StromalMSCsHSCTEmbryonicTherapyTherapiesTherapeutic2023Allogeneic transplantationDifferentiateTransplantRegenerationMarrowTherapeuticsImmunomodulatoryTissueDifferentiation potentialHaploidenticalInfusionRegenerativeEfficacyGraftAdult StemPopulationsMalignantPatientsCordProliferationSurvivalSevereLeukemicImmuneVitroProgenitor cellHair transplantationPatient'sInvolvesParacrineTissuesAcute
Stromal24
- In working with the sheep model, we also proposed that transplanting human BM-derived mesenchymal stromal/stem cells (MSCs) would outcome inside a "humanized" sheep HSC niche. (ack1inhibitor.com)
- Mesenchymal stromal cells (MSCs) are multipotent cells with high capacity of immunoregulation, which emerged as a promising cell-based therapy for many immune disorders. (biomedcentral.com)
- Mesenchymal stromal cells (MSCs) are non-hematopoietic, multipotent cells that can be sourced from various tissues, including bone marrow, umbilical cord (UC), and adipose tissue. (biomedcentral.com)
- Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
- Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
- Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
- Mesenchymal stem cells (MSCs) are multipotent stromal cells in connective tissues capable of differentiating into a variety of specialized and functional cells, including osteoblasts, chondroblasts, myocytes, and adipocytes. (hindawi.com)
- Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
- Systematic review and meta-analysis of randomized controlled trials of mesenchymal stromal cells to treat coronavirus disease 2019: is it too late? (mathec.com)
- Since endometrial stromal cells are easy to isolate, and expand rapidly from patients without leading to major ethical and technical problems. (scirp.org)
- There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
- 1, 2 Recently, Prolotherapists have begun to utilize the potential of autologous adipose (fat)-derived stem/stromal cells (AD-SC) within non-manipulated fat graft scaffolding, combined with high-density PRP concentrates (HD-PRP) to provide a potent biological therapeutic combination. (journalofprolotherapy.com)
- Recognition of the vast number of undifferentiated cells associated with the stromal vascular fraction has resulted in extensive research demonstrating the heterogeneity of such cells, and their ability to participate in production of all mesodermal-derived tissues. (journalofprolotherapy.com)
- 7 There has been some variation and question regarding the correct terminology for this population of stromal adipose cells. (journalofprolotherapy.com)
- At first, the mesenchymal stem cell was thought to be the primary component of this undifferentiated cell type, however it is now evident that within the adipose extracellular matrix are also adipocytic precursors (known as progenitor cells) adherent to adipocytes, and in close approximation to a variety of additional undifferentiated multipotent and pluripotent cells, including pericytes and endothelial cells, all thought to play important roles in mesenchymal-stromal derived tissue regeneration. (journalofprolotherapy.com)
- Therefore we have chosen to use the term "adipose-derived stem/stromal cells" (AD-SC's), rather than simply "mesenchymal stem cells. (journalofprolotherapy.com)
- however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)
- The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
- It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
- These Fgfr3-creER -marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by Lepr-cre -marked stromal cells in adult stages. (nature.com)
- Further, Fgfr3 + endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor through unregulated self-renewal and aberrant osteogenic fates. (nature.com)
- These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
- Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
- Another key molecular axis is the interaction between MK2-IN-1 hydrochloride stromal cell-derived factor 1 (SDF1 or CXCL12) and its receptor CXCR4, expressed on the cell surface of HSPC. (conferencedequebec.org)
MSCs30
- Background: Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). (uni-hannover.de)
- The functional interactions between NK cells and MSCs have the potential to influence the leukemia relapse rate after HSCT. (uni-hannover.de)
- Until date, MSC-NK cell interaction studies are largely focussed on bone marrow derived (BM)-MSCs. (uni-hannover.de)
- Thus, we studied the interaction of UC-MSCs with unstimulated allogeneic NK cells.Results: UC-MSCs could potently suppress NK cell cytotoxicity in overnight cultures via soluble factors. (uni-hannover.de)
- Maximal PGE2 release involved IL-1β priming of MSCs after close contact between the NK cells and UC-MSCs. (uni-hannover.de)
- MSCs are known to promote HSC engraftment and immune recovery right after HSC transplantation, iNOS web likely via the provision of hematopoietic supportive components including cytokines, matrix proteins, and cell-to-cell contacts inside the BM niche, while also modulating the immune response thereby advertising tolerance (18-24). (ack1inhibitor.com)
- MSCs as much as passage 7 had been transplanted immediately after digestion into single cells on day of transplantation based on typical protocols (26, 27). (ack1inhibitor.com)
- The objective of this study was to examine the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with T1D. (biomedcentral.com)
- One repeated intravenous dose of allogeneic UC-MSCs is safe in people with recent-onset T1D and may result in better islet β cell preservation during the first year after diagnosis compared to standard treatment alone. (biomedcentral.com)
- thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. (biomedcentral.com)
