Ovarian mixed germ cell tumor germ cell differentiation occurs differentiation of cells. Medical search. Frequent questions

The main neoplasms in the differential diagnosis of ovarian dysgerminoma are lymphoma/leukemia, yolk sac tumor , embryonal carcinoma , and Sertoli cell tumor. (medscape.com)
When present, embryonal cell carcinoma exhibits more nuclear hyperchromasia and nuclear pleomorphism, amphophilic cytoplasm, high mitotic index, and necrosis than ovarian dysgerminomas. (medscape.com)
The cells of embryonal carcinoma express CD30 and cytokeratin (strong, diffuse), whereas those of dysgerminoma do not. (medscape.com)
Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
The degree and the route of differentiation determine the histological type: the proliferation of undifferentiated germ cells induces a dysgerminoma, that of totipotent germ cells leads to an embryonic carcinoma, that of cells progressing in the extraembryonic differentiation pathway leads to a tumor of the yolk sac or choriocarcinoma and that of cells with embryonic differentiation to mature and/or immature teratomas. (biomedres.us)
Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)
However, as explained below, recent morphologic findings and molecular analyses have demonstrated that each morphologic subtype of ovarian carcinoma might be derived from a Müllerian-type epithelium. (biomedcentral.com)
Endometrioid carcinoma (EC) and clear cell carcinoma (CC) are associated with endometrial tissue hyperplasia and endometriosis, and they occur in the endometrium and ovaries. (bvsalud.org)
The histological subtypes for the 1347 OC patients with biological material were 911 (68%) serous adenocarcinoma, 97 (7%) endometrioid adenocarcinoma, 80 (6%) mucinous adenocarcinoma, 58 (4%) clear cell carcinoma, and for 201 (15%) no information were registered. (bvsalud.org)
In particular, ovarian endometriomas, cystic lesions of deeply invasive endometriosis, are considered the precursor lesion for ovarian clear-cell carcinoma (OCCC). (bvsalud.org)
We report a rare and very aggressive case of lung carcinoma showing trophoblastic differentiation, so-called choriocarcinoma, for which postoperative recurrence was treated using gefitinib. (journalmc.org)
This is the first case report using gefitinib to the lung carcinoma showing trophoblastic differentiation. (journalmc.org)
A review of the literature on lung cancer with trophoblastic differentiation suggested that a chemotherapeutic regimen for primary lung cancer other than germ cell tumor might be suitable for the lung carcinoma with trophoblastic differentiation. (journalmc.org)
We report a case of the lung carcinoma with trophoblastic differentiation so-called choriocarcinoma of the lung, of which the postoperative recurrence was treated by gefitinib. (journalmc.org)
This carcinoma was very aggressive and we had difficulty selecting the chemotherapeutic agents for the treatment of the postoperative recurrences, therefore, we reviewed the literatures concerning the chemotherapeutic regimen of the lung carcinoma with trophoblastic differentiation or the choriocarcinoma of the lung. (journalmc.org)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
The paternal cell lines are (1) the p53-wt (wild type) pluripotent gonadal germ cell tumor cell line NTERA-2, (2) the p53-mutated pluripotent extragonadal nonseminomatous germ cell tumor cell line NCCIT and (3) the p53-wt nullipotent embryonal cell carcinoma 2102EP, derived from a primary human testicular teratocarcinoma. (biomedcentral.com)
SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
A fragment of the Dab2 human cDNA was also isolated based on its frequent loss of expression in ovarian cancer, and was termed DOC-2 (Differentially expressed in ovarian carcinoma gene 2) [ 2 ]. (biomedcentral.com)

