicular DSD. (orpha.net)
  • These are most often ovarian tumors. (medlineplus.gov)
  • Malignant gonadal tumors are rare (less than 3% of cases). (orpha.net)
  • Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal extracranial tumors. (cigna.com)
  • Gonadal germ cell tumors form in the gonads (testicles and ovaries). (cigna.com)
  • Testicular germ cell tumors are divided into two main types, seminoma and nonseminoma. (cigna.com)
  • Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
  • Testicular germ cell tumors in adolescents (11 years and older) and young adults are different from those that form in early childhood. (cigna.com)
  • Ovarian germ cell tumors are more common in adolescent girls and young women. (cigna.com)
  • Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
  • Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
  • A subset of patients with disorders of sex development (DSD) is at risk for malignant germ cell tumors (GCTs). (pediatricendoreviews.com)
  • Gonal-f ® Multi-Dose is contraindicated in women and men who exhibit prior hypersensitivity to rhFSH or excipients, high levels of FSH indicating primary gonadal failure, uncontrolled thyroid, adrenal or pituitary disorders, sex hormone dependent tumors of the reproductive tract/accessory organs, tumors of pituitary gland or hypothalamus. (emdseronofertility.com)
  • 1-6 Gonadectomy reduces pet overpopulation and euthanasia in animal shelters and decreases the risk for gonadal tumors, mammary neoplasia and pyometra in dams and queens, and perianal adenomas and benign prostatic hyperplasia in male dogs. (cliniciansbrief.com)
  • Mainly virilized females as a result of congenital adrenal hyperplasia (CAH) and girls with aberrant ovarian development. (wikipedia.org)
  • Androgen-producing tumours of either adrenal or ovarian origin may also lead to masculinization of a female fetus . (britannica.com)
  • 12 ] described the first two NR5A1 variants in individuals with 46,XY DSD who presented primary adrenal insufficiency and complete gonadal dysgenesis. (biomedcentral.com)
  • These conditions may be caused by numerical or structural variations in sex chromosomes as well as autosomes, variations in genes involved in gonadal and/or genital development, and changes in gonadal and/or adrenal steroidogenesis. (e-apem.org)
  • Adipose tissue secretes a variety of substances, including hormones like leptin and adiponectin, which are crucial in regulating appetite, metabolism, and insulin sensitivity. (medicaltourism.com)
  • These hormones also impact reproductive function, as they can influence the hypothalamic-pituitary-gonadal (HPG) axis, the primary system responsible for controlling the reproductive process. (medicaltourism.com)
  • In adult female rodents, acute HPA function following a stressor is markedly greater than it is in males, and this difference has largely been attributed to modulation by the gonadal hormones testosterone and estradiol. (nature.com)
  • These gonadal hormones are produced by the hypothalamic-pituitary-gonadal (HPG) axis and have been shown to determine sex differences in adult HPA function after acute stress via their activational and organizational effects. (nature.com)
  • Although these actions of gonadal hormones are well supported, the possibility that sex chromosomes similarly influence HPA activity is unexplored. (nature.com)
  • Moreover, questions remain regarding sex differences in the activity of the HPA axis following chronic stress and the underlying contributions of gonadal hormones and sex chromosomes. (nature.com)
  • We primarily outline what is known about how gonadal hormones and sex chromosomes modulate HPA axis activity following acute stress, and then focus on sex-biased HPA axis activity post-chronic stress, which is far less well understood. (nature.com)
  • Throughout a female's reproductive lifespan, the ovaries undergo continual structural changes that are crucial for the maturation of ovarian follicles and the production of sex steroid hormones. (mdpi.com)
  • Changes in sex hormones following the impact of nicotine appear to affect the release of hypothalamic-releasing hormones through hypothalamic-pituitary-gonadal (HPG) axes, such as luteinizing hormone-releasing hormone (LHRH) [ 2 ]. (biomedcentral.com)
  • These will promote testis differentiation and ultimately the production of hormones that will lead to male development and testicular function during adulthood. (benthamscience.com)
