Outcomes lung transplantation. Medical search. Frequent questions

This article is meant not only to serve as an overview of the field of lung transplantation but also to highlight the unique challenges faced by pediatric lung transplant recipients, their families, and their healthcare teams. (medscape.com)
All solid organ transplant recipients are at risk, and lung transplant recipients are among those at highest risk. (secondwindstl.org)
These cases generally occur in recipients who have never been infected with Epstein-Barr virus and have no immunity to the virus who receive lungs from a donor who has been infected with the virus. (secondwindstl.org)
Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. (nature.com)
The outcomes of a large UK cohort of CF lung transplantation recipients is reported. (ncl.ac.uk)
This meta-analysis is conducted to assess the impact of EVLP on donor lungs and outcomes of recipients compared with the standard lung transplantation. (xvivoperfusion.com)
The recipients of allografts from those 47 donors had higher Lung Allocation Scores and more frequently underwent double lung transplantation (43/47). (aats.org)
Infection rates among lung transplant recipients appear to be higher than those encountered in other solid organ transplant populations, likely related to the unique exposure of the lung allograft to the external environment and to the greater magnitude of immunosuppression employed 1 , 2 . (ersjournals.com)
Via genome sequencing of both lung transplant recipients and donors, we examine genetic ancestral markers that are associated with graft rejection and dysfunction. (nih.gov)
These sites collect longitudinal bio-samples and clinical data in heart- and lung-transplant recipients for the GRAFT consortium. (nih.gov)
Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction. (ucsf.edu)
Tolerability and Feasibility of the Upper Esophageal Sphincter Assist Device in Preventing Acute and Chronic Allograft Rejection Among Lung Transplant Recipients. (ucsd.edu)
Early clinical experience of bacteriophage therapy in 3 lung transplant recipients. (ucsd.edu)
Low dose posaconazole delayed release tablets for fungal prophylaxis in lung transplant recipients. (ucsd.edu)
In the absence of any reliable treatments for established bronchiolitis obliterans, investigators from Mayo Clinic in Jacksonville, Florida, are conducting a clinical trial of mesenchymal stem cells in lung transplant recipients with chronic rejection. (mayoclinic.org)
With a new antiviral treatment regimen, could it be possible to transplant these organs, prevent the establishment of hepatitis C in the recipients, and produce an excellent outcome in patients? (brighamandwomens.org)
Effect of an Electrostimulation Program in Lung Transplant Recipients During Their Stay in the Intensive Critical Care Unit. (who.int)
[ 8 ] Little is known about the outcomes of undocumented immigrant recipients of kidney transplants. (medscape.com)
Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)

Lastly, Bowdish et al and other groups demonstrated that living-donor lobar lung transplantation can be successfully performed. (medscape.com)

4 These diseases are not only the major causes of death but are also associated with chronic lung allograft dysfunction (CLAD). (nature.com)
In our cohort of patients, we examine demographic and clinical characteristics, as well as differential levels of cell free DNA, to explore outcomes of allograft failure, acute cellular rejection, and chronic lung allograft dysfunction in individuals of European and non-European ancestry. (nih.gov)
Maintenance of immunosuppression after solid-organ transplant is essential in order to prevent short-and long-term complications such as acute cellular rejection and chronic lung allograft dysfunction. (nih.gov)
INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. (smw.ch)
We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction. (smw.ch)
An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline. (smw.ch)
RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). (smw.ch)
0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. (smw.ch)
Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90-1.06, p = 0.64 over a period of 382.97 patient-years). (smw.ch)
CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. (smw.ch)
Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors. (smw.ch)
Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT. (smw.ch)
Extracorporeal photopheresis to attenuate decline in lung function due to refractory obstructive allograft dysfunction. (ucsd.edu)
Short Airway Telomeres are Associated with Primary Graft Dysfunction and Chronic Lung Allograft Dysfunction. (ucsf.edu)
The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation. (ucsf.edu)

Journal of Heart and Lung Transplantation. (monash.edu)

However, the phrase "children are not just small adults" is nowhere more true than in the field of lung transplantation. (medscape.com)
Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)
Discuss most challenging case series in the field of lung transplantation and thoracic surgery, and learn how to manage them. (ersnet.org)

Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined in lung transplantation. (nih.gov)
1 Nevertheless, the overall survival after a lung transplant is still inferior compared to other solid-organ transplantation modalities. (nature.com)
11 , 12 Compelling evidences have also showed that the gut microbiome could modulate alloimmunity and rejection, directly implicating the gut microbiome as a therapeutic target in organ transplantation. (nature.com)
12 These results supported that potential gut microbiome-targeted interventions could influence the survival of patients received solid organ transplantation. (nature.com)
The goal of this research is to better inform pre- and post-transplant clinical management and further refine donor-recipient organ matching to improve long-term outcomes and survival in lung transplant patients. (nih.gov)
Scholars@Duke publication: Assessing the causal effect of organ transplantation on the distribution of residual lifetime. (duke.edu)
Because the number of patients waiting for organ transplants exceeds the number of organs available, a better understanding of how transplantation affects the distribution of residual lifetime is needed to improve organ allocation. (duke.edu)
Previous methods developed to estimate the causal effects of treatment in the presence of time-varying confounders have assumed that treatment assignment was independent across patients, which is not true for organ transplantation. (duke.edu)
We demonstrate our method on the survival benefit of lung transplantation using data from the United Network for Organ Sharing. (duke.edu)
He has joined UNMC to continue their strong tradition in solid organ transplantation with a program in lung transplantation. (unmc.edu)
The decision concerning single- or double-lung transplantation is often of major concern to patients and is influenced by organ availability, age and functional status - single lung is generally a shorter, less complex operation - as well as past surgical history, but in general, carefully selected patients have good quality of life and often excellent lung function after single-lung transplantation. (mayoclinic.org)
Piper Beatty, a two-time double-lung transplant recipient, testifies at an FDA meeting on organ transplantation. (cff.org)
Today, the Cystic Fibrosis Foundation announced plans to improve lung transplantation for people with CF at an Organ Summit, hosted by the White House. (cff.org)
The event focused on new and innovative ways to improve outcomes for individuals waiting for organ transplants and to improve support for living donors. (cff.org)
For many, they are the result of a systemic "spill-over" of the inflammatory and reparatory events occurring in the lungs of patients with COPD, with the disease remaining at the centre of the process (fig. 1 ⇓ ), whereas for others the pulmonary manifestations of COPD are one more form of expression of a "systemic" inflammatory state with multiple organ compromise 3 , 4 . (ersjournals.com)
Despite the considerable amount of data available on the effect of donor age upon the outcomes of organ transplantation, these still represent an underutilized resource in aging research. (lifeboat.com)
Dr. A.G.K. Gokhale said, "Most areas of organ transplant and related technology are progressing aggressively in our country, but in certain specialities it's been in a slumber, one of them is lung transplant. (apollohospitals.com)
Currently listed or being evaluated for major organ transplantation (i.e. heart, lung, liver, kidney). (mayo.edu)
Pneumonia in people whose immune system is weakened or impaired (for example, by acquired immunodeficiency syndrome [AIDS], cancer, organ transplantation. (msdmanuals.com)

PH-ILD: does treatment improve outcomes? (pulmonaryfibrosis.org)
When appropriate, we use minimally invasive lung surgery, including video-assisted thoracoscopic surgery (VATS) and robotic-assisted surgery, to minimize recovery time and improve outcomes. (montefiore.org)
Family-centred rounds benefit families and clinicians and improve outcomes in general paediatrics, but are understudied in subspecialty settings. (stanfordchildrens.org)

In this study, we prospectively analyzed the functional outcome and the survival after lung-volume reduction surgery (LVRS) in patients with end-stage emphysema who were initially potential candidates for lung transplantation (LTX), and investigated the impact of LVRS on posttransplant course in patients who underwent LTX after LVRS. (nih.gov)
Results: 176 patients with CF underwent lung transplantation at our centre. (ncl.ac.uk)
Patients who underwent single lung transplantation in our center (Marseille, France) between January 2009 and January 2022 were retrospectively included. (frontiersin.org)
one patient died, two underwent bilateral lung transplantation, and one was evaluated for a lung transplant, all because of their silicosis diagnoses. (cdc.gov)
71% underwent transplantation in California, and 61% underwent transplantation after 2005. (medscape.com)

