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  • study
  • changes in serum thrombopoietin level (as measured by enzyme-linked immunosorbent assay, R&D Systems), and health related quality of life (as measured by the Medical Outcomes Study 36-item Short Form General Health. (clinicaltrials.gov)
  • 2000
  • Sung-Yun Pai, MD, a pediatric hematologist/oncologist at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, was lead author on two articles published last year on Severe Combined Immune Deficiency (SCID) in The New England Journal of Medicine: "Transplantation Outcomes for Severe Combined Immunodeficiency, 2000-2009" July 31, 2014 and "A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency" October 9, 2014. (primaryimmune.org)
  • There was no significant improvement in outcomes over the two time periods (1992-1999 versus 2000-2009). (haematologica.org)
  • graft
  • globulin as part of their conditioning regimen and bone marrow graft. (aamds.org)
  • Although graft or bone marrow rejection can have detrimental effects, there are immunotherapy benefits when cytotoxic T lymphocytes are specific for a self antigen and can target antigens expressed selectively on leukemic cells in order to destroy these tumor cells referred to as graft-versus- leukemia effect (GVL). (wikipedia.org)
  • acute
  • Acute myeloblastic leukemia (AML) is a group of malignant bone marrow neoplasms of myeloid precursors of white blood cells. (wikipedia.org)
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • Disease
  • In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (wikipedia.org)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • The drug was noted to increase the risk of veno-occlusive disease in the absence of bone marrow transplantation. (wikipedia.org)
  • Low-risk disease in babies typically has a good outcome with surgery or simply observation. (wikipedia.org)
  • genetic
  • 1 Congenital disorders account for approximately one third of cases of bone marrow failure in childhood and include many different genetic diseases, such as Fanconi anemia, dyskeratosis congenita (DC), 2 Diamond-Blackfan anemia (DBA) 3 and others. (haematologica.org)
  • donors
  • Results Sixty-four patients with hereditary bone marrow failure syndromes were transplanted from related (n=20) or unrelated donors (n=44). (haematologica.org)
  • Prochymal® is an intravenous preparation of MSCs using MSCs isolated from the bone marrow of healthy young adult donors. (cnbc.com)
  • aspirate
  • Diagnostic methods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. (wikipedia.org)
  • cells
  • Bone marrow cells from mice will be exposed to the biolipid under investigation and then incubated in the laboratory with growth factors to induce production of migratory, fibrosis-inducing cells. (telethonkids.org.au)
  • Alternatively, biolipid-pulsed bone marrow cells will be injected into new mice and the cells will develop naturally. (telethonkids.org.au)
  • Through this study, we hope to determine exactly how the biolipid does this - does the biolipid directly alter the stem cells or does it alter other cells in the bone marrow which send signals to the stem cells? (telethonkids.org.au)
  • Some types have an increase in immature blood cells, called blasts, in the bone marrow or blood. (wikipedia.org)
  • The types of MDS are based on specific changes in the blood cells and bone marrow. (wikipedia.org)
  • The outlook depends on the type of cells affected, the number of blasts in the bone marrow or blood, and the changes present in the chromosomes of the affected cells. (wikipedia.org)
  • One known cause is an autoimmune disorder in which white blood cells attack the bone marrow. (wikipedia.org)
  • Intact females, if not mated, will remain in heat, and after some time the high levels of estrogen will cause the bone marrow to stop producing red blood cells. (wikipedia.org)
  • The crowding that results from such cells makes the bone marrow unable to produce healthy blood cells. (wikipedia.org)
  • This divides leukemias into lymphoblastic or lymphocytic leukemias and myeloid or myelogenous leukemias: In lymphoblastic or lymphocytic leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (wikipedia.org)
  • In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (wikipedia.org)
  • These long chains of sugar carbohydrates occur within the cells that help build bone, cartilage, tendons, corneas, skin and connective tissue. (wikipedia.org)
  • The female recipient obtained MHC-matched bone marrow cells but still had active cytotoxic T cells (CD8+). (wikipedia.org)
  • The CD8+ T cells were active and targeted the male bone marrow cells. (wikipedia.org)
  • The male bone marrow cells were found to be presenting a peptide in the MHC groove encoded by a gene on Y chromosome. (wikipedia.org)
  • This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
  • The transplantation may be autologous (an individual's own blood cells saved earlier), allogeneic (blood cells donated by someone else with matching HLA), or syngeneic (blood cells donated by an identical twin). (wikipedia.org)
  • procedure
  • PBSCT is now a much more common procedure than its bone marrow harvest equivalent, this is in-part due to the ease and less invasive nature of the procedure. (wikipedia.org)
  • abnormal
  • Physical symptoms generally include coarse or rough facial features (including a flat nasal bridge, thick lips, and enlarged mouth and tongue), short stature with disproportionately short trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs such as liver (hepatomegaly) or spleen (splenomegaly), hernias, and excessive body hair growth. (wikipedia.org)
  • Procedure
  • Called the "Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases", or MOTION, the study aims to assess the effectiveness and safety of cryoablation therapy to treat patients with painful bone metastases and document the effects the procedure has on their condition. (advancingyourhealth.org)
  • positive
  • Investigators, clinicians, and research authors frequently analyze and discuss the effects and efficacy of this intervention as a whole, with the result that it is often difficult to attribute positive or negative outcomes to any of the specific techniques that contribute to guided meditation. (wikipedia.org)
  • therapy
  • Until now insulin replacement is still the major therapy, because islet transplantation has been limited by donor availability and by the need for long-term immunosuppression. (jove.com)
  • group
  • This protocol resulted in the creation of 4 groups: (1) AM infusion plus MNC transplantation (AM+MNC group, n=10), (2) AM infusion plus PBS injection (AM group, n=10), (3) vehicle infusion plus MNC transplantation (MNC group, n=10), and (4) vehicle infusion plus PBS injection (control group, n=10). (ahajournals.org)