  • Endocrinology is a branch of healthcare science that deals with the disorders and functioning of the endocrine system, and its secretions are known as hormones. (asterhospitals.ae)
  • Purpose: Undercarboxylated-Osteocalcin (ucOCN), acting on its putative receptor GPRC6A, was shown to stimulate of testosterone (T) production by Leydig cells in rodents, in parallel with the hypothalamus-pituitary-gonadal axis (HPG) mediated by luteinizing hormone (LH). (endocrine-abstracts.org)
  • The hypothalamic-pituitary-gonadal (HPG) axis plays a crucial and integrative role in the mammalian endocrine regulation to maintain homeostasis. (intechopen.com)
  • This panel is useful in determining the health of the hypothalamic-pituitary-testicular axis (HPTA) and whether a man has primary or secondary hypogonadism. (discountedlabs.com)
  • It is also recommended for assessing the health of the hypothalamic-pituitary-testicular axis, also known as HPTA. (discountedlabs.com)
  • Moreover, orexins have been reported to greatly influence gonadotropin-releasing hormone neurons and their secretions to regulate reproductive functions via modulation of the hypothalamic-pituitary-gonadal axis. (researchgate.net)
  • This study showed ginseng protects folliculogenesis via alteration of hypothalamic- pituitary-gonadal (HPG) axis, induction of proliferation in ovarian somatic cells, reduction of lipid peroxidation, and downregulation of apoptotic markers in the mouse ovary, treated with nicotine. (biomedcentral.com)
  • The hypothalamic-pituitary-gonadal (HPG) axis is a key neuroen-docrine regulation system involved in the growth and reproduction of poultry. (scielo.br)
  • The hypothalamic-pituitary-gonadal (HPG) axis is an important component of the endocrine system, regulating reproductive functions of the body. (scielo.br)
  • Ovaries and ovarian portions of ovotestes appear normal and demonstrate follicular growth with estradiol production. (medscape.com)
  • We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)
  • In the absence of the Y chromosome, the fetal tissue in a female fetus (XX) will form the female sex organs - the ovaries, uterus and the fallopian tubes. (targetwoman.com)
  • Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. (medscape.com)
  • H&E stain of ovotestis demonstrating ovarian parenchyma (left) with multiple primary follicles and testicular parenchyma (right). (medscape.com)
  • The presence of estradiol in developing ovarian follicles usually inhibits spermatogonia development in adjacent or contralateral seminiferous tubules. (medscape.com)
  • In the female body, FSH promotes the development of ovarian and follicles in the first phase of the cycle, the growth of the endometrium, the formation of estrogen and the synthesis of estradiol granulosa cells. (vittoriavita.com)
  • This led to the Chicago Consensus, recommending a new terminology based on the umbrella term disorders of sex differentiation. (wikipedia.org)
  • Individuals with abnormal testicular differentiation, defects in testosterone biosynthesis, and impaired testosterone action. (wikipedia.org)
  • Sex specific development in the human comprises irreversible sexual differentiation of the external genitalia during embryogenesis, sexual maturation of secondary sex characteristics during puberty (e.g., sex specific body proportions, pubertal voice change) and eventually sex specific development of extragenital tissues and organs, including the brain. (pediatricendoreviews.com)
  • The degree of gonadal differentiation (or "testicularization" in the presence of a specific part of the Y chromosome), in combination with expression of embryonic germ cell markers, and (a) Y specific gene(s) related to cell-cycle control and proliferation, determines this risk. (pediatricendoreviews.com)
  • pseudohermaphroditism , a condition in which the individual has a single chromosomal and gonadal sex but combines features of both sexes in the external genitalia , causing doubt as to the true sex. (britannica.com)
  • Disorders of sex development (DSDs), also known as differences in sex development, diverse sex development and variations in sex characteristics (VSC), are congenital conditions affecting the reproductive system, in which development of chromosomal, gonadal, or anatomical sex is atypical. (wikipedia.org)
