Outcomes of salvage treatment for biochemical recurrence. Medical search. Frequent questions

These important studies have illuminated the extent to which postoperative radiotherapy (RT) may provide benefit to patients with adverse pathologic features (extraprostatic extension, seminal vesicle invasion, or positive surgical margins) or biochemical recurrence after radical prostatectomy. (jnccn.org)
This study involving patients with biochemical recurrence of prostate cancer following radical prostatectomy found that early initiation of salvage radiotherapy at a PSA level ≤0.5 ng/mL was predictive of better oncologic outcomes. (practiceupdate.com)
The researchers calculated PSA doubling time prior to salvage radiotherapy and chose a dividing line of 6 months because a previous study found it meaningful. (urology-kalamaria.gr)
It is exploring outcomes for patients randomly assigned to salvage radiotherapy with or without ADT. (urology-kalamaria.gr)
Comparison of Clinical Outcomes Stratified by Target Delineation for Patients Undergoing Stereotactic Body Radiotherapy for Spinal Metastases. (ohsu.edu)
Management followed this treatment algorithm accordingly with PSMA results: prostate bed salvage radiotherapy (SRT) if negative or positive within prostate bed, stereotactic body radiotherapy (SBRT) if pelvic nodal recurrences or oligometastatic disease, androgen deprivation therapy (ADT) if nonoligometastatic disease. (hunimed.eu)
Twenty-one patients underwent observation because of prior postoperative radiotherapy (RT)/treatment refusal. (hunimed.eu)
Pak S, You D, Jeong IG, Kim YS, Hong JH, Kim CS and Ahn H: Time to biochemical relapse after radical prostatectomy and efficacy of salvage radiotherapy in patients with prostate cancer. (spandidos-publications.com)
The new findings showed no difference in the rate of 10-year freedom from distant metastases or overall survival in patients who received adjuvant radiotherapy vs those who underwent observation with salvage radiotherapy if their disease progressed and provided further confirmation of earlier results reported in The Lancet in 2020 . (medscape.com)
Observation with early salvage radiotherapy in cases of biochemical failure should be the standard of care, concluded study co-author Noel Clarke, MBBS, who presented the results at the European Society for Medical Oncology (ESMO) Congress 2023 in Madrid on October 20. (medscape.com)
Invited discussant and session co-chair Shahneen Sandhu, MBBS, said that the findings definitively confirm the value of observation with salvage radiotherapy over adjuvant radiotherapy in this patient population. (medscape.com)
The approach of early salvage radiotherapy spared morbidity [from] radiation in the vast majority of patients, and further bowel and bladder toxicity is reduced in the setting of salvage radiotherapy," said Sandhu, an associate professor and consultant medical oncologist at Peter MacCallum Cancer Centre, Victoria, Australia. (medscape.com)
In the study, 697 patients were randomly assigned to adjuvant radiotherapy and 699 to observation with salvage radiotherapy. (medscape.com)
Patients in the observation arm received salvage radiotherapy if they experienced two consecutive PSA increases ≥ 0.1 ng/mL or three consecutive rises. (medscape.com)
However, self-reported urinary and fecal incontinence rates at 1 year were significantly higher in the adjuvant radiotherapy group vs the observation group, 60% of whom had not received salvage radiotherapy at that time. (medscape.com)
Overall, the trial results "support the use of early salvage radiotherapy for PSA failure after radical prostatectomy rather than early adjuvant intervention, " concluded Clarke, a professor and consultant urologist at The Christie Hospital and Salford Royal Hospital, Manchester, United Kingdom. (medscape.com)
Are all prostate cancer patients 'fit' for salvage radiotherapy? (wjgnet.com)
González-San Segundo C, Gómez-Iturriaga A, Couñago F. Are all prostate cancer patients "fit" for salvage radiotherapy? (wjgnet.com)
The indication for salvage radiotherapy (RT) (SRT) in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen (PSA) levels at the time of biochemical recurrence. (wjgnet.com)
This multicenter, randomized, non-inferiority study will compare specialist-based (usual care) versus general practitioner-based (intervention) follow-up care of prostate cancer survivors who have completed primary treatment (prostatectomy or radiotherapy) for localized prostate cancer. (biomedcentral.com)
Radiotherapy traditionally involves a series of lower dose treatments that take place over several days or week. (healthyprostateclub.com)
The Phase II, limited-participation study comparing salvage radiotherapy (SRT) with standard androgen deprivation therapy (ADT) to enhanced ADT with enzalutamide in patients with post-prostatectomy PSA recurrences with aggressive disease features was expected to enroll 170 patients, however the trial official closed to patients with 188 patients accrued. (rtog.org)