- MSCs are multipotent stem cells with the ability to self-renew and differentiate in multiple directions [ 3 ]. (biomedcentral.com)
- By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
- However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
- Mesenchymal stem cells (MSCs) are known for their immunomodulatory and anti-inflammatory properties. (kintaro.com)
- Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
- One trial is testing whether MSCs with or without peripheral blood stem cells could treat poor graft function and delayed platelet engraftment. (drugdiscoverynews.com)
- In another trial, this group is evaluating whether peripheral blood stem cells combined with MSCs can treat poor graft function. (drugdiscoverynews.com)
- One of the reasons of such outcomes is non-standardized and often disadvantageous ex vivo manipulation of MSCs prior therapy. (frontiersin.org)
- In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
- Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
- Autologous human adipose tissue-derived mesenchymal stem cells (MSCs) have the potential for clinical translation through their induction into osteoblasts for regeneration. (hindawi.com)
- Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
- MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. (techscience.com)
- The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)
- This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
- The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
- MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
- Therefore, MSCs may help resolve issues restricting the application of hepatocyte transplantation. (springer.com)
- 6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
- Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) were derived from syngenic mouse bone marrow. (vinastemcelllab.com)
HSCT20
- Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
- Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
- The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
- This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
- In the early reconstitution phase following HSCT, natural killer (NK) cells represent the major lymphocyte population in peripheral blood and display graft-vs-leukemia (GvL) effects. (uni-hannover.de)
- Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-γ levels in the recipient's body can strongly influence the clinical outcome. (uni-hannover.de)
- Stem cell therapies, such as hematopoietic stem cell transplantation (HSCT), aim to reset the immune system. (kintaro.com)
- In HSCT, a patient's own stem cells are harvested, and then high-dose chemotherapy is used to suppress the immune system. (kintaro.com)
- Hematopoietic stem cells are commonly used in HSCT. (kintaro.com)
- There are different approaches to stem cell therapy for MS, including hematopoietic stem cell transplantation (HSCT), mesenchymal stem cell therapy, and neural stem cell therapy. (kintaro.com)
- HSCT involves using high-dose chemotherapy to suppress the immune system and then reintroducing the patient's own stem cells to rebuild a new immune system. (kintaro.com)
- Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
- Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
- Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
- Haploidentical donors are increasingly used for patients requiring hematopoietic stem cell transplantation (HSCT). (hla-dr.com)
- His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
- In conclusion, the HSCT must offer the best overall survival, quality of life, and cost outcomes compared to any other treatment strategy. (ajbm.net)
- More studies will need a lot of data, and careful data analysis will help get clear data on HSCT outcomes. (ajbm.net)
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) involves the infusion of stem cells following administration of high-dose chemotherapy or total body irradiation for either tumor control or to prevent solid transplant rejection. (gvhdhub.com)
- Allo-HSCT is an important treatment strategy, which allows administration of myeloablative therapy and the elimination of cancer cells by the transplanted donor T and natural killer (NK) cells in a phenomenon known as the graft- versus -leukemia (GvL) effect. (gvhdhub.com)
Embryonic9
- Unlike embryonic stem cells which are pluripotent, cord blood stem cells are multipotent. (wikipedia.org)
- In addition, we found that in the presence of LIF, MDLS could replace feeder cells to maintain the undifferentiated state of OG2-mES cells (Oct4-GFP reporter gene mouse embryonic stem cell line), and the MDLS-expanded OG2-mES cells showed an elevated expression levels of pluripotency markers in vitro. (biomedcentral.com)
- It is expressed in ESCs, embryonic germ (EG) cells and embryonic carcinoma (EC) cells and essential for early embryonic development [ 14 , 15 ]. (biomedcentral.com)
- Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
- Embryonic stem cells isolation primarily requires the consent of donors and can include the killing of fertilized eggs. (techscience.com)
- Specifically, about the paracrine activities of amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cell, induced pluripotent stem cells as well as other stem cells. (biomedcentral.com)
- 6 Induced pluripotent stem cells from human extra-embryonic amnion cells: role of dna methylation in mainting stemness. (vinastemcelllab.com)
- 7 Smooth muscle cell differentiation from embryonic stem cells: role of hdac7 and pdgf-bb. (vinastemcelllab.com)
- 9 Tendon injury: role of differentiation of aduilt and embryonic derived stem cells. (vinastemcelllab.com)
Therapy45