  • PURPOSE: To provide agreed-upon guidelines on the management of a hyper-responsive patient undergoing ovarian stimulation (OS) METHODS: A literature search was performed regarding the management of hyper-response to OS for assisted reproductive technology. (researchportal.be)
  • Polycystic Ovary Syndrome (PCOS), the most common endocrine disorder of women during the reproductive period, is often implicated with NAFLD.Aim: To investigate the potential involvement of PCOS on the aggravation of NAFLD by. (endocrine-abstracts.org)
  • In the intricate world of reproductive health, the role of adipose tissue (commonly known as body fat) in fertility has emerged as a subject of significant interest. (medicaltourism.com)
  • The distribution and amount of adipose tissue in the body significantly influence overall health, including reproductive health. (medicaltourism.com)
  • The relationship between adipose tissue and fertility is a dynamic and multifaceted aspect of reproductive health. (medicaltourism.com)
  • Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. (researchgate.net)
  • Disorders of the external genitalia are especially troubling for parents because of the potential emotional significance of these reproductive structures and, probably, the possible impact of the anomalies on the child and on future generations. (medscape.com)
  • The male and female reproductive organs have the same precursor tissues. (benthamscience.com)
  • Disorders of sex development (DSDs) are a genetically and clinically heterogeneous group of congenital conditions of the urogenital tract and reproductive system. (e-apem.org)
  • Aromatase deficiency - A disorder which, in females, is characterized by androgen excess and estrogen deficiency, and can result in inappropriate virilization, though without pseudohermaphroditism (i.e., genitals are phenotypically appropriate) (with the exception of the possible incidence of clitoromegaly). (wikipedia.org)
  • 46,XY and 46,XX DSDs can be further subdivided into the subclasses of disorders of gonadal development, disorders of androgen biosynthesis and excess, and unclassified. (e-apem.org)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • Anatomical resources for either male or female development and variations are present in the early weeks of gestation ( Table 2 ) gonadal ridge, Wolffian (mesonephric) and Müllerian (paramesonephric) ducts, cloaca and subsequent urogenital sinus, genital tubercle and labioscrotal swellings. (pediatricurologybook.com)
  • In the next period, called sex determination (lasting from approximately 6 to 8 weeks of gestation), the bipotent gonadal anlagen eventually develops into ovarian or testicular cells. (e-apem.org)
  • On the C57BL/6J background, embryos homozygous for byg exhibit consistent XY gonadal sex reversal. (plos.org)
  • To identify the clinical characteristics of SRY -negative male patients and genes related to male sex reversal, we performed a retrospective study using cases of 46,XX testicular disorders of sex development with a review of the literature. (e-kjgm.org)
  • 46,XX male sex reversal (also known as testicular DSD) is reported in 1:20,000 to 1:25,000 of newborn males [ 1 ], and is categorized using clinical phenotypes or molecular genetic analysis depending on the presence or absence of the SRY gene. (e-kjgm.org)
  • DSDs range from common disorders like cryptorchidism to very rare and complex conditions like complete XX or XY sex reversal. (e-apem.org)
  • Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
  • Therewith, excessive amounts of adipose tissue can decrease testosterone concentrations and thereby spermatogenesis through increase of leptin and oestrogen. (nature.com)
  • This is likely due to increased conversion of testosterone to estrogen in adipose tissue and inflammation-related impairments in testicular function. (medicaltourism.com)
  • In men, LH stimulates the activity of Leydig testicular cells, which is why it is also called the interstitial cell-stimulating hormone. (discountedlabs.com)
  • Ovotesticular disorder of sexual development, which was previously termed "intersex," describes disorders in which there is a discrepancy between a person's phenotype, genetic material, and gonads. (medscape.com)
  • Such gonads are found exclusively in people with ovotesticular disorder of sexual development (OT-DSD), formerly known as true hermaphroditism. (medscape.com)