From 1986 through June 2016, 2330 lung and 730 heart-lung transplants in children were reported to the Registry for the International Society for Heart and Lung Transplantation (ISHLT). (medscape.com)
Following a steady increase in pediatric lung transplants in the first decade of this millennium, with 125 reported to the ISHLT registry in 2009, numbers have remained stable with a range of 90 to 137 observed during the past 12 years. (medscape.com)
Although one-year survival rates have improved, long-term outcomes for children receiving lung transplants have not (see the image below). (medscape.com)
According to the International Society of Heart and Lung Transplantation (ISHLT) Registry, 2,330 pediatric lung and 730 pediatric heart-lung transplants have been performed through June 30, 2016. (medscape.com)
Our recent research has also explored recipient and donor variables in the success or failure of lung transplants , and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients. (hopkinsmedicine.org)
Research in the Pali Shah Lab focuses on lung transplants . (hopkinsmedicine.org)
Specifically, we're interested in ch ... ronic rejection and quality and safety as they relate to lung transplants . (hopkinsmedicine.org)
Our experienced thoracic and transplant surgeons perform single and double lung transplants and heart-lung transplants. (brighamandwomens.org)
Conditions that may lead to lung transplants include pulmonary fibrosis and other interstitial lung diseases, cystic fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease (COPD) and rare lung diseases such as sarcoidosis and LAM. (brighamandwomens.org)
Speaking on the occasion Dr. Sangita Reddy said, "It is extremely commendable that the team from Montefiore Medical Center has a collective experience of over 1000 lung transplants, that in itself is a record with very few teams being in a position to match. (apollohospitals.com)
Here our own experience of just around 200 lung transplants in all, across the country in all medical centers, should set the perspective for where we are and how far behind we are. (apollohospitals.com)
Let's now try to expand our horizon, capability and outcome of the lung transplant by replicating the success we have tasted in the heart and other transplants. (apollohospitals.com)
We explored whether nonresident aliens have similar outcomes to US citizens after receiving kidney transplants covered by Medicaid, a joint federal and state health insurance program. (medscape.com)
The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)
Though, with the need for lung transplants increasing globally, and a limited number of donor's lungs, many patients only survive for a few years once diagnosed. (lu.se)

Background: Lung transplantation is an important option to treat patients with advanced cystic fibrosis (CF) lung disease. (ncl.ac.uk)
Transplantation of patients with underlying cystic fibrosis (CF), whose native airways and sinuses are chronically infected with virulent bacterial pathogens, initially raised unique concerns about the potential excessive risk of postoperative infections. (ersjournals.com)
omes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. (hopkinsmedicine.org)

Among asymptomatic patients with idiopathic pulmonary fibrosis (diagnosed by radiographic abnormalities found on routine chest radiograph screening and lung biopsy showing usual interstitial pneumonia), symptoms developed approximately 1000 days after the recognition of the radiographic abnormality. (medscape.com)
It is critical to obtain a complete history, including medication history, drug use, social history, occupational, recreational, and environmental respiratory exposure history, risk factors for human immunodeficiency virus infection, and review of systems, to ensure other causes of interstitial lung disease are excluded. (medscape.com)
Montefiore's Advanced Lung Disease Program is the only provider of interstitial lung service and advanced emphysema treatment to our community. (montefiore.org)
Patients with interstitial lung disease, who have the highest death rates among patient diagnostic groups awaiting transplant, make up one of the largest groups referred for transplantation. (mayoclinic.org)
The patient with interstitial lung disease presents a few unique challenges, particularly if the lung condition is a manifestation of a systemic disease such as a rheumatologic disorder. (mayoclinic.org)
Right now there is very limited treatment modalities available for interstitial lung disease and COPD, even as the incidence of these diseases are growing with a fairly significant number of patients suffering from them. (apollohospitals.com)

I am interested in examining the potential for leveraging sensitive biomarkers, such as donor-derived cell free DNA (ddfcfDNA), to augment immunosuppression monitoring, specifically in patients with equivalent immunosuppressive blood levels, but who go on to have disparate outcomes. (nih.gov)
Scheffert JL, Raza K. Immunosuppression in lung transplantation. (smw.ch)

In some patients, chronic prostacyclin analogue therapy (epoprostenol) can be of benefit, particularly as a bridge to heart-lung transplantation. (medscape.com)

METHODS: In this retrospective cohort study we recruited 71 patients with a lung transplant between 2010 and 2014 which survived the first year after transplantation up to 1 July 2021. (smw.ch)