OBJECTIVES: Salvage Robotic-Assisted Laparoscopic Prostatectomy (sRALP) is a treatment option for biochemical recurrence (BCR) in prostate cancer. (edu.au)
Overall, peri-operative outcomes were encouraging with low complication rates and estimated blood loss (EBL) equivocal to open and laparoscopic salvage radical prostatectomy (sRP). (edu.au)
CONCLUSIONS: Salvage Robotic-Assisted Laparoscopic Prostatectomy is a technically feasible operation with a low risk of significant associated complications. (edu.au)
Robotic technology can aid the surgeon in salvage prostatectomy. (edu.au)
The optimal timing to initiate salvage radiation therapy after prostatectomy is unclear. (practiceupdate.com)
For the study, published online ahead of print in the Scandinavian Journal of Urology , the investigators reviewed the medical records of 76 hospital patients treated with salvage EBRT following radical prostatectomy. (urology-kalamaria.gr)
PSA doubling time of 6 months or less and seminal vesicle invasion in the prostatectomy specimen were significant predictors of biochemical recurrence. (urology-kalamaria.gr)
a format which led to an engrossing session covering salvage prostatectomy and the extent of primary lymph node dissection (ePLND). (uroweb.org)
Prof. Axel Heidenreich (DE) argued for open salvage prostatectomy and discussed his surgical techniques as well as pre-surgical preparation, outcomes and complications. (uroweb.org)
He showed videos of the crucial steps necessary to reduce complications since salvage prostatectomy is known to be more technically demanding than primary prostatectomy. (uroweb.org)
Radical salvage prostatectomy (RSP) depends on patient selection, and functional outcome depends on the type of radiation therapy and the surgeon's expertise," said Heidenreich as he pointed out that particularly with complications, the surgeon's expertise plays a crucial role. (uroweb.org)
Prof. Declan Murphy (AU) gave the opposing view and pushed for robotic salvage prostatectomy, saying that "experience is what matters, not the surgical approach. (uroweb.org)
Open salvage radical prostatectomy (RP) is an excellent option if the surgeon is very experienced. (uroweb.org)
But the same applies for robotic salvage prostatectomy," argued Murphy. (uroweb.org)
Biochemical recurrence is a difficult problem after radical prostatectomy in prostate cancer ( 1 ). (snmjournals.org)
Design, setting, and participants: The study included 189 patients who experienced prostate-specific antigen (PSA) rise and nodal-only recurrence after radical prostatectomy (RP) and underwent sLND at 11 tertiary referral centers between 2002 and 2011. (uni-koeln.de)
PSMA guided approach for bIoCHEmical relapse after prostatectomy- (PSICHE) trial (NCT05022914). (hunimed.eu)
Salvage Radical Prostatectomy for Recurrent Prostate Cancer: A Systematic Review (French ccAFU). (urotoday.com)
Multiparametric MRI-based 5-year Risk Prediction Model for Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy. (urotoday.com)
His drive to perfect nerve-sparing prostatectomy has led to many technical innovations, and his pioneering efforts in standardizing an active surveillance regimen has led to many patients postponing radical treatment while maintaining a low risk of cancer progression. (grandroundsinurology.com)
Recurrence was defined as a PSA level of ≥0.2 ng mL at more than 6 weeks following prostatectomy or a PSA increase of ≥2 ng/mL above nadir following radiation therapy. (urologytimes.com)
Patients with high‑risk prostate cancer after prostatectomy have a particularly high chance of being diagnosed with biochemical recurrence (BCR). (spandidos-publications.com)
Boorjian SA, Eastham JA, Graefen M, Guillonneau B, Karnes RJ, Moul JW, Schaeffer EM, Stief C and Zorn KC: A critical analysis of the long-term impact of radical prostatectomy on cancer control and function outcomes. (spandidos-publications.com)
Freedland SJ, Humphreys EB, Mangold LA, Eisenberger M, Dorey FJ, Walsh PC and Partin AW: Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. (spandidos-publications.com)
Inclusion Criteria: - Willing and able to provide signed informed consent and HIPAA authorization for the release of personal health information - Males aged 18 years and above - Prior local therapy with prostatectomy or EBRT / brachytherapy is required - Prior salvage or adjuvant radiation therapy is allowed but not mandated. (mycancergenome.org)
The STEEL study was designed to address a dire need for improved outcomes for prostate cancer patients with PSA recurrences with aggressive features following prostatectomy. (rtog.org)
Although SRT is a widely-accepted treatment option for patients with post-prostatectomy PSA recurrences, including those with aggressive features, up to half of the patients treated with SRT will experience disease progression," stated Edwin Posadas, MD, FACP, of Cedars-Sinai Medical Center and the Principal Investigator of the STEEL study. (rtog.org)
PROCEDURES: [68Ga]THP-PSMA positron emission tomography (PET)/x-ray computed tomography (CT) was performed in 25 patients with biochemical recurrence after radical prostatectomy for prostate cancer. (tum.de)
Delayed radical prostatectomy for intermediate-risk prostate cancer is associated with biochemical recurrence: Possible implications for active surveillance from the SEARCH database. (ommegaonline.org)
European Urology Best Clinical Research Paper Published in 2011 - Salvage radical prostatectomy for radiation-recurrent prostate cancer: A multi-institutional collaboration. (mayoclinic.org)
Currently you will find four salvage options with curative intention: radical prostatectomy brachytherapy high-intensity focused ultrasound and cryoablation. (researchdataservice.com)
Relative to Pelitinib probably the most aggressive and definitive approach of salvage prostatectomy cryoablation seeks to strike a balance between malignancy control and toxicity. (researchdataservice.com)
Individual Selection Cryotherapy continues to be used for principal entire gland and focal treatment salvage entire gland and focal ablation and regional recurrence after radical prostatectomy [9]. (researchdataservice.com)
Open prostatectomy surgery with general anesthesia, substituting epidural analgesia for postoperative opioids, was associated with substantially less risk of biochemical cancer recurrence. (asahq.org)

