• Dr. Moore will investigate the association of low fibrinolysis and microvascular clots in the organs of donors for Aim 1, followed by Aim 2, defining the association between low fibrinolysis and impaired early graft function in liver transplant recipients. (ucdenver.edu)
  • The success of graft survival after kidney transplantation is closely associated with early graft function based on intraoperative perfusion characteristics of the allograft and good urine output. (intechopen.com)
  • Thus the need of early reliable, sensitive and specific markers to predict the early graft function is of utmost requirement. (mek-signaling.com)
  • The primary endpoints comprised the rate and the severity of acute rejection episodes as well as the 3-year graft function and survival. (sciepub.com)
  • We did not find any significant difference between the 2 groups regarding the length of hospital stay, the rate and severity of acute rejection, the rate of CMV infection, the occurrence of delayed graft function and the rate and type of surgical complications at 1 year. (sciepub.com)
  • Since its first successful attempt in 1954, kidney transplantation (KT) has witnessed tremendous progression in graft survival (GS), as well as acute rejection (AR) rate and severity. (sciepub.com)
  • based on the MDRD equation), acute rejection, and graft and patient survival. (atcmeetingabstracts.com)
  • The introduction of cyclosporine in 1983 significantly improved the outcomes of all solid-organ transplants by reducing the risk of rejection. (medscape.com)
  • We evaluated ethnic influences on patient and graft survival, delayed graft function, allograft failure, and rejection. (ectrx.org)
  • Having African American ethnicity was not a significant predictor of rejection, graft survival, or patient survival. (ectrx.org)
  • Our results indicate that recipient ethnicity is not a predictor of rejection, graft survival, or patient survival. (ectrx.org)
  • Patients with African American (AA) ethnicity are well-documented as being at higher risk for graft rejection and failure. (ectrx.org)
  • When the cohort of deceased donor single kidney recipients between 1994 and 2007 (n=99,860) is studied, all important end points after transplantation, including acute rejection and graft survival, are strongly influenced by a few hours rise in cold ischemic time above 8 hours (Figure 1a-e). (5dok.net)
  • Recipients in the low-dose tacrolimus + daclizumab group had a 3.8% better 1-year graft survival, a 1.8% lower incidence of acute rejection, and a creatinine clearance at 1 year which was 2.3 ml/min higher (relative increase 4%) compared to patients in the standard-dose ciclosporin group without daclizumab. (5dok.net)
  • Transplant characteristics recorded by chart review included donor/recipient demographics, recipient weight (RW), transplant immunological matching, history of acute rejection, delayed graft function, and/or viral infections, and recipient creatinine values at multiple time points. (rsna.org)
  • In the immediate posttransplant period, there were no surgical or infectious complications, delayed graft function, or acute rejection episodes. (hindawi.com)
  • In a US nationwide study, graft failure and death did not differ significantly between recipients of COVID-19 positive vs negative donor kidneys. (renalandurologynews.com)
  • Recipients of COVID-19 positive donor kidneys had no worse graft outcomes than other recipients. (renalandurologynews.com)
  • Yet the risks for all-cause graft failure and death did not differ significantly between recipients of COVID-19 positive vs negative donor kidneys, he stated. (renalandurologynews.com)
  • RESULTS: Delayed graft function requiring dialysis occurred in 23 (56.1%) DKT and 70 (39.1%) SKT recipients. (uniba.it)
  • Their use in kidney transplant recipients (KTRs) was aiming mainly to avoid early AR historically known to predict graft loss 3 , in patients suffering from delayed graft function (DGF) 4 and in many immunosuppression protocols used to avoid or to minimize calcineurin inhibitors (CNIs) 5 based immunosuppression therapy. (sciepub.com)
  • Outcomes in Elderly Renal Transplant Recipients Using Thymoglobulin or Interleukin-2 Receptor Antagonist Induction. (atcmeetingabstracts.com)
  • Induction with rATG or IL-RA in elderly transplant recipients showed similar efficacy in terms of preserving patient and graft survival. (atcmeetingabstracts.com)
  • Jasiak N, Thielke J, Chen J, Hilal N, Salah S, Wu D, Benedetti E, West-Thielke P. Outcomes in Elderly Renal Transplant Recipients Using Thymoglobulin or Interleukin-2 Receptor Antagonist Induction. (atcmeetingabstracts.com)
  • First-day urine volumes were lower (P=0.043) and delayed graft function rates were higher (P = 0.013) in the AKI group than in the non-AKI group recipients. (unican.es)
  • Graft survival and other outcome variables were not different between AKI and non-AKI recipients. (unican.es)
  • Our aim was to assess outcomes in White and African American kidney transplant recipients after induction with alemtuzumab. (ectrx.org)
  • Thus, our objective was to determine whether the use of alemtuzumab in kidney transplant recipients was associated with varied outcomes with respect to recipient ethnicity. (ectrx.org)
  • We only included recipients of deceased-donor allografts to make outcomes more comparable. (ectrx.org)
  • Recipients were divided into DGF and non-DGF groups according to early post-transplant graft function. (e-ultrasonography.org)
  • The input from this public workshop will help in developing topics for further discussion and may serve to inform recommendations on clinical trial design for products for the mitigation of IRI and/or for the prophylaxis and/or treatment of delayed graft function ( DGF ) and related conditions in kidney transplant recipients. (myast.org)
  • Recipients in the highest tertile had a significantly reduced risk of developing diminished renal function as compared to recipients in the lowest tertiles at 12 and 24 months post transplant (adjusted OR = 0.15 & 0.10, respectively). (rsna.org)
  • Delayed diagnosis of TB and drug interactions may contribute to extremely high mortality in RT recipients [ 7 ]. (hindawi.com)
  • We evaluated clinical outcomes among organ recipients with donor-derived hepatitis B virus (HBV) or hepatitis C virus (HCV) infections investigated by CDC from 2014-2017 in the United States. (cdc.gov)
  • Quark Pharmaceuticals Inc. reported completion of a randomized, placebo-controlled multicenter Phase 2 trial of QPI-1002 for the prophylaxis of delayed graft function (DGF) in ESRD dialysis-dependent patients undergoing deceased donor kidney transplantation. (rdworldonline.com)
  • The secondary end points included a set of parameters measuring other definitions of DGF, dialysis occurrence, duration and severity per patient immediately after transplantation and during the follow up period (up to 6 month post-transplant) as well as kidney function parameters. (rdworldonline.com)
  • Marked improvements in early graft survival and long-term graft function have made kidney transplantation a more cost-effective alternative to dialysis. (medscape.com)
  • Patients who receive a kidney transplant from a deceased donor are at risk of delayed graft function (DGF), which is defined as the requirement for dialysis within the first week after transplantation due to poor kidney function. (anmj.org.au)
  • A modifiable risk factor for delayed graft function may be the performance of dialysis on the same day as renal transplant. (psu.edu)
  • We reviewed our institutional experience to determine whether dialysis performed within 24 hours of engraftment increased the incidence or length of delayed graft function. (psu.edu)
  • Conclusions: Normokalemic patients who did or did not undergo dialysis within 24 hours before transplant had equivalent incidence and duration of delayed graft function, graft outcomes, and patient outcomes. (psu.edu)
  • In some postmarketing cases of impaired neