Outcomes following hematopoietic stem cell transplantation graft allogeneic stem cell transplantation. Medical search. Frequent questions

Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. (hindawi.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
Inherited genetic variants such as single-nucleotide polymorphisms (SNPs) of candidate genes, encoding various cytokines, chemokines, and inflammatory regulators, have become a subject of interest of genetic studies searching for independent predictors of GVHD development and HSCT outcome [ 4 - 7 ]. (hindawi.com)
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells. (wikipedia.org)
Infection and graft-versus-host disease are major complications of allogeneic HSCT. (wikipedia.org)
Autologous HSCT requires the extraction (apheresis) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
For other cancers such as acute myeloid leukemia, though, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, so the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
There is a paucity of data examining the tolerance and outcome of hematopoietic stem cell transplantation (HSCT) for relapse after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
There is a paucity of data examining the tolerance andoutcome of hematopoietic stem cell transplantation (HSCT) for relapse aftertositumomab/iodine-131 tositumomab. (cancernetwork.com)
Five patients received autologous HSCT: threemarrow and two peripheral blood stem cells. (cancernetwork.com)
CONCLUSION: These data demonstrate the feasibility of allogeneic orautologous HSCT in heavily pretreated lymphoma patients who also receivedtositumomab/iodine-131 tositumomab. (cancernetwork.com)
Myeloablative allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure usually accompanied by multifactorial malnutrition, prompting the recommendation of systematic artificial nutritional support. (biomedcentral.com)
Recently published data suggest that enteral nutrition (EN), given as systematic artificial nutrition support, could decrease grade III-IV graft-versus-host disease (GVHD) and infectious events, which are associated with early toxicity after allo-HSCT and then have an impact on early transplant-related mortality (D100 mortality). (biomedcentral.com)
We report on the NEPHA trial: an open-label, prospective, randomised, multi-centre study on two parallel groups, which has been designed to evaluate the effect of EN compared to PN on early toxicity after an allo-HSCT procedure. (biomedcentral.com)
Two hundred forty patients treated with allo-HSCT for a haematological malignancy will be randomly assigned to two groups to receive either EN or PN. (biomedcentral.com)
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure, and is usually conducted to consolidate remission of haematological malignancies. (biomedcentral.com)
Allo-HSCT includes administration of a chemotherapy-based conditioning regimen (myelo-ablative or non-myelo-ablative), followed by infusion of alloreactive haematopoietic stem cells, with the aim of inducing an active immunological anti-tumoral effect. (biomedcentral.com)
BACKGROUND: Immune recovery following allogeneic hematopoietic stem cell transplantation (allo-HSCT) decisively influences the occurrence of opportunistic infections, one of the leading causes of death among this group of patients. (bvsalud.org)
INTRODUCTION: Pre-emptive therapy for cytomegalovirus (CMV) reactivation has been used in allogeneic hematopoietic stem cell transplantation (allo-HSCT). (bvsalud.org)
Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD). (haematologica.org)
Allogeneic hematopoietic stem-cell transplantation (HSCT) may provide cure in this scenario. (unisr.it)
We compared outcomes of HSCT from HLA-identical (HLA-id, n = 1654) sibling or haploidentical (Haplo, n = 389) donors in patients with R/R-AML, performed during the period 2007-2015. (unisr.it)
This comprehensive course will enhance your understanding of hematopoietic stem cell transplant (HSCT) and provide concepts to apply to your care of HSCT patients. (ons.org)
You'll learn about concepts of HSCT patient care, outcomes, acute and late effects of transplant as well as resources for effective HSCT programs. (ons.org)
The learner will apply evidence-based care concepts of hematopoietic stem cell translant into nursing care to improve outcomes for HSCT patients. (ons.org)
Allogeneic hematopoietic stem cell transplantation (HSCT) can effectively induce immunological antileukaemic control in patients with ALL by means of the graft-versus-leukaemia effect (GvL), but treatment related mortality (TRM), morbidity and late effects remain serious problems of this treatment modality. (gpoh.de)
In the last decade the short term outcome of 900 children with ALL from more than 60 different study centres who received allogeneic HSCT has improved, due to the use of donors more closely matched by Human leukocyte antigen (HLA) typing, resulting in less severe graft vs host disease (GvHD) and better supportive care. (gpoh.de)
The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
ABO blood group incompatibility is not a contraindication for allogeneic hematopoietic stem cell transplantation (allo-HSCT). (blood-genomics.com)
Currently, whether the recipient-donor ABO incompatibility has detrimental effects on post-HSCT outcomes is a matter of debate. (blood-genomics.com)
