AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
StrokeBrain IschemiaTreatment OutcomeCerebrovascular DisordersCerebral HemorrhageTissue Plasminogen ActivatorFibrinolytic AgentsRisk FactorsOutcome Assessment (Health Care)Prospective StudiesCerebral InfarctionAcute DiseaseTime FactorsIschemic Attack, TransientThrombolytic TherapyFollow-Up StudiesPerindoprilChlormethiazoleIntracranial HemorrhagesIncidenceKentuckyCohort StudiesSeverity of Illness IndexTomography, X-Ray ComputedRecurrencePregnancy OutcomePrognosisIndapamideRecovery of FunctionRetrospective StudiesPredictive Value of TestsCerebral Arterial DiseasesAfrican Continental Ancestry GroupSoutheastern United StatesAge FactorsRegistriesInfarction, Middle Cerebral ArteryNeurologic ExaminationDouble-Blind MethodNew York CityRandomized Controlled Trials as TopicDisability EvaluationRisk AssessmentPlacebosMultivariate AnalysisOhioEuropean Continental Ancestry GroupLogistic ModelsOdds RatioUnited StatesMagnetic Resonance ImagingNeuroprotective AgentsMulticenter Studies as TopicAspirinComorbiditySurvival AnalysisBrainRiskSex FactorsRegression AnalysisOutcome and Process Assessment (Health Care)Proportional Hazards ModelsReproducibility of ResultsHemodilutionDenmarkDemographyPatient SelectionActivities of Daily LivingLongitudinal StudiesCase-Control StudiesAge DistributionParesisStroke VolumeSex DistributionStroke, LacunarHypertensionPrevalenceBrain InfarctionBlood PressureEuropeAfrican AmericansHispanic AmericansSurvival RateInjections, IntravenousInfusions, IntravenousHemiplegiaPostoperative ComplicationsIntracranial EmbolismAnticoagulantsHeat StrokePregnancyAtrial FibrillationInfant, NewbornKaplan-Meier EstimateLength of StayRecombinant ProteinsQuality of LifeHospitalizationHospital UnitsCarotid Stenosis
CohortClinical outcomesCentersImprove outcomesModified RankiPredictors of outcomeNational Institutes of HealtSurvivorsIncidenceFavorableEfficacyMulticenterComplicationsOnsetFunctional outcomeHemorrhagic strokeMethodsAdverse outcomesIschaemicThrombolysisTissue plasminogAtrial fibrillationTrialsNeurologyThrombectomyConclusionsNIHSSTransientPatients with acute ischemicPost-stroke2017WorseNeurologic deficitClot-removalDesigned to assessFindingsDisabilityGood outcomeRetrospectiveSecondary outcomesHypertensionPatient outcomesMortality after acuteTreat ischemic strokeResearchersAnalyzed the relationship between clinicalThrombolytic therapyInterventionSevereTreatment OutcomeImproves
Cohort23
  • This cohort study examines the use of endovascular recanalization in pediatric patients with arterial ischemic stroke and clinical outcomes. (uni-koeln.de)
  • The aim of this study was to analyze the influence of age on outcome and safety after endovascular therapy in a large cohort of patients aged between 20 and 90 years. (nih.gov)
  • Methods: A matched cohort study was performed. (uea.ac.uk)
  • abstract = "Objective: To evaluate post-stroke outcomes in patients with Parkinson's disease (PD).Methods: A matched cohort study was performed. (uea.ac.uk)
  • and (2) demographic, clinical or radiological differences between patients with known AF (and not treated) and patients with newly diagnosed AF, in a cohort of patients who presented with ischaemic stroke or transient ischaemic attack (TIA) not previously treated with anticoagulation. (bmj.com)
  • Design We reviewed cross-sectional baseline demographic and clinical data from a prospective observational cohort study, (CROMIS-2). (bmj.com)
  • Main outcome measures Proportion of patients with known AF before index ischaemic stroke or TIA from a cohort of patients who have not been previously treated with oral anticoagulation. (bmj.com)
  • Prospective cohort study. (bmj.com)
  • In the present prospective cohort study, the 3-month outcome of patients (mortality, disability) with acute ischemic stroke admitted to neurology department an educational hospital, Kermanshah, Iran, from 2016 to 2019, who had received thrombolytic therapy was assessed. (ac.ir)
  • Stroke incidence and survival among middle-aged adults: 9-year follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort. (ac.ir)
  • We compared the highest three, putatively therapeutic ALB dose tiers (1.37 to 2.05 g/kg) with the lowest three, presumed subtherapeutic doses (0.34 to 1.03 g/kg) and with historical cohort data derived from the NINDS rt-PA Stroke Study. (ox.ac.uk)
  • Conclusions - In this large cohort study, HF was observed in 9.1% of AIS patients. (ices.on.ca)
  • A retrospective cohort study was conducted to evaluate the independent and interactive effects of pulse pressure and antihypertensive class (specifically angiotensin converting enzyme inhibitor/angiotensin type 1 receptor blocker, or beta blocker) on mortality following acute ischemic stroke. (scirp.org)
  • Clinical outcomes from the observational cohort included swollen and tender joint counts (28), physician global assessment, and the RA Clinical Disease Activity Index (CDAI). (springer.com)
  • METHODS: Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were administered to 10-year survivors from a population-based cohort of first-ever stroke patients included in the Lund Stroke Register, Sweden, in 2001-2002. (lu.se)
  • Another nested stroke cohort study of 480,604 hospitalized stroke patients determined the adjusted odds ratios (ORs) and 95% CIs for adverse events after stroke in patients with and without HF between 2000 and 2009. (tmu.edu.tw)
