Outcomes in patients with prostate cancer. Medical search. Frequent questions

Secondary endpoints included overall survival plus progression-free survival, prostate-specific antigen (PSA) response, tumor response, pain response, time to a symptomatic skeletal event, safety, health-related quality of life, and biomarker analysis. (ascopost.com)
Outcomes included prostate-specific antigen (PSA) at 6 and 24 months in PC, and overall survival (OS) (for the full sample) and survival time (for the deceased patients) in NSCLC. (heartmathbenelux.com)
After the second dose, researchers analyzed the men's prostate specific antigen (PSA) levels and the 177 Lu-SPECT response to determine ongoing management. (axisimagingnews.com)
Factors associated with progression to treatment among DT patients included younger age, higher clinical stage, higher Gleason score, and higher prostate-specific antigen at diagnosis. (harvard.edu)
The overwhelming majority of men diagnosed with prostate cancer either present symptomatically to a clinician or by a prostate specific antigen (PSA) test as part of a general/private health check [ 3 ]. (biomedcentral.com)
There was only a slight decrease in prostate-specific antigen (PSA) level and pelvic disease post treatment. (jpalliativecare.com)
The widespread use of the prostate-specific antigen (PSA) blood test has resulted in some patients enduring unnecessary invasive biopsies and potentially unnecessary treatments. (atlantichealth.org)
Nordstrom and colleagues found that the detection of clinically insignificant tumors and benign findings on biopsy were lower by 64% and 74%, respectively, among men with elevated prostate-specific antigen (PSA) levels, when biopsy was performed when MRI results were positive rather than using a standard strategy. (medpagetoday.com)
Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. (researchgate.net)
Testing further for a form of prostate-specific antigen (PSA) can help urologists find, stage, and classify prostate cancer in men whose PSA tests are ambiguous, according to a multicenter study that included The Johns Hopkins Hospital. (cancernetwork.com)
Dr McKay concluded by examining the results of the PSMAfore study that presented compelling data supporting the use of 177 Lu-PSMA-617 radioligand therapy before chemotherapy, resulting in improved prostate-specific antigen responses, objective responses, and progression-free survival. (medscape.com)
Axumin is indicated for positron emission tomography (PET) imaging in men with suspected prostate cancer recurrence based on elevated prostate specific antigen (PSA) levels following prior treatment. (fda.gov)
The impact of prostate-specific membrane antigen (PSMA) PET/CT on management of prostate cancer (PCa) patients with biochemical recurrence (BCR) is well established. (snmjournals.org)
The goal of the U.K. study involving 147 patients was to combine the Episwitch prostate cancer test with a common prostate-specific antigen (PSA) test to increase accuracy. (healthnews.com)
Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance. (urotoday.com)
Men's Acceptance of Screening for Prostate Cancer with Prostate-specific Antigen, Magnetic Resonance Imaging, and Prostate Biopsy. (urotoday.com)
MADRID - Screening for prostate cancer using MRI and a lower prostate-specific antigen (PSA) threshold could result in fewer men needing biopsies with no compromise to cancer detection rates, a pilot study suggests. (medscape.com)
The Evaluation of Genomic Applications in Practice and Prevention Working Group found insufficient evidence to recommend prostate cancer antigen 3 testing to inform decisions for when to rebiopsy previously biopsy-negative patients for prostate cancer or to inform decisions to conduct initial biopsies for prostate cancer in at-risk men (e.g., previous elevated prostate-specific antigen test or suspicious digital rectal examination). (egappreviews.org)
The Evaluation of Genomic Applications in Practice and Prevention Working Group found insufficient evidence to recommend prostate cancer antigen 3 testing in men with cancer-positive biopsies to determine if the disease is indolent or aggressive in order to develop an optimal treatment plan. (egappreviews.org)
Based on the available evidence, the overall certainty of clinical validity to predict the diagnosis of prostate cancer using prostate cancer antigen 3 is deemed "low. (egappreviews.org)
I. Prostate Specific Membrane Antigen Theranostics to improve prostate cancer patient outcome. (uclahealth.org)
A UCLA-led study found treatments that reduce the risk of being diagnosed with a cancer recurrence based on rising prostate-specific antigen (PSA) levels after radiotherapy, commonly referred to as biochemical recurrence, do not necessarily improve a patient's long-term overall survival. (news-medical.net)
Best practice for active surveillance at the time of study design was followed (ie, biopsy at 12-month intervals and prostate-specific antigen measurement and digital rectal examination at 3-month intervals). (lu.se)
[ 1 ] Long-term follow-up from the European Randomised Study of Screening for Prostate Cancer (ERSPC) has shown a significant reduction in PCa specific mortality applying prostate-specific antigen (PSA) based screening. (medscape.com)
Selecting initial treatment requires assessing the risk of the disease spreading or progressing, which is based on evaluating the patient's life expectancy, comorbidities, biopsy grade (Gleason score), clinical stage, and prostate-specific antigen (PSA) level. (medscape.com)

Owing to its anatomic location, the prostate may be palpable transrectally and accessed for biopsy via either the rectum or the perineum. (medscape.com)
For a more detailed description of prostate biopsy, see Workup/Prostate Biopsy . (medscape.com)
Patients whose MRI results are highly suspicious for clinically significant prostate cancer should undergo prostate biopsy. (medscape.com)
In elderly patients with suspected prostate cancer, PSMA PET/CT can diagnose advanced disease and aid in therapy selection without the need for a biopsy. (news-medical.net)
A prostate cancer screening strategy using MRI with targeted and standard biopsy reduced the detection of clinically insignificant cancers as well as unnecessary biopsies, researchers reported. (medpagetoday.com)
Such an approach was also as effective as a standard biopsy strategy in detecting clinically significant cancers, said Tobias Nordstrom, MD, PhD, of the Karolinska Institutet in Stockholm, in a presentation at the virtual European Association of Urology Congress. (medpagetoday.com)
We all know from studies performed before that MRI with targeted biopsies reduces overdiagnosis in men referred to prostate biopsy in clinical cohorts. (medpagetoday.com)
Of these, 603 were randomized to undergo standard biopsy, and 929 to MRI, with targeted and standard biopsy if the MRI results indicated prostate cancer. (medpagetoday.com)
The findings showed that the addition of standard biopsy resulted in the discovery of 30 more clinically significant cancers among the men in the experimental biopsy group and the detection of 18 fewer insignificant cancers. (medpagetoday.com)
Patients with more than 25% free PSA probably did not need a biopsy unless they had a family history of prostate cancer. (cancernetwork.com)
The first compared 105 Axumin scans in men with suspected recurrence of prostate cancer to the histopathology (the study of tissue changes caused by disease) obtained by prostate biopsy and by biopsies of suspicious imaged lesions. (fda.gov)
Only about a quarter of people who have a prostate biopsy due to an elevated PSA level are found to have prostate cancer. (healthnews.com)
Comparison of procedural anxiety and pain associated with conventional transrectal ultrasound prostate biopsy to magnetic resonance imaging-ultrasound fusion-guided biopsy: a prospective cohort trial. (urotoday.com)
However, when the PSA threshold was lowered to 1.8 ng/mL, the detection rate of significant cancers increased to 5.9% with targeted biopsy. (medscape.com)
Significant cancers were missed with all three screening strategies, but a PSA cutoff of 1.8 ng/mL plus MRI-targeted biopsy missed the fewest," Dr Bergdahl reported. (medscape.com)
With the 3.0 ng/mL PSA threshold, the rate of insignificant cancer detection was 1.2% with systematic biopsy, which dropped to 0.3% with targeted biopsy. (medscape.com)
We're not at the point where we can get rid of the systematic biopsy yet, because when MRI was added to exempt men from biopsy, sensitivity decreased a little bit and we missed a couple of significant cancers. (medscape.com)
If the MRI is positive, we might want to do both a targeted and a systematic biopsy in those few patients," she explained. (medscape.com)
Such an approach "results in increased cancer detection per biopsy core, better detection of high-grade and clinically significant cancers, and improved clinicopathological correlation," he told Medscape Medical News . (medscape.com)
The high percentage of previously screened and previously biopsied patients makes the findings difficult to generalize to biopsy-naïve patients," he explained. (medscape.com)
In patients with a positive biopsy for prostate cancer who are being evaluated to distinguish between insignificant/indolent and aggressive disease, what is the effectiveness of using PCA3 testing alone, or in combination with the standard prognostic workup (e.g., tumor volume, Gleason score, clinical staging) or monitoring tests (e.g. (egappreviews.org)
Diagnosis of prostate cancer begins with PSA screening, often followed by multiparametric MRI imaging or a biomarker test to confirm suspicion (and location, if MRI) of cancer, before biopsy. (pcf.org)
If successful, this project will improve understanding of tumor visibility by Micro-Ultrasound, and result in a 3-minute prostate scan and urine sample test that identifies patients at risk for prostate cancer and improves decisions on whether patients should undergo prostate biopsy or not. (pcf.org)
Micro-Ultrasound, possibly with a urine biomarker test, to accurately determine a patient's risk for prostate cancer and aid in decisions about whether to undergo prostate biopsy. (pcf.org)
Active surveillance includes periodic PSA testing, digital rectal examination (DRE), and prostate biopsy. (medscape.com)
We aim to perform a head-to-head comparison of seven well known RCs predicting biopsy outcome. (medscape.com)
Our study comprised 7,119 men from ten independent contemporary cohorts in Europe and Australia, who underwent prostate biopsy between 2007 and 2015. (medscape.com)
No particular RC stands out when predicting biopsy outcome on the presence of any PCa. (medscape.com)
[ 2 ] This, next to the fact that PSA is a well-developed, easy to implement, and cheap test, made PSA testing the mainstay in the decision for further clinical workup (i.e., prostate biopsy). (medscape.com)
We aimed to address this lack of information by evaluating the performance (discrimination, calibration, and clinical impact) of the most well-known RCs developed to predict prostate biopsy outcome in a head-to-head comparison. (medscape.com)

Rana R. McKay, MD, reviewed the exciting and practice-changing developments in the field of advanced prostate cancer presented at the European Society for Medical Oncology (ESMO) 2023 meeting. (medscape.com)
Cite this: ESMO 2023: Advancing Prostate Cancer Care - Medscape - Oct 27, 2023. (medscape.com)
MONDAY, Oct. 16, 2023 (HealthDay News) -- At five years, five-fraction stereotactic body radiotherapy (SBRT) is noninferior to control radiotherapy for biochemical/clinical failure (BCF) in men with localized prostate cancer (LPCa), according to a study presented at the annual meeting of the American Society for Radiation Oncology (ASTRO), held from Oct. 1 to 4 in San Diego. (msdmanuals.com)

Metastatic castrate resistant prostate cancer (mCRPC) is a prostate cancer that has spread to other parts of the body, and which keeps growing even when the amount of male hormones in the body are reduced to very low levels. (vivli.org)
This disease state is now subdivided into castrate-sensitive or castrate-resistant locally recurrent prostate cancer and castrate-sensitive or castrate-resistant metastatic prostate cancer. (medscape.com)
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has issued a new consensus statement to provide standardized guidance for the selection and management of metastatic castrate-resistant prostate cancer (mCRPC) patients being treated with 177Lu-PSMA radionuclide therapy. (news-medical.net)
Figure 1 : Example of a patient with metastatic castrate resistant prostate cancer responding to Lu177-PSMA radionuclide therapy. (uclahealth.org)
Abiraterone is indicated for use in combination with prednisone for the treatment of patients with metastatic, castrate-resistant prostate cancer who have received prior chemotherapy containing docetaxel. (medscape.com)

False-negative results often occur, so multiple biopsies may be needed before prostate cancer is detected. (medscape.com)
It is now well-appreciated that analysis of circulating tumor cells (CTCs) from liquid biopsies-blood samples-is one approach to understand the architecture of tumors present within an individual patient more comprehensively. (pcf.org)
CTCs can be present at high levels in patients with advanced disease and represent an alternative to invasive biopsies for studying tumor biology. (pcf.org)
Dr. Alumkal and team will deploy blood- and tissue-based biomarker tests using liquid and tumor biopsies to identify patients whose tumors are at high risk for disease progression and switching to an even more aggressive form of the disease called neuroendocrine prostate cancer. (pcf.org)
Key secondary outcomes included the detection of clinically insignificant cancers and biopsies with benign findings. (medpagetoday.com)
Long-term outcomes with active surveillance are not yet available, but for younger men active surveillance may still be a reasonable option given that surgery or radiation can be done if regular blood tests and prostate biopsies suggest the cancer is growing. (scienceblog.com)
Using free PSA would detect 95% of cancers and spare 20% of men with benign disease from having to undergo biopsies. (cancernetwork.com)
There is currently no single test for prostate cancer, but PSA blood tests are among the most used, alongside physical examinations, MRI scans and biopsies," Pshezhetskiy said. (healthnews.com)
or in men with cancer-positive biopsies to determine if the disease is indolent or aggressive in order to develop an optimal treatment plan. (egappreviews.org)
Current prostate cancer screening methods either lack specificity (PSA tests) or are costly and not widely available (MRI), thus many more patients undergo invasive prostate biopsies than are necessary. (pcf.org)

This study evaluated the outcomes of salvage radiation therapy initiated at a PSA level ≤0.5 ng/mL in patients with biochemically recurrent prostate cancer. (practiceupdate.com)
Imaging tests are not able to determine the location of the recurrent prostate cancer when the PSA is at very low levels," said Libero Marzella, M.D., Ph.D., director of the Division of Medical Imaging Products in the FDA's Center for Drug Evaluation and Research. (fda.gov)
A negative image does not rule out the presence of recurrent prostate cancer and a positive image does not confirm the presence of recurrent prostate cancer. (fda.gov)
Salvage Radical Prostatectomy for Recurrent Prostate Cancer: A Systematic Review (French ccAFU). (urotoday.com)

The results suggest that nuclear HSF1 expression could serve as a novel prognostic marker for patient risk-stratification on disease progression and survival after radical prostatectomy. (nih.gov)
This study involving patients with biochemical recurrence of prostate cancer following radical prostatectomy found that early initiation of salvage radiotherapy at a PSA level ≤0.5 ng/mL was predictive of better oncologic outcomes. (practiceupdate.com)
Multiparametric MRI-based 5-year Risk Prediction Model for Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy. (urotoday.com)