  • Development of external genitalia ranges from apparent female to male genitalia with hypospadias or isolated bilaterally undescended ovotestes (gonads containing ovarian and testicular elements). (orpha.net)
  • Definitive diagnosis is based on gonadal histology (testicular and ovarian tissue). (orpha.net)
  • Possible XY, SRY+ testicular DSDs include hypospadias, cryptorchidism, testicular agenesis and hypoplasia, segmental aplasia of the epididymis, deferent ducts and penile hypoplasia (Lyle 2007). (scielo.org.za)
  • These genes were studied in XX testicular/ovotesticular disorders of sex development (DSDs) in the absence of the SRY gene. (e-kjgm.org)
  • An ART cycle in which ovarian stimulation or monitoring has been initiated with the intention to treat, but which did not proceed to follicular aspiration or in the case of a thawed or warmed embryo did not proceed to embryo transfer. (icmartivf.org)
  • Accessory or ectopic breast tissue responds to hormonal stimulation and may cause discomfort during menstrual cycles. (medscape.com)
  • Also it is used to indicate the cause of early puberty or its developmental delay in children and adolescents, also during menstrual disorders (anovulation, oligomenorrhea and amenorrhea), chromosomal congenital abnormalities and to check the effectiveness of hormone therapy. (vittoriavita.com)
  • Most men with KS suffer from an early germ cell loss and testicular fibrosis from puberty onwards. (researchportal.be)
  • GU tract pathologies can arise potentially at any stage of a person's life: newborns and infants can start showing signs and symptoms of congenital GU abnormalities, early or delayed puberty can become a burden for adolescents, STDs remain a major public health concern in sexually active teens and adults, and the potential for gonadal or cervical malignancy is constantly looming in particular cases. (lecturio.com)
  • This panel is helpful in determining primary or secondary hypogonadism disorder. (discountedlabs.com)
  • Advancing stem cell and gonadal tissue transplantation therapies for infertility. (upmc.com)
  • A rare disorder of sex development (DSD) characterized by histologically confirmed testicular and ovarian tissue in an individual with a 46,XX karyotype. (orpha.net)
  • A diagnosis of OT-DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. (medscape.com)
  • An estimated 2,000 babies are born 'intersex' each year, referring to a set of over 60 different conditions that fall under the diagnosis of 'DSD' (Differences/Disorders of Sex Development). (targetwoman.com)
  • Local penile factors and systemic diseases, including diabetes, cardiac disease, and neurologic disorders, can cause ED. Diagnosis is via physical exam and history. (lecturio.com)
  • Many chromosome configurations other than simple 46, XX or 46, XY can result in disorders of sex development. (medlineplus.gov)
  • These include 45, XO (only one X chromosome), and 47, XXY or 47, XXX - both cases have an extra sex chromosome, either an X or a Y. These disorders do not result in a condition in which there is a discrepancy between internal and external genitalia. (medlineplus.gov)
  • Disorders of sexual development (DSD), formerly termed 'intersex', are congenital abnormalities in the development of chromosomal (abnormalities in XX or XY sex chromosome number or structure), gonadal (testicular, ovarian and ovotesticular DSD, previously termed true hermaphrodite, or dysgenesis) or phenotypic (male or female with abnormalities of tubular and external genitalia) sex. (scielo.org.za)
  • Chromosome analysis of cultured peripheral blood cells of 8,386 individuals found 19 cases (0.23%) with 46,XX testicular disorders of sex development. (e-kjgm.org)
  • Epigenetic mechanisms like DNA methylation and histone modifications are essential for multiple physiological processes like development, establishment of tissue identity, imprinting, X-chromosome inactivation, chromosomal stability and gene transcription regulation. (pediatricendoreviews.com)
  • Disorders/differences of sex development ( DSD , also referred to as intersex) are congenital conditions in which chromosomal, gonadal or phenotypic sex are different from what is seen as typically male or female. (pediatricurologybook.com)
  • A new, broad DSD classification was introduced in 2006 via the "Consensus Statement on Management of Intersex Disorders. (pediatricurologybook.com)