Discrepancies across studies referring to various graft sources, donor types, conditioning regimens, and the use of immunomodulators complicate interpretations of the clinical outcomes of ABOi-HSCT, such as transfusion requirements, graft-versus-host disease (GVHD), disease relapse, overall survival (OS), and non-relapse mortality (NRM). (blood-genomics.com)
Isohemagglutinins (ISO) targeting red blood cell (RBC) antigens are associated with post-HSCT immunohematological complications, including hemolysis, passenger lymphocyte syndrome (PLS), and pure red cell aplasia (PRCA). (blood-genomics.com)
In this review, we summarized literature of the impact of ABO incompatibility on post-HSCT outcomes and outlined important immune-mediated hematological events. (blood-genomics.com)
Background This study aimed to determine incidence of kidney complications in pediatric allogeneic hematopoietic stem cell transplantation (HSCT) patients. (hacettepe.edu.tr)
Methods Pediatric allogeneic HSCT patients were included. (hacettepe.edu.tr)
We report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell Transplantation Group. (hacettepe.edu.tr)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for patients affected by Wiskott-Aldrich syndrome (WAS). (hacettepe.edu.tr)
Abstract Background: Allogeneic hematopoietic stem cell transplantation (HSCT) alters the diversity of the intestinal bacterial microbiota. (hacettepe.edu.tr)
The potential role of elastin in patients with myeloid leukemia treated with hematopoietic stem cell transplantation (HSCT) has not been investigated so far. (medscimonit.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) and coronavirus disease 2019 (COVID-19) infection can both lead to severe cytokine release syndrome (sCRS) resulting in critical illness and death. (akjournals.com)
In this single institution, preliminary comparative case-series study we compared clinical and laboratory co-variates as well as response to tocilizumab (TCZ)-based therapy of 15 allogeneic-HSCT- and 17 COVID-19-associated sCRS patients. (akjournals.com)
Reaction to a TCZ plus posttransplant cyclophosphamide (PTCY) consolidation therapy in the allogeneic-HSCT-associated sCRS group yielded significantly inferior long-term outcome as compared to TCZ-based therapy in the COVID-19-associated group ( P = 0.003). (akjournals.com)
Serum levels of cytokines and chemokines show similar changes in allogeneic-HSCT- and COVID-19-associated sCRS with marked elevation of interleukin-6 (IL-6), regulated upon activation normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1) and interferon γ -induced protein 10 kDa (IP-10) levels. (akjournals.com)
In addition, levels of IL-5, IL-10, IL-15 were also elevated in allogeneic-HSCT-associated sCRS. (akjournals.com)
Our multi-cytokine expression data indicate that the pathophysiology of allogeneic-HSCT and COVID-19-associated sCRS are similar therefore the same clinical grading system and TCZ-based treatment approaches can be applied. (akjournals.com)
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation. (biomedcentral.com)
Hematopoietic stem cell transplantation and associated risk factors precipitate endothelial injury, leading to HSCT-TMA and other endothelial injury syndromes such as hepatic veno-occlusive disease/sinusoidal obstruction syndrome, idiopathic pneumonia syndrome, diffuse alveolar hemorrhage, capillary leak syndrome, and graft-versus-host disease. (biomedcentral.com)
Here, we present a case of an over 60-years old male patient with AML, and the possibility for him to receive an allogeneic hematopoietic stem cell transplantation (allo-HSCT). (pensoft.net)
However, very limited research has been done to investigate how AA secondary to nivolumab therapy may affect the outcome of HSCT. (pensoft.net)
In the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT), this review outlines and analyzes recent developments in the understanding of the properties of tissue-resident memory T cells (TRMs). (blood-genomics.com)
The TRM distribution in graft-versus-host disease (GVHD)-targeted organs and correlations between allo-HSCT outcomes and various GVHD subtypes were also reviewed, mainly focusing on skin and gut GVHD. (blood-genomics.com)
In conclusion, the HSCT must offer the best overall survival, quality of life, and cost outcomes compared to any other treatment strategy. (ajbm.net)
More studies will need a lot of data, and careful data analysis will help get clear data on HSCT outcomes. (ajbm.net)
Allogeneic hemopoietic stem cell transplantation (HSCT) is the only curative option for many patients with hematological malignancies. (nih.gov)
Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
Allogeneic hematopoietic stem cell transplantation, or HSCT, can cure sickle cell disease. (reachmd.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) appears safe for treatment of hepatitis-associated aplastic anemia, according to a study results reported in the International Journal of Hematology . (hematologyadvisor.com)
The study was a retrospective analysis of 37 adult patients who received their first allogeneic HSCT for hepatitis-associated aplastic anemia between 1985 and 2014. (hematologyadvisor.com)
According to the authors, "our results suggested that allogeneic HSCT for hepatitis-associated aplastic anemia would provide favorable survival. (hematologyadvisor.com)
The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. (bvsalud.org)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