That is, patients trade their end-stage lung disease for transplant lung disease, with the hope that it can be better managed. (medscape.com)
Lung transplantation is a potentially curative therapy for patients with end-stage pulmonary disease. (nature.com)
Subjective improvement was observed for up to 5 years after LVRS, and 53% (31 of 58) of the patients were still alive and had not undergone transplantation after a median follow-up of 44 months. (nih.gov)
Postoperative recovery after transplantation and median survival time were comparable between the 8 patients of the LVRS/LTX group and the 31 patients of the LTX group (96.5 months versus 118.5 months, p = 0.9). (nih.gov)
Lung-volume reduction surgery can significantly improve symptoms and lung function in selected patients who are initially potential candidates for LTX. (nih.gov)
Patients with BCC infection had poorer outcomes and represented the majority of those who had a septic death. (ncl.ac.uk)
Conclusion: Lung transplantation is an important therapeutic option in patients with CF even in those with more complex microbiology. (ncl.ac.uk)
Patients with low alphatorquevirus levels at 2 weeks post-transplantation were more likely to develop acute rejection within 3 months after transplant (P =.013). (wustl.edu)
The Conversional Efficacy of Ex Vivo Lung Perfusion and Clinical Outcomes in Patients Undergoing Transplantation of Donor Lungs by Ex Vivo Lung Perfusion: A Meta-Analysis. (xvivoperfusion.com)
However, its effect on outcomes of lung transplantation patients is uncertainty. (xvivoperfusion.com)
Pulmonary hypertension is a common comorbidity in patients with idiopathic pulmonary fibrosis, and an estimated 20-40% of patients with idiopathic pulmonary fibrosis who are evaluated or listed for lung transplantation have pulmonary hypertension at rest. (medscape.com)
Takashi Harano, MD, and colleagues at Keck Medicine, University of Southern California, analyzed lung transplantation data from April 2020 to June 2022, to identify the early outcomes for patients who received lungs from COVID-19-positive donors. (aats.org)
While offering a vital therapeutic option for patients with advanced lung disease, LTx remains fraught with complications that threaten both the quality and duration of the recipient's life. (ersjournals.com)
Two recent series from North American centres with extensive experience in transplantation of CF patients have documented 1-yr survival rates of 50% versus 83% and 67% versus 96% among CF patients with and without B. cepacia , respectively 7 , 8 . (ersjournals.com)
APO is now exploring whether these novel genomic approaches risk stratify other pulmonary patients for long-term outcomes. (nih.gov)
APO is also planning a clinical trial to assess whether early detection and treatment of rejection improves survival in lung transplant patients and also engaged in additional studies to understand molecular mechanisms of transplant rejection. (nih.gov)
We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. (hopkinsmedicine.org)
Dr. Castleberry has industry experience in advanced data analytics, and his research interest include utilizing large-scale databases and informatics to develop innovative clinical and health services research focused on outcomes, quality, efficiency, and cost in the care of surgical patients and as part of broader healthcare systems. (unmc.edu)
At each step along the way, we educate and inform patients to build understanding, address questions and ensure the best outcomes possible. (montefiore.org)
When providing surgical oncology interventions for lung cancer patients, our collaborative approach extends to include our Montefiore Einstein Cancer Center. (montefiore.org)
Working closely with Montefiore's new COVID-19 Recovery (CORE) clinic, we provide follow-up and recovery lung care to patients who had COVID-19, addressing ongoing symptoms and chronic conditions, as well as any new issues that arise. (montefiore.org)
We serve all Comprehensive Lung Program patients from a single location. (montefiore.org)
The care of patients with progressive lung disease has been transformed by orthotopic lung transplantation. (mayoclinic.org)
The current allocation system favors such patients by adjusting the lung allocation score based on underlying disease, in the hopes of a more timely intervention. (mayoclinic.org)
She performs lung transplant surgery and lung volume reduction surgery for emphysema, and treats patients with tumors of the chest, including lung cancer, esophageal cancer, mediastinal tumors and mesothelioma. (ucsf.edu)
He is one of the attending physicians on the inpatient lung transplantation service, where he cares for patients with advanced lung disease before and after lung transplantation. (ucsf.edu)
His outpatient clinical time is split between three clinics (1) the lung transplantation clinic, where he sees patients with advanced lung disease before and after transplantation, (2) the pulmonary hypertension clinic, where he sees patients with pulmonary hypertension and pulmonary emboli, and (3) the general pulmonary clinic, where he supervises the excellent care provided by fellows in the UCSF Pulmonary and Critical Care Fellowship Program. (ucsf.edu)
Nicholas Kolaitis' research focuses on ways to improve health-related quality of life for patients with advanced lung disease. (ucsf.edu)
The International Society for Heart and Lung Transplantation is a not-for-profit, multidisciplinary professional organization dedicated to improving the care of patients with advanced heart or lung disease through transplantation, mechanical support and innovative therapies. (ishlt.org)
Importantly, the presence of airflow limitation greatly increases the likelihood that patients may develop lung cancer over time. (ersjournals.com)
Our lung team is devoted to providing the best care and prompt evaluation to all patients. (brighamandwomens.org)
The Brigham and Women's Hospital Lung Transplant Program, the largest program in New England over the past decade, is committed to providing the most innovative, effective, and compassionate care to our patients with advanced lung disease. (brighamandwomens.org)
For patients in need of lung transplantation, our experts at The Lung offer the most advanced surgical, therapeutic and life-preserving techniques-performed with skill and compassion. (brighamandwomens.org)
Building upon these groundbreaking efforts, we continue to work to provide the best possible outcomes for our patients by providing the most advanced therapies available, teaching tomorrow's leaders in lung transplantation, and studying new methods for improving transplantation. (brighamandwomens.org)
Most of these patients will benefit from lung transplant. (apollohospitals.com)
Lung related ailments pose a challenge for both patients and clinicians. (apollohospitals.com)
These are outcomes so shamefully poor that, when comparing patients with the same risk factors and status, Medicaid patients at times fared worse than those with no insurance at all. (thehealthcareblog.com)
Likewise, whether specific patient and disease characteristics predict perioperative outcomes for these patients is not well known. (researchsquare.com)
Research outcomes are often directly applicable in clinical situations for patients with cancer, Parkinson's, epilepsy, neurological damage, diabetes, tissue regeneration and more. (lu.se)
Policymakers should consider expanding coverage for kidney transplantation in nonresident aliens, including undocumented immigrants, given the associated high-quality outcomes in these patients. (medscape.com)
[ 4 ] This is despite the fact that transplantation is a more cost-effective form of renal replacement therapy and provides better outcomes for patients with end-stage kidney disease. (medscape.com)
[ 5-7 ] Although some states provide funding for kidney transplantation for this population, most undocumented immigrants must rely on either charitable donations or private insurance to cover the costs of this procedure, making it unfeasible for the vast majority of these patients. (medscape.com)
The persistent and widening gap between patients' need for organs and the number available for transplantation has become a major concern to many Member States. (who.int)
Even between countries which have similar levels of health resources, patients' access to transplantation also varies. (who.int)
Moreover, for patients who have kidney failure, access to transplantation is reduced when funds are spent on other forms of treatment that are less cost-effective. (who.int)
These cells are heavily damaged in patients with lung fibrosis. (lu.se)