- Here we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy for pulmonary arterial hypertension (PAH). (nature.com)
- Although intensive insulin therapy allows for improved glucose homeostasis, it cannot replace the highly specialized work done by pancreatic islets, neither can it suppress the autoimmune destruction of residual β cells. (biomedcentral.com)
- Stem cell therapy has garnered attention as a potential approach to manage MS symptoms and potentially halt or reverse the disease progression. (kintaro.com)
- This has led to the investigation of stem cell therapy as a means to promote repair and regeneration of damaged nerve tissue in MS. (kintaro.com)
- While there have been cases of positive outcomes, stem cell therapy for MS is not without challenges. (kintaro.com)
- Responses to stem cell therapy can vary among individuals. (kintaro.com)
- The course of MS is highly variable, and not all patients are suitable candidates for stem cell therapy. (kintaro.com)
- If considering stem cell therapy for MS, it's crucial to consult with neurologists or medical professionals who specialize in MS treatment. (kintaro.com)
- Presently, there is no definitive cure for multiple sclerosis (MS), and while stem cell therapy shows promise in the treatment of MS, it's important to approach the topic with realistic expectations. (kintaro.com)
- Stem cell therapy for MS involves using various types of stem cells to potentially modulate the immune system, promote repair of damaged nerve tissues, and reduce inflammation. (kintaro.com)
- Application of prophylactic or pre-emptive therapy after allogeneic transplantation for high-risk patients with t(8;21) acute myeloid leukemia. (stembook.org)
- Refractory patients with favorable/intermediate-risk acute myeloid leukemia benefit from azacytidine maintenance therapy following allogeneic hematopoietic stem cell transplantation. (stembook.org)
- Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
- Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
- For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
- For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
- For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
- Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
- In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
- Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
- We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
- However, one of the bottlenecks in the stem cell therapy is that stem cells tend to differentiate into other types of cells during culture in vitro. (biomedcentral.com)
- Autologous stem cell transplantation in refractory Crohn's disease - low intensity therapy evaluation (ASTIClite): study protocols for a multicentre, randomised controlled trial and observational follow up study. (wizaxe-prod.com)
- A Review on Behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation In Refractory CD-Low Intensity Therapy Evaluation Study Investigators. (wizaxe-prod.com)
- Such cell-based therapy is likely to simultaneously target several different immunological pathways, thereby utilizing numerous physiological mechanisms for re-establishing immune tolerance and induction of cellular repair mechanisms. (uu.se)
- Stem cells have the potential to revolutionize contemporary medicine and therapy methods. (hindawi.com)
- Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
- It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. (biomedcentral.com)
- An experimental stem cell therapy for the treatment of mild to moderate amyotrophic lateral sclerosis (ALS) received a resounding rejection today from a US Food and Drug Administration (FDA) advisory panel that cited efficacy, safety, and product manufacturing concerns. (medscape.com)
- Second, inadequate engraftment is usually another unsolved obstacle that affects the outcome of HSC gene therapy. (eyesoftheelephants.com)
- Bone marrow stem cells from adults have been viewed as the ideal target for gene- and cell-based therapy of genetic diseases, selected malignant diseases, and AIDS. (eyesoftheelephants.com)
- This is because heart failure is one disorder that has proven difficult to treat using conventional measures but can be managed through stem cell therapy and lifestyle changes which largely are contributed by the person himself. (stemfinitycord.com)
- Stem cell therapy offers a very promising way of treating heart failure - the procedure involves using stem cells to promote the regeneration of heart muscle and blood vessel cells. (stemfinitycord.com)
- Our specialists reckon that the primary mechanism intricated in stem cell therapy is through paracrine effects. (stemfinitycord.com)
- Studies reveal that the use of stem cell therapy is effective in the improvement of the function of the left ventricle and occasional attenuation of left ventricle dilation. (stemfinitycord.com)
- Several studies have shown that stem cell therapy is effective in managing heart failure, however, stem cells are affected by inflammatory environments and thus develop inflammatory properties. (stemfinitycord.com)
- The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
- In addition to mobilizing HSPC, the interference with the CXCR4-SDF1 axis has also been proposed as a possible strategy to mobilize malignant stem cells from their protective niche, hence making tumor stem cells even more susceptible to irradiation or chemo- therapy. (conferencedequebec.org)
- Trang chủ Công trình KHCN Sách/Chương sách Improving the Efficacy of Diabetes Mellitus Treatment by Combining Cell Replacement Therapy. (vinastemcelllab.com)
- Stem cell therapy has the potential to overcome these limitations and may offer the best outcomes for treating diabetes mellitus. (vinastemcelllab.com)