Most of the cervical epithelial neoplasms and their precursors occur at the squamocolumnar junction or within the transformation zone. (cytojournal.com)
Teratomas (from Greek teras, meaning "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors are relatively common solid neoplasms in children. (medscape.com)
Ovarian tumors account for a considerable proportion of clinically relevant neoplasms in females, exhibiting a wide range of age at presentation (from infant to elderly patients). (biomedcentral.com)
Epithelial neoplasms of the ovary are thought to arise either directly or indirectly from the ovarian surface epithelium according to incessant ovulation theory[ 4 ]. (biomedcentral.com)
While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
and human chorionic gonadotropin (hCG), seen in choriocarcinoma testicular germ cell neoplasms. (doctorlib.info)
Nurden provides reported that platelet glycoprotein dysfunction and signaling defects might occur in myeloproliferative neoplasms (MPNs), including CML [3]. (cancercurehere.com)

Primary malignant germ cell tumors of the ovary are rare. (biomedres.us)
We carried out a retrospective and descriptive study of the cases of primary malignant germ cell tumors of the ovary diagnosed at the paraclinical training and research unit in Pathological Anatomy and Cytology of the HU/JRA, over a period of 10 years, going from January 2010 to December 2019. (biomedres.us)
We included all cases of malignant germ cell tumors of the ovary of any age. (biomedres.us)
Germ cell tumors of the ovary are a heterogeneous group of tumors developed from primordial cells derived from the embryonic gonad. (biomedres.us)
Malignant germ cell tumors of the ovary are linked to the existence of a cytogenetic characteristic common to all ovarian, testicular or extra-gonadal germ cell tumors, the presence of an isochromosome of the short arm of chromosome 12 [i(12p)] which is not found in any other type of cancer [6]. (biomedres.us)
Malignant ovarian lesions include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. (medscape.com)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
Leiomyomas are rare solid tumours of the ovary accounting for 0.5 - 1% of the benign ovarian tumours [1] . (ommegaonline.org)
Moreover, in agreement with the high expression of these genes in the testis and ovary, we found significant impairment of the reproductive process and pathological alterations, including tumors, mainly limited to the gonads. (biomedcentral.com)
Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)
Its essence is ovarian follicle depletion, and the resulting low estrogen levels in the ovary induce the occurrence and development of many other diseases [ 1 ]. (biomedcentral.com)
It was found that ovoid cells in the epithelial layer of the ovary simultaneously expressed the germ cell specific marker MVH and the proliferation of cell marker BrdU using double-immunofluorescence staining. (biomedcentral.com)
This discovery invalidated the "fixation theory of primordial follicle pool" and suggested for the first time the hypothesis that germ stem cells also exist in the ovary. (biomedcentral.com)
Niikura [ 5 ] and others observed germ cells expressing Stra8 (stimulated by retinoic acid gene 8) in the ovarian surface epithelium, indicating that there may be germ cells with meiotic function in the ovary. (biomedcentral.com)

Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)
Benign epithelial tumors (adenoma and cystadenoma) are characterized by the absence of cell proliferation and invasion. (biomedcentral.com)
Borderline tumors are characterized by cell proliferation and a minor degree of nuclear atypia without stromal invasion. (biomedcentral.com)
Carcinomas are characterized by cell proliferation, nuclear atypia, and stromal invasion. (biomedcentral.com)
Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
Tumors develop when the normal regulation of the balance between cell proliferation (mitosis) and programmed cell death (apoptosis) is lost. (doctorlib.info)
These genes are deleted or inactivated in cancer cells, allowing unregulated proliferation. (doctorlib.info)
The ovarian microenvironment affects the proliferation and differentiation of OGSCs, and immune cells and related cytokines are important components of the microenvironment. (biomedcentral.com)
However, whether improving the ovarian microenvironment can regulate the proliferation of OGSCs and remodel ovarian function has not been reported. (biomedcentral.com)
With increasing time, the fluorescence intensity of cells gradually increased, and the cytokines IL-2 and TNF-α significantly promoted the proliferation of OGSCs. (biomedcentral.com)
It is worth noting that the proliferation and differentiation of stem cells cannot be separated from the surrounding microenvironment, and immune system related cells are an important part of the microenvironment of the OGSCs nest [ 14 ]. (biomedcentral.com)
Chronic myelogenous leukemia (CML) is certainly a clonal myeloproliferative neoplasm (MPN) characterized by dysregulated and uncontrolled proliferation of mature and maturing granulocytes with normal differentiation. (cancercurehere.com)
These cells are the original precursors of various cells in a tumor, whereas other intratumoral cells are limited in terms of their potential for proliferation and pluripotent differentiation. (biomedcentral.com)