Third-line treatment with cabazitaxel extended progression-free survival and overall survival in men with metastatic castration-resis tant prostate cancer in the CARD trial. (ascopost.com)
Docetaxel, enzalutamide, and abiraterone have all shown an overall survival benefit in metastatic castration-resistant prostate cancer, but a common clinical dilemma is how best to sequence these drugs. (ascopost.com)
In NSCLC patients, HRV did not predict OS and survival time, but it did positively predict survival time in patients under the age of 65, independent of confounders. (heartmathbenelux.com)
Personalized dosing allowed one-third of the men in this study to have treatment breaks while still achieving the same progression-free and overall survival outcomes they would have if they received continuous treatment," notes Nguyen. (axisimagingnews.com)
Darolutamide is the newest and least toxic ARAT approved for delaying metastasis and overall survival in non-metastatic castration sensitive prostate cancer (nmCRPC). (vivli.org)
The study showed that this treatment has long-term survival without recurrence in certain patients. (medivizor.com)
Metformin inhibits cancer cell proliferation and epidemiology studies suggest an association with increased survival in cancer patients taking Metformin, however, the mechanism by which Metformin improves cancer outcomes remains controversial. (jimjimjimjim.com)
In a joint model with the clinical Cancer of the Prostate Risk Assessment post-Surgical (CAPRA-S) score, nuclear HSF1 remained a predictive factor of shortened disease-specific survival. (nih.gov)
They found that pre-radiation therapy PSA level was the most significant predictor of biochemical recurrence-free survival and metastasis-free survival outcomes. (practiceupdate.com)
Methods: This preplanned interim retrospective analysis investigated safety and survival outcomes with 177 Lu-PSMA in patients treated with prior 223 Ra. (wustl.edu)
While the five-year survival rate of localized prostate cancer is nearly 100%, this plummets to 30% when it spreads to other parts of the body. (atlantichealth.org)
Over the past three decades, the number of men age 49 and younger developing prostate cancer has increased, and they have a lower survival rate. (atlantichealth.org)
The results are consistent with those of a previous report that focused on outcomes in the randomized cohort and showed an overall prostate cancer-specific survival rate of 98.8% at 10 years in the ProtecT study. (medpagetoday.com)
Larger clinical trials are warranted to study (223)Ra on the prevention of SREs and on overall survival in patients with hormone-refractory prostate cancer. (researchgate.net)
A comprehensive appraisal of the management and treatment options for low-risk prostate cancer found that the rates of survival and tumor recurrence are similar among the most common treatment approaches, although costs can vary considerably. (scienceblog.com)
The ICER review found that there are no definitive head-to-head studies comparing these options, but that accumulated evidence from multiple studies over the years suggests that overall survival and the rate of cancer recurrence are quite similar among all options, including active surveillance. (scienceblog.com)
Radiographic progression-free survival outcomes with olaparib plus abiraterone acetate and prednisone appear to be consistent with prior analyses of the phase 3 PROpel trial. (cancernetwork.com)
In a Phase III trial, The Radiation Therapy Oncology Group (RTOG) showed improved progression-free survival (PFS) for high-risk prostate cancer patients treated with Whole Pelvis Radiation Therapy (WPRT) compared with prostate-only radiation therapy (PORT) [4]. (scirp.org)
Biochemical recurrences occur much earlier in the disease course than metastases or survival, and could potentially be the ideal surrogate endpoint for prostate cancer. (news-medical.net)
The strength of the correlation between biochemical recurrence and overall survival varied depending on how deaths from non-cancer-related causes were accounted for. (news-medical.net)
Because of this, it has been theorized to be a potential marker to predict a patient's overall survival outcome. (news-medical.net)
However, previous analyses have yielded conflicting conclusions about whether or not biochemical recurrence could be a reliable predictor of overall survival for patients treated for prostate cancer. (news-medical.net)
Despite the potential of using biochemical recurrence as a potential marker to predict overall survival in patients with prostate cancer, the results of the study indicates that it should not be the main focus or primary measure in future clinical trials for localized prostate cancer. (news-medical.net)
Instead, metastasis-free survival, which refers to the period without cancer spreading to other parts of the body, is a more suitable endpoint for future trials involving radiation therapy in localized prostate cancer cases. (news-medical.net)
Even so, survival rates for prostate cancer are generally good, with a five-year relative survival of 97.5 percent. (diagnosticimaging.com)
Survival is high because many prostate cancers grow slowly or not at all. (diagnosticimaging.com)
Five ways to improve international comparisons of cancer survival: lessons learned from ICBP SURVMARK-2. (who.int)
International variation in oesophageal and gastric cancer survival 2012-2014: differences by histological subtype and stage at diagnosis (an ICBP SURVMARK-2 population-based study). (who.int)
Trends in long-term cancer survival in Cali Colombia: 1998-2017. (who.int)
Pancreatic cancer survival by stage and age in seven high-income countries (ICBP SURVMARK-2): a population-based study. (who.int)

A few mechanisms have been suggested that statins may heighten novel androgen receptor inhibitors like darolutamide, including: hampering of steroid hormone production by the tumor itself, inhibition of production of other elements of the cholesterol pathway, as well as inhibition of androgens (male hormone) being brought into the cancer cells. (vivli.org)
To compare DNA methylation as a marker of tumor aggressiveness in WTCHP prostate cancer patients and in matched prostate cancers not related to WTC. (cdc.gov)
Furthermore, some tumor cells can adapt and change over time to assume a different identity that is more like a nerve or brain cell, rather than a prostate cell. (pcf.org)
These results can be used to determine which patients may be best suited for new clinical trials that seek to investigate treatments designed to prevent treatment resistance to ADT + ARSIs and/or tumor switching to neuroendocrine prostate cancer. (pcf.org)
According to the study, the higher the percentage of free PSA compared to the bound form, the smaller the tumor is likely to be, the less chance there is that it has spread from the prostate, and the less likely it is that the disease is the most aggressive form. (cancernetwork.com)
The most popular assessment of whether the tumor has spread beyond the prostate involves a nomogram that measures PSA, clinical staging, and Gleason score. (cancernetwork.com)
Results from a phase 1 of study of 177Lu-PSMA-617 in combination with pembrolizumab show significant anti-tumor activity with low toxicity in patients with metastatic castration-resistant prostate cancer. (cancernetwork.com)
With RapidArc, Varian's Clinac® medical linear accelerator can target radiation beams at a tumor while making one continuous rotation around the patient. (varian.com)
A single normal cell randomly acquires a series of mutations that allows it to proliferate and to be transformed into a cancer cell (i.e., founding clone), which initiates tumor progression and recurrence. (nature.com)
Hence, pre-existing germline variants provide a profound constraint on the evolution of tumor founding clones and subclones and therefore have a contingent effect on the genetic makeup of tumor and presumably patient outcomes. (nature.com)
Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)
Dr Jeremie Calais has designed and initiated at UCLA exploratory clinical studies of FAPI PET targeting the tumor stroma (fibroblast activation protein) in multiple cancers. (uclahealth.org)
Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localised pancreatic cancer. (cdc.gov)
Bioinformatic Methods and Bridging of Assay Results for Reliable Tumor Mutational Burden Assessment in Non-Small-Cell Lung Cancer. (cdc.gov)
Association of Tumor Mutational Burden With DNA Repair Mutations and Response to Anti-PD-1/PD-L1 Therapy in Non-Small-Cell Lung Cancer. (cdc.gov)

Germline variants such as BRCA1/2 play an important role in tumorigenesis and clinical outcomes of cancer patients. (nature.com)
However, only a small fraction (i.e., 5-10%) of inherited variants has been associated with clinical outcomes (e.g. (nature.com)
The challenge remains in using these inherited germline variants to predict clinical outcomes of cancer patient population. (nature.com)
9 Here we reasoned that the collective impact of germline variants in cancer patients might largely determine tumorigenesis, evolution, and even clinical outcomes. (nature.com)
However, the technique requires more time and resources than more standard procedures and it was previously unclear whether MRg-A-SBRT has an impact on clinical outcomes and adverse effects (AE) compared with other methods of delivering radiation. (pharmacytimes.com)
The Evaluation of Genomic Applications in Practice and Prevention Working Group discourages clinical use unless further evidence supports improved clinical outcomes. (egappreviews.org)

People who have "warning strokes," or transient ischemic attacks (TIAs), before suffering a stroke have better outcomes than those who have full-blown strokes with no prior warning. (dotmed.com)
Radiotherapy studies correlate the ability to spare more healthy tissue with reduced complications and better outcomes. (varian.com)
Although additional studies will need to confirm these benefits over time, we're hopeful that these results will lead to better outcomes for men with prostate cancer. (ecancer.org)
The evolving culture of cancer care, puting to radiotherapy planning (e.g. nologies undeniably contribute to and cancer medicine more broadly, deep learning to facilitate automated better outcomes for cancer patients has also played a major part in these treatment contouring and planning). (who.int)

