DiseasesAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Leukemia, Biphenotypic, AcuteImmunophenotypingLeukemiaLeukemia, Myeloid, AcutePrecursor Cell Lymphoblastic Leukemia-Lymphoma
Refractory Acute MyeloidLymphoblastic leukaemiaMyeloid leukemiasLeukaemiaRelapsed or refractory acuteMyeloblastic leukemiaAmbiguous lineageLymphocyticChemotherapyChronic myeloidMyelogenousAggressiveChimericHematopoieticFLT3LymphoidOncologyAdultAbnormalitiesSurvivalSubtypeImmunophenotypeClassificationDiseaseTreatmentTherapyPatientsCancerBloodChildrenIncludeSymptomsConditionsTypesOccurNormal
Refractory Acute Myeloid2
  • Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. (drugbank.com)
  • Gilteritinib is indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia with an FLT3 mutation detected by an FDA-approved test. (drugbank.com)
Lymphoblastic leukaemia4
  • 50% of Down syndrome-associated acute lymphoblastic leukaemia (Mullighan et al. (atlasgeneticsoncology.org)
  • As P2RY8-CRLF2 fusion in B-acute lymphoblastic leukaemia (B-ALL) and Down syndrome-associated acute lymphoblastic leukaemia (DS-ALL) (Mullighan et al. (atlasgeneticsoncology.org)
  • Intensification of treatment for adults with acute lymphoblastic leukaemia: results of U.K. Medical Research Council randomized trial UKALL XA. (medscape.com)
  • One of the first cancers where major developments occurred for adolescents and young adults was acute lymphoblastic leukaemia. (leukaemia.org.au)
Myeloid leukemias1
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Leukaemia3
  • Biphenotypic acute leukaemia (BAL) is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ability to differentiate into both myeloid and lymphoid lineages. (wikipedia.org)
  • About 5% of acute leukaemia cases are BAL. (wikipedia.org)
  • Using retroviral expression screening for transforming genes in biphenotypic acute leukaemia, P2RY8 has been confirmed to have oncogenic potential (Fujiwara et al. (atlasgeneticsoncology.org)
Relapsed or refractory acute1
  • This trial is studying a combination of drugs, venetoclax and navitoclax, to see how well they work in treating children with relapsed or refractory acute lymphoblastic leukemia or lymphoma. (withpower.com)
Myeloblastic leukemia1
Ambiguous lineage1
  • Acute leukemias of ambiguous lineage, not otherwise specified (ALAL-NOS) is a rare type of acute leukemia. (biomedcentral.com)
Lymphocytic6
  • Myeloid markers in adult acute lymphocytic leukemia. (medscape.com)
  • Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (medscape.com)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • In lymphoblastic or lymphocytic leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (rxharun.com)
  • Most lymphocytic leukemias involve a specific subtype of lymphocyte, the B cell. (rxharun.com)
  • Chronic lymphocytic leukemia (CLL) - most often affects adults over the age of 55. (rxharun.com)
Chemotherapy6
  • Most people with leukemia are treated with chemotherapy. (healthline.com)
  • Leukemia and other cancers are often treated with chemotherapy and radiation therapy . (healthline.com)
  • PRIMARY OBJECTIVES: I. Determine maximum tolerated dose (MTD) of MEK162 (MEK inhibitor MEK162 ) in patients with RAS-mutated acute myeloid leukemia ( AML ) when combined with sequential induction chemotherapy (3 +4 ) as measured by development of grade 3-4 dose-limiting toxicities (DLT). (mycancergenome.org)
  • Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses. (medscape.com)
  • Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. (medscape.com)
  • The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia. (medscape.com)
Chronic myeloid1
  • As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
Myelogenous2
  • In myeloid or myelogenous leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (rxharun.com)
  • Acute myelogenous leukemia (AML) - occurs more commonly in adults than in children, and more commonly in men than women. (rxharun.com)
Aggressive3
  • The rearrangement of MLL are related with different kinds of aggressive acute leukemias. (wikipedia.org)
  • Leukemia is grouped according to how aggressive the cancer is and the type of cells that are affected. (healthline.com)
  • One subtype is B-cell prolymphocytic leukemia, a more aggressive disease. (rxharun.com)
Chimeric1
  • Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
Hematopoietic3
  • Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
  • Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
FLT33
  • As well, data showed a gilteritinib-driven inhibition of the receptor tyrosine kinase AXL which is known to modulate the activity of FLT3 in acute myeloid leukemia. (drugbank.com)
  • The interest in FLT3 transmembrane tyrosine kinases was raised when studies reported that approximately 30% of the patients with acute myeloid leukemia presented a mutationally activated isoform. (drugbank.com)