These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. (biomedcentral.com)
According to the 2014 World Health Organization (WHO) classification and tumor morphology, primary ovarian tumors are subdivided into three categories: epithelial (60%), germ cell (30%), and sex-cord stromal tumors (8%)[ 1 ]. (biomedcentral.com)
Malignant germ cell and sex-cord stromal tumors comprise approximately 10% of all malignant ovarian tumors. (biomedcentral.com)

They may occur in both gonadal and extragonadal locations. (medscape.com)
Normal migration of these germ cells may cause gonadal tumors, whereas abnormal migration produces extragonadal tumors. (medscape.com)
In 1965, Teilum first suggested the germ cell origin of gonadal tumors. (medscape.com)
Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
The precise levels and timing of NR0B1 gene expression are critical for gonadal differentiation and sex determination during embryogenesis [ 1 ]. (oncotarget.com)

Indeed, it has been postulated that the possible mechanisms by which repetitive ovulation could influence the development of ovarian carcinomas include an increased formation of inclusion cysts, repeated bathing of the surface epithelium by an estrogen-rich follicular fluid, excessive production of growth factors or cytokines, and an aberration of the repetitive repair process that follows the trauma to the surface epithelium as a consequence of ovulation. (biomedcentral.com)

They are considered to be lesions linked to errors in the differentiation and/or migration of primordial cells [2]. (biomedres.us)
Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. (biomedcentral.com)
Based on these findings, the researchers proposed the bold idea of directly transplanting entire mitochondria, rather than drugs or whole cells, into lesions to explore the rescue effects of exogenous mitochondria. (biomedcentral.com)
We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. (biomedcentral.com)

We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). (biomedcentral.com)
They represent 30% of all epithelial tumors and 80%-85% of all ovarian cancers. (biomedcentral.com)
Introduction: Endometriosis, a benign inflammatory disease whereby endometrial-like tissue grows outside the uterus, is a risk factor for endometriosis-associated ovarian cancers. (bvsalud.org)
These genes, acquired at conception or mutated during life, make the affected person prone to most cancers by altering or impairing several processes: & Production of nuclear transcription factors that control cell growth. (ehd.org)
I. To evaluate the Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 overall response rate (ORR) in subsets of patients with advanced rare cancers treated with ipilimumab plus nivolumab combination immunotherapy. (clinicaltrialsgps.com)
The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)

Although germ cell tumors arise from primordial ovarian and testicular germ cells, the pathogenesis of the ovarian germ cell tumors is unknown. (medscape.com)
We demonstrated that the silencing of the ambra1b gene determines a reduction of primordial germ cells (PGCs), a condition that, in the zebrafish, leads to the development of all-male progeny. (biomedcentral.com)

The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
Approximately 75%-80% of ovarian tumors are benign, occurring in patients under 40 years of age. (biomedcentral.com)

and they express sex cord stromal markers such as calretinin, inhibin, and steroidogenic factor-1, and they lack germ cell markers. (medscape.com)
Most of the malignant tumors produce markers that can be serologically assessed. (medscape.com)
Tumour markers including CA 125, AFP (Alfa feto protein), B-HCG (Beta human chorionic gonadotrophin) and LDH (Lactate Dehydrogenase) were within normal limits. (ommegaonline.org)
In view of imaging findings, normal levels of tumour markers, young age and incomplete family, tentative plan of treatment was right salpingo-oophorectomy and decision on chemotherapy based on histopathological report. (ommegaonline.org)
Tumor markers are substances that can be detected in the peripheral blood and are derived from neoplastic populations, but lack functional hormonal or other physiologic activity. (doctorlib.info)
In general, serum tumor markers are characterized by low sensitivity and low specificity. (doctorlib.info)
Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? (biomedcentral.com)

Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
However, soft-tissue sarcomas of the hand are rapidly growing tumors with a high metastatic potential. (temptationsbite.com)

See Ovarian Cancer and Borderline Ovarian Cancer for more information on these topics. (medscape.com)
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
Early ovarian cancer causes minimal, nonspecific, or no symptoms. (medscape.com)
Symptoms independently associated with the presence of ovarian cancer include pelvic and abdominal pain, increased abdominal size and bloating, and difficulty eating or feeling full. (medscape.com)
The presence of advanced ovarian cancer is often suspected on clinical grounds, but it can be confirmed only pathologically by removal of the ovaries or, when the disease is advanced, by sampling tissue or ascitic fluid. (medscape.com)
The US Preventive Services Task Force (USPSTF) recommends against screening (with serum CA125 level or transvaginal ultrasonography) for ovarian cancer in the general population. (medscape.com)
Routine imaging is not required in all patients in whom ovarian cancer is highly suggested. (medscape.com)
Fine-needle aspiration (FNA) or percutaneous biopsy of an adnexal mass is not routinely recommended, as it may delay diagnosis and treatment of ovarian cancer. (medscape.com)
Instead, if a clinical suggestion of ovarian cancer is present, the patient should undergo laparoscopic evaluation or laparotomy, based on the presentation, for diagnosis and staging. (medscape.com)
The age-specific incidence of ovarian epithelial cancer rises from the age of 20 to 80 and subsequently declines[ 2 ]. (biomedcentral.com)
The aim is to describe the degree of biological material collected and stored in DCB for patients diagnosed with primary ovarian cancer registered in The Danish Gynecologic Cancer Database (DGCD). (bvsalud.org)
Biological materials are present for 1.347 (62%) of 2.172 patients with primary ovarian cancer (OC). (bvsalud.org)
These time windows are considered as specific periods of susceptibility for breast cancer because significant structural and functional changes occur in the mammary gland, as well as alterations in the mammary micro-environment and hormone signaling that may influence risk. (biomedcentral.com)
Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)
Tumors or cancer of the MOUTH. (lookformedical.com)
Tumors or cancer of the SKIN . (lookformedical.com)
Tumors or cancer of the LUNG. (lookformedical.com)
Tumors or cancer of the LIVER. (lookformedical.com)
Tumors or cancer of the UTERINE CERVIX. (lookformedical.com)
Chlorine dioxide (ClO2), a strong oxidant, can safely be injected into a subject's body, including a tumor, although the compound has not yet been utilized as a cancer treatment in this manner. (justia.com)
Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
ix Capacity of cancer tissue to produce abundant PA likely contributes to cancer cell's higher growth rates.ix ,x High concentrations of PA enhance cancer cells to invade, and is associated with less apoptosis and increased expression of the genes affecting metastasis.ix ,xi The association of increased polyamine synthesis and cancer was first reported in the late 1960s. (justia.com)
Only the has-miR-10b involved in breast cancer invasion and metastasis and has-miR-512-3p appeared to be up-regulated (2-3-fold) in all three cell lines. (biomedcentral.com)
Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent widely used in the treatment of several solid tumors, among them testicular cancer, lung cancer, breast cancer, and bladder cancer. (biomedcentral.com)
Specifically, recent studies show that aberrant regulation of alternative splicing frequently occurs in cancer to affect tumor cell transformation and growth. (biomedcentral.com)
Substances that cause cancer can be tumor initiators. (doctorlib.info)
The two main types of genes that are now recognized as playing a role in cancer are oncogenes and tumor suppressor genes. (doctorlib.info)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Since its expression is lost in several cancer types, Dab2 has been suggested to be a tumor suppressor. (biomedcentral.com)
Therefore, investigations on testing and maintaining the integrity of genomic DNA within precancerous stem cells (pCSCs), which are within the framework of the cancer stem cell (CSC) hypothesis, are necessary. (biomedcentral.com)