For additional information please see Prostate Cancer: Diagnosis and Staging , a Critical Images slideshow, to help determine the best diagnostic approach for this potentially deadly disease and/or Advanced Prostate Cancer: Signs of Metastatic Disease , a Critical Images slideshow, for help identifying the signs of metastatic disease. (medscape.com)
CONCLUSION: Our preliminary data indicate that acoustophoresis provides excellent possibilities to detect and characterize CTC-clusters as a putative marker of metastatic disease and outcomes. (lu.se)
Treatment protocols for prostate cancer are provided below, including general treatment recommendations and those for localized prostate cancer, for recurrent disease, and for advanced or metastatic disease. (medscape.com)
Also, see the Advanced Prostate Cancer: Signs of Metastatic Disease slideshow for help identifying the signs of metastatic disease. (medscape.com)

Between 2015 and 2018 , the multicenter CARD trial enrolled men with metastatic castration-resistant prostate cancer that has progressed within 12 months of either enzalutamide or abiraterone therapy, before or after treatment with docetaxel. (ascopost.com)
The CARD study confirmed that cabazitaxel should be offered as third-line therapy after docetaxel and abiraterone or enzalutamide in men with metastatic castration-resistant prostate cancer who are fit for chemotherapy. (ascopost.com)
PSA test is used to monitor men after surgery or radiation therapy for prostate cancer to see if their cancer has come back. (vivli.org)
Prostate cancer may recur in up to a third of men after definitive local therapy. (medscape.com)
The study aimed to understand the long-term outcomes of focal laser therapy (FLT) in patients with prostate cancer. (medivizor.com)
The study included 397 patients, with 45.8% of the patients receiving treatment when their pre-radiation therapy PSA levels were ≤0.5 ng/mL. (practiceupdate.com)
In this project, the team will use this technology to study molecular features in CTCs at baseline and throughout the course of treatment in patients with newly diagnosed, hormone-naïve metastatic prostate cancer who are starting treatment with androgen deprivation therapy (ADT) and ARSIs. (pcf.org)
Our ability to treat prostate cancer that's caught early has gotten better with improved surgical techniques, including robotic surgery, and stereotactic precise radiation therapy known as CyberKnife ®, which has reduced the risk of urinary, sexual and gastrointestinal side effects," Dr. Rahman says. (atlantichealth.org)
A simple blood draw can provide physicians with valuable information that can determine if peptide receptor radionuclide therapy (PRRT) is likely to be effective in a patient with neuroendocrine cancer. (news-medical.net)
Radiation therapy works by sending targeted beams of high-energy rays or particles to kill cancer cells. (riversideonline.com)
It is injected between the rectum and the prostate before radiation treatment and is gradually absorbed by the body after therapy. (riversideonline.com)
Other highlights included the presentation by Dr William Kevin Kelly on promising interim results from the AMG 509 phase 1 study showing early efficacy and PSA responses and the ENZA-p study, which revealed enhanced outcomes with combination therapy of enzalutamide and 177 Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer . (medscape.com)
RapidArc delivers a volumetric intensity-modulated radiation therapy treatment in a single or multiple arcs of the treatment machine around the patient and makes it possible to deliver advanced image-guided IMRT two to eight times faster than is possible with conventional IMRT. (varian.com)
Varian Medical Systems, Inc., of Palo Alto, California, is the world's leading manufacturer of medical devices and software for treating cancer and other medical conditions with radiotherapy, radiosurgery, proton therapy, and brachytherapy. (varian.com)
ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers. (urotoday.com)
A feasibility study of adaptive radiation therapy for postprostatectomy prostate cancer. (urotoday.com)
Data from 29 clinical studies showed that using magnetic resonance-guided daily adaptive stereotactic body radiotherapy (MRg-A-SBRT) as a guide can make radiation therapy safer for patients with prostate cancer, according to authors of a recent analysis posted in Cancer . (pharmacytimes.com)
The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
Androgen deprivation therapy (ADT) was given for all patients before and during radiation therapy. (scirp.org)
Journal of Cancer Therapy , 10 , 654-670. (scirp.org)
The Theranostics Clinical Research Program is conducting clinical trials to determine the impact of PSMA PET imaging and PSMA radionuclide therapy on care and outcome of patients with prostate cancer. (uclahealth.org)
Biochemical recurrence develops in almost one-third of men with prostate cancer after treatment with prostatectomy or radiation therapy for localized prostate cancer. (news-medical.net)
VIOLET is a phase I/II trial that will test a new PSMA-targeted radionuclide therapy, 161-Terbium-PSMA-I&T, in patients with progressive mCRPC. (pcf.org)
Background: Vascular-targeted photodynamic therapy, a novel tissue-preserving treatment for low-risk prostate cancer, has shown favourable safety and efficacy results in single-arm phase 1 and 2 studies. (lu.se)
Men with low-risk, localised prostate cancer (Gleason pattern 3) who had received no previous treatment were randomly assigned (1:1) to vascular-targeted photodynamic therapy (4 mg/kg padeliporfin intravenously over 10 min and optical fibres inserted into the prostate to cover the desired treatment. (lu.se)
Men with low-risk, localised prostate cancer (Gleason pattern 3) who had received no previous treatment were randomly assigned (1:1) to vascular-targeted photodynamic therapy (4 mg/kg padeliporfin intravenously over 10 min and optical fibres inserted into the prostate to cover the desired treatment zone and subsequent activation by laser light 753 nm with a fixed power of 150 mW/cm for 22 min 15 s) or active surveillance. (lu.se)
Findings: Between March 8, 2011, and April 30, 2013, we randomly assigned 206 patients to vascular-targeted photodynamic therapy and 207 patients to active surveillance. (lu.se)
Interpretation: Padeliporfin vascular-targeted photodynamic therapy is a safe, effective treatment for low-risk, localised prostate cancer. (lu.se)
Having the right technology in place can boost patient confidence in therapy. (diagnosticimaging.com)
These include intensity modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), SpaceOAR, Calypso 4D Localization System, and brachytherapy alone, or combined with other modalities in managing prostate cancer. (diagnosticimaging.com)
For treatment recommendations for patients with a life expectancy ≥20 y, see initial therapy for Low Risk of Recurrence, below. (medscape.com)
Radiation Therapy Oncology Group (RTOG) grade 2 or worst (G2+) genitourinary toxicity at five years occurred in 3.2 percent of control patients and 5.5 percent of patients in the SBRT group. (msdmanuals.com)
Androgen deprivation therapy use and duration with definitive radiotherapy for localised prostate cancer: an individual patient data meta-analysis. (bvsalud.org)
Randomised trials have investigated various androgen deprivation therapy (ADT) intensification strategies in men receiving radiotherapy for the treatment of prostate cancer . (bvsalud.org)
Antiandrogen therapy is not recommended for localized prostate cancer. (medscape.com)
Antiandrogen therapy appears to be less effective than medical or surgical castration, except possibly in patients without overt metastases (M0). (medscape.com)
Prolia was later approved to treat men with osteoporosis, glucocorticoid induced osteoporosis, bone loss in men receiving androgen deprivation therapy for prostate cancer and in women receiving aromatase inhibitor therapy for breast cancer. (medlineplus.gov)
10. Most countries in Africa do not have the satisfactory infrastructure and facilities for cancer therapy requiring surgery, chemotherapy and radiotherapy. (who.int)
Because cancer therapy requires a multidisciplinary approach, satisfactory infrastructure and good facilities, the availability of effective cancer therapy is often an unrealistic objective. (who.int)

Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)
An ongoing GETUG-AFU-18 phase III trial is evaluating the impact of dose escalation in combination with 3-year androgen deprivation treatment on 5-year biochemical or clinical control in high-risk prostate cancer patients [8]. (scirp.org)

Stereotactic body radiotherapy for prostate cancer usually delivers radiation in five or fewer precisely targeted doses. (ecancer.org)
This clinical trial, Magnetic Resonance Imaging-Guided Stereotactic Body Radiotherapy for Prostate Cancer (MIRAGE), was led at UCLA and included 154 analyzable patients with prostate cancer who were randomised to either a CT-guidance arm (76 patients) or an MRI-guidance arm (78 patients). (ecancer.org)