  • Results: Compared with the non-HF cohort, HF patients had an increased risk of stroke (HR 2.32, 95% CI 2.21-2.43), including ischemic stroke and hemorrhagic stroke. (tmu.edu.tw)
  • Methods: We conducted a retrospective cohort study of adults with pulmonary hypertension having surgery at a single large medical referral center. (researchsquare.com)
  • Forslund T, Wettermark B, Andersen M, Hjemdahl P. Stroke and bleeding with NOAC or warfarin treatment in patients with non-valvular atrial fibrillation: a population based cohort study. (janusinfo.se)
  • HIV-infection and psychiatric illnesses - A double edged sword that threatens the vision of a contained epidemic: The Greater Stockholm HIV Cohort Study. (janusinfo.se)
  • Sveréus S, Larsson K, Rehnberg C. Clinic continuity of care, clinical outcomes and direct costs for COPD in Sweden: a population based cohort study. (janusinfo.se)
  • Eriksson I, Cars T, Piehl F, Malmström R, Wettermark B, von Euler M. Persistence with dimethyl fumarate in relapsing-remitting multiple sclerosis: a population based cohort study. (janusinfo.se)
  • Evans M, Carrero JJ, Bellocco R, Barany P, Qureshi AR, Seeberger A, Jacobson SH, Hylander-Rössner B, Rotnitzky A, Sjölander A. Initiation of erythropoiesis-stimulating agents and outcomes: a nationwide observational cohort study in anaemic chronic kidney disease patients. (janusinfo.se)
Clinical outcomes7
  • however, any association of therapy with clinical outcomes in children is unknown. (uni-koeln.de)
  • Secondary clinical outcomes included the modified Rankin scale (mRS) (score range: 0 [no deficit] to 6 [death]) at 6 and 24 months and rate of complications. (uni-koeln.de)
  • Time to treatment and clinical outcomes were compared among treatment groups. (springer.com)
  • The aim of this study is to evaluate time to treatment and clinical outcomes of patients receiving thrombolytic treatment among different thrombolytic delivery protocol in the Chulalongkorn Stroke Network. (springer.com)
  • Here, we retrospectively analyzed the relationship between clinical outcomes and the CONUT score in aSAH patients during hospitalization. (nature.com)
  • Clinical question: How does the timing of endoscopic intervention affect clinical outcomes in patients with acute non-variceal upper gastrointestinal (GI) bleeding? (the-hospitalist.org)
  • Bergqvist J, Iderberg H, Mesterton J, Bengtsson N, Wettermark B, Henriksson R. Healthcare resource use, comorbidity, treatment and clinical outcomes for patients with primary intracranial tumors: a Swedish population-based register study. (janusinfo.se)
Centers9
  • Results Seventy-three children from 27 participating stroke centers were included. (uni-koeln.de)
  • According to the American Heart Association/American Stroke Association (AHA/ASA), telestroke facilitates the use of thrombolytic therapy in acute ischemic stroke with similar safety as the primary stroke centers [ 8 ]. (springer.com)
  • however, endovascular therapy can only be performed in selected high-performing stroke centers. (frontiersin.org)
  • Patients in the study were enrolled at 22 centers in the United States within approximately 5.5 hours of their stroke onset. (nih.gov)
  • Methods Records of patient undergoing ET for acute ischemic stroke at seven major centers in the United States between January 2013 and December 2017 were retrospectively reviewed for patient characteristics, procedural variables, complications, incidence of post-procedural hemorrhage and functional outcomes measured by 90 day mRS scores. (bmj.com)
  • Well, he explains, "By extension, if a stroke knocks out certain centers in the brain with androgen receptors, it is not a big jump to consider it possible for a stroke to alter sexual orientation. (salon.com)
  • The study will be conducted at 10 to 12 Centers of Excellence across the United States, with an estimated four PoNS devices per site. (ptproductsonline.com)
  • The study compared outcomes of patients in the MR CLEAN trial - the first successful randomized controlled trial of endovascular therapy - with outcomes in a registry of real-world patients receiving endovascular treatment for stroke in the MR CLEAN centers after the trial ended. (medscape.com)
  • For the current study, the researchers analyzed data from 1488 patients undergoing endovascular therapy for acute ischemic stroke within 6.5 hours from onset of symptoms at 1 of 16 centers in the Netherlands between March 2014 and June 2016. (medscape.com)
Improve outcomes4
  • For example, women with an irregular heart rhythm called atrial fibrillation are less likely to be prescribed blood thinners or receive cardiac ablation-both of which are known to improve outcomes. (birminghamheart.com)
  • Intravenous tissue plasminogen activator (t-PA), a drug that dissolves clots has been shown to improve outcomes in such stroke patients. (nih.gov)
  • Despite a lack of evidence showing that these clot-removal devices improve outcomes, they are already widely used in patients who are not able to get to the hospital in time to receive t-PA," said Walter J. Koroshetz, M.D., deputy director of NINDS. (nih.gov)
  • Intervention to reduce sedentary behaviour and improve outcomes after stroke (Get Set Go): a study protocol for the process evaluation of a pilot cluster randomised controlled trial (RECREATE). (bvsalud.org)
Modified Ranki2
  • The 30-day and 6-month mortality rate is 39% and 49%, respectively, and only 23% of patients have a favorable outcome, as evaluated using a modified Rankin scale (mRS) score of 0-2 2 . (nature.com)