Contrast enhanced computed tomography (CECT) of the abdomen revealed 13 X 13 X 11 cm lobulated mixed (predominantly solid) markedly enhancing soft tissue mass is noted in the right adnexal region with enhancing intralesional and perilesional vessels with peripheral irregular dense calcification suggestive of yolk sac tumour (Figure 1a). (ommegaonline.org)
CECT abdomen showing mixed, markedly enhancing soft tissue mass arising in the right adnexal region with enhancing intralesional and perilesional vessels with peripheral irregular dense calcification suggestive of yolk sac tumour. (ommegaonline.org)
The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
I. To evaluate the association of tumor mutational burden measured by tissue sequencing with durable response (complete response [CR] or partial response [PR] lasting 24 weeks or more). (clinicaltrialsgps.com)
A diagnosis of OT-DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. (medscape.com)
Patients with ovotesticular disorder of sexual development are individuals who have both ovarian and testicular tissue. (medscape.com)
Ovotestes are usually compartmentalized, with connective tissue separating the ovarian components from the testicular components. (medscape.com)
Tumor promoters are not able to cause tumors to form, but increase the frequency of tumor formation in tissue previously exposed to the tumor initiator. (doctorlib.info)
Errors arising in stem and progenitor cells have a much greater influence on the tissue in which they are found than errors arising in postmitotic differentiated cells. (biomedcentral.com)

A study that investigated nuclear protein in the testis (NUT) expression in ovarian germ cell tumors found that most malignant ovarian germ celll tumors express NUT protein, albeit focally. (medscape.com)

1, 2016, entitled "A New Method for Promoting Tumor Necrosis" and provisional application Ser. (justia.com)

It is hypothesized that the epithelium covering the ovarian surface and the peritoneum retains the potential for Müllerian differentiation given the proximity to the coelomic epithelium from which the Müllerian ducts are derived. (biomedcentral.com)
Serous carcinomas are thought to be derived from the fallopian tubes through foci of endosalpingiosis, which are inclusion cysts from the tubal epithelium at the ovarian and peritoneal surface. (biomedcentral.com)
It may also occur in sites where glandular or columnar epithelium is normally present. (lookformedical.com)
although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
Persistent stem cells in the oral epithelium of adults are the only cells that can accumulate sufficient mutations for OSCC to develop [ 18 , 19 ]. (biomedcentral.com)

The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)

therefore, in this study, we aimed to analyze the clinicopathological correlations between these tumors using immunostaining and to develop new treatments based on histological subtypes. (bvsalud.org)
These differences in tumor site and histological subtypes shown in this study will lead to the establishment of treatment based on histological and immunohistological classification. (bvsalud.org)

Teratomas may be classified as mature or immature on the basis of the presence of immature neuroectodermal elements within the tumor. (medscape.com)
Mutter suggested that these genes or the cells have only the maternal imprint because many teratomas arise from a parthenogenetically activated egg. (medscape.com)
[4] [9] Most ovarian teratomas are mature. (mdwiki.org)
Treatment of tailbone, testicular, and ovarian teratomas is generally by surgery. (mdwiki.org)
Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
[5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)
[18] There also may be a cultural difference, with fetiform teratoma being reported more often in ovarian teratomas (by gynecologists) and fetus in fetu being reported more often in retroperitoneal teratomas (by general surgeons). (mdwiki.org)

Yolk sac tumors may exhibit a solid pattern, simulating dysgerminoma, but other classic architectural patterns of yolk sac tumor (ie, reticular, microcystic, glandular, or Schiller-Duvall bodies) are also invariably present. (medscape.com)