This discounts that nearly 250,000 men are diagnosed every year with prostate cancer, and nearly 35,000 will die in 2021 from their disease, making it the second leading cause of men's cancer deaths. (atlantichealth.org)
Nevertheless, according to statistics released by Statistics Korea last year, cancer remained the primary cause of mortality in Korea in 2021. (news-medical.net)
Since the Persona CT system was installed in January 2021, we have had nothing but great success in treatment planning for prostate cancer. (diagnosticimaging.com)
Building on a pilot study they began in March 2020, they matched 390,885 patients with cancer diagnosed from 1996 to 2020 with 343,269 patients who tested positive for COVID-19 from March 11, 2020, to March 1, 2021. (cdc.gov)

The evidence for and against screening, a summary of screening guidelines, and the observed impact of the USPSTF guidelines on prostate cancer incidence and mortality are presented in full detail in Workup/Prostate Cancer Screening . (medscape.com)
PCa mortality did not differ between DT and active treatment patients. (harvard.edu)
Among 997 patients who chose their own treatment approach, 10-year prostate cancer-specific mortality was 1.85% with AS, 0.67% with surgery, and 0.73% with RT, a difference that did not achieve statistical significance ( P =0.08). (medpagetoday.com)
An exploratory analysis that included treatment-choice cohorts as well as 1,637 randomized patients showed a stronger trend for lower prostate cancer mortality with active treatment ( P =0.003). (medpagetoday.com)
While we note that such comparisons of PCa [prostate cancer] mortality should be considered exploratory, as they were not in the original randomization protocol, these data still represent relatively high-quality evidence and underscore the small but increased risk of PCa mortality for patients on AM compared to treatment," wrote Vidit Sharma, MD, and R. Jeffrey Karnes, MD, both of the Mayo Clinic in Rochester, Minnesota. (medpagetoday.com)
The primary objective of ProtecT was prostate cancer-specific mortality after a median follow-up of 10 years in the randomized portion of the study population. (medpagetoday.com)
Secondary outcomes included rates of disease progression and distant metastasis and all-cause mortality. (medpagetoday.com)
Given the long-term, although potentially fatal, nature of prostate cancer, there is increasing observational evidence for the reduction in disease progression and mortality through changes in lifestyle factors. (springer.com)
We systematically reviewed dietary, nutritional, and physical activity randomized interventions aimed at modifying prostate cancer progression and disease-specific mortality, including a detailed assessment of risk of bias and methodological quality. (springer.com)
Forty-four randomized controlled trials of lifestyle interventions, with prostate cancer progression or mortality outcomes, were identified. (springer.com)
The remaining trials were either underpowered, at high or unclear risk of bias, inadequately reported, of short duration or measured surrogate outcomes of unproven relationship to mortality or disease progression, which precluded any benefits reported being reliable. (springer.com)
However, prostate cancer may behave more aggressively and is an important cause of morbidity and mortality [ 4 ]. (springer.com)
Given the long-term chronic, but potentially fatal, nature of the disease, there is growing interest in low-toxicity interventions in the tertiary prevention of morbidity and mortality due to prostate cancer. (springer.com)
PSA, PSA velocity), with regard to diagnostic accuracy (clinical validity) for aggressive (high-risk) prostate cancer, intermediate outcomes (e.g., improved decisionmaking about prognosis and triage for active surveillance and/or aggressive treatment), and long-term health outcomes (clinical utility), including mortality/morbidity, quality of life, and potential harms? (egappreviews.org)
Can UGT1A1 Genotyping Reduce Morbidity and Mortality in Patients with Metastatic Colorectal Cancer Treated with Irinotecan? (cdc.gov)
Cancer control is understood as the main public health action designed to reduce incidence and mortality as well as improve quality of life of patients. (who.int)

More patients in the control arm discontinued treatment due to disease progression (71% vs 43.7% in the cabazitaxel arm). (ascopost.com)
Patients must have demonstrated disease progression while on enzalutamide and/or abiraterone. (mayo.edu)
MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression. (urotoday.com)
The co-primary endpoints were treatment failure (histological progression of cancer from low to moderate or high risk or death during 24 months' follow-up) and absence of definite cancer (absence of any histology result definitely positive for cancer at month 24). (lu.se)
Moreover, patients with loss of libido and erectile dysfunction due to the disease and treatment are at increased risk of depression, fatigue, anxiety, irritability, and fear of disease progression. (diagnosticimaging.com)

In 2019, 224,733 new prostate cancers were reported in the U.S. along with 31,636 deaths from the disease. (healthnews.com)

Patients then receive a second endorectal coil MRI, followed by 2 months of external-beam radiotherapy plus TAS. (knowcancer.com)
Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of (223)Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. (researchgate.net)

As of 2006 she is a professor of surgery at the University of Bristol In 2000, Blazeby was awarded a Medical Research Council Clinician Scientist award to investigate principles and practices of outcome measures in surgical oncology. (wikipedia.org)
Judd W. Moul, MD, spoke with CancerNetwork® about the latest research from the journal ONCOLOGY® on the treatment of a patients with evidence of prostate cancer despite multiple negative prognostic tests. (cancernetwork.com)
Mr McCormack, from Warrington in Cheshire, received the fast and efficient treatment at Clatterbridge centre for Oncology in the Wirral, the first UK cancer centre to introduce the revolutionary new treatment technique. (varian.com)
RapidArc is a major advance in radiotherapy technology that will change the way radiotherapy is planned and delivered for selected patients," says Angela Heaton, research radiographer at Clatterbridge Centre for Oncology. (varian.com)
Patient care is at the heart of everything we do so the decision to invest in this equipment was very straightforward," says Brian Haylock, clinical director at Clatterbridge Centre for Oncology. (varian.com)
The work was supported in part by grants from the Prostate Cancer National Institutes of Health Specialized Programs of Research Excellence (P50CA09213), the Department of Defense (PC210066), the Prostate Cancer Foundation and the American Society for Radiation Oncology. (news-medical.net)
Once diagnosed, effective radiation treatment planning is a key factor in driving successful outcomes.At UroPartners' Cancer Treatment Center in Gurnee, we have found that a state-of-the-art oncology CT Simulation System that increases accuracy of treatment-while also keeping patients comfortable-is delivering excellent results for our clinicians to define treatment volumes. (diagnosticimaging.com)
Simply stated the male patient- and especially the male patient undergoing prostate cancer treatment-needs to feel confidence with his physicians as well as with his oncology treatment plan. (diagnosticimaging.com)
Cancer Trials Ireland and St Luke's Radiation Oncology Network, Dublin, Ireland. (bvsalud.org)
Family history of cancer and childhood rhabdomyosarcoma: a report from the Children's Oncology Group and the Utah Population Database. (cancercentrum.se)
11. In addition to lack of equipment for the management of cancer, Africa has an acute shortage of cancer experts such as pathologists for diagnosis, oncologists for treatment and oncology nurses for care. (who.int)

Of the men having a PSA test for any reason 12% were referred to secondary care within 14 days and 4% had a diagnosis of prostate cancer [ 9 ]. (biomedcentral.com)
These results may contribute to a paradigm shift in the screening and diagnosis of prostate cancer," Dr Bergdahl said here at the European Association of Urology 30th Annual Congress. (medscape.com)
These results may contribute to a paradigm shift in the screening and diagnosis of prostate cancer. (medscape.com)
Now imagine the man who gets a diagnosis of prostate cancer. (diagnosticimaging.com)

For high risk prostate cancer, the treatment volumes and even dose levels are still a controversial issue. (scirp.org)
Dose escalation in two phases utilizing Simultaneous integrated boost (SIB) combined with ADT in high risk prostate cancer patient is feasible and associated with acceptable acute GI and GU toxicity. (scirp.org)