Androgen deprivation therapy (ADT) is the main treatment for biochemical recurrence. (snmjournals.org)
Association of Gleason Grade With Androgen Deprivation Therapy Duration and Survival Outcomes: A Systematic Review and Patient-Level Meta-analysis. (ohsu.edu)
The secondary outcomes were overall mortality, clinical recurrence (CR), biochemical recurrence (BCR), and androgen deprivation therapy (ADT)-free survival after sLND. (uni-koeln.de)
A significant survival benefit associated with the administration of androgen deprivation therapy after sLND suggests that sLND should be considered part of a multimodal approach rather than an exclusive treatment strategy. (uni-koeln.de)
Two phase 3 trials have compared SRT with and without androgen deprivation therapy (ADT), finding that combined treatment (SRT+ADT) improves both PFS and overall survival. (wjgnet.com)
found that most (63%) were initially observed without treatment, and an additional 20% received androgen deprivation (ADT)-only within a year of diagnosis. (prostatecancer.news)
The current standard of care treatment for patients with biochemically recurrent prostate cancer is either surveillance or androgen deprivation therapy (ADT). (mycancergenome.org)

We aim to summarise the current literature regarding sRALP with specific reference to patient selection, complications and peri-operative functional and oncological outcomes. (edu.au)
Long-term follow-up for functional and oncological outcomes was limited. (edu.au)
Data on functional and oncological outcomes lack long-term information but initial results are encouraging. (edu.au)
Objective: To investigate long-term oncological outcomes after sLND in a large multiinstitutional series. (uni-koeln.de)
It is likely that their oncological outcomes might have been improved by better patient selection. (prostatecancer.news)

Regarding next steps, Ferdinandus said, "Future randomized trials need to evaluate the impact of management changes on oncologic outcomes. (urologytimes.com)
Each treatment choice offers varying oncologic results side-effect profiles and complication rates. (researchdataservice.com)
Desk?1 Oncologic outcomes of latest whole-gland salvage cryotherapy studies Absent biopsy information no standardized definition Pelitinib of treatment success or failure continues to be established. (researchdataservice.com)