Greer M, Werlein C, Jonigk D. Surveillance for acute cellular rejection after lung transplantation. (smw.ch)

The post-transplant length of hospital stay, needs of Extracorporeal membrane oxygenation at 72 hours after transplantation, and survival outcomes were comparable between the two groups. (aats.org)
Extracorporeal membrane oxygenation ( ECMO ), also known as extracorporeal life support ( ECLS ), is an extracorporeal technique of providing prolonged cardiac and respiratory support to persons whose heart and lungs are unable to provide an adequate amount of gas exchange or perfusion to sustain life. (wikipedia.org)
Management of primary graft dysfunction after lung transplantation with extracorporeal life support: an evidence-based review. (ucsf.edu)
As the leading national cardiac centre and the only heart and lung transplant centre in Singapore, NHCS provides comprehensive advanced HF management, from medical treatments to advanced therapies such as Extracorporeal Membrane Oxygenation (ECMO), as well as mechanical heart device implantations, and heart transplantations. (kron4.com)
During the acute phase, while immunosuppressive therapy is initiated, venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is commonly used as a bridge to heart transplantation or recovery. (hindawi.com)
Recently, venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been used as a bridge to cardiac transplantation or recovery [ 1 , 2 ]. (hindawi.com)

Pediatric lung transplantation actuarial survival by era. (medscape.com)
We hypothesized that low anellovirus levels, reflecting relative immunocompetence, would be associated with adverse outcomes in pediatric lung transplantation. (wustl.edu)
There was an association between low anellovirus levels and adverse outcomes in pediatric lung transplantation. (wustl.edu)

Previous longitudinal studies based on gene sequencing have revealed that the microbiome is appreciable in healthy subjects, altered in pathological diseases, and significantly associated with clinical outcomes. (nature.com)
For children and adult with advanced lung diseases, transplantation is often the only treatment. (nih.gov)
Ozasa M, Fuluka J, Smith ML. Chronic diffuse lung diseases. (medlineplus.gov)
In treating benign lung diseases, lung tumors and emphysema, our care is state-of-the-art. (montefiore.org)

Replacement with a healthy lung can promote the recovery of the diaphragm to its anatomical morphology, reinforcing the close relationship between these two organs. (frontiersin.org)
As the nationwide need for organs continues to grow, the shortage of donor lungs is a major limitation. (mayoclinic.org)
Ex vivo lung perfusion (EVLP) offers the potential of providing many more organs for transplant. (mayoclinic.org)
In this review, we have compiled relevant studies that analyze the effect of donor age in graft and patient survival following liver, kidney, pancreas, heart, lung and cornea transplantation , with the aim of deriving insights into possible differential aging rates between the different organs. (lifeboat.com)
Overall, older donor age is associated with worse outcomes for all the organs studied. (lifeboat.com)
And while the current opioid crisis has produced more available organs for transplantation, those with hepatitis C viral infection have previously been considered ineligible. (brighamandwomens.org)
Transplantation of human organs and tissues1 saves many lives and restores essential functions in circumstances when no medical alternative of comparable effectiveness exists. (who.int)
The transplantation of solid organs, such as kidney, liver, heart or lung, is increasingly a regular component of health care in all countries, and is no longer a feature of health care in high-income countries alone. (who.int)
Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
With a longstanding interest in biomedical research and a passion for better understanding one of the least regenerative organs in the body, the lung, he has spent the past four years helping to uncover some of the mechanisms that may drive a lung disease currently without a cure, idiopathic pulmonary fibrosis. (lu.se)