The second project will use DNA sequencing and subsequent bioinformatics analysis to better understand how prostate cancer tumors evolve and metastasize to kill patients. (uclahealth.org)
We hope to use this opportunity to better understand what makes prostate cancer tumors spread," said Dr. Boutros. (uclahealth.org)
The 2016 World Health Organization classification provides a comprehensive listing of prostate tumors, including acinar adenocarcinoma subtypes. (medscape.com)
We compare clinical characteristics of prostate cancer tumors diagnosed within WTCHP with those characteristics of an age-matched group of prostate cancers who are not related to WTC. (cdc.gov)
To explore how Metformin might directly affect cancer cells, we analyzed how metformin altered the metabolism of prostate cancer cells and tumors. (jimjimjimjim.com)
We now appreciate that prostate tumors are often heterogeneous, containing a mixture of cells with different behaviors and responses to treatment. (pcf.org)
If successful, the team will establish new blood- or tissue-based approaches to identify patients at high risk of treatment failure, explain how these tumors evade treatment, and nominate new treatment approaches that can be moved forward to clinical trials to improve outcomes for patients diagnosed with particularly aggressive forms of metastatic prostate cancer. (pcf.org)

OBJECTIVES: I. Establish whether changes between baseline and 2-month post androgen suppression endorectal coil MRI results predict for biochemical control following radiotherapy with androgen suppression in patients with adenocarcinoma of the prostate. (knowcancer.com)
[ 4 ] In this article, the term prostate cancer refers to prostatic acinar adenocarcinoma. (medscape.com)
Metastatic Adenocarcinoma of Prostate in a 28-Year-Old Male: The outcome is poor in young patients? (jpalliativecare.com)
The index case is being presented for its rarity and probable poor outcome in young patients and to stress on the fact that the possibility of primary prostatic adenocarcinoma should be investigated in a male presenting with bone metastasis irrespective of the age. (jpalliativecare.com)
Patients must have documented histological or cytological evidence of adenocarcinoma of the prostate. (mayo.edu)

Approved by the U.S. FDA in 2022, 177 Lu-PSMA is an effective treatment for metastatic castration-resistant prostate cancer. (axisimagingnews.com)
Combining data from 29 clinical trials between January 1, 2018, and August 31, 2022, the researchers tested prostate SBRT. (pharmacytimes.com)
They confirm interim findings presented at the 2022 ASCO Genitourinary (GU) Cancers Symposium in San Francisco. (ecancer.org)

In mCRPC disease, the data regarding statins and outcomes are conflicting. (vivli.org)
There is a need for improved therapeutic approaches for patients with advanced metastatic castration-resistant prostate cancer (mCRPC), whilst on the other extreme, there is a need to accurately identify clinically significant prostate cancer in individuals presenting with elevated PSA levels or inconclusive MRI results. (pcf.org)

This identity switch is most commonly exemplified as neuroendocrine prostate cancer-a form of prostate cancer that is particularly difficult to treat. (pcf.org)

Thus, detection of 1.7 clinically significant cancers would be delayed for each clinically insignificant cancer avoided," the investigators calculated. (medpagetoday.com)

The primary outcome was the probability of detection of clinically significant prostate cancer (the percentage of patients with a Gleason score of 3+4 or greater). (medpagetoday.com)
The team did find, however, that the MRI-targeted strategy detected fewer clinically insignificant cancers (Gleason score 6). (medpagetoday.com)

Learn about the APP's evolving role in caring for patients receiving PARP inhibitors for prostate cancer in this on-demand webcast capturing a live presentation by Clinical Nurse Specialist Frank dela Rama, RN, MS, AOCNS, AGN-BC. (practicingclinicians.com)

Overall, 5 patients failed treatment and underwent salvage whole gland treatment. (medivizor.com)

Multiple institutions and collaborative groups have addressed prostate cancer screening. (medscape.com)
The United States Preventive Services Task Force (USPSTF) recomended against prostate cancer screening in 2011-2012, but in 2018 reversed the recommendation to include screening after an informed discussion. (medscape.com)
Is the excess in prostate cancer cases observed among WTC-exposed subjects associated with WTC-related exposures or represents an artifact due to regular prostate cancer screening? (cdc.gov)
A large segment of family practice doctors do not believe in the benefits of screening for prostate cancer. (atlantichealth.org)
The National Comprehensive Cancer Network's 2018 guidelines for prostate cancer early detection support baseline screening for healthy men at age 45. (atlantichealth.org)
Men with a close male family relative with prostate cancer or female relative with breast or ovarian cancer should consider earlier screening. (atlantichealth.org)
As a urologist on the front line against prostate cancer, I believe a continued emphasis on screening is necessary to help reduce the development of advanced disease, and ultimately save lives in the process. (atlantichealth.org)
Overdiagnosis is a critical barrier to any screening implementation of prostate cancer," Nordstrom said. (medpagetoday.com)
The prospective, randomized, population-based STHLM3-MRI trial included men ages 50 to 74 and was designed to evaluate different screening strategies for prostate cancer. (medpagetoday.com)
It is known as the Prostate Screening EpiSwitch or new PSE test. (healthnews.com)
The NHS says it currently has no screening program for men dealing with prostate cancer in the U.K. due to potential risks that come with screening. (healthnews.com)
Dr Aoun, who was involved in a similar study of men with suspected prostate cancer ( Biomed Res Int . 2015;2015:571708 ), said that the Göteborg results "highlight a new concept to revisit PSA screening strategies and add to what we know about MRI. (medscape.com)
The authors reported outcomes from the Göteborg randomized screening arm of the European Randomized trial of Screening for Prostate Cancer (ERSPC). (medscape.com)
The cumulative incidence of prostate cancer in this trial is higher than that reported at other ERSPC sites or from other screening trials, even those with high-intensity strategies of screening. (medscape.com)
In this project, Dr. Brisbane and team will create a machine learning-based image analysis algorithm to improve cancer specificity following PSA screening. (pcf.org)
This model will use data including age, PSA, DRE findings, prostate volume, and whole gland Micro-Ultrasound images to risk stratify patients following PSA screening. (pcf.org)
The goal of screening is to detect cancers that may grow if not treated. (diagnosticimaging.com)
Appointments for routine tests, including cancer screening tests, were postponed. (cdc.gov)
Registry staff are also working to educate doctors about the need to make sure their patients get any cancer screening tests they missed during the pandemic. (cdc.gov)
We have seen a considerable decline in cancer screening during the pandemic. (cdc.gov)
Regular screening tests are important because they can help find cancers early when treatment is likely to work best. (cdc.gov)
Defining a mutational signature for endometrial cancer screening and early detection. (cdc.gov)

The decline in prostate cancer screenings due to concerns of overdiagnosis and overtreatment is having a serious consequence: The number of men diagnosed with metastatic prostate cancer has doubled in just five years," says Naeem Rahman, MD , medical director, Urology at Summit/Bridgewater , who is a board-certified urologist by the American Board of Urology and member of the American Urological Association and the Society of Robotic Surgery. (atlantichealth.org)
Design: A cross-sectional study with stratified simple random sampling Setting: Urology Unit, Korle Bu Teaching Hospital Participants: One hundred and thirty-seven male patients with long-term urinary catheters Interventions: Participants were grouped into 3 weeks, 6 weeks, and 8 weeks duration of catheter replacementsPrimary outcomes measures: Symptoms due to the urinary catheters, urinalysis, urine and catheter tip cultures, sensitivity, and catheter encrustations were assessed. (bvsalud.org)

The study results will have practical implications on the surveillance and clinical management of prostate cancer, which is the most common cancer among male WTC Health Program members. (cdc.gov)
Purpose: To examine consequences of deferred treatment (DT) as initial management of prostate cancer (PCa) in a contemporary, prospective cohort of American men diagnosed with PCa. (harvard.edu)
The study is the first to directly evaluate the benefits of MR-guided adaptive prostate radiation in comparison to another more standard and conventional form of radiation, and it provides support for use of this treatment in the management of prostate cancer," said lead researcher Jonathon E. Leeman, MD, of the Dana-Farber Cancer Institute and Brigham and Women's Hospital, in a press release. (pharmacytimes.com)
Does PCA3 Testing for the Diagnosis and Management of Prostate Cancer improve patient health outcomes? (egappreviews.org)