Graft versus host disease (GVHD) is an immune-mediated condition resulting from a complex interaction between donor and recipient adaptive immunity. (medscape.com)
[ 1 ] Acute GVHD describes a distinctive syndrome of dermatitis (see the image below), hepatitis, and enteritis developing within 100 days after allogeneic hematopoietic cell transplantation (HCT). (medscape.com)
In addition to allogeneic HCT, procedures associated with high risk of GVHD include transplantation of solid organs containing lymphoid tissue and transfusion of unirradiated blood products. (medscape.com)
Autologous graft versus host disease (GVHD) involving the skin of a patient's arm appeared shortly after signs of engraftment appeared. (medscape.com)
Graft versus host disease (GVHD) represents the most frequent cause of TRM. (hindawi.com)
Shortly before graft infusion, GVHD prophylaxis (immunosuppression) is started. (hindawi.com)
The histocompatibility differences between the donor and the recipient, the presence of donor's immunocompetent cells, and the inability of the recipient to reject these cells were defined as the basic pathogenic prerequisites for GVHD development by Billingham in 1966 [ 10 ]. (hindawi.com)
Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
In cases where there is a myelo-ablative-conditioning regimen, drug-induced toxicities, immunosuppression-induced infections and acute graft-versus-host disease (GVHD) are responsible for 15-25% of early mortalities (D100 mortality) [ 1 ]. (biomedcentral.com)
The inclusion of ATG resulted in a significantly lower rate of chronic GVHD after allogeneic transplantation than the rate without ATG. (bmj.com)
The plain English version would read: "In this two year, open-label trial, our company's antihuman T-lymphocyte immune globulin (ATG) halved the rate of chronic graft-versus-host disease (GVHD) in people who had previously undergone allogeneic haematopoietic stem-cell transplantation, but made no difference to mortality. (bmj.com)
Despite advances in post-transplant care, the morbidity and mortality of complications such as graft versus host disease (GVHD) and infections remain significant limitations, and hinder the application of this life-saving procedure. (damonrunyon.org)
Dr. Turtle will test the hypotheses that alterations in the bacterial composition of the human gastrointestinal tract regulate the reconstitution of a specialized bacteria-responsive subset of immune cells after HCT, and that impaired regulation of this immune cell subset is associated with an increased risk of infection or GVHD. (damonrunyon.org)
Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
Graft-versus-host disease (GVHD) presents a barrier to its wider application. (uky.edu)
Successful gastrointestinal decontamination using high doses of non-absorbable antibiotics likely affect allo-HCT outcomes leading to significantly less acute GVHD (aGVHD). (uky.edu)
Butyrate-producing Clostridia directly result in the increased presence of regulatory T cells in the gut, which are protective in GVHD development. (uky.edu)
Reduced number of goblet cells and Paneth cells have been shown to associate with GVHD and has a significant impact on the micro- and mycobiome density and their composition. (uky.edu)
Lower levels of 3-indoxyl sulfate at initial stages after allo-HCT are related with worse GVHD outcomes and increased mortality. (uky.edu)
Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. (medscimonit.com)
My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
Acute GVHD occurs in approximately 50% of patients who receive an allogeneic bone marrow transplant (BMT). (einpresswire.com)
Risk factors for acute GVHD and survival after hematopoietic cell transplantation. (ajbm.net)
While many of my patients were cured of their disease with allogeneic hematopoietic stem cell transplantation, underscoring the importance of anti-tumor immunotherapy in eradicating leukemia, I witnessed face-to-face their suffering from the long-term consequence of graft-versus-host disease (GVHD). (stanford.edu)
Under the mentorship of Professor Hiromitsu Nakauchi at the University of Tokyo, an international leader in hematopoiesis, I developed allele-specific anti-human leukocyte antigen (HLA) monoclonal antibodies for severe GVHD caused by HLA-mismatched hematopoietic stem cell transplantation (Nakauchi et al. (stanford.edu)
That success gave me the motivation and confidence to further my research beyond targeting GVHD to targeting leukemic stem cells through my postdoctoral fellowship in the laboratory of Professor Ravindra Majeti here at Stanford University. (stanford.edu)
The most common graft-versus-host-disease (GVHD) prophylaxis strategies used tacrolimus with methotrexate (15 patients) or cyclosporine with methotrexate (15 patients). (hematologyadvisor.com)

Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
Focusing on this gene, I mapped TET2-dependent 5hmC, epigenetic and transcriptional programs matched to competitive advantage, myeloid skewing, and reduced erythroid output in TET2-deficient hematopoietic stem and progenitor cells (HSPC). (stanford.edu)
The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. (hku.hk)
Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)

In 2006, 50,417 first HSCTs were recorded worldwide, according to a global survey of 1,327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018 8 25 (1): 100-106. (cdc.gov)
69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 6 25 (10): 1975-1983. (cdc.gov)