Nuclear receptor subfamily 0 group B member 1 ( NR0B1 ), which is located on the X chromosome, is abundantly expressed in normal reproductive testicular and ovarian tissues. (oncotarget.com)

Ovarian carcinomas are characterized by a Müllerian morphology although the ovaries do not originate from the Müllerian ducts. (biomedcentral.com)
Usually these tumours occur in the reproductive age group and affect both ovaries [2,3] . (ommegaonline.org)
Interestingly, ovaries occur more commonly on the left side than the right. (medscape.com)
Ovaries and ovarian portions of ovotestes appear normal and demonstrate follicular growth with estradiol production. (medscape.com)
COS was given to mice through the best route of administration, and the changes in ovarian and immune function were detected using assays of organ index, follicle counting, serum estrogen (E 2 ) and anti-Mullerian hormone (AMH) levels, and the expression of IL-2 and TNF-α in the ovaries. (biomedcentral.com)

Tumor initiation is the process by which normal cells are changed so that they are able to form tumors. (doctorlib.info)

Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. (biomedcentral.com)
The protein products of tumor suppressor genes are normal genes that slow down cell division, repair DNA mistakes, and tells when to undergo apoptosis (programmed cell death). (doctorlib.info)

Mature tumors (grade 0) have no immature elements. (medscape.com)
Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)

These tumors are grouped together because they all appear to arise from postmeiotic germ cells. (medscape.com)
The best evidence suggests that most are due to abnormal differentiation of fetal germ cells that arise from the fetal yolk sac. (medscape.com)
Arise from sex cord cells (e.g. (amboss.com)

An ovarian dysgerminoma consists of primitive, undifferentiated germ cells. (medscape.com)
Sertoli cell tumors may be mistaken for dysgerminoma when tubules are indistinct and/or solid, especially if they are poorly fixed. (medscape.com)
Although these tumors are thought to be hormonally inert, at least one case of precocious puberty occurring in association with ovarian dysgerminoma has been reported. (medscape.com)

A 51-year-old woman with pathological stage IIA adenocarcinoma with trophoblastic differentiation underwent left lower lobectomy with lymph node dissection and postoperative adjuvant chemotherapy, remaining tumor-free for 10 months until the detection of the brain metastasis. (journalmc.org)
CT-guided needle biopsy revealed poorly differentiated adenocarcinoma with partial trophoblastic differentiation. (journalmc.org)

When this connection was made, it launched a whole new field," says Isidore Rigoutsos, Ph.D., professor of pathology, anatomy, and cell biology and director of the Computational Medicine Center at Thomas Jefferson University. (pharmaceuticalintelligence.com)

and the tumor suppressor genes WT1 and MASH2 are imprinted, depending on their maternal or paternal origin. (medscape.com)

No benefit of addition of other biomarkers like p63 or ki67 is found in problem-solving in differentiation of HSIL from mimics or low-grade squamous intraepithelial lesion. (cytojournal.com)

A malignant epithelial tumor with a glandular organization. (lookformedical.com)

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. (cancerindex.org)
P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)
Detection of mutations in this gene has confirmed the fundamental role of aromatase for the fetal-placental unit and for sexual differentiation of the female fetus. (health.am)
Antigen standard for annexin A4 (ANXA4) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. (creativebiomart.net)
The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)

Inhibition of polyamine by DFMO in animal experiments reduced tumor growth and decreased the amount of metastasis, resulting in prolonged survival of the animals.ix With the introduction of the present "Intume Oxidant," polyamine synthesis will be halted by ClO2 oxidation of existing PA, along with oxidation of PA precursor molecules, arginine and ornithine. (justia.com)
Although the incidence is lower than that of other malignant tumors, it is often accompanied by local invasion and distant metastasis during diagnosis and treatment, and the overall 5-year survival rate is only 50-55% [ 2 ]. (biomedcentral.com)