This study evaluated the outcomes of salvage radiation therapy initiated at a PSA level ≤0.5 ng/mL in patients with biochemically recurrent prostate cancer. (practiceupdate.com)
The study included 397 patients, with 45.8% of the patients receiving treatment when their pre-radiation therapy PSA levels were ≤0.5 ng/mL. (practiceupdate.com)
They found that pre-radiation therapy PSA level was the most significant predictor of biochemical recurrence-free survival and metastasis-free survival outcomes. (practiceupdate.com)
Salvage external beam radiation therapy (EBRT) is effective in some patients with detectable and rising PSA levels following prostate cancer (PCa) surgery, a new study confirms. (urology-kalamaria.gr)
Three patients additionally received salvage radiation therapy (sRT) including the prostatic lodge and docetaxel chemotherapy was started in one case. (frontiersin.org)
Besides the known oncological benefits of ADT and sRT, in case of sole MLN metastases individualized therapy like salvage lymphadenectomy or RT with a defined radiation field could be options for these patients. (frontiersin.org)
Although focal retreatment of the prostate using LDRBT has been used after failure of external beam radiation, there have been very few reports of salvage LDRBT after an initial treatment with LDRBT failed. (prostatecancer.news)
And when biochemical recurrence does occur, Sandhu noted that prostate-specific membrane antigen PET is increasingly used in practice to help "define the extent of disease" and "tailor radiation fields. (medscape.com)
Salvage cryoablation of the prostate offers another treatment option to men who have failed radiation treatment. (healthyprostateclub.com)
If prostate cancer recurs after a patient has had surgery, salvage radiation is often the next step in treatment. (healthyprostateclub.com)
If the recurrence is localized radiation may be able to encompass the area and control the disease. (healthyprostateclub.com)
Salvage radiation therapy invloves an external beam of radiation aimed at the prostate bed. (healthyprostateclub.com)
Bryan Wong, MD: Salvage radiation occurs after men have already had prior surgery for the prostate cancer, but have subsequently suffered a recurrence of their disease. (healthyprostateclub.com)
So, the idea behind salvage radiation therapy is that when a patient who has had initial treatment with surgery, they may have suffered recurrence. (healthyprostateclub.com)
Salvage radiation often involves external beam radiation to the prostate bed. (healthyprostateclub.com)
Similarly, it is also not clear whether or not adding hormonal therapy to salvage radiation is of clear benefit. (healthyprostateclub.com)
The new treatment is called high dose-rate brachytherapy and it delivers radiation via a set of tiny tubes. (healthyprostateclub.com)
Is it still worthwhile to attempt salvage radiation (SRT) after positive pelvic lymph nodes ( PLN ) have been pathologically detected (stage pN1 )? (prostatecancer.news)
Zareba and Touijer did not report the toxicity of the salvage treatment, but with improved external beam radiation techniques and scrupulous image guidance, toxicity has been improving. (prostatecancer.news)
My next step is to under go Radiation Treatment with Hormonal Treatment (total of 39 treatments and 6 mos of hormonal therapy. (cancer.org)
Any advice on going through radiation treatment and hormonal treatment (6 mos) regarding side effects would be much appreciated. (cancer.org)
Salvage radiation is the standard of care as your next step. (cancer.org)
The concurrent use of ADT for salvage cases is controversial but the most recent studies suggest that it helps as it does when used with primary radiation. (cancer.org)
I intended to flag your thread for the title you used and the sales link provided but abstained for the sincere question on the radiation plus HT treatment. (cancer.org)
Brachytherapy is a cancer treatment using high radiation dose to the tumor, without irradiating the adjacent tissues. (brachycenter.com)

Emerging treatments with limited long-term data include targeted therapy and whole-gland ablation. (medscape.com)

Outcome measurements and statistical analysis: The primary outcome of the study was cancer-specific mortality (CSM). (uni-koeln.de)
Treatment with whole pelvic SRT+ADT decreased 10-yr mortality by 31% compared to observation only, and by 35% compared to ADT-only. (prostatecancer.news)
Retrospective analyses of clinical data suggest that SRT has provided long-term durable responses and potential improvement of outcomes for prostate cancer-specific mortality when compared to observation following biochemical recurrence. (rtog.org)
The STEEL trial has several secondary objectives to compare rates of biochemical failure, an alternative biochemical failure endpoint, hormone-refractory disease, distant metastasis, cause-specific mortality, overall mortality, acute and late physician- and patient-reported toxicity, fatigue, and global quality of life between patients on both treatment arms. (rtog.org)
However, it is interesting that despite more than 3 decades of increasingly sensitive disease-detection tools (such as high-resolution neck ultrasonography and ultrasensitive thyroglobulin assays), which led to even more aggressive therapeutic interventions (such as prophylactic and therapeutic neck dissections for small-volume disease and repeated administrations of RAI for biochemical evidence of persistent disease), thyroid cancer mortality remains stable or slightly increased ( 8 ). (snmjournals.org)