It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
Also, the incidence of patients experiencing rejection is very rare (and graft-versus-host disease impossible) due to the donor and recipient being the same individual. (wikipedia.org)
Currently, my work aims to establish strategies to reduce the risk of relapse after allogeneic hematopoietic stem cell transplantation without exacerbating graft-versus-host disease or interfering with donor stem cell engraftment. (stanford.edu)
In multivariate analysis, the risk of CMV reactivation was higher in patients with multiple myeloma, with CMV seropositivity of the recipient and donor, administered with a higher dose of anti-thymocyte globulin (ATG), and with acute graft-versus-host disease (aGVHD) ≥ grade 2. (bvsalud.org)
As Stem cell source has to be used an classical mismatched donor, a haploidentical donor or, cord blood. (gpoh.de)
Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 + T cells drive gastrointestinal acute graft-versus-host disease[J]. Sci Transl Med , 2021, 13(576): eabc0227. (blood-genomics.com)
Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
Well, it's transplanting blood stem cells from a donor without sickle cell disease into a recipient who does have sickle cell disease. (reachmd.com)
Other donor cells can come from unrelated match donors, partially matched or half-matched family members, or in some circumstances, from an umbilical cord blood donor. (reachmd.com)
The blood cells are harvested from the donor and stored, and then the sickle cell disease patient is given high doses of chemotherapy to get rid of all the remaining blood cells in the bone marrow in order for them to be able to receive the healthy donated cells. (reachmd.com)
The cells from the donor which are healthy are then infused into the sickle cell patient through a simple IV. (reachmd.com)
But unfortunately, only about 20% of patients with sickle cell disease in the United States have a matched donor. (reachmd.com)
It's also important to think about what patients are appropriate for hematopoietic stem cell transplantation and to understand what some of the donor requirements are. (reachmd.com)
And if a full sibling match can't be found, it's also possible to transplant hematopoietic stem cells from a donor who's only a half match. (reachmd.com)
The main requirement for a donor is to not have sickle cell disease or infection, such as HIV or hepatitis C. But what's important to know is that it's perfectly fine for the donor to have sickle cell trait. (reachmd.com)
Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)
Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil. (cdc.gov)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)

Telomere length is a strong predictor of post-allogeneic hematopoietic stem cell transplantation nonrelapse mortality (NRM) in patients with myelodysplastic syndrome (MDS), especially among those with severe acute graft-versus-host disease. (astct.org)
The mortality and long-term survival of post-allogeneic hematopoietic stem cell transplant patients are improving due to improvements in condition procedures, methods, novel medicines, and supportive care practices. (ajbm.net)

Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
BACKGROUND: Reduced intensity conditioning regimens permit the delivery of a potentially curative graft-versus-leukemia effect in older patients with acute myeloid leukemia. (ox.ac.uk)
Hematopoietic stem cell transplantation (HCT) is a potentially curative procedure for patients with hematologic malignancies who are otherwise incurable with conventional therapies. (damonrunyon.org)

All patients except two who received reduced intensity had severe mucositis.Reversible veno-occlusive disease of the liver also developed in two patients.There was one death from graft-vs-host disease and no regimen-related mortality.Engraftment was prompt, with a median recovery of absolute neutrophil count to ³ 500/µL of 12 days (range: 11-18 days). (cancernetwork.com)
The primary endpoint will assess the effect of EN on D100 mortality. (biomedcentral.com)
The impacts of nutritional support should exceed the limits of nutritional status improvement: EN may directly reduce immunological and infectious events, as well as decrease early transplant-related morbidity and mortality. (biomedcentral.com)
Short Telomere Length Predicts Nonrelapse Mortality After Stem Cell Transplantation for Myelodysplastic Syndrome. (astct.org)
We performed a systematic review and meta-analysis to assess mortality post allo-HCT through a comprehensive literature search using PUBMED/MEDLINE, CINAHL, Web of Science, and EMBASE up to April 30, 2023 and extracted clinical outcome data relating to benefits followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. (ajbm.net)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)