The abundant melatonin levels in children are believed to inhibit sexual development, and pineal tumors have been linked with precocious puberty. (wikipedia.org)

[ 1 ] Primitive, unipotential germ cells are the precursors to ovarian dysgerminomas, whereas pleuripotential germ cells diverge along several lines of differentiation. (medscape.com)

We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)

These malignant elements are typically yolk sac tumors but may also represent primitive neuroectodermal tumor (PNET). (medscape.com)

Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
Mucinous cells cause gelatinous ascites and intraabdominal adhesions. (amboss.com)
mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)

Histopathological examination revealed tumour composed of interlacing bundles of smooth muscles with oedematous intervening stroma suggestive of leiomyoma (Figure 1d). (ommegaonline.org)

Considering the different effects of ambra1a and ambra1b on sexual differentiation, we decided to investigate the role of Ambra1 in this process. (biomedcentral.com)
Other drugs, like danazol, which are also used in pregnancy, have been associated with abnormalities of sexual differentiation. (health.am)

[ 5 ] These tumors are highly susceptible to radiotherapy. (medscape.com)
Ovarian dysfunction includes a "natural" decline in ovarian function caused by age factors and pathological ovarian function decline caused by pathogenic factors such as radiotherapy, chemotherapy and surgery. (biomedcentral.com)

Epithelial ovarian tumors are the most common tumor subtype. (amboss.com)

Large-cell lymphomas typically occur bilaterally. (medscape.com)
thus, tumors with a high cell turnover are most susceptible (certain leukemias and lymphomas, small proliferating tumors, "recruited" tumor cells, and micrometastases). (doctorlib.info)

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)

Approximately two-thirds of ovarian tumors occur in women during reproductive age, whereas less than 5% occur in children. (biomedcentral.com)
It has been observed that PLO occurring in the reproductive age group is predominantly bilateral whereas those affecting the post menopausal age group are predominantly unilateral [7] . (ommegaonline.org)

Conditional deletion indicates that Dab2 is dispensable for organ development, when the vast majority of the embryonic cells are dab2 null. (biomedcentral.com)

During the study period, we recruited 68 cases of primary ovarian malignancy with 11 cases of germ cell tumor, i.e., 16.17% of cases. (biomedres.us)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
H&E stain of ovotestis demonstrating ovarian parenchyma (left) with multiple primary follicles and testicular parenchyma (right). (medscape.com)

Patients with more advanced disease may present with ovarian or pelvic mass, ascites, pleural effusion, or abdominal mass or bowel obstruction. (medscape.com)

Secondary tumors are uncommon. (cytojournal.com)

Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)

Untreated maternal virilizing CAH is another potential cause, though androgen-secreting adrenal tumor in the mother is rare. (health.am)

This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)

Anatomy13

Diseases18

Chemicals and Drugs5

Phenomena and Processes5

Information Science1

Carcinoma25

Neoplasms10

Ovary14

Proliferation16

Stromal tumors3

Gonadal5

Surface epithelium1

Lesions4

Cancers6

Primordial2

Benign2

Markers7

Metastatic3

Cancer30

Tissue14

Expression in ovarian1

Necrosis1

Epithelium5

Mesenchymal tumors1

Histological2

Teratomas7

Yolk sac t1

Testicular and ovarian1

Ovaries5

Form tumors1

Apoptosis3

Immature2

Arise3

Dysgerminoma3

Adenocarcinoma2

Pathology1

Suppressor genes1

Squamous1

Glandular1

Gene6

Metastasis2

Precocious puberty1

Precursors1

Testis2

Primitive1

Mucinous3

Histopathological1

Sexual differentiation2

Radiotherapy2

Subtype1

Lymphomas2

Epithelial cells3

Reproductive2

Embryonic1

Primary3

Ascites1

Uncommon1

Invasive1

Adrenal1

Oncogenic1