  • The primary outcome was the modified Rankin Scale (mRS) score, ranging from 0 (no symptoms) to 6 (death) at 90 days. (medscape.com)
Predictors of outcome4
  • Logistic regression analysis was performed to determine predictors of outcome and linear regression analysis to evaluate the association of age and outcome after 3 months. (nih.gov)
  • Similar results have been seen in observational studies but many have not corrected for selection bias or independent predictors of outcome. (bmj.com)
  • Conclusions In routine practice, stroke unit admission is associated with a greater likelihood of discharge home and with lower mortality up to 1 year, after correcting for known independent predictors of outcome, and excluding early non-modifiable mortality. (bmj.com)
  • In this work, we evaluated functional outcomes, complications, and predictors of outcome after ET in the elderly compared to younger patients. (bmj.com)
National Institutes of Healt2
Survivors9
Incidence4
  • Among 2555 patients, 812 (32%) had cryptogenic events (incidence of cryptogenic stroke 0·36 per 1000 population per year, 95% CI 0·23-0·49). (nih.gov)
  • The secondary objectives include: 1) to compare the effectiveness of common treatment regimens, 2) to analyze the cost-effectiveness of different treatment regimens for AIS, 3) to analyze the incidence of adverse events and complications in enrolled patients with AIS, 4) to analyze the effect of Trial of Org 10,172 in Acute Stroke Treatment (TOAST) classification on the specific therapies during acute phase treatment period. (biomedcentral.com)
  • An epidemiological population-based study in Germany revealed that ischemic stroke can be classified several subtypes with different incidence rates and should not be regarded as a homogeneous disease condition [ 5 ]. (biomedcentral.com)
  • Wilhelmsen L, Ko¨ster M, Harmsen P, and Lappas G (2005) Differences between coronary disease and stroke in incidence, case fatality, and Citations risk factors, but few differences in risk factors for fatal and non-fatal events. (cdc.gov)
Favorable9
  • most of the treated children had favorable neurologic outcomes. (uni-koeln.de)
  • The study findings suggest that neurologic outcomes of the children were mostly favorable and comparable with those noted in adult trials. (uni-koeln.de)
  • The CASTOR study will help to find favorable cost-utility treatment regimens for AIS and improve the overall treatment outcome of Chinese patients with AIS. (biomedcentral.com)
  • Elderly patients generally experience less favorable outcomes and higher mortality after acute stroke than younger patients. (nih.gov)
  • Advancing age was associated with a decline of favorable outcomes and survival after endovascular therapy. (nih.gov)
  • Multivariate regression analysis showed that tirofiban treatment independently predicted a favorable functional outcome ( P ≤ 0.001). (frontiersin.org)
  • Favorable (mRS 0-2) and moderate (mRS 0-3) clinical outcome at 90 days was achieved in 21 (63.6%) and 30 (90.9%) patients, respectively. (ajnr.org)
  • The clinical outcome of patients undergoing mechanical thrombectomy for acute ischemic stroke with mild stroke due to large-vessel occlusion appears to be predominately favorable, even in a prolonged time window. (ajnr.org)
  • The researchers note that these outcomes are reported in a broad group of patients without imaging selection (apart from computed tomography angiography to confirm occlusion of proximal vessels), in contrast to the trend in current clinical trials to select patients before treatment with a favorable prognosis based on imaging characteristics. (medscape.com)
Efficacy11
  • WOODCLIFF LAKE, N.J.--( BUSINESS WIRE )--Eagle Pharmaceuticals, Inc. ("Eagle" or "the Company") (Nasdaq:EGRX) today announced positive results from a recently-completed study evaluating the safety and efficacy of RYANODEX® (dantrolene sodium for injectable suspension) for the treatment of exertional heat stroke ("EHS"), an investigational new indication for the product. (mhaus.org)
  • We believe that the study data successfully supports establishing the safety and efficacy of RYANODEX for the treatment of EHS, potentially expanding the product's label to include EHS as an authorized second indication," said Scott Tarriff, President and Chief Executive Officer of Eagle Pharmaceuticals. (mhaus.org)
  • The efficacy of endovascular stroke therapy seems to be preserved also in the elderly and other factors than efficacy of endovascular therapy such as decreased plasticity are likely to explain the worse outcome with advancing age. (nih.gov)
  • The aim of this study was to evaluate the efficacy and safety of early low-dose tirofiban treatment in AIS patients with early neurological deterioration (END) after IVT. (frontiersin.org)
  • However, the therapeutic efficacy of tirofiban treatment in END patients needs to be determined by future randomized clinical trials with a large study population. (frontiersin.org)
  • Further studies on how to improve the therapeutic efficacy of intravenous thrombolysis are always important. (frontiersin.org)
  • The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--II: neurologic outcome and efficacy analysis. (ox.ac.uk)
  • Efficacy outcomes were determined at 3 months. (ox.ac.uk)
  • These results have led to a multicenter, randomized, placebo-controlled efficacy trial of ALB in acute ischemic stroke-the ALIAS Phase III Trial. (ox.ac.uk)