The safety profile of venetoclax following allogeneic hematopoietic stem cell transplantation in patients with chronic lymphocytic leukemia appears to be comparable with other reports in clinical trials. (cancernetwork.com)
The American Society of Parenteral and Enteral Nutrition (ASPEN) and the French-speaking society of clinical nutrition and metabolism (SFNEP) recommend nutritional support during haematopoietic transplantation for patients who are malnourished or have decreased intake or decreased intestinal absorption over a prolonged period (grade B) [ 11 , 12 ]. (biomedcentral.com)
It is unclear if this strategy has poorer clinical outcomes in CMV-endemic areas and if more aggressive prophylaxis is required. (bvsalud.org)
Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
In the current study, the authors investigated whether patients expressed regret after undergoing HCT and the relationships between clinical outcomes and quality of life. (cdc.gov)
In this study we seek to investigate the implications of loss of gut microbiota diversity by correlating them with long-term clinical outcomes in alloHSCT recipients. (mayo.edu)
We report 33 patients with cGVHD who were referred to the National Institutes of Health (NIH) for the Natural History of Clinical and Biological Factors Determining Outcomes in Chronic Graft-versus-Host Disease Study (NCT 0092235) and underwent formal BMD assessment via dual-energy X-ray absorptiometry (DEXA). (qxmd.com)
The Abstracts newsletter highlights the latest research in the clinical research and translational science studies aspects of transplantation and cellular therapy. (astct.org)
In the phase II SWOG 1318 trial reported in the Journal of Clinical Oncology, Advani et al found that blinatumomab induction and consolidation followed by maintenance with POMP (prednisone, vincristine, mercaptopurine, and methotrexate) produced good outcomes in patients aged ≥ 65 years with newly. (ascopost.com)
In a study reported in the Journal of Clinical Oncology, Elsayed et al developed a risk score based on single nucleotide polymorphisms (SNPs) associated with cytarabine pharmacodynamics or clinical outcomes that identified pediatric patients with acute myeloid leukemia (AML) who could benefit from. (ascopost.com)
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
4. Xue S, Liu F, Zhang Y, Tan Y, Wang J. Clinical study of cord blood mesenchymal stem cells combined with Eltrombopag when treating graft dysfunction after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
So what are the realities and clinical outcomes associated with hematopoietic stem cell transplantation in sickle cell disease? (reachmd.com)
DESIGN/METHODS: To determine the cumulative incidence and review the clinical data of PTLD diagnosed in the cohort of pediatric patients (<18 years) who had liver transplantation performed between 1 January 2001 and 31 December 2012 in the major liver transplantation centre (Queen Mary Hospital) of Hong Kong. (hku.hk)

Among seven allogeneic transplants,three received matched related peripheral blood stem cells and four receivedmatched unrelated marrow (n = 3) or peripheral blood (n = 1) stem cells.Allogeneic recipients received tacrolimus and methotrexate for graft-vs-hostdisease prophylaxis. (cancernetwork.com)
Six patients relapsed, includingall five autologous and one allogeneic recipients. (cancernetwork.com)
The other three allogeneic recipients died from either graft-vs-hostdisease, relapse, or acetaminophen-induced hepatic necrosis. (cancernetwork.com)
Recipients of allogeneic transplantation had significantly improved overall survival compared to non-transplanted patients. (oncotarget.com)
Impact of SARS-CoV-2 in hematopoietic stem cell transplant and CAR-T cell therapy recipients. (stembook.org)
Impact of COVID-19 in Hematopoietic stem cell transplant recipients: A systematic review and meta-analysis. (stembook.org)
Pediatric allogeneic hematopoietic stem cell transplantation (AHSCT) recipients with chronic graft-versus-host disease (cGVHD) are at high risk for endocrinopathies, particularly impaired bone mineral density (BMD). (qxmd.com)
We reviewed the epidemiology and outcome of PTLD diagnosed in pediatric liver transplant recipients. (hku.hk)
Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)

Chronic graft-versus-host disease (cGVHD) is a long-term complication of allogeneic hematopoietic stem cell transplantation. (elsevierpure.com)
Covariance pattern models were used to determine predictors of regret over time, including baseline characteristics and post-alloHCT outcomes (acute or chronic graft-versus-host-disease, disease recurrence). (cdc.gov)
Although T-cell depletion is increasingly used to reduce the risk of graft-versus-host disease its impact on the graft-versus-leukemia effect and long-term outcome post-transplant is unknown. (ox.ac.uk)
Humanigen believes that GM-CSF neutralization with lenzilumab also has the potential to reduce the hyper-inflammatory cascade known as cytokine release syndrome common to chimeric antigen receptor T-cell (CAR-T) therapy and acute Graft versus Host Disease (aGvHD). (businesswire.com)
Impaired Bone Mineral Density in Pediatric Patients with Chronic Graft-versus-Host Disease. (qxmd.com)
The adverse impact of shorter telomeres on NRM was most notable following higher intensity conditioning and in patients who developed severe acute graft-versus-host disease. (astct.org)
Four patients developed acute, grade 2 to 3, graft- versus -host disease and four patients developed extensive chronic graft- versus -host disease. (aacrjournals.org)
Efficacy and Safety of 1% Progesterone Gel to the Forehead for Ocular Chronic Graft-versus-Host Disease. (harvard.edu)
Remestemcel-L is being developed for inflammatory diseases in children and adults including steroid refractory acute graft versus host disease, biologic-resistant inflammatory bowel disease, and acute respiratory distress syndrome. (einpresswire.com)
Berger M, Pessolano R, Carraro F, Saglio F, Vassallo E, Fagioli F. Steroid-refractory acute graft-versus-host disease graded III-IV in pediatric patients. (einpresswire.com)
Rashidi A, DeFor T, Holtan S, Blazar B, Weisdorf D, MacMillan M. Outcomes and Predictors of Response in Steroid-Refractory Acute Graft-versus-Host Disease. (einpresswire.com)
The link between tissue-resident memory T cells and graft-versus-host disease[J]. Blood&Genomics, 2022, 6(2): 81-90. (blood-genomics.com)
Graft-versus-host disease[J]. Nat Rev Immunol , 2007, 7(5): 340−352. (blood-genomics.com)
Tissue-resident PSGL1 lo CD4 + T cells promote B cell differentiation and chronic graft-versus-host disease-associated autoimmunity[J]. J Clin Invest , 2021, 131(1): e135468. (blood-genomics.com)
Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survival. (ajbm.net)
6. Gao J, Zhang Y, Su L. Advances in prevention of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (ajbm.net)
However, since there are transplant-related risks such as graft versus host disease and life-threatening infection, as well as organ toxicity, one could likely not be transplanted if their sickle cell disease was not under really good control or if they had minimal disease manifestations. (reachmd.com)
High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. (cdc.gov)
Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)
Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation. (cdc.gov)

CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)

Bristol Myers Squibb (NYSE: BMY) today announced six-year results from Part 1 of the Phase 3 CheckMate -227 trial, which continues to demonstrate long-term, durable survival benefits of Opdivo (nivolumab) plus Yervoy (ipilimumab) compared to chemotherapy in the first-line treatment of patients with metastatic non-small cell lung cancer (mNSCLC), regardless of PD-L1 expression levels. (advfn.com)
We are ecstatic to see Opdivo plus Yervoy continue to demonstrate almost double the overall survival rates as chemotherapy after six years of follow-up - the longest-ever for a Phase 3 trial with immunotherapy in metastatic non-small cell lung cancer. (advfn.com)
Risk factors and survival of graft failure in pediatric patients with hematological malignancies treated with allogeneic hematopoietic stem-cell transplantation from haploidentical donors using exviv T-cell-depletion. (bjh.be)
Factors predicting long-term survival after T-cell depleted reduced intensity allogeneic stem cell transplantation for acute myeloid leukemia. (ox.ac.uk)
Survival outcomes have not improved over the past two decades for children or adults with the most severe forms of SR-aGVHD. (einpresswire.com)
1 -3 The lack of any approved treatments for children under 12 means that there is an urgent need for a therapy that improves the dismal survival outcomes in children. (einpresswire.com)
Additionally, the improved process controls we have put in place to assure robust and consistent commercial product, together with a potency assay that predicts consistent survival outcomes, makes remestemcel-L a compelling treatment for these children. (einpresswire.com)
For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)

These data confirm the presence of a potent graft-versus-leukemia effect after a T-cell depleted reduced intensity conditioning allograft in acute myeloid leukemia and identify CsA exposure as a manipulable determinant of outcome in this setting. (ox.ac.uk)
The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
providing evidence for an immunological graft-versus-leukemia effect (GvL). (frontiersin.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses[J]. Nat Med , 2005, 11(11): 1244−1249. (blood-genomics.com)
Riddell SR. The graft-versus-leukemia effect-breaking the black box open[J]. Biol Blood and Marrow Transplant , 2008, 14(1 Suppl 1): 2−3. (blood-genomics.com)
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues[J]. J Exp Med , 2006, 203(8): 2021−2031. (blood-genomics.com)

The patient had undergone autologous peripheral blood stem-cell transplantation to treat ovarian cancer. (medscape.com)
High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (msdmanuals.com)

Could enteral nutrition improve the outcome of patients with haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation? (biomedcentral.com)
Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
Allogeneic hematopoietic stem cell transplantation is a well-proven treatment for hematologic malignancies and non-malignancies, but it has a high risk of disease recurrence and severe transplant-related morbidity and death. (ajbm.net)
TET2 is known to be involved in the clonal expansion of cells, and people with this mutation are more likely to suffer from hematologic malignancies. (stanford.edu)

Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)

In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
Laboratory investigations revealed white blood cell count (WBC) 44×109/L with 86% blasts, hemoglobin 8.1 g/dL and a platelet count of 37×109/L. After obtaining an informed consent, the patient was treated with an induction chemotherapy with IA regimen (cytarabine 1.5 g/m2 by vein daily on days 1-3, with idarubicin 12 mg/m2 by vein daily on days 1-3). (pensoft.net)

Hematology, transfusion and cell therapy 2018 7 40 (2): 136-142. (cdc.gov)