After a median of 82 months (maximum 16 years), 17 patients experienced biochemical recurrence, 7 developed metastatic disease, and 2 died of PCa. (urology-kalamaria.gr)
Treatment protocols for prostate cancer are provided below, including general treatment recommendations and those for localized prostate cancer, for recurrent disease, and for advanced or metastatic disease. (medscape.com)

OBJECTIVE: To determine the impact of Radical Local Treatment (RLT) on overall survival (OS) and other survival outcomes in patients with OligoMetastatic Prostate Cancer (OMPC). (bvsalud.org)

Recent developments in the urologic oncology literature suggest that residual local disease-as opposed to the presence of occult metastases at surgery-may characterize a more substantial component of the natural history of the recurrence and progression of initially clinically localized prostate cancer than previously appreciated. (jnccn.org)

Nevertheless, the question of whether all patients with the aforementioned adverse features should undergo immediate adjuvant RT versus initial observation with more selective-but early-salvage RT in the event of biochemical failure remains the subject of heated controversy. (jnccn.org)
Secondary outcome measures, including biochemical progression-free survival and time to further hormone therapy, were also similar in the treatment and observation arms. (medscape.com)
Treatment with ADT-only was not associated with an increase in survival compared to observation, although prostate cancer-specific survival was increased. (prostatecancer.news)
More recently, the thyroid cancer guidelines of both the American Thyroid Association (ATA) and the National Comprehensive Cancer Network have evolved to allow for low-intensity treatment options (observation or thyroid lobectomy without the need for RAI therapy or thyroid-stimulating hormone suppressive therapy) in properly selected patients ( 1 , 5 ). (snmjournals.org)

The Progression Free Survival is usually used in analysing the results of the treatment for the advanced disease. (wikipedia.org)
In retrospective series, 5-year biochemical progression-free survival (PFS) ranges from 35%-85%, depending on the PSA level at the start of RT. (wjgnet.com)

In the UK study, only bone scans and CTs were used to rule out metastasis, and there were no biopsies done to assure that they were treating a local recurrence. (prostatecancer.news)

Several other small studies have demonstrated higher rates of biochemical re-recurrence-free survival ( Blasko et al . (prostatecancer.news)
The addition of ADT to SRT has already made improvements in lowering rates of biochemical recurrence. (rtog.org)

MLN metastases detected by 68 Ga-PSMA-PET/CT seem to be a relevant localization of tumor manifestation and may serve as index lesion in the treatment of recurrent PCa. (frontiersin.org)
Increasingly discussed salvage treatment of recurrent PCa also demands exact staging ( 4 , 10 , 12 , 13 ). (frontiersin.org)
Patient summary: We assessed long-term outcomes of patients treated with salvage lymph node dissection (sLND) for node-recurrent prostate cancer (PCa). (uni-koeln.de)
That is, survivorship care should, in addition to surveillance for recurrent disease, manage late treatment effects, address comorbid conditions, attend to psychosocial needs, and promote healthy behaviors and lifestyle. (biomedcentral.com)
For men who previously received definitive treatment for prostate cancer and subsequently develop detectable prostate specific antigen (PSA) levels, the clinical state is known as biochemically recurrent prostate cancer. (mycancergenome.org)
This review will examine the controversies surrounding 3 important topics in thyroid cancer management: the option of thyroid lobectomy as initial therapy, the use of preoperative neck imaging to optimize the completeness of the initial surgery, and the selective use of radioactive iodine for remnant ablation, adjuvant treatment, or treatment for known persistent or recurrent disease. (snmjournals.org)
and that early detection and treatment of very small volume persistent or recurrent structural disease has little clinical benefit. (snmjournals.org)
Dietary intervention with isoflavone supplementation may have biologic activity in men with biochemical recurrent prostate cancer as shown by a decline in the slope of PSA. (biomedcentral.com)

Because of better treatment planning possible with the advanced MRI imaging, UCSF also had minimal treatment-related toxicity. (prostatecancer.news)
however, sexual toxicity is high with both, and urinary and rectal toxicity is high with salvage surgery. (prostatecancer.news)
Used together these groundbreaking technical developments along with improvements in technique possess resulted in dramatic reductions in toxicity and even more favorable outcomes. (researchdataservice.com)

0.4 ng/ml is associated with very low risk of biochemical failure. (brachycenter.com)

Background: Long-term outcomes of patients treated with salvage lymph node dissection (sLND) for nodal recurrence of prostate cancer (PCa) remain unknown. (uni-koeln.de)
Conclusions: A third of men treated with sLND for PET-detected nodal recurrence of PCa died at long term, with PCa being the main cause of death. (uni-koeln.de)
Third Prize for the Best Abstract (Oncology): 11C-choline versus 68Ga-PSMA PET/CT scan for the detection of nodal recurrence from prostate cancer: Results from a large, multi-institutional salvage lymph node dissection series. (mayoclinic.org)

In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)

Two patients had a second focal brachytherapy re-treatment. (prostatecancer.news)
High dose-rate brachytherapy boost for intermediate risk prostate cancer: Long-term outcomes of two different treatment schedules and early biochemical predictors of success. (brachycenter.com)

One benefit of salvage cryoablation of the prostate is that it is a minimally invasive procedure. (healthyprostateclub.com)
If youve been treated for prostate cancer and it has come back, your healthcare provider might suggest that you have a salvage cryoablation. (healthyprostateclub.com)

In 2010, the dilemma is not in the question of whether postprostatectomy adjuvant or salvage RT are effective among high-risk patients as a group, but rather which individual patients ought to receive it and when. (jnccn.org)
RP, combined with adjuvant or salvage treatment when needed, may result in better outcomes than RT alone, similar to the combination of RT plus HT therapy. (ommegaonline.org)

Lymph node recurrence was documented by positron emission tomography/computed tomography (PET/CT) scan using either C-11-choline or Ga-68 prostate-specific membrane antigen ligand. (uni-koeln.de)

Background: Ultrasensitive imaging has been demonstrated to influence biochemical relapse treatment. (hunimed.eu)

Twelve PCa patients with biochemical recurrence (BCR) after primary therapy who prospectively underwent a baseline 68 Ga-PSMA-PET/CT initially showed MLN metastases. (frontiersin.org)
For the intended management cohort, management pathway recommendations "predominantly aligned with PSMA PET disease stages: focal or salvage therapy for local disease, and systemic treatment for distant metastases," said Ferdinandus. (urologytimes.com)
Other treatments aimed at bone metastases might be used as well. (healthyhormonesclub.com)
Dear Sir, There have been a number of articles recently, addressing treatment of the primary prostate tumour in presence of metastases. (ommegaonline.org)

Further, our review intended to draw attention to a lack of PTSD prognosis in TBI, SAH, and stroke patients who could benefit from early treatment. (preprints.org)
Dr. Carroll lays out the potential relevance of polygenic risk scores, showing where the scores have the potential to impact clinical care by supporting risk prediction, diagnosis, treatment decision-making, and prognosis of disease course and outcome. (grandroundsinurology.com)
Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
Understanding how these genomic events impact prognosis and/or treatment response is vital for optimising clinical outcomes. (cdc.gov)

Salvage focal cryotherapy, as well as other focal ablative therapies may increasingly be used for this purpose. (prostatecancer.news)
Salvage focal HDRBT may be used for this purpose as well. (prostatecancer.news)
The irreversible electroporation is an emergent approach on focal treatment of localized PCa. (elsevier.es)
The nonthermal mechanism that preserves the tissue architecture without damaging tissue structures, such as vessels and nerves within the target region, is the main advantage comparatively to other techniques used in focal treatment. (elsevier.es)

Salvage LND alone was associated with durable long-term outcomes in a minority of men who significantly benefited from additional treatments after surgery. (uni-koeln.de)
Conversely, advocates of low-intensity treatment options are confident that with proper patient selection and follow-up, similar long-term outcomes can be achieved. (snmjournals.org)

The seven key themes were evidence inclusion and exclusion, patient- and clinician-reported outcomes, the learning curve, allocation of costs, appropriate time horizons, economic analysis methods, and robotic ecosystem/wider benefits. (bvsalud.org)

When treatments such as hormone therapy , chemotherapy , or immunotherapy are used for more advanced prostate cancer, the PSA level can help show how well the treatment is working or when it might be time to try a different treatment. (healthyhormonesclub.com)
Abiraterone is indicated for use in combination with prednisone for the treatment of patients with metastatic, castrate-resistant prostate cancer who have received prior chemotherapy containing docetaxel. (medscape.com)

Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance. (urotoday.com)

Biochemical-free recurrence rates after salvage EBRT at 50 months and 75 months were 84% and 79%, respectively. (urology-kalamaria.gr)

Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)

Lower biochemical recurrence (BCR) is a benefit, but prospective studies are needed. (uroweb.org)
PSICHE is a multicentric prospective study, aimed at exploring detection rate with 68Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) and outcomes with a predefined treatment algorithm tailored to the imaging. (hunimed.eu)
Unfortunately, the literature comparing low-intensity with high-intensity treatments is largely retrospective, observational, and devoid of high-quality prospective randomized clinical trials. (snmjournals.org)

This trial will evaluate the effectiveness of primary care-based follow-up, in comparison to usual care, in terms of adherence to the prostate cancer surveillance guideline for the timing and frequency of prostate-specific antigen assessments, the time from a biochemical recurrence to retreatment decision-making, the management of treatment-related side effects, health-related quality of life, prostate cancer-related anxiety, continuity of care, and cost-effectiveness. (biomedcentral.com)

A common germline variant in CYP11B1 is associated with adverse clinical outcome of treatment with abiraterone or enzalutamide. (urotoday.com)
Adding enhanced ADT with enzalutamide to the SRT treatment could allow us to intensify the effects of ADT to further improve and lengthen survival. (rtog.org)

Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a target outcome in clinical research trials. (wikipedia.org)

Rising PSA and a high Gleason score following surgery can indicate a recurrence of the disease. (healthyprostateclub.com)
Gleason score and tumor size (percent of prostate involved) were also independent predictors of recurrence (hazards ratios of 1.19 [1.08, 1.52], P = 0.004, and 1.17 [1.03, 1.34] for 10% size difference, P = 0.01, respectively). (asahq.org)
Selecting initial treatment requires assessing the risk of the disease spreading or progressing, which is based on evaluating the patient's life expectancy, comorbidities, biopsy grade (Gleason score), clinical stage, and prostate-specific antigen (PSA) level. (medscape.com)

Best Poster in the non-muscle invasive bladder cancer: Diagnosis, treatment, and prognostic factors. (mayoclinic.org)

Comparing Active Surveillance and Watchful Waiting With Radical Treatment Using Machine Learning Models Among Patients With Prostate Cancer. (urotoday.com)
Treatment-Related Cognitive Impairment in Patients with Prostate Cancer: Patients' Real-World Insights for Optimizing Outcomes. (urotoday.com)
The study included patients with prostate adenocarcinoma and biochemical recurrence who were recruited at the University of California, Los Angeles and the University of California, San Francisco. (urologytimes.com)

For patients with high-risk features at RP or who experience biochemical recurrence after RP, solid evidence now shows that secondary RT provides benefit. (jnccn.org)

HDR boost with single fraction 15 Gy provides durable long-term biochemical disease-free survival. (brachycenter.com)

As far as other kinds of re-irradiation goes, there has only been a single case report of salvage SBRT after LDRBT failure. (prostatecancer.news)