  • 1 As well, the mutation ITD is associated with poor patient outcomes while the mutation TKD produces a resistance mechanism to FLT3 tyrosine kinase inhibitors and the AXL tyrosine kinase tends to produce a resistance mechanism to chemotherapies. (drugbank.com)
Lymphoid2
  • Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
  • There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
Oncology1
  • Guideline] NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia, Version 2:2015. (medscape.com)
Adult5
  • Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364. (medscape.com)
  • Treatment of adult acute lymphoblastic leukemia. (medscape.com)
  • Treatment of 218 adult acute lymphoblastic leukemias. (medscape.com)
  • Short course high dose mitoxantrone with high dose cytarabine is effective therapy for adult lymphoblastic leukemia. (medscape.com)
  • Cytarabine with high-dose mitoxantrone induces rapid complete remissions in adult acute lymphoblastic leukemia without the use of vincristine or prednisone. (medscape.com)
Abnormalities2
  • Most of biphenotypic leukemia in children is due to the rearrangement of MLL Besides them, other gene abnormalities has been reported. (wikipedia.org)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
Survival1
  • The survival rates vary by age: 85% in children and 50% in adults.Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt's leukemia, and acute biphenotypic leukemia. (rxharun.com)
Subtype1
  • It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
Immunophenotype1
Classification1
  • Before 2008, the diagnosis of BAL was based on a score system proposed by the European Group for the Immunological Classification of Leukemias (EGIL) which could differentiate from other kinds of acute leukemia. (wikipedia.org)
Disease1
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
Treatment6
  • Once the cause is determined, prompt treatment is a major factor ensuring a good outcome. (healthline.com)
  • Chronic leukemia showed higher treatment duration. (sld.cu)
  • Giving MEK inhibitor MEK162, cytarabine, and idarubicin may be an effective treatment for acute myeloid leukemia. (mycancergenome.org)
  • Outcome measures can provide a clearer picture of what you can expect from a treatment. (withpower.com)
  • Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (rxharun.com)
  • Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy. (rxharun.com)
Therapy1
  • Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. (medscape.com)
Patients2
  • The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
  • As noted earlier, patients with acute lymphoblastic leukemia (ALL) may present with fever without any other evidence of infection. (medscape.com)
Cancer4
  • This coincided with a burgeoning interest internationally in trying to improve the outcomes for teenagers and young adults with cancer. (leukaemia.org.au)
  • Leukemia is a cancer of the blood or bone marrow.It is a form of cancer that affects the body's ability to make healthy blood cells. (rxharun.com)
  • Despite improved outcome of surgical approaches and developed therapeutic modalities, CCA recurrence rates remain high with CSCs as the proposed main driver behind cancer relapse [ 10 ]. (springer.com)
  • Acute myeloid leukemia is cancer that impacts the blood and bone marrow with a rapid progression. (drugbank.com)
Blood4
  • Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
  • Leukemia is the name for a group of cancers of the blood cells. (healthline.com)
  • Acute leukemia - is characterized by a rapid increase in the number of immature blood cells. (rxharun.com)
  • Chronic leukemia - is characterized by the excessive buildup of relatively mature, but still abnormal, white blood cells. (rxharun.com)
Children2
Include1
  • Other conditions that should be considered in the evaluation of suspected acute ALL include acute biphenotypic leukemia and natural killer (NK)-cell leukemia. (medscape.com)
Symptoms2
  • BAL has similar symptoms to other types of leukemia, but they are usually more serious. (wikipedia.org)
  • It shares many of the symptoms of bandemia, but people with leukemia may also notice that they have swollen lymph nodes, pain in their bones or joints, or discomfort and swelling in their abdomen. (healthline.com)
Conditions1
  • It can also be an indicator of more serious conditions such as leukemia or autoimmune diseases. (healthline.com)
Types1
  • The hybrid gene product ABL/BCR is an oncogene which could lead several types of leukemia including BAL. (wikipedia.org)
Occur1
Normal1
  • The MLL -partial tandem duplication (PTD) associates with high-risk cytogenetically normal acute myeloid leukemia (AML). (ashpublications.org)