  • Here, this study aims to investigate the efficacy and safety of electroacupuncture (EA) in combination with SZRD in the treatment of insomnia following stroke. (biomedcentral.com)
  • After the MR CLEAN trial, which proved the efficacy of endovascular therapy in stroke, we started using this treatment routinely and all patients treated were entered into a registry so we could compare how outcomes in the real world compared with those in the clinical trial," lead author, Ivo Jansen, MD, Academic Medical Center, Amsterdam, the Netherlands, commented to Medscape Medical News . (medscape.com)
Multicenter3
  • In several randomized multicenter stroke trials, mechanical thrombectomy has proved to be an effective treatment for large intracranial vessel occlusion in patients with acute ischemic stroke in the anterior circulation. (ajnr.org)
  • A prospective, multicenter, single-arm study. (bestbets.org)
  • Multicenter, international, observational study. (the-hospitalist.org)
Complications8
  • Logistic regressions were used to evaluate the association between PD and in-hospital outcomes (mortality and complications). (uea.ac.uk)
  • Thus, there are limited data for patient selection, prediction of clinical outcome, and occurrence of complications in this patient population. (ajnr.org)
  • However, although infrequent, angiographic complications could impair clinical outcome. (ajnr.org)
  • reported in a prospective study of 58 SAH patients that a negative energy balance during the first 7 days after SAH correlated with the number of infectious complications 10 . (nature.com)
  • These researchers also showed in a prospective observational study of 229 SAH patients that a negative nitrogen balance during the first 14 post-bleed days is a risk factor for infectious complications and is associated with poor outcomes (mRS ≥ 4) at 3 months 11 . (nature.com)
  • Multi-variate analysis including patient demographics, comorbidities, procedural variables, and complications showed that age ≥80 years was an independent predictor of good outcomes (mRS 0-2) at 90 days, mortality and symptomatic ICH. (bmj.com)
  • Conclusion: HF was associated with a higher risk of stroke, and patients with HF had more complications and greater mortality after stroke. (tmu.edu.tw)
  • Cars T, Eriksson I, Granath A, Wettermark B, Hellman J, Norman C, Ternhag A. Antibiotic use and bacterial complications following upper respiratory tract infections: a population based study. (janusinfo.se)
Onset10
  • The use of an advanced imaging shortly after the onset of acute stroke failed to identify a subgroup of patients who could benefit from a clot-removal procedure, a study has found. (nih.gov)
  • Based on the imaging results, the 118 study patients were randomly assigned to receive a clot-removal procedure within eight hours of symptom onset (64 patients) or standard therapy (54 patients) according to medical protocols. (nih.gov)
  • METHODS: Eighty-two subjects with acute ischemic stroke (NIH Stroke Scale [NIHSS] of 6 or above) received 25% ALB beginning within 16 hours of stroke onset. (ox.ac.uk)
  • Prevailing praxis is for thrombolysis to be given only to patients who reach hospital within three hours after the onset of stroke. (sciencedaily.com)
  • Subjects 18 years and older presenting within 8 hours of symptom onset of an acute neurologic deficit consistent with acute stroke and a score of TIMI 0 or 1 in a vessel accessible by the Penumbra system. (bestbets.org)
  • Patients with NIHSS score greater than or equal to 8 presenting within 8 hours of symptom onset of acute ischemic stroke and with an angiographic occlusion (TIMI grade 0 or 1) of a large intracranial vessel. (bestbets.org)
  • Since 2007, intravenous thrombolysis has been recommended for the treatment of ischaemic stroke initially within 3 h of symptom onset, 1-6 and more recently within 4 ½ h of symptom onset. (bmj.com)
  • We performed a systematic review of imaging biomarkers used in randomized controlled trials of acute ischemic stroke, in which a therapeutic intervention was trialed within 48 hours of symptom onset. (ajnr.org)
  • The time from stroke onset to treatment was faster in the registry study - by about 1 hour," he said, probably because more efficient systems of care have now been set up. (medscape.com)
  • Duration from onset of stroke to start of endovascular treatment and from onset of stroke to successful reperfusion or last contrast bolus was 1 hour shorter for patients in the MR CLEAN registry. (medscape.com)
Functional outcome4
  • 4 at admission independently predicted patients' functional outcome status at 3 months after aSAH 7 . (nature.com)
  • The study will rate subjects' adherence to PoNS therapy, which combines the PoNS device with physical therapy, to better understand the relationship between adherence to the treatment regimen and therapeutic functional outcome. (ptproductsonline.com)
  • Results showed that a higher proportion of patients reached a good functional outcome after 90 days in the registry, despite older age and more comorbidities. (medscape.com)
  • Good functional outcome (mRS score of 0 - 2) was achieved in 37.9% of patients in the registry compared with 32.6% in the randomized trial intervention arm and 19.1% in the control arm. (medscape.com)
Hemorrhagic stroke5
  • Other medicines, surgery, or procedures may be needed to stop the bleeding from hemorrhagic stroke and save brain tissue. (cdc.gov)