  • 2,3,4 In particular, some members of the CAH community identify as having an endocrine disorder, not a DSD /intersex condition. (pediatricurologybook.com)
  • International experts held a conference (International Consensus Conference on Intersex) in 2006 and have reached a consensus that the term DSD or disorder of sex development should replace all those terms. (targetwoman.com)
  • Courtesy of Cureus [De Jesus Escano MR, Mejia Sang ME, Reyes-Mugica M, Colaco M, Fox J. Ovotesticular Disorder of Sex Development: Approach and Management of an Index Case in the Dominican Republic. (medscape.com)
  • Online at https://www.cureus.com/articles/70052-ovotesticular-disorder-of-sex-development-approach-and-management-of-an-index-case-in-the-dominican-republic]. (medscape.com)
  • Patients with ovotesticular disorder of sexual development are individuals who have both ovarian and testicular tissue. (medscape.com)
  • Many patients with ovotesticular disorder of sexual development have a uterus. (medscape.com)
  • Disorders of sexual development (DSD) in wild mammals are rarely described. (scielo.org.za)
  • However, long-term follow-up studies evaluating the effects on their gonadal development and function related to the testicular biopsy procedure are rather limited. (researchportal.be)
  • These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
  • We predict that loss of MAP3K4 or other MAPK components may underlie disorders of sexual development (DSD) in humans as well. (plos.org)
  • Primordial germ cells migrate to the gonadal ridge prior to 6 weeks and the infrastructure to support gonad development is further influenced by various genes. (pediatricurologybook.com)
  • SF-1 and WT-1 have influence over gonadal development and subsequent endocrine communication to the Wolffian (mesonephric-blue) and Müllerian (paramesonephric-orange) ducts. (pediatricurologybook.com)
  • Methods to use frozen testicular tissue in reproduction are still in development. (upmc.com)
  • SRY -negative cases of 46,XX testicular disorders of sex development referred for cytogenetic analysis from 1983 to 2013 were examined using clinical findings, seminal analyses, basal hormone profiles, conventional cytogenetic analysis and polymerase chain reaction. (e-kjgm.org)
  • We report three rare cases of SRY -negative 46,XX testicular disorders of sex development. (e-kjgm.org)
  • The child is born with a disorder of sex development (DSD). (targetwoman.com)
  • But, if at any stage of sex development an atypical development takes place it results in a 'disorder of sex development. (targetwoman.com)
  • When the ambient temperature exceeds the upper limit of the thermoneutral zone of poultry, the body will be under stress, resulting in tissue and endocrine system disorders and suppressed organ development. (scielo.br)
  • Adolescents with 46,XY disorders of sex development (DSD) face additional medical and psychological challenges. (biomedcentral.com)
  • We described a novel NR5A1 variant and demonstrated its adverse effects on the functional integrity of the NR5A1 protein resulting in serious impairment of its modulation of gonadal development. (biomedcentral.com)
  • Nuclear receptor subfamily 5 group A member 1 ( NR5A1, also known as SF-1 , AD4BP and FTZF1 ) is a key transcription factor that determines gonadal development and regulates coordinates endocrine functions [ 9 ]. (biomedcentral.com)
  • In multicellular organisms, and particularly in mammals, both gonadal and germ cell development are essential for the transmission of genetic information to the next generations. (benthamscience.com)
  • In this chapter, we will provide a brief overview of the testicular anatomy and functional organization, as well as its embryonic development. (benthamscience.com)
  • All individuals with a suspected disorders of sex development need to undergo a thorough diagnostic evaluation, including extensive whole-body and genital physical examinations, biochemical and genetic investigations, and imaging studies. (e-apem.org)
  • Ovotestes are usually compartmentalized, with connective tissue separating the ovarian components from the testicular components. (medscape.com)
  • Soon after birth, the nipples are raised from the shallow mammary pits by proliferation of the surrounding connective tissue. (medscape.com)
  • NR2F2 gene variants have been described in individuals with a 46,XX testicular / ovotesticular DSD phenotype associated with cardiac defects, some with congenital diaphramatic hernia and blepharophimosis-ptosis-epicanthis inversus. (orpha.net)
