• For in vitro culture of follicles, there are various techniques to optimize the growth of follicles, including the use of defined media, growth factors and three-dimensional extracellular matrix support. (wikipedia.org)
  • There are various activator signalling pathways that are involved in the control of ovarian follicle activation, including: Neurotropin, nerve growth factor (NGF) and its tyrosine receptor kinase (NTRK1), neurotrophin 4 (NT4), brain-derived neurotrophic factor (BDNF) and their receptor NTRK2. (wikipedia.org)
  • Rupture of the follicle can result in abdominal pain (mittelschmerz) and is to be considered in the differential diagnosis in women of childbearing age. (wikipedia.org)
  • Removing GDF9 from mice, through knock-out experiments, halts follicle progression beyond the first stage, and prevents granulosa cell proliferation. (wikipedia.org)
  • Cryopreservation of ovarian tissue is of interest to women who want to preserve their reproductive function beyond the natural limit, or whose reproductive potential is threatened by cancer therapy, for example in hematologic malignancies or breast cancer. (wikipedia.org)
  • Additional ligands have a role in facilitating primordial follicle activation such as transforming growth factor-beta (TGF-B), growth differentiation factor 9 (GDF9) and bone morphogenic protein 15 (BMP15). (wikipedia.org)
  • It is widely understood that androgens act primarily on preantral follicles and that this activity is important for preantral follicle growth. (wikipedia.org)