The pooled results indicated that EVLP could be used to assess and improve high-risk donor lungs and had non-inferior postoperative outcomes compared with the standard cold storage. (xvivoperfusion.com)
Initial attempts to perform lung transplantation (LTx) were marred by technical limitations that often resulted in early postoperative death. (ersjournals.com)
Erasmus ME, van der Bij W. Death after lung transplantation: improving long term survival despite perilous early postoperative years. (smw.ch)

Coagulation factor-XII induces interleukin-6 by primary lung fibroblasts: a role in idiopathic pulmonary fibrosis? (monash.edu)
The focus of my Ph.D. studies has been lung fibrosis, and more specifically, idiopathic pulmonary fibrosis (IPF). (lu.se)

The hazard ratio (HR), relative risk (RR), and weighted mean difference (WMD) were used as the effect size (ES) to evaluate the survival outcomes, categorical variables, and continuous variables respectively. (xvivoperfusion.com)

A Society that Includes Basic Science, the Failing Heart and Advanced Lung Disease. (ishlt.org)

To examine the construct and predictive validity of frailty phenotypes in lung transplant candidates. (nih.gov)
We estimated the association between frailty and disability using the Lung Transplant Valued Life Activities disability scale. (nih.gov)
By either measure, frailty correlated more strongly with exercise capacity and grip strength than with lung function. (nih.gov)
Frailty is prevalent among lung transplant candidates and is independently associated with greater disability and an increased risk of delisting or death. (nih.gov)
HRs and 95% CIs estimated by applying Cox proportional hazards frailty models with transplantation center as a random effect. (medscape.com)

His interests are heart transplantation, mechanical circulatory support, surgical therapies for heart failure, and coronary and valvular heart disease. (unmc.edu)

In contrast to the early cases of PTLD after lung transplantation, those that manifest after the first year are usually extra-thoracic, often presenting in the abdomen or pelvis with abdominal pain, gastrointestinal bleeding, or non-healing ulcers. (secondwindstl.org)
He completed his Cardiothoracic Surgery residency at the University of California San Francisco, CA. Dr. Um also completed a fellowship in Thoracic Transplantation and Mechanical Assist Devices at Duke University School of Medicine in Durham, NC. (unmc.edu)
Dr. Berkheim's research and professional interests include, thoracic surgery, thoracic oncology, lung cancer screening, esophageal cancer and advanced stage lung cancer treatments. (unmc.edu)

Sirolimus Long-Term Tolerability and Impact on Kidney Function in Lung Transplantation: A Single-Center Experience. (ucsd.edu)
In kidney transplantation , this age is within the third decade of life while the data for heart transplantation suggest a significant effect starting from donors over age 40. (lifeboat.com)
The results for the pancreas are also suggestive of a detrimental effect starting at a donor age of around 40, although these are mainly derived from simultaneous pancreas-kidney transplantation data. (lifeboat.com)
Although individuals classified as nonresident aliens, including undocumented immigrants, are entitled to receive emergency dialysis in the United States regardless of their ability to pay, most states do not provide them with subsidized care for maintenance dialysis or kidney transplantation. (medscape.com)
Access to kidney transplantation for this population is even more limited because there is no federal mandate to subsidize kidney transplantation for noncitizens. (medscape.com)
We hypothesized that undocumented immigrants would have similar outcomes to US citizens following kidney transplantation if they were equally insured. (medscape.com)
For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)

The development of improved immunosuppressants or, better yet, the development of agents that allow for immunologic tolerance would certainly provide improved clinical outcomes and potentially reduce the risk of infection. (medscape.com)
Other clinical outcomes between the 2 groups were similar. (xvivoperfusion.com)

Methods: Retrospective review of case notes and transplantation databases. (ncl.ac.uk)

With more than 3,800 members in more than 45 countries, ISHLT is the world's largest organization dedicated to the research, education and advocacy of end-stage heart and lung disease. (ishlt.org)

La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)