  • Clinical characteristics, risk factors, and outcomes associated with neonatal hemorrhagic stroke: a population-based case-control study. (bvsalud.org)
  • In hemorrhagic stroke, bleeding occurs directly into the brain parenchyma. (medscape.com)
  • The terms intracerebral hemorrhage and hemorrhagic stroke are used interchangeably in this article and are regarded as separate entities from hemorrhagic transformation of ischemic stroke. (medscape.com)
  • Brain imaging is a crucial step in the evaluation of suspected hemorrhagic stroke and must be obtained on an emergent basis. (medscape.com)
Methods4
  • Methods We used routine data from National Scottish datasets for acute stroke patients admitted between 2005 and 2011. (bmj.com)
  • METHODS AND RESULTS--A 9-member expert panel reviewed evidence to identify measures of upper and lower extremity function used to date as outcomes in trials with patients who experienced a stroke ≥6 months before assessment. (rand.org)
  • Methods - We included AIS patients admitted to the institutions participating in the Registry of the Canadian Stroke Network. (ices.on.ca)
  • However, long-term studies on PSCI are scarce and may be influenced by assessment methods and selection bias. (lu.se)
Adverse outcomes3
  • Objective: To evaluate the long-term risk of stroke and poststroke adverse outcomes in patients with heart failure (HF). (tmu.edu.tw)
  • Besides the intrinsic, complex cardiopulmonary pathologic conditions associated with PH, numerous comorbid conditions can substantially contribute to adverse outcomes [5]. (researchsquare.com)
  • Troponin T is an independent prognostic indicator of adverse outcomes and can be used as a patient risk-stratifying tool in patients with unstable angina or non-Q-wave MI. (medscape.com)
Ischaemic7
  • A third of transient ischaemic attacks (TIAs) and ischaemic strokes are of undetermined cause (ie, cryptogenic), potentially undermining secondary prevention. (nih.gov)
  • In a population-based study in Oxfordshire, UK, among patients with a first TIA or ischaemic stroke from April 1, 2002, to March 31, 2014, we compared cryptogenic events versus other causative subtypes according to the TOAST classification. (nih.gov)
  • PD patients had decreased odds of in-hospital death: OR (95% CI) 0.66 (0.52 - 0.84) and 0.61 (0.43 - 0.85) after ischaemic and haemorrhagic strokes, respectively. (uea.ac.uk)
  • Ischaemic stroke patients with PD also had increased odds of developing pneumonia, sepsis and AKI: 1.52 (1.2 - 1.83), 1.54 (1.16 - 2.05), and 1.33 (1.02 - 1.73). (uea.ac.uk)
  • 95% CI 0.37 - 0.68 haemorrhagic stroke), but leads to an increased mortality risk approximately 1 and 3 months after ischaemic and haemorrhagic stroke, respectively. (uea.ac.uk)
  • Participants Patients were eligible if they were adults who presented with ischaemic stroke or TIA and AF and had not been previously treated with oral anticoagulation. (bmj.com)
  • The time span in which treatment should be given for acute ischaemic stroke -- i.e. stroke caused by a clot or other obstruction to the blood supply -- can be lengthened. (sciencedaily.com)
Thrombolysis12
  • The Ministry of Public Health and the National Health Security Office (NHSO) had accepted the use of intravenous thrombolysis as the standard treatment of acute ischemic stroke in 2008. (springer.com)
  • Intravenous thrombolysis (IVT) is a standard procedure for the treatment of patients with acute ischemic stroke (AIS). (frontiersin.org)
  • Early neurological deterioration (END) within the first 24 h after intravenous thrombolysis is a major problem leading to poor outcomes in AIS patients ( 5 ). (frontiersin.org)
  • Mechanical thrombectomy, in addition to intravenous thrombolysis, has become standard in acute ischemic stroke treatment in patients with large-vessel occlusion in the anterior circulation. (ajnr.org)
  • In the event of acute ischemic stroke, treatment with 'clot-busting' drugs - thrombolysis - should be administered as early as possible. (sciencedaily.com)
  • Background Stroke thrombolysis is strongly supported as an effective therapy for selected cases of early stroke. (bmj.com)
  • This paper describes a cooperative model that uses the skills already present in a DGH to deliver a thrombolysis service initiated in the emergency department by the emergency physicians, and describes the outcomes of that service in comparison with the SITS-MOST trial. (bmj.com)
  • Data at Scarborough DGH were compared with data from the SITS-MOST European-wide study of stroke thrombolysis. (bmj.com)
  • Conclusion Stroke thrombolysis can be effectively delivered in a non-specialist (a non-hyper-acute stroke centre) DGH in the UK. (bmj.com)
  • An alternative model is for stroke and emergency medicine services to work collaboratively to provide thrombolysis at the location of the patient. (bmj.com)
  • Scarborough has adopted a collaborative approach that aims to deliver timely and appropriate thrombolysis for a population of stroke victims presenting to a district general hospital (DGH). (bmj.com)
  • The aim of this paper is to describe the service and to describe outcomes for stroke thrombolysis in a DGH setting. (bmj.com)
Tissue plasminog1
Atrial fibrillation5
Trials15
  • Background and aim Randomised trials indicate that stroke unit care reduces morbidity and mortality after stroke. (bmj.com)
  • Meta-analyses of randomised control trials indicate that stroke unit care (defined by the Stroke Unit Trialists' Collaboration as care of the patient in a defined area with specialist multidisciplinary staffing) is effective in reducing death, dependency and increasing likelihood of return to home in patients with acute stroke. (bmj.com)