Reflecting this, the most recent update of the NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer states "new evidence supports offering adjuvant/salvage RT in all men with adverse pathologic features or detectable PSA" 3 (to view the most recent version of these guidelines, visit the NCCN Web site at www.NCCN.org ). (jnccn.org)
Additional Lumpectomy and Irradiation for In-Breast Recurrence of Cancer-When Less Is More. (ohsu.edu)
He explains that hereditary factors have a strong influence on prostate cancer risk and outcomes and that prostate cancer has high heritability. (grandroundsinurology.com)
Of course, other factors, such as whether youre having symptoms from your cancer and whether imaging tests show it is growing, are also important when deciding if it might be time to change treatments. (healthyhormonesclub.com)
If your prostate-specific antigen blood level or another test shows that your prostate cancer has not been cured or has come back after the initial treatment, further treatment can often still be helpful. (healthyhormonesclub.com)
Follow-up treatment will depend on where the cancer is thought to be and what treatment you've already had. (healthyhormonesclub.com)
When prostate cancer has spread to other parts of the body , hormone therapy is probably the most effective treatment. (healthyhormonesclub.com)
This is CureTalks' 96th episode, and we are talking about role of HIFU in prostate cancer treatment and the recent FDA approval of the same. (curetalks.com)
Venclovas Z, Stanionis M, Matjosaitis AJ and Milonas D: Significance of time until PSA recurrence on clinical progression of surgically treated high-risk prostate cancer patients. (spandidos-publications.com)
CA 125 is useful for evaluating pelvic masses in postmenopausal women, monitoring response to therapy in women with ovarian cancer, and detecting recurrence of this malignancy. (aafp.org)
PSA is used to screen for prostate cancer, detect recurrence of the malignancy, and evaluate specific syndromes of adenocarcinoma of unknown primary. (aafp.org)
Currently, patients who have completed primary treatment for localized prostate cancer are often included in a specialist-based follow-up care program. (biomedcentral.com)
Currently in most Western countries, patients who have completed primary treatment for localized prostate cancer are often included in a specialist-based follow-up care program at the hospital. (biomedcentral.com)
In addition, it can be repeated if the first treatment did not completely kill the cancer. (healthyprostateclub.com)
for more information on options after a prostate cancer recurrence. (healthyprostateclub.com)
There is no medical research that documents that cannabis can be used for the treatment of prostate, or any cancer. (cancer.org)
The RTOG Foundation is a nonprofit organization dedicated to improving outcomes for cancer patients through the conduct of practice changing clinical trials. (rtog.org)
This Topic is a continuation of the previous successful Topic "Prostate Cancer: Symptoms, Diagnosis & Treatment" ( https://www.mdpi.com/topics/prostate_Cancer ). (mdpi.com)
Despite significant treatment improvements having been achieved with the advent of targeted and immune-checkpoint-inhibitor-based therapies, cancer remains one of the primary causes of death worldwide. (mdpi.com)
Thyroid cancer management has seen a dramatic shift away from a one-size-fits-all approach to a more risk-adapted treatment paradigm in which the extent of surgery, the use of radioactive iodine (RAI) therapy, the goals for thyroid-stimulating hormone suppression, and follow-up recommendations are individually tailored for each patient ( 1 - 7 ). (snmjournals.org)
RP has a place in the treatment of locally advanced prostate cancer is supported by a few studies recently conducted in the United States [5] . (ommegaonline.org)
Leuprolide is indicated as palliative treatment for advanced prostate cancer when orchiectomy or estrogen administration is not indicated or is unacceptable to the patient. (medscape.com)
Triptorelin is indicated for palliative treatment of advanced prostate cancer. (medscape.com)
Goserelin is used in the palliative treatment of advanced prostate cancer. (medscape.com)
Therefore, the authors evaluated prostate cancer recurrence in patients who received either general anesthesia with epidural anesthesia/analgesia or general anesthesia with postoperative opioid analgesia. (asahq.org)
Although there are various treatment options for prostate cancer, control of advanced disease often hinges on effective surgical removal of the primary tumor. (asahq.org)
Whether this minimal residual disease results in local or metastatic recurrence is thought to depend largely on the efficacy of host defenses, especially natural killer (NK) cells, which are the primary defense against cancer. (asahq.org)

All of the men who were initially classified as intermediate risk suffered biochemical failure. (prostatecancer.news)

Conversely, tumor marker levels may rise after effective treatment (possibly related to cell lysis), but the increase may not portend treatment failure. (aafp.org)
However, a consistent increase in tumor marker levels, coupled with lack of clinical improvement, may indicate treatment failure. (aafp.org)
Unfortunately, recurrence occurs in a significant fraction of patients, perhaps in part because even with the best technique, tumor surgery is usually associated with release of tumor cells into the lymphatic and blood streams. (asahq.org)

Anatomy9

Diseases39

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment96

Phenomena and Processes20

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Humanities1

Information Science10

Named Groups2

Health Care51

Geographicals1

Radiotherapy22

Prostatectomy34

Androgen deprivation7

Oncological outcomes5

Oncologic3

Radiation25

Targeted therapy1

Mortality5

Metastatic disease2

Survival outcomes1

Clinically localized prostate cancer1

Observation4

Progression-free sur2

Local recurrence1

Rates of biochemical2

Recurrent8

Toxicity3

Risk of biochemical1

Nodal recurrence3

Disease recurrence1

Brachytherapy2

Cryoablation2

Adjuvant or salvage2

Lymph1

Relapse1

Metastases4

Prognosis4

Focal4

Long-term outcomes2

METHODS1

Chemotherapy2

Membrane antigen1

EBRT1

Nonseminomatous Germ Cell T1

Prospective3

Retreatment1

Enzalutamide2

Clinical outcomes1

Gleason3

Prognostic1

Patients with prostate3

Secondary1

Durable long-term1

SBRT1

Cancer27

Intermediate risk1

Tumor3