Lung transplantation has matured into an accepted therapeutic alternative for children with end-stage lung disease. (medscape.com)
After transplantation, lymphoma is often called post-transplant lymphoproliferative disease or PTLD because this represents the full spectrum of lymphoid proliferations seen after transplantation, ranging from an infectious mononucleosis-like illness to malignant non-Hodgkin's lymphoma. (secondwindstl.org)
The influence of lung disease on the diaphragm has been poorly studied. (frontiersin.org)
Lung transplantation (LTx), by replacing a diseased lung with a healthy one, is an interesting model to evaluate the evolution of the diaphragmatic morphology before and after transplantation in the context of lung disease. (frontiersin.org)
Rheumatoid lung disease is a group of lung problems related to rheumatoid arthritis (RA). (medlineplus.gov)
The cause of lung disease associated with RA is unknown. (medlineplus.gov)
Sometimes, the medicines used to treat RA, especially methotrexate, may result in lung disease. (medlineplus.gov)
Symptoms depend on the type of lung disease RA is causing in the lungs. (medlineplus.gov)
There is emerging evidence that pirfenidone and nintedanib may work for people with fibrosis due to rheumatoid lung disease. (medlineplus.gov)
Outcome is related to the underlying disorder and the type and severity of lung disease. (medlineplus.gov)
Becoming disenthralled with our conventional understanding of occupational lung disease. (ucsf.edu)
In addition to general cardiothoracic surgery he has a particular interest in the surgical treatments of end-stage lung disease, especially lung transplantation and aortic surgery. (unmc.edu)
Silicosis is a progressive, incurable, fibrotic lung disease caused by inhalation of respirable crystalline silica dust produced in industries such as construction, quarrying, and coal mining ( 2 ). (cdc.gov)
An Unexpected Cause of Lung Disease Identified After Lung Transplantation. (ucsd.edu)
Heart and Lung Transplant for Mixed Connective Tissue Disease: A Case Report and Implications for Pretransplant Testing. (ucsd.edu)
We treat all conditions, from the benign to the malignant, the simple to the complex, with highly trained experts providing disease management and treatment, surgery and transplantation. (montefiore.org)
His clinical research has primarily been directed toward surgical issues in complex congenital heart care and cardiac transplantation (focusing on advances with operative techniques, outcomes research and transplantation for congenital heart disease), with a particular emphasis on the development of mechanical ventricular assist devices for children, as well as stem-cell based valved conduits for pediatric application. (chop.edu)
Silicosis is a potentially fatal but preventable occupational lung disease caused by inhaling respirable particles containing crystalline silicon dioxide (silica). (cdc.gov)
Right now, the most common theory is that the disease could potentially be triggered by an initial injury to the lung epithelium which in turn induces an abnormal repair pathway, leading to d amage of the lung. (lu.se)
However, in lung fibrosis, these molecules are abnormally active and are responsible for causing disease characteristics like tissue scarring. (lu.se)

Ex vivo lung perfusion (EVLP) is a relatively new technique that can be used to assess and repair the donor lungs, increasing the utilization of high-risk lungs. (xvivoperfusion.com)
A partnership explores ex vivo lung perfusion and ventilation to resuscitate and support donor lungs that would otherwise be unavailable for transplant. (mayoclinic.org)
In a unique academic-industry partnership with United Therapeutics Corp., Mayo Clinic is furthering the study of ex vivo lung perfusion and ventilation to resuscitate and support donor lungs that would otherwise be unavailable for transplant. (mayoclinic.org)

In addition toallograft rejection (a topic covered elsewhere in this series), a multitude of medical complications mark the post-transplantation course. (ersjournals.com)

Dr. Castleberry completed his medical degree at the University of Pittsburgh School of Medicine, Pittsburgh, PA, his general surgery and cardiothoracic surgery residencies (respectively) and advanced fellowship in Cardiac Transplantation and Aortic Surgery at Duke University, Durham, NC. (unmc.edu)

During lung transplantation, wound healing must occur, yet unchecked responses can result in negative outcomes including bronchiolitis obliterans. (cdc.gov)
Nationwide, one-year survival following lung transplant continues to improve, but longer term outcomes remain a challenge, due in large part to chronic allograft rejection from bronchiolitis obliterans, characterized by inexorable small airways obstruction. (mayoclinic.org)

Joel Cooper, MD, at the University of Toronto achieved success in 1983 with the transplantation of a single lung. (medscape.com)
The study aimed to evaluate the diaphragm morphology (height and thickness) in single-lung transplantation (SLTx), using computed tomography (CT), by assessing the evolution of the hemidiaphragm of the transplanted and the native side. (frontiersin.org)
Even more appealingly, single lung transplantation (SLTx) allows a healthy and a diseased lung to coexist in the same patient, along with their respective hemidiaphragm. (frontiersin.org)

This article will review the major medical complications, excluding allograft rejection, which may be encountered in the lung transplant recipient. (ersjournals.com)
Infection is an ever-present threat to the well-being of the lung transplant recipient and is a leading cause of both early and late mortality. (ersjournals.com)
Development of Host Immune Response to Bacteriophage in a Lung Transplant Recipient on Adjunctive Phage Therapy for a Multidrug-Resistant Pneumonia. (ucsd.edu)

Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)