  • However, previous randomized controlled stroke trials were not focused on patients with mild-to-moderate symptoms. (ajnr.org)
  • 1 2 3 4 5 Similarly, the benefit in reducing stroke in trials of treatment is that predicted from observational studies. (bmj.com)
  • A systematic literature review yielded 115 clinical trials of upper and lower extremity function in chronic stroke that used a total of 34 outcome measures. (rand.org)
  • CONCLUSIONS--The panel recommends that the Fugl-Meyer Upper and Lower Extremity scales be used as primary outcomes in intervention trials targeting motor function in populations with chronic stroke. (rand.org)
  • Introduction Although endovascular thrombectomy (ET) is currently a standard of care in managing acute ischemic stroke, the design of major trials on ET either excluded or under-represented patients older than 80 years old. (bmj.com)
  • The aim of this study was to systematically review the use of imaging biomarkers in randomized controlled trials in patients with acute ischemic stroke, exploring the purposes for which the imaging biomarkers were used. (ajnr.org)
  • Data bases searched included MEDLINE, EMBASE, strokecenter.org, and the Virtual International Stroke Trials Archive (1995-2014). (ajnr.org)
  • However, within imaging modalities, there has been little consistency between stroke trials. (ajnr.org)
  • Event rates were based on outcomes in clinical trials and observational studies. (cdc.gov)
  • The risk of a first stroke is significantly higher among of cholesterol-lowering treatment: prospective meta-analysis of data tobacco smokers as well as among subjects with high blood from 90056 participants in 14 randomised trials of statins. (cdc.gov)
  • Endovascular therapy for patients with acute ischemic stroke in the real world is at least as effective and safe as in randomized clinical trials, a new registry study from the Netherlands suggests. (medscape.com)
  • He noted that traditionally, results from real-world studies can be less impressive than those from randomized trials because the trials often have stricter inclusion criteria and high motivation levels from all involved. (medscape.com)
  • The World Health Organization, through its International Clinical Trials Registry Platform, has developed the ICTRP database to provide patients, family members and members of the public current information about clinical research studies. (who.int)
Neurology4
  • A examine involving UT Southwestern neurology researchers discovered lower-quality outcomes for Hispanic ischemic stroke sufferers who obtain endovascular thrombectomies than for comparable white and Black sufferers. (visualassembler.com)
  • Dr. Jones is a member of the Stroke Editor Coaching Program in addition to the American Academy of Neurology, the American Coronary heart Affiliation, and the Society of Vascular and Interventional Neurology. (visualassembler.com)
  • Neuroscience of multilingualism is the study of multilingualism within the field of neurology. (wikipedia.org)
  • Insights into the neurology of multilingualism have been gained by the study of multilingual individuals with aphasia, or the loss of one or more languages as a result of brain damage. (wikipedia.org)
Thrombectomy4
  • This study may support clinicians' practice of off-label thrombectomy in childhood stroke in the absence of high-level evidence. (uni-koeln.de)
  • The purpose of this analysis was to assess clinical and interventional data in patients treated with mechanical thrombectomy in case of ischemic stroke with mild-to-moderate symptoms. (ajnr.org)
  • Inclusion criteria were anterior circulation ischemic stroke treated with mechanical thrombectomy at our institution between September 2010 and October 2015 with an NIHSS score of ≤8. (ajnr.org)
  • A 2017 examine discovered that thrombectomy therapy inside 24 hours after an acute stroke can lead to a 73% decrease danger of incapacity. (visualassembler.com)
Conclusions3
  • However, the results of MR RESCUE are not consistent with the conclusions of a separate NINDS-funded observational study called DEFUSE-2 that suggested that a slightly different brain imaging strategy could predict patients who benefited from the clot-removal procedure. (nih.gov)
  • Conclusions About 1/3 of patients who present with stroke and have AF who have not been treated with oral anticoagulation have previously known AF. (bmj.com)
  • CONCLUSIONS: Our data suggest that high-dose ALB therapy may be neuroprotective after ischemic stroke. (ox.ac.uk)
NIHSS2
  • National Institute of Health Stroke Scale (NIHSS) and Modified Rankin Score (MRS) were used for measuring the degree of disability (on admission, at the time of discharge and 3 months after thrombolytic therapy). (ac.ir)
  • This study emphasizes that advanced age coupled to higher NIHSS on admission and an anticipated long procedure should prompt careful discussion of the risks and benefits of ET in the elderly. (bmj.com)
Transient2
  • The risk of stroke within 90 days of a transient ischemic attack (TIA) may be as high as 17%, with the greatest risk during the first week. (cdc.gov)
  • Participants in the studies who had transient language exposure as an infant or were multilingual showed greater brain activation in non-verbal working memory patterns, compared to monolingual speakers. (wikipedia.org)