The EasySep™ Release Human PE Positive Selection Kit is designed to isolate cells that are labeled with PE-conjugated antibodies from fresh or previously frozen peripheral blood mononuclear cells or washed leukapheresis samples by immunomagnetic positive selection. (stemcell.com)
Human leukocyte antigen-identical siblings were sources of bone marrow (19 patients) or peripheral blood stem cells (5 patients) for some patients, while unrelated donors provided bone marrow (11 patients) or cord blood (2 patients) for others. (hematologyadvisor.com)
1 This includes human cells for transplantation such as haematopoietic stem cells from bone marrow, peripheral blood or cord blood. (who.int)

Other conditions treated with stem cell transplants include sickle cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease, Hodgkin's disease and Wiskott-Aldrich syndrome. (wikipedia.org)
The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
Up to 4.25 ILNA points may be applied to Basic Concepts for Transplantation OR Early Post-Transplant Management OR Pre-Transplant Care OR Types of Transplants and Sources of Stem Cells. (ons.org)
Blood-forming stem cell transplants. (mayoclinic.org)
Report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders. (ajbm.net)
The number of human tissue transplants is increasing in both developed and developing countries, but global data on this form of transplantation are less complete. (who.int)
Access to transplantation is limited in low- and many medium-income countries, where the rate of transplants remains far below that of richer nations. (who.int)

Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
Over-activated T-cells will cause immune-related adverse events such as Aplastic Anemia (AA). (pensoft.net)
Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia [published online April 8, 2019]. (hematologyadvisor.com)

It can lead to life-threatening complications in immunocompromised host, and little is known about CMV disease in patients after CAR-T cell therapy. (bvsalud.org)

Here, we report a patient who developed possible CMV-pneumonia three months after anti-CD19 and anti-CD22 CAR-T cell therapy for relapsed B-ALL, contributing to the understanding of severe side-effects mediated by virus infection or reactivation in patients receiving CAR-T cell infusion. (bvsalud.org)
Although uncommon, graft failure is a severe complication following allogeneic haematopoietic stem cell transplantation (aHSCT) in paediatric patients. (bjh.be)
Mesoblast is a world leader in developing allogeneic (off-the-shelf) cellular medicines for the treatment of severe and life-threatening inflammatory conditions. (einpresswire.com)
The Company has leveraged its proprietary mesenchymal lineage cell therapy technology platform to establish a broad portfolio of late-stage product candidates which respond to severe inflammation by releasing anti-inflammatory factors that counter and modulate multiple effector arms of the immune system, resulting in significant reduction of the damaging inflammatory process. (einpresswire.com)

Investigating this, a Spanish research group retrospectively analysed risk factors and outcomes in 148 T-cell deprived haploidentical transplantations. (bjh.be)
Transduced cells were transfused either after day +60 (matched donors) or on day +42 (haploidentical donors). (frontiersin.org)
2002 until 2007), two were included in TK007 (2005-2009) and six serves as a control group for outcome after haploidentical transplantation without HSV-TK-transduced DLI. (frontiersin.org)

Let's learn more about how and when hematopoietic stem cell transplantation is used in the management of sickle cell disease. (reachmd.com)
This essentially cures the patient of sickle cell disease. (reachmd.com)
So the goal is to transplant someone with sickle cell disease before they become too sick, particularly before they develop significant organ damage, such as kidney disease, liver disease, or heart disease, that might even preclude their ability to safely undergo the rigors of a transplant. (reachmd.com)

The purpose of this study is to evaluate the effects that psychological and health behavior factors have on quality of life, level if sickness, and death after blood and bone marrow transplantation. (mayo.edu)
AML is a type of blood cancer with excess immature white blood cells in bone marrow. (pensoft.net)
Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
Long-term outcome and late effects in patients transplanted with mobilised blood or bone marrow: a randomised trial. (ajbm.net)
The cells are remarkable in that they can find their way into the recipient's bone marrow, where they begin to divide and repopulate the patient's bone marrow as his or her own. (reachmd.com)
Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (msdmanuals.com)
Bone Marrow Transplantation. (bvsalud.org)

Hematopoietic cell transplantation is an intensive therapy used to treat high-risk hematological malignant disorders and other life-threatening hematological and genetic diseases. (uky.edu)

Graft-vs-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model[J]. Biol Blood Marrow Transplant , 1999, 5(6): 357−368. (blood-genomics.com)

Allogeneic Hematopoietic Stem Cell Transplantation Can Improve Prognosis of Extramedullary Infiltration Pos. (annalsoftransplantation.com)

Currently, there are no known risk factors to identify paediatric patients who may be at a greater risk of this complication when patients are treated with an ex vivo T-cell depletion protocol beforehand. (bjh.be)
All patients received a T-cell depletion protocol consisting of fludarabine, busulfan and thiotepa. (bjh.be)
To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)