- Based on the pathophysiology of diabetes mellitus, stem cell therapy targets two mechanisms, namely cell replacement and immune correction. (vinastemcelllab.com)
- The aim of this series of studies was to evaluate the efficiency of diabetic treatment by combining cell replacement therapy with immune correction therapy. (vinastemcelllab.com)
- These findings provide hope for a new strategy that can improve the outcomes of stem cell-based therapy for diabetes in humans. (vinastemcelllab.com)
- 18 Adipose-derived stem cells: therapy through paracrine actions. (vinastemcelllab.com)
- This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
Therapies9
- I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
- There is growing interest from cell therapeutics companies in developing genetically modified allogenic natural killer cells from umbilical cord blood as an alternative to CAR T cell therapies for rare diseases. (wikipedia.org)
- Such insights could business lead in turn towards the advancement of book cell therapies predicated on endogenous biologic differentiation potential. (morainetownshipdems.org)
- In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
- More importantly, their greatest potential lies in cell-based and tissue engineering therapies to combat a range of diseases [ 3 ]. (hindawi.com)
- Generally, it is rapidly lethal, and survival outcomes for adults with AML are very poor despite intensive chemotherapy and/or targeted therapies together with supportive care [ 4 ]. (researchsquare.com)
- There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
- 21 The cancer stem cell hypothesis and its impact on the design of new cancer therapies. (vinastemcelllab.com)
- hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Therapeutic12
- The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. (biomedcentral.com)
- Novel approaches need to be developed to achieve ideal therapeutic outcomes for patients with periodontitis. (biomedcentral.com)
- PLX-R18 cells, derived from mesenchymal-like cells collected from donated placentas, are designed to release a combination of therapeutic proteins to jumpstart the regeneration of a poorly functioning hematopoietic system. (drugdiscoverynews.com)
- Mesenchymal stem cells (MSC) is an important type of cell that is highly acclaimed for their safety and efficacy as a therapeutic agent cells. (hla-dr.com)
- In addition, this cell population might be a novel therapeutic target for AML. (researchsquare.com)
- In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)
- So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
- This gives mesenchymal stem cell treatment an added therapeutic advantage since they serve as allogeneic graft eliminating the need for bone marrow harvesting which many patients find unpleasant. (stemfinitycord.com)
- According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. (bmbreports.org)
- The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
- 14 Pluripotent cell-derived glial precursor cells for the delivery of therapeutic proteins to the central nervous system. (vinastemcelllab.com)
- This article is a summary of the European Society for Blood and Marrow Transplantation (EBMT) webinar entitled 'Pathophysiology of acute and chronic GvHD, novel therapeutic strategies in the preclinical phase' delivered by Ernst Holler on May 5th, 2020. (gvhdhub.com)
20232
- Stem Cell Rev Rep. 2023. (stembook.org)
- We performed a systematic review and meta-analysis to assess mortality post allo-HCT through a comprehensive literature search using PUBMED/MEDLINE, CINAHL, Web of Science, and EMBASE up to April 30, 2023 and extracted clinical outcome data relating to benefits followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. (ajbm.net)
Allogeneic transplantation1
- As reported by the researchers, allogeneic transplantation of mesenchymal stem cells from adipose tissue was shown to be safe and able to reduce proteinuria and disease activity. (sscb-stembiotech.com)
Differentiate6
- Stem cells possess regenerative properties and the potential to differentiate into various cell types, including those present in the nervous system. (kintaro.com)
- Neural stem cells are being explored for their potential to differentiate into neural cells. (kintaro.com)
- Neural stem cells have the potential to differentiate into various neural cell types, which makes them a candidate for repairing damaged nerve tissue in MS. Research in this area is still in its early stages. (kintaro.com)
- However, it can be challenging to differentiate when they are connected with wounded tissue, opposed to when they instruct tissue-specific progenitor cells responsible for the redevelopment of damaged tissue. (techscience.com)
- In addition cIAP1 Ligand-Linker Conjugates 14 to HSC, bone marrow contains mesenchymal stem/progenitor cells (MSC), which can differentiate into mature cells of multiple mesenchymal tissues cIAP1 Ligand-Linker Conjugates 14 including fat, bone, and cartilage. (eyesoftheelephants.com)
- Intradermal adipocyte progenitor cells are activated toward the end of the telogen phase to proliferate and differentiate into mature adipocytes. (jcadonline.com)
Transplant8
- This process of neutrophil and platelet production after the transplant, however, takes much longer than that of stem cells. (wikipedia.org)
- Early efforts to use CBT in adults led to mortality rates of about 50%, due somewhat to the procedure being done in very sick people, but perhaps also due to slow development of immune cells from the transplant. (wikipedia.org)
- Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
- J Stem Cell Ther Transplant. (biologymedjournal.com)
- Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has a high risk of disease recurrence and severe transplant-related morbidity and death. (ajbm.net)
- The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. (ajbm.net)
- Allogeneic hematopoietic stem cell transplant (allo-HCT) findings, nonetheless, still present a chance for recovery. (ajbm.net)
- Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. (ajbm.net)
Regeneration9
- The properties of HUCMSCs were validated by untargeted label-free quantitation of the cell and CM proteome, suggesting increased activity of regeneration, autophagy and anti-inflammation pathways and mitochondrial function. (nature.com)
- In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)
- Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. (stembook.org)
- 1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
- Third, it may summon the appropriate mesenchymal stem cells to the site of regeneration. (medscape.com)
- Schwann cells (SCs) have important roles in development, myelination and regeneration in the peripheral nervous system. (scirp.org)
- With improved understanding of tissue healing and regeneration, stem cell Prolotherapy is gaining significant clinical importance and potential. (journalofprolotherapy.com)
- These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
- Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Marrow40
- Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
- Mesenchymal stem cells (found in bone marrow and other tissues) are being investigated for their immunomodulatory and anti-inflammatory effects. (kintaro.com)
- Some non-hematopoietic stem cell types are also present in cord blood, for example, mesenchymal stem cells, however these are present in much lower numbers than what can be found in adult bone marrow. (wikipedia.org)
- Cord blood is used the same way that hematopoietic stem cell transplantation is used to reconstitute bone marrow following radiation treatment for various blood cancers, and for various forms of anemia. (wikipedia.org)
- In Dr. Moise's article about umbilical cord blood, it was found that there is approximately 10% less stem cells in cord blood than there is in bone marrow. (wikipedia.org)
- however the source of this activity whether a primitive osteoprogenitor or a transplantable marrow cell with dual hematopoietic and osteogenic potential has eluded detection. (morainetownshipdems.org)
- Secondary Genkwanin BMT studies demonstrated that a single marrow cell able to contribute to hematopoietic reconstitution in primary recipients also drives robust osteopoiesis and LT hematopoiesis in secondary recipients. (morainetownshipdems.org)
- Intro Bone and bone tissue marrow (BM) are anatomically contiguous and harbor cell types that are functionally interrelated.1 Conceivably Genkwanin a stem cell could bring about both hematopoietic and osteopoietic progeny beneath the control of a particular genetic system or particular environmental cues. (morainetownshipdems.org)
- Identifying a transplantable osteoprogenitor or simply a putative dual hematopoietic-osteopoietic progenitor could possibly be key to your knowledge of the biology of marrow transplantation as well as the hematopoietic stem cell (HSC) market. (morainetownshipdems.org)
- Using supplementary BMT assays we display here a solitary marrow cell in a position to donate to hematopoietic reconstitution in major recipients drives both osteopoiesis and long-term (LT) hematopoiesis in supplementary recipients. (morainetownshipdems.org)
- European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP). (wizaxe-prod.com)
- Autologous Haematopoietic Stem Cell Transplantation for Crohn's Disease: A Retrospective Survey of Long-term Outcomes from the European Society for Blood and Marrow Transplantation. (wizaxe-prod.com)
- The bone marrow contains not only hematopoietic cells, but also mesenchymal stem cells (MSC). (uu.se)
- In mice treated with daily low doses of the beta-cell toxin streptozotocin, MSC obtained from human bone marrow were found to home to and promote repair of pancreatic islets, thereby ameliorating the level of diabetes. (uu.se)
- Hematopoietic stem cells from bone marrow are one of the few clinically approved stem cells which are proven to increase the survival rate for thousands of patients [ 4 ]. (hindawi.com)
- Bone marrow-derived mesenchymal stem cells, or the blood stem cells that are nonhematopoietic, are currently being used in clinical trials and show promise in improving recovery based on early indicators [ 5 ]. (hindawi.com)
- We examined the CD45 dim CD34 + CD38 - CD133 + cells on bone marrow samples of hematologic malignancies and healthy controls using four-color flow cytometry experiments. (researchsquare.com)
- Interestingly, the CD45 dim CD34 + CD38 - CD133 + cells were highly expressed in bone marrow of patients with AML compared to that of healthy controls (HC). (researchsquare.com)
- In this study, we focused on measuring LSCs easily in the bone marrow cells from AML patients by developing a four-color flow cytometric analysis. (researchsquare.com)
- While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
- A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
- BrainStorm Cell Therapeutics), uses mesenchymal stem cells harvested from patients' own bone marrow that are engineered to secrete neurotrophic factors, proteins important for the survival and function of neurons. (medscape.com)
- Long-term outcome and late effects in patients transplanted with mobilised blood or bone marrow: a randomised trial. (ajbm.net)
- Our data provide evidence that adult stem cells in bone marrow can be efficiently transduced vector administration without preconditioning. (eyesoftheelephants.com)