In an analysis using SEER data showed that patients treated with IMRT were less likely to have physician reported gastrointestinal morbidity compared to those treated with 3-DCRT but more likely to have erectile dysfunction [11]. (scirp.org)
The goals of pharmacotherapy for prostate cancer are to induce remission, reduce morbidity, and prevent complications. (medscape.com)

In 2016, an estimated 21,600 men were diagnosed with prostate cancer and 4000 men died from the disease. (vivli.org)

Further, to ensure the treatment is directed accurately, MRg-A-SBRT can monitor the position of the patient's prostate in real time while the radiation beam remains on. (pharmacytimes.com)

We found that the MRI-targeted strategy was non-inferior for the detection of significant cancers," Nordstrom reported. (medpagetoday.com)
Of course, the detection of significant cancers must be balanced against the detection of insignificant cancers. (medscape.com)

BRCA germline mutation test for all woman with ovarian cancer? (cdc.gov)
Ovarian cancer today and tomorrow: A global assessment by world region and Human Development Index using GLOBOCAN 2020. (who.int)

This study provides level 1 evidence that after patients with the disease experience treatment failure on docetaxel and one of the newer androgen signaling-targeted inhibitors (ie, abiraterone or enzalutamide), cabazitaxel can extend their lives. (ascopost.com)
Two-thirds of patients had pain at study entry. (ascopost.com)
The present study tested the prognostic role of HRV in prostate cancer (PC) and non-small cell lung cancer (NSCLC) patients, using a historical prospective design. (heartmathbenelux.com)
PROJECTED ACCRUAL: Approximately 180 patients (approximately 60 per year) will be accrued for this study over a 34 months. (knowcancer.com)
To date, no prospective clinical trials in PCa have evaluated statin use in combination with other anti-cancer treatments, although our lab remains very interested in the hypothesis of synergy between statins and other drugs that may influence the cholesterol metabolism pathway and other prostate cancer therapies (including androgen axis inhibitors like darolutamide, the subject of the proposed study). (vivli.org)
36 men who underwent FLA for localized prostate cancer were enrolled in the study. (medivizor.com)
The study concluded that FLA has good long-term outcomes in certain patients with localized prostate cancer. (medivizor.com)
This study represents the first in-depth analysis of prostate cancer among World Trade Center (WTC) rescue and recovery workers. (cdc.gov)
The study will generate novel data on biomarkers of prostate cancer aggressiveness that could be used to make decisions on clinical treatment. (cdc.gov)
The radium lutetium (RALU) study evaluated the feasibility of sequential a- and b-emitter use in patients with bone-predominant metastatic castration-resistant prostate cancer. (wustl.edu)
Observational study - observes people and measures outcomes without affecting results. (mayo.edu)
The goal of this clinical study is to determine the safety and efficacy of VT-464, a lyase-selective inhibitor of CYP17 and an androgen receptor antagonist, in patients with castration-resistant prostate cancer (CRPC) who have been previously treated with enzalutamide or abiraterone. (mayo.edu)
Patients who have received combination enzalutamide/abiraterone or combination ARN509/abiraterone as part of ongoing clinical trials are allowed and will be included in "Prior Abiraterone" arm of this study. (mayo.edu)
Patients on LHRH agonists/antagonists must remain on these agents for the duration of the study. (mayo.edu)
Patients must have discontinued enzalutamide or abiraterone/prednisolone ≥4 weeks prior to study drug initiation. (mayo.edu)
We aimed to study mature outcomes from a randomised, multicentre, phase II study of (223)Ra. (researchgate.net)
The study, involving seven medical centers, looked at 379 men with prostate cancer and 394 with benign prostatic disease. (cancernetwork.com)
The second study evaluated the agreement between 96 Axumin and C11 choline (an approved PET scan imaging test) scans in patients with median PSA values of 1.44 ng/mL. (fda.gov)
The goal of this study was to determine the impact of 68 Ga-PSMA-11 PET/CT on initial and subsequent management decisions in a cohort of PCa patients referred for various indications (i.e., a basket trial) excluding the 2 main classic indications: BCR and presurgical staging. (snmjournals.org)
This was a prospective study of 197 patients that aimed to determine the impact of 68 Ga-PSMA-11 PET/CT on PCa stage and management. (snmjournals.org)
Prostate cancer blood test created by U.K. scientists shown to be 94% effective in a newly released study. (healthnews.com)
Investigators admit their study was limited to a population with a high cancer prevalence. (healthnews.com)
One reason for our finding could be that many patients in the study died from causes unrelated to prostate cancer. (news-medical.net)
MRI technology is more costly than CT, both in terms of upfront equipment expenses and longer treatment times, which is one reason our study set out to determine if MRI-guided technology offers tangible benefits for patients. (ecancer.org)
A unique aspect of the study was its inclusion of outcome measures assessed by patients as well as physicians. (ecancer.org)
The Arkansas Central Cancer Registry began to study the effect of COVID-19 on patients with cancer in the state right away. (cdc.gov)
Our study shows how COVID-19 is affecting patients with cancer. (cdc.gov)
The outcomes for patients in both study arms were better than we expected," van As said in a statement. (msdmanuals.com)
Familial pancreatic cancer risk: a population-based study in Utah. (cdc.gov)
Our review of interim results from an ongoing safety study of Prolia suggests an increased risk of hypocalcemia, or low calcium levels in the blood, in patients with advanced kidney disease. (medlineplus.gov)
Preliminary results from a separate internal FDA study further investigating hypocalcemia in dialysis patients treated with Prolia show a substantial risk with serious outcomes, including hospitalization and death. (medlineplus.gov)
Our review of the interim results from this ongoing safety study suggests an increased risk of hypocalcemia with Prolia in patients with advanced kidney disease. (medlineplus.gov)
Preliminary results from a separate internal FDA study investigating the risk of hypocalcemia suggest that patients on dialysis treated with Prolia are at substantial risk for severe and symptomatic hypocalcemia, including hospitalization and death. (medlineplus.gov)
3: Mörner M, Gunnarsson U, Jestin P, Egenvall M. Volume of blood loss during surgery for colon cancer is a risk determinant for future small bowel obstruction caused by recurrence--a population-based epidemiological study. (cancercentrum.se)
Objectives: This study compared the infection rates, degree of encrustation, symptoms, and complications in patients regarding the duration of urethral catheterisation (three weeks, six weeks, and eight weeks). (bvsalud.org)

Fortunately, for the 191,000 men who will be diagnosed with prostate cancer in 2020, it is often treatable. (riversideonline.com)
As the number of COVID-19 cases began to rise in 2020, the North Carolina Central Cancer Registry wanted to find out which groups of cancer patients in the state were more likely to get the virus. (cdc.gov)
Current and future burden of breast cancer: Global statistics for 2020 and 2040. (who.int)
Cancer in sub-Saharan Africa in 2020: a review of current estimates of the national burden, data gaps, and future needs. (who.int)
The preventability of cancer in Europe: A quantitative assessment of avoidable cancer cases across 17 cancer sites and 38 countries in 2020. (who.int)
If no interventions are put in place, it is projected that by the year 2020, the number of new cancer cases will be 804 000 and the number of deaths due to cancer will be 626 400. (who.int)

The seminar will explore how different studies and methods identify and address the varying needs patient with PCa over treatment and survivorship. (southampton.ac.uk)
A new prostate cancer blood test developed in the United Kingdom proves more effective than current methods. (healthnews.com)
Wayne Brisbane is investigating methods to improve Micro-Ultrasound specificity and evaluate Micro-Ultrasound versus MRI for prostate cancer visualization. (pcf.org)
Methods: Localized PCa patients (N = 431) within one year of treatment completion were randomized to receive educational booklets or PROGRESS + educational booklets. (cdc.gov)