Patients with acute ischemic2
  • The relationship between blood pressure (BP) control and short and long term outcomes in patients with acute ischemic stroke (AIS) is highly complex and not well understood with conflicting data. (scirp.org)
  • Treatment options for patients with acute ischemic stroke are limited. (ajnr.org)
Post-stroke5
  • Objective: To evaluate post-stroke outcomes in patients with Parkinson's disease (PD). (uea.ac.uk)
  • Using a standardised protocol, the researchers then determined survival at three months post-stroke and the extent of any neurological impairment affecting the patients. (neuronewsinternational.com)
  • A total of 240 patients with post-stroke insomnia will be included and randomized into four groups: the EA group, SZRD group, EA & SZRD group, and sham group. (biomedcentral.com)
  • This study will contribute to assessing whether the combination of these two therapies is more beneficial for post-stroke insomnia than their independent use, and the results of this clinical trial will improve our understanding of the possible mechanisms underlying the effects of combination therapies. (biomedcentral.com)
  • OBJECTIVES: Post-stroke cognitive impairment (PSCI) has considerable impact on patients and society. (lu.se)
20172
  • Acute ischemic stroke patients who received thrombolytic treatment during January 2016-December 2017 in the Chulalongkorn Stroke Network were studied. (springer.com)
  • The study looked at 1,543 cases between February 2017 and October 2019. (neuronewsinternational.com)
Worse5
  • Despite advances in stroke prevention and treatment, women still face worse outcomes after stroke than men based on study data from the past ten years. (birminghamheart.com)
  • Overall, researchers found that women continue to experience more activity limitations and worse quality of life than men after stroke. (birminghamheart.com)
  • Specific clinical (functional status), diagnostic (serum NT-proBNP), and intraoperative factors (higher-risk surgery) are predictive of worse outcomes. (researchsquare.com)
  • Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working risk of worse outcome. (cdc.gov)
  • 1, 2] Moreover, those whose statins were discontinued during their hospitalization had worse outcomes than those who remained on statins. (medscape.com)
Neurologic deficit1
  • Strokes are a heterogeneous group of disorders involving sudden, focal interruption of cerebral blood flow that causes neurologic deficit. (msdmanuals.com)
Clot-removal2
  • NIH-funded study assessed benefits of targeted clot removal based on brain status. (nih.gov)
  • Though some patients have had dramatic improvements with clot removal, it has not been shown effective in this or another larger study, the Interventional Management of Stroke (IMS III), which was halted early because it did not find the procedure to be of significant benefit. (nih.gov)
Designed to assess2
  • The study was primarily designed to assess the change in the level of neurological impairment in subjects suffering from the symptoms of EHS, from baseline to 90 minutes post-randomization, using the Glasgow Coma Scale ("GCS"), a validated and widely used tool among clinicians. (mhaus.org)
  • The Therapeutic Experience Program is a Helius-sponsored, open label observational, interventional multi-center outcome research trial designed to assess adherence to on-label PoNS therapy for improvement in gait deficits for patients with MS in a real-world clinical setting. (ptproductsonline.com)
Findings4
  • The findings, printed within the Journal of Stroke and Cerebrovascular Ailments , add to the physique of information on enhancing stroke therapy in underserved teams. (visualassembler.com)
  • These findings indicate that CONUT score during hospitalization may be a useful daily marker for predicting poor outcomes in aSAH patients. (nature.com)
  • Clinical Findings and Outcome after Stroke. (lu.se)
  • Even so, none of these findings reliably distinguishes between hemorrhagic and ischemic stroke. (medscape.com)
Disability13
  • Stroke is the leading cause of death and disability in Thailand and worldwide [ 1 ]. (springer.com)
  • Acute ischemic stroke (AIS) is a leading cause of disability and death in China and worldwide ( 1 , 2 ). (frontiersin.org)
  • Studies show that patients with ischemic strokes who receive tPA are more likely to recover fully or have less disability than patients who do not receive the drug. (cdc.gov)
  • Other benefits of minimally invasive surgery include less time in hospital and lower chance of disability, said Adnan I. Qureshi, M.D., senior investigator of the study, who is also the director of the Minnesota Stroke Initiative. (scienceblog.com)
  • In a study published in The Journal of the American Medical Association (JAMA) , researchers have found that stroke patients in Berlin for whom STEMOs (Stroke-Einsatz-Mobile) were dispatched were more likely to survive without long-term disability. (neuronewsinternational.com)
  • In our study, dispatch of a mobile stroke unit was linked to increased survival and reduced risk of disability," says Heinrich J Audebert (Center for Stroke Research Berlin, Charité -Universitätsmedizin). (neuronewsinternational.com)
  • Stroke is the second leading cause of death and a major cause of disability worldwide. (biomedcentral.com)
  • HF is an independent predictor of death and disability and hospital readmissions after stroke at 30 days. (ices.on.ca)