- gene transfer, hematopoietic stem cells, lentiviral vectors, mesenchymal stem/progenitor cells, bone marrow transplantation, hematopoiesis Introduction HIV-based lentiviral vectors (LV) were proven to be capable of transducing a broad spectrum of nondividing cells in multiple mammalian species cIAP1 Ligand-Linker Conjugates 14 [1]. (eyesoftheelephants.com)
- Following intravenous administration of a first-generation LV into adult mice, we found that bone marrow exhibited the highest levels of transgene among nine organs examined, with more than 10% green fluorescent protein-positive (GFP+) cells detected in peripheral blood leukocytes (PBL) in these mice [9]. (eyesoftheelephants.com)
- Recently, we exhibited detectable levels of transgene (up to 3.9%) in PBL of mice 4 months after secondary bone marrow transplantation (BMT) of HSC transduced by delivery of LV in newborn pups [11]. (eyesoftheelephants.com)
- Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
- The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
- The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
- External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)
- The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
- In the case of hematopoietic stem and progenitor cells, the dormancy of the most primitive HSPC is maintained by the bone marrow niche by means of several key molecular interactions between receptor-ligand pairs1C3. (conferencedequebec.org)
- In recent years, peripheral HSPC have largely replaced bone marrow-derived cells for autologous transplants, and they have become the major source of stem cells also for allogeneic transplantations16C21. (conferencedequebec.org)
- G-CSF, the standard and most widely used agent for this purpose over the past 25 years, mobilizes stem cells from the marrow niche by secretion of neutrophil-associated extracellular proteases which subsequently releases HSPC from their niche22,23. (conferencedequebec.org)
- Diabetic mice were transplanted with HSCs and insulin-producing cells (IPCs) via the tail vein after destroying the bone marrow. (vinastemcelllab.com)
- 13 Proliferation of bone marrow-derived human mesenchymal stem cells: role of enamel matrix proteins. (vinastemcelllab.com)
- Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
- Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
- Effect of autograft/allograft combination of bone marrow stem cells and Schwann cells on complete chronic and subacute spinal cord injuries. (who.int)
Therapeutics3
- Pluristem Therapeutics, based in Haifa, Israel, is currently recruiting patients in the United States and Israel for its Phase 1 trial of PLX-R18 cells in this unmet need. (drugdiscoverynews.com)
- Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
- We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
Immunomodulatory2
- To date, the immunomodulatory capacity of mesenchymal stem cells is well known. (sscb-stembiotech.com)
- The hypothesis tested in these projects is that the development of TID may be halted at diagnosis by the immunomodulatory properties of mesenchymal stem cells (MSC). (uu.se)
Tissue13
- Specifically, 9 patients received systemic infusion of mesenchymal stem cells derived from adipose tissue and followed up for a 12-month follow-up period. (sscb-stembiotech.com)
- For this reason, multiple infusions of adipose tissue mesenchymal stem cells over time are necessary to maintain long-term remission of refractory lupus nephritis. (sscb-stembiotech.com)
- A knowledge from the systems that regulate this differentiation potential can lead to book remedies for disorders of bone tissue aswell as options for conserving the integrity of endosteal hematopoietic niches. (morainetownshipdems.org)
- Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
- Stem and other cells gradually inhabit the tissue, regenerating collagen, blood vessels, and other components of a living tendon. (medscape.com)
- Critical to the hypothesis is the experimental fact that human endometrial-derived stem cells (hEnSCs) as multipotent accessible source of cells are known as useful cell candidates in the field of nerve tissue engineering. (scirp.org)
- These novel differentiated cells in fibrin gel might open new opportunities for the management of cell survival and neurotrophic potential in tissue engineering approaches for nerve repair. (scirp.org)
- These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
- One explanation for deficient repair is when undifferentiated adult stem repair cells are inadequate in number or cannot be stimulated within the damaged tissue site. (journalofprolotherapy.com)
- Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
- An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. (mdpi.com)
- 10 The potential of stem cells and tissue engineered scaffolds for repair of the central nervous system. (vinastemcelllab.com)
- 24 Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. (vinastemcelllab.com)
Differentiation potential2
- Furthermore, MDLS could promote teratoma formation and enhanced differentiation potential of P19 cells in vivo. (biomedcentral.com)
- CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. (bmbreports.org)
Haploidentical1
- Hematopoietic stem cell transplantation from an infected SARS-CoV2 haploidentical donor: A case report. (stembook.org)
Infusion2
- Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
- A few exceptions emerged when successful functional correction was exhibited in children with severe combined immunodeficiency (ADA-SCID and X-SCID) or chronic granulomatous disease following infusion of retrovirally transduced autologous CD34+ cells [12C14]. (eyesoftheelephants.com)
Regenerative4