Pulmonary function tests and a carbon monoxide diffusion capacity test of the lungs for carbon monoxide (DLCO) may be performed. (medscape.com)
e Diffusing capacity of lung for carbon monoxide. (medscape.com)

The full abstracts were published in a special supplement to the Journal of Heart and Lung Transplantation's April 2021 issue. (ishlt.org)
We sought to improve family presence and participation in rounds in a paediatric acute care cardiology unit.We created operational definitions for family presence, our process measure, and participation, our outcome measure, and gathered baseline data over 4 months of 2021. (stanfordchildrens.org)

The primary short-term outcome of interest was acute rejection, and longer-term outcomes were analyzed individually and as "composite" (death, chronic rejection, or retransplant within 2 years). (wustl.edu)
Alphatorquevirus levels were associated with short-term outcomes (ie, acute rejection), while betatorquevirus levels were associated with longer-term outcomes (ie, death, or composite outcome within 2 years). (wustl.edu)

Advanced training was in cardiopulmonary transplantation and mechanical circulatory support at Freeman Hospital, NUTH NHS Foundation Trust, UK. (unmc.edu)

A prospective multicenter cohort of LTRs was identified in the four lung transplant centers. (nature.com)
Generally, it is used either post-cardiopulmonary bypass or in late-stage treatment of a person with profound heart and/or lung failure, although it is now seeing use as a treatment for cardiac arrest in certain centers, allowing treatment of the underlying cause of arrest while circulation and oxygenation are supported. (wikipedia.org)
In the United Kingdom , veno-venous ECMO deployment is concentrated in designated ECMO centers to potentially improve care and promote better outcomes. (wikipedia.org)
In the last five years, our Program's one-year outcomes have consistently exceeded Centers for Medicare & Medicaid Services (CMS) benchmarks, and our three-year survival rates routinely meet targeted thresholds. (brighamandwomens.org)

Overall swelling Loss of appetite Shortness of breath (dyspnea), especially with activity Breathing difficulty while lying down This medical term for this symptoms is orthopnea, it occurs because fluid builds up in the posterior portion of both lungs, making it difficult to breathe. (wikipedia.org)
Because of the underlying lung disorder, the symptoms and outcome are generally worse in secondary spontaneous pneumothorax. (msdmanuals.com)

Median age at transplantation was 26 years. (ncl.ac.uk)
Pulmonary function (forced expiratory volume in 1 s % predicted) improved from a pretransplantation median of 0.8 I (21% predicted) to 2.95 I (78% predicted) at 1 year following transplantation. (ncl.ac.uk)

J Heart Lung Transplant. (smw.ch)

Our program has been the source of several transplant milestones , including the first adult lung transplant in Massachusetts and the first bilateral (double) lung transplant in New England. (brighamandwomens.org)

In severe cases, lung transplantation can be considered. (medlineplus.gov)
Sometimes most or all of the lung collapses, leading to severe shortness of breath. (msdmanuals.com)
There is no cure for silicosis and only symptomatic treatment is available, including lung transplantation for the most severe cases. (cdc.gov)

The indications for transplantation, the pharmacokinetics of immunosuppressants, and the complications of transplantation can be strikingly different for children compared with their adult counterparts. (medscape.com)
Treatment is aimed at the health problems causing the lung problem and the complications caused by the disorder. (medlineplus.gov)

Future mechanistic and therapeutic investigations are warranted to ascertain the clinical usefulness of these lipids in regulating lung repair processes relevant to lung transplantation. (cdc.gov)

Anatomy5

Organisms6

Diseases46

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment82

Phenomena and Processes11

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science4

Named Groups2

Health Care33

Geographicals1

Recipients19

Living-donor1

Allograft dysfunction15

Journal of Heart and Lung Transplantation1

Field of lung transplantation3

Organ19

Improve Outcomes3

Underwent5

Transplants16

Cystic fibrosis3

Interstitial6

Immunosuppression2

Bridge to heart-lung transplant1

Year after transplantation1

Patients46

Rejection after lung transplantation1

Extracorporeal6

Pediatric Lung Transplantation3

Diseases4

Organs11

Postoperative3

Pulmonary fibrosis2

Survival outcomes1

Advanced lung disease1

Frailty5

Therapies1

Thoracic3

Kidney7

Clinical outcomes2

Methods1

ISHLT1

20191

Disease20

Vivo lung perfusion3

Post-transplantation1

Cardiac Transplantation1

Bronchiolitis obliterans2

Single lung3

Transplant recipient3

Progenitor Cells1

Carbon Monoxide2

20212

Longer-term outcomes2

Mechanical circulatory support1

Centers4

Symptoms2

Median2

Heart Lung Trans1

Adult lung transplant1

Severe3

Complications2

Therapeutic1