  • Feb. 12, 2020 Promising new stimulation treatment increases blood flow to the brain, improves hand strength in patients with minor stroke and may decrease disability in many patients with stroke. (sciencedaily.com)
  • Acute ischemic stroke is a serious cause of mortality and disability. (bestbets.org)
  • This investigator-initiated study was supported by Zogenix and in part by a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research H133P120002. (springer.com)
  • In the US, stroke is the 5th most common cause of death and the most common cause of neurologic disability in adults. (msdmanuals.com)
  • Numerous studies suggest that functional limitations are causally linked to disability. (cdc.gov)
Good outcome4
  • The tPA-treated subjects who received higher-dose ALB were three times more likely to achieve a good outcome than subjects receiving lower-dose ALB, suggesting a positive synergistic effect between ALB and tPA. (ox.ac.uk)
  • Fifty (51%) had a good outcome, seven (8%) had partial resolution of their symptoms, and 41 (42%) showed no improvement or deterioration. (bmj.com)
  • As previously discussed, the keys to achieving a good outcome in patients with cardiogenic shock are rapid diagnosis, prompt supportive therapy, and expeditious coronary artery revascularization in patients with myocardial ischemia and infarction. (medscape.com)
  • The percentage of patients achieving a good outcome was higher in the registry. (medscape.com)
Retrospective2
  • We performed a retrospective analysis of a prospectively collected stroke data base. (ajnr.org)
  • A single-center, retrospective observational study was conducted at Gifu University Hospital. (nature.com)
Secondary outcomes3
  • The other 6 measures are recommended as secondary outcomes. (rand.org)
  • The primary and secondary outcomes will be assessed at baseline (before treatment), during the 2nd and 4th weeks of the intervention, and at the 8th and 12th weeks of follow-up. (biomedcentral.com)
  • Secondary outcomes included disposition, death at 3 months and at 1 year, and 30-day hospital readmissions. (ices.on.ca)
Hypertension6
Patient outcomes2
  • Effect of the COVID-19 Pandemic on Hip and Knee Arthroplasty In what ways did the COVID-19 pandemic impact hip and knee arthroplasty volumes and patient outcomes? (medscape.com)
  • 2014 - 2015 CSO Effect of outpatient pharmacists' non-dispensing roles on patient outcomes and healthcare professionals' prescribing patterns. (abdn.ac.uk)
Mortality after acute1
  • The effect of pulse pressure and interactions with type of antihypertensive therapy on mortality after acute ischemic stroke has not been previously evaluated. (scirp.org)
Treat ischemic stroke1
  • Doctors may also treat ischemic stroke with other medicines, such as blood thinners, as well as surgery to remove the clot. (cdc.gov)
Researchers4
  • Researchers also found that women were up to three times more likely to show signs of depression after stroke than men. (birminghamheart.com)
  • Researchers also found that women tend to receive poorer treatment for these risk factors, further contributing to poorer outcomes. (birminghamheart.com)
  • Outcomes had been comparable between Black and white ischemic stroke sufferers who obtain endovascular thrombectomies, the researchers decided. (visualassembler.com)
  • The researchers compared 11,865 patients treated within three hours of stroke with 644 patients who, for various reasons, were treated within three to four and a half hours afterwards. (sciencedaily.com)
Analyzed the relationship between clinical1
  • However, few studies have analyzed the relationship between clinical presentation of PH and outcomes after noncardiac surgery [6, 11]. (researchsquare.com)
Thrombolytic therapy5
Intervention3
  • 4) establish the contextual factors that influence implementation, intervention mechanisms and outcomes. (bvsalud.org)
  • This process evaluation study , underpinned by the Medical Research Council guidance, will be undertaken in six of the randomised services (four intervention, two control). (bvsalud.org)
  • 7 The need for timely intervention in stroke has led to the redesign and development of services for stroke patients across the country. (bmj.com)
Severe5
  • For example, women tend to be older at the time of stroke and experience more severe strokes than men. (birminghamheart.com)
  • Subjects with ICH, greater than 1/3 MCA distribution stroke or severe cerebral edema were excluded. (bestbets.org)
  • We posited 20 scenarios for events that included four possibilities for ischemic strokes (mild, moderate, severe, death) and 16 possibilities for hemorrhages. (cdc.gov)
  • RESULTS: The greatest cost-generating events were virtually the same for the two drugs and included severe stroke ($1,758,548 for 1 year for both drugs), moderate stroke ($380,355 for 1 year for both drugs), and severe lower gastrointestinal (GI) hemorrhage ($193,804 for 1 year for warfarin and $193,474 for second drug). (cdc.gov)
  • SPs who had a myocardial infarction within the past six weeks, chest or abdominal surgery within the past three weeks, knee surgery or knee replacement surgery, severe back pain, a history of brain aneurysm or stroke are excluded from the muscle strength exam. (cdc.gov)
Treatment Outcome1
  • The Chinese Acute Ischemic Stroke Treatment Outcome Registry (CASTOR) is designed to evaluate the patterns and cost-effectiveness of current treatments for AIS in real-world settings in China. (biomedcentral.com)
Improves2