  • In this condition of sexual ambiguity, the individual pseudohermaphrodite possesses gonadal tissue of one sex but exhibits external phenotype of the opposite sex. (targetwoman.com)
  • The patient's underlying genetic defect and phenotype might be informative in assessing the degree of gonadal "testicularization" on a clinical basis. (pediatricendoreviews.com)
  • These accessory tissues have been reported to undergo malignant transformation and should be removed. (medscape.com)
  • Ovotesticular disorder: patients having both ovarian and testicular tissue. (wikipedia.org)
  • Research question: Which early-diagnosed Klinefelter syndrome patients have been offered cryopreservation of testicular tissue as part of fertility preservation before spermatogonial stem cell (SSC) loss? (researchportal.be)
  • In women, both excessive and insufficient adipose tissue can lead to fertility issues. (medicaltourism.com)
  • Similarly, in men, abnormal adipose tissue levels can affect fertility. (medicaltourism.com)
  • Metabolic health, closely linked with the function and amount of adipose tissue, is a key factor in fertility. (medicaltourism.com)
  • Metabolic disorders such as insulin resistance and type 2 diabetes, often associated with excess body fat, can impair fertility in both sexes. (medicaltourism.com)
  • Additionally, lifestyle interventions are often the first line of management for fertility issues associated with adipose tissue. (medicaltourism.com)
  • Recent research has delved deeper into understanding how adipose tissue influences fertility at a molecular level. (medicaltourism.com)
  • Emerging therapeutic approaches aimed at modulating adipose tissue function and its hormonal outputs are being investigated as potential treatments for fertility issues. (medicaltourism.com)
  • On the other hand, inadequate body fat, often seen in extremely low body weight or in conditions like anorexia nervosa, can lead to amenorrhea (absence of menstruation) and decreased ovarian function. (medicaltourism.com)
  • This disorder arises from an inherited defect in one of the enzymes needed for the production of cortisol , a hormone that plays a major role in the physiological response to stress . (britannica.com)
  • Wolffian duct structures tend to be observed on the gonadal side containing functioning testicular tissue. (medscape.com)
  • Gonal-f ® Multi-Dose is also contraindicated in women who exhibit abnormal uterine bleeding and/or ovarian cyst enlargement of undetermined origin. (emdseronofertility.com)
  • Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)
  • There are two primary types of adipose tissue: white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which is involved in thermogenesis and energy expenditure. (medicaltourism.com)
  • This includes pharmacological agents targeting adipose tissue metabolism and interventions designed to modify adipose tissue distribution. (medicaltourism.com)
  • Athelia (ie, absence of nipples) and amastia (ie, absence of breast tissue) may occur bilaterally or unilaterally. (medscape.com)
  • Mastitis neonatorum or infections of the breast tissue may also occur during the newborn period. (medscape.com)
  • These discrepancies can be manifested in different gonadal combinations, including ovotestis with ovary, ovary and testis, bilateral ovotestis, and ovotestis and tesis. (medscape.com)
  • The ovotestis can be anatomically located in an ovarian position, or along the anatomical path of the testes in the labioscrotal fold, the inguinal canal, or at the internal inguinal ring. (medscape.com)
  • Breast disorders occurring in pediatric patients range from congenital conditions to neonatal infections and from benign disorders such as fibroadenoma in females and gynecomastia in males to breast carcinoma and rhabdomyosarcoma . (medscape.com)
  • Term Amniotic membrane (AM) is a very attractive source of Mesenchymal Stem Cells (MSCs) due to the fact that this fetal tissue is usually discarded without ethical conflicts, leading to high efficiency in MSC. (biomedcentral.com)
  • Previous genomics studies on testis tissue from men with KS focused on germ cell loss, while a transcriptomic analysis focused on testicular fibrosis has not yet been performed. (researchportal.be)
  • Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)