- A comparative analysis of single-cell RNA sequencing data collected from three HUCMSCs and two human umbilical vein endothelial cell (HUVEC) controls identified eight common cell clusters, all of which indicated regenerative potential specific for HUCMSCs. (nature.com)
- Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases. (biomedcentral.com)
- This involves the release of cytokines, chemokines and growth factors responsible for the inhibition of apoptosis and fibrosis, enhancing contractility and activating endogenous regenerative mechanisms by the endogenous circulation or site-specific stem cells. (stemfinitycord.com)
- It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
Efficacy5
- In this phase one clinical trial, the efficacy of these cells for the treatment of refractory lupus nephritis (LN) was verified. (sscb-stembiotech.com)
- Clinical trials have been conducted to assess the safety and efficacy of various stem cell-based treatments for MS. These trials aim to determine the optimal protocols for administration, evaluate the impact on disease progression, and assess potential side effects. (kintaro.com)
- Efficacy of venetoclax combined with decitabine conditioning regimen for allogeneic hematopoietic stem cell transplantation in high-risk and elderly patients with myeloid neoplasms. (stembook.org)
- Promising preliminary results are also emanating from an ongoing open randomized clinical study conducted in collaboration with Prof Katarina LeBlanc, KI, Stockholm, in which the efficacy of islet transplantation with or without the support of autologous MSC is investigated. (uu.se)
- Pending positive outcome in safety and efficacy of the proposed pilot study it can be expanded to include more patients also at other centers. (uu.se)
Graft7
- [ 1 ] The number continues to increase by 10-20% annually, and reductions in organ damage, infection, and severe, acute graft versus host disease (GVHD) seem to be contributing to improved outcomes. (medscape.com)
- Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)
- Adverse effects are similar to hematopoietic stem cell transplantation, namely graft-versus-host disease if the cord blood is from a genetically different person, and the risk of severe infection while the immune system is reconstituted. (wikipedia.org)
- 1. Ozdemir ZN, Civriz Bozdağ S. Graft failure after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
- 4. Xue S, Liu F, Zhang Y, Tan Y, Wang J. Clinical study of cord blood mesenchymal stem cells combined with Eltrombopag when treating graft dysfunction after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
- 6. Gao J, Zhang Y, Su L. Advances in prevention of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
- The graft usually comes from a human leukocyte antigen (HLA)-matched donor and contains hematopoietic cells as well as immune cells, including T lymphocytes. (gvhdhub.com)
Adult Stem3
- Endothelial progenitor cells and multipotent unrestricted adult stem cells can also be found in cord blood. (wikipedia.org)
- Bone healing can be driven by biophysical stimulation using electricity for activating quiescent adult stem cells. (hindawi.com)
- More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
Populations3
- MACS-sorted populations for sheep transplantation usually had been 97 pure for CD34+ by flow cytometry. (ack1inhibitor.com)
- Also, these cell populations directly correlated with poor survival [ 2 , 5 ]. (researchsquare.com)
- Here we investigate the ability of resident skeletal stem-cell (SSC) populations to regenerate cartilage in relation to age, a possible contributor to the development of osteoarthritis5,6,7. (howhelp.org)
Malignant2
- Searching for the LSCs population is one of the best ways to find treatment strategies, or improve treatment outcomes in AML and other malignant diseases [ 3 ]. (researchsquare.com)
- 20 Malignant gliomas: treatment using genetically-modified neural stem cells. (vinastemcelllab.com)
Patients11
- The outcome of acute leukemia patients with SET-NUP214 fusion after allogeneic stem cell transplantation. (stembook.org)
- Improving safety of autologous haematopoietic stem cell transplantation in patients with Crohn's disease. (wizaxe-prod.com)
- The patients will receive autologous MSC, although substantially expanded in vitro prior to transplantation, thereby avoiding potential risk of HLA immunization, transfer of viral infections and other diseases. (uu.se)
- Additionally, the high levels of the CD45 dim CD34 + CD38 - CD133 + cells in AML patients were an independently significant poor risk factor for overall survival and event free survivals. (researchsquare.com)
- Also, AML is a very heterogeneous disease, with abundant pathogenetic mutations defined, numerous mutations present, and significant differences in clinical outcome seen in individual patients [ 3 ]. (researchsquare.com)
- For examples, Rhenen et al showed that a high percentage of CD34 + CD38 - stem cells at diagnosis significantly correlated with a high minimal residual disease frequency and subsequently to relapse especially after the third course of chemotherapy in AML patients. (researchsquare.com)
- Our studies suggest that CD45 dim CD34 + CD38 - CD133 + cells have the potential of leukemic stem cells in AML patients. (researchsquare.com)
- 11. Cornelissen JJ, Blaise D. Hematopoietic stem cell transplantation for patients with AML in first complete remission. (ajbm.net)
- The medical outcome should be discussed with the patients. (stemfinitycord.com)
- About 10C15% of patients intended for autologous transplantation have difficulties in mobilizing an adequate amount of HSPC for transplantation24. (conferencedequebec.org)