She is also known for her work on patient-reported outcomes and research into optional wound dressings following surgery. (wikipedia.org)
In a patient-directed summary, they emphasized the generally favorable outlook for localized prostate cancer: "More than 95 out of every 100 men with low or intermediate-risk localized prostate cancer do not die of prostate cancer within 10 years, irrespective of whether treatment is by means of monitoring, surgery, or radiotherapy. (medpagetoday.com)
The majority of men receiving PSA tests for prostate cancer may not be receiving adequate information before deciding whether to be screened, and whether to undergo surgery if cancer is spotted, two new papers conclude. (dotmed.com)
Patients with BCR and candidates for curative surgery were excluded. (snmjournals.org)
These minimally invasive devices, called daVinci surgical robots, offer patients substantially less pain, short recovery time and quicker return to normal activities than traditional open surgery. (thehealthcareblog.com)
Most importantly, with regard to prostate surgery, using the robot has demonstrated improved outcomes over open prostatectomy. (thehealthcareblog.com)
Another important factor in my decision is that once radiation is performed, and if the cancer were to come back, surgery is not an option after radiation due to the high complication rate and difficulty created by the effects of radiation on the tissues. (thehealthcareblog.com)
Conversely, if I had surgery first, and the cancer came back, then radiation was still an option. (thehealthcareblog.com)
Robot-assisted surgery allowed me to return to my normal activities quickly and this was important for my patients and practice. (thehealthcareblog.com)
Compared to the open surgical incision, these incisions are significantly smaller and for many patients this alone is reason enough to consider the procedure over traditional open surgery. (thehealthcareblog.com)
The typical prostate surgery patient after a more traditional operation is in the hospital two to three days and is recovering for four to six weeks. (thehealthcareblog.com)
Almost all my patients have gone home the day following surgery, and most are back to normal activities by two weeks. (thehealthcareblog.com)
this has created an expo- precision surgery, including the intel- to send money to family members nentially increasing number of types ligent scalpel (which provides instan- to pay for treatment or by doctors of cancers, as well as pathways of taneous diagnosis during surgery), to evaluate images and patholo- care, defined by prognostic stratifi- nanorobotics (Felfoul et al. (who.int)

For men who undergo radiotherapy for localised prostate cancer, the precise targeting capabilities of MRI guidance resulted in fewer toxicities and better quality of life, as judged by patients and the doctors treating them, according to new research from UCLA Jonsson Comprehensive Cancer Center. (ecancer.org)
MRI guidance offers several advantages over standard CT guidance, most notably the ability to dramatically reduce planning margins, providing more focused treatment with less injury to nearby normal tissues and organs," said Amar Kishan, M.D., a radiation oncologist at the David Geffen School of Medicine at UCLA and the UCLA Jonsson Comprehensive Cancer Center and the study's lead author. (ecancer.org)

These men underwent additional treatments following recurrence including FLA, high-intensity focused ultrasound (HIFU - kills cancer cells using high-frequency sound waves), and cryotherapy (uses extreme cold to kill cancer cells). (medivizor.com)
Approximately one-third of patients with newly diagnosed metastatic prostate cancer do not achieve deep or durable responses following standard of care treatments such as ADT + ARSIs. (pcf.org)
Many new treatments for castration resistant prostate cancer (CRPC) have been developed in the past decade. (pcf.org)
Shortly we intend to start using RapidArc for complex head & neck cancer treatments and we expect the beam-on time will be reduced from 25 minutes using IMRT to about two and a half minutes using two arcs with RapidArc, resulting in more efficient treatments and potentially shortening waiting lists," she said. (varian.com)
By using this state- of-the-art technology we can speed up the time of some of our most complex treatments and in doing so we will be able to treat more patients comfortably with less stress to the individual. (varian.com)
This seminar will focus on the early findings from two such studies, Life After Prostate Cancer Diagnosis (LAPCD) and True Nth UK Decision Support: Understanding consequences of prostate cancer treatments. (southampton.ac.uk)
Over diagnosis for prostate cancer is a concern due to possible treatments that may be harmful to someone who does not contain the disease. (healthnews.com)

That data will then be made available to with prostate cancer researchers around the world to create a centralized resource for researchers and clinicians and reduce wasteful costs on repeated genomic studies. (uclahealth.org)
Studies have shown positive associations between statin use and PCa outcomes, though nearly all the studies have been "retrospective" meaning the data had already been collected (perhaps for another reason) and researchers went back to look at the statin-cancer associations. (vivli.org)

Does focal laser ablation improve outcomes in the long-term for patients with prostate cancer? (medivizor.com)
5-Year Outcomes Following Focal Laser Ablation of Prostate Cancer. (medivizor.com)

However, monitoring early-response biomarkers to adjust treatment intervals may improve patient outcomes. (axisimagingnews.com)
Ultimately, this type of research can help improve patient outcomes and overall value in the healthcare system. (scienceblog.com)

HRs for time to metastasis or death as a result of PCa were compared between patients who deferred treatment and those who underwent immediate treatment within 1 year of diagnosis. (harvard.edu)
Here, we report a case of prostate cancer in 28-year-old male who presented with bone metastasis. (jpalliativecare.com)
In our decision analytic cost-effectiveness modeling of the original ProtecT data, initial treatment was the preferred option for patients with more than a 2.4% 10-year risk of metastasis on active surveillance. (medpagetoday.com)
Bone-targeting properties of (223)Ra could also potentially be used for treating skeletal metastasis from other primary cancers. (researchgate.net)
In general, cancer recurrence and metastasis are the result of the interactions of multiple mutated genes. (nature.com)

Until now, the optimal sequencing of new agents available for metastatic castration-resistant prostate cancer has been unknown. (ascopost.com)
Once-daily Oral VT-464 in Patients With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone. (mayo.edu)
PSMA-directed endoRadiothErapy of Castration-reSISTant Prostate Cancer (RESIST-PC). (uclahealth.org)
GnRH agonists provide medical castration in patients with prostate cancer. (medscape.com)

Surgical removal of the prostate gland is often recommended as a treatment for prostate cancer. (medivizor.com)

Patients may not respond to abiraterone after treatment with enzalutamide, and vice versa, yet this sequence is widely used in clinical practice," Dr. de Wit noted. (ascopost.com)
Patients must have received enzalutamide or abiraterone for CRPC. (mayo.edu)
A common germline variant in CYP11B1 is associated with adverse clinical outcome of treatment with abiraterone or enzalutamide. (urotoday.com)

secondary outcomes). (cdc.gov)

Anatomy10

Organisms4

Diseases34

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment86

Psychiatry and Psychology2

Phenomena and Processes45

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science10

Named Groups4

Health Care45

Geographicals5

Antigen25

Biopsy30

20233

Castrate resistant5

Biopsies10

Recurrent prosta4

Radical Prostatectomy3

Survival30

Tumor15

Clinical outcomes6

Better outcomes4

Metastatic disease4

Therapy39

Androgen deprivation2

Radiotherapy for Prostate Cancer2

20214

Mortality16

Progression5

20191

External-beam radioth2

Oncology11

Diagnosis of prostate cancer4

High-Risk Prostate Cancer2

Tumors7

Adenocarcinoma5

20223

MCRPC2

Neuroendocrine prostate cancer1

Clinically significant cancers1

Gleason2

Receiving PARP inhibitors1

Failed treatment1

Screening22

Urology2

Management of prostate4

Morbidity2

20161

Patient's1

Detection of significant cancers2

Ovarian cancer2

Study35

20206

Methods4

Surgery13

Jonsson Comprehensive Cancer2

Treatments7

Researchers2

Laser Ablation2

Improve patient outcomes2

Metastasis5

Castration4

Removal of the prostate1

Enzalutamide3

Secondary1