Hastening the return of the body's white blood cells can reduce the possibility of serious or overwhelming infection associated with stem cell transplantation," Peter Marks, MD, PhD, director of the FDA's Center for Biologics Evaluation and Research, said in an agency press release . (medscape.com)
Conclusion: CMV infection/reactivation can occur in patients long after receiving anti-CD19/22 CAR-T cell therapy, and induce fatal pneumonia, which reminds us of the late side effects associated with immunosuppression after CAR-T cell infusion. (bvsalud.org)
We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4+ T cells. (hku.hk)

A conditioning regimen and medications given to patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT) are capable of disturbing the homeostatic crosstalk between the microbiome and the host immune system and of leading to dysbiosis. (uky.edu)
Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8+ T-cell-mediated immune control. (hku.hk)

In this retrospective analysis, paediatric AML/ALL patients who were treated with an ex vivo T-cell depleting protocol and were subsequently treated with aHSCT, being under the age of 9 and having a CD8+ concentration ≥150 μL was associated with a higher risk of graft failure. (bjh.be)

Case presentation: A 21-year old male patient with relapsed B-ALL received anti-CD19/22 CAR-T cell therapy, and achieved complete remission 2 weeks after the infusion. (bvsalud.org)
Although further prospective research is required to validate these findings, these results highlight the significance of pre-existing cellular immunity and support the use of T-cell population analysis in the pre-transplant patient workup. (bjh.be)
Since 1975, ONS has provided a professional community for oncology nurses, developed evidence-based education programs and treatment information, and advocated for patient care, all in an effort to improve the quality of life and outcomes for patients with cancer and their families. (ons.org)
However, the reality is that most of the mutations are not easily 'druggable,' and the discovery of these mutations has not yet significantly impacted patient outcomes. (stanford.edu)

RESULTS: Among 75 cases of pediatric liver transplantation performed during the study period, 17 cases of PTLD (seven males) were diagnosed, giving cumulative incidence of 6.8% at 1 year and 22% at 5 years. (hku.hk)

Over 30,000 patients worldwide undergo an allogeneic BMT annually, primarily during treatment for blood cancers, including about 20% in pediatric patients. (einpresswire.com)
And that's because we need generally healthier patients in order for them to meet the requirements to undergo transplantation. (reachmd.com)

Allogeneic transplantation was performed in five patients, two of whom achieved complete remission despite residual or refractory disease. (oncotarget.com)

CONCLUSIONS: Disease stage, presentation karyotype and post-transplant CsA exposure are important predictors of outcome in patients undergoing a T-cell depleted reduced intensity conditioning allograft for acute myeloid leukemia. (ox.ac.uk)
A woman with human immunodeficiency virus (HIV) who received a cord blood stem cell transplant to treat acute myeloid leukemia has had no detectable levels of HIV for 14 months, despite cessation of antiretroviral therapy, according to research presented at the Conference on Retroviruses and. (ascopost.com)

11. Cornelissen JJ, Blaise D. Hematopoietic stem cell transplantation for patients with AML in first complete remission. (ajbm.net)

Outcomes with CD34-selected stem cell boost for poor graft function after allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis. (stembook.org)

Haematopoietic cell transplantation as immunotherapy[J]. Nature , 2001, 411(6835): 385−389. (blood-genomics.com)

Of course, these findings would also be of value in understanding the biology of normal hematopoietic stem cells (HSCs) and various other TET2-related cancers. (stanford.edu)

In summary, steroid dependency in cGVHD for more than 1 year was significantly associated with poor transplant outcomes. (elsevierpure.com)
Endothelial injury triggers activation of the complement system-significantly through the lectin pathway-via altered cell-surface patterns on injured endothelial cells, initiating an inflammatory response [ 7 ]. (biomedcentral.com)

Transplant Cell Ther. (stembook.org)

Bio My research is focused on using preclinical models to develop novel therapies which improve outcomes for patients receiving allogeneic hematopoietic stem cell transplantation. (stanford.edu)

Anatomy18

Organisms5

Diseases37

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Psychiatry and Psychology2

Phenomena and Processes18

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Named Groups5

Health Care16

Geographicals1

HSCT74

GVHD28

Progenitor cells5

Blood and Marrow Transplantation5

Donor24

Post-allogeneic hema2

Curative3

Mortality6

Clinical14

Recipients10

Host disease20

Relapse2

Survival9

Versus7

Autologous peripheral blood stem-cell transplant2

Malignancies4

20231

Chemotherapy4

20181

Peripheral3

Transplants7

Aplastic anemia3

Complications1

Severe4

Haploidentical3

Sickle cell di3

Bone8

Hematological1

Biol Blood Marrow Transplant1

PROGNOSIS1

Depletion3

Infection3

Immune2

AHSCT1

Patient4

Pediatric Liver Transplantation1

Undergo2

Refractory1

Myeloid2

Remission1

Systematic1

20011

Biology1

Significantly2

Transplant Cell Ther1

Improve outcomes1