- 25 Severe combined immunodefieciency patients: immune recovery after stem cell transplantation. (vinastemcelllab.com)
Cord11
- Cord blood is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders such as cancer. (wikipedia.org)
- Cord blood is composed of all the elements found in whole blood - red blood cells, white blood cells, plasma, platelets. (wikipedia.org)
- Compared to whole blood some differences in the blood composition exist, for example, cord blood contains higher numbers of natural killer cells, lower absolute number of T-cells and a higher proportion of immature T-cells. (wikipedia.org)
- However, the interest in cord blood is mostly driven by the observation that cord blood also contains various types of stem and progenitor cells, mostly hematopoietic stem cells. (wikipedia.org)
- Therefore a sufficient amount of cord blood must be obtained in order to collect an adequate cell dose, however this amount varies from infant to infant and is irreplaceable. (wikipedia.org)
- Collected cord blood is cryopreserved and then stored in a cord blood bank for future transplantation. (wikipedia.org)
- Cord blood collection is typically depleted of red blood cells before cryopreservation to ensure high rates of stem cell recovery. (wikipedia.org)
- They performed an initial study (Duke ABC study), published in Stem Cells Translational Medicine , for 25 children, ages 2-6 years, which demonstrated that autologous cord blood infusions were safe and that approximately 70% of children had improvement in one or more core symptom of autism. (parentsguidecordblood.org)
- Children received autologous cord blood if they had a qualifying unit that contained a minimum of 25 million cells per kg of the child's weight, based on the pre-cryopreservation count. (parentsguidecordblood.org)
- Both the autologous and donor cord blood units had to contain a minimum cell dose of 25 million cells per kg. (parentsguidecordblood.org)
- using good manufacturing practice (GMP) to separate hematopoietic and mesenchymal stem cells from umbilical cord Wharton Jelly. (stemfinitycord.com)
Proliferation4
- They reduce the generation and differentiation of dendritic cells and B-cells, and down regulate NK cell cytotoxicity and proliferation. (uu.se)
- Moreover, they increase the percentage of regulatory T-cells, and suppress effector T-cell proliferation in response to nominal antigens or alloantigens. (uu.se)
- Second, it may enhance cell proliferation and angiogenesis. (medscape.com)
- 1 Neural stem/progenitor cell proliferation and differentiation: role of sonic hedgehog and wingless/int-1 proteins. (vinastemcelllab.com)
Survival3
- The Composite Immune Risk Score predicts overall survival after allogeneic hematopoietic stem cell transplantation: A retrospective analysis of 1838 cases. (stembook.org)
- Risk factors for acute GVHD and survival after hematopoietic cell transplantation. (ajbm.net)
- The results showed that transplantation of both IPCs and HSCs elicited greater improvements in body weight, blood glucose level and survival time than did transplantation of HSCs or IPCs alone. (vinastemcelllab.com)
Severe1
- Hematopoietic stem cell transplantation in a severe refractory Crohn's disease patient with intestinal stoma: a case report. (wizaxe-prod.com)
Leukemic2
- Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)
- 2 Sensitivity of hematopoietic and leukemic stem cells to hoxa gene levels. (vinastemcelllab.com)
Immune2
- The harvested stem cells are then reintroduced into the body to regenerate a new, less aggressive immune system. (kintaro.com)
- Immune Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Crohn's Disease: Current Status and Future Directions. (wizaxe-prod.com)
Vitro5
- However, the limited amount of stem cells and their tendency to undergo spontaneous differentiation upon extended propagation in vitro restrict their practical application. (biomedcentral.com)
- Therefore, finding a way to effectively maintain the pluripotency of stem cells cultured in vitro is important for the application of stem cells. (biomedcentral.com)
- the isolation, selection of a certain phenotype of cells and in vitro expansion is done. (stemfinitycord.com)
- Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
- The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. (mdpi.com)
Progenitor cell2
- Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
- Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
Hair transplantation1
- 24,25 Current well-established treatment modalities focus on reducing the androgenic effects on hair follicles (5a-reductase inhibitors), stimulating hair growth (minoxidil), or transferring androgen-independent hair to the affected scalp (hair transplantation). (jcadonline.com)
Patient's1
- The manipulated stem cells are then injected into a patient's spine. (medscape.com)
Involves1
- It involves the transplantation of immature progenitor cells in the affected hearts which are then intended to lead to the production of new blood vessels and muscle cells of the cardiac cavity. (stemfinitycord.com)
Paracrine1
- EVs, a group of nano-sized particles, are important paracrine products that engage in communication between cells [ 14 ]. (biomedcentral.com)
Tissues1
- In a rat model of an ACL injury, ACL-derived CD34+ cells were isolated from remnant human ACL tissues. (medscape.com)
Acute4
- Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
- The journal also highlights that new generation clinical trials utilize specific cell types that are known to produce cardiac lineage cells focusing on repairing of acute or chronic myocardial damage due to infarction. (stemfinitycord.com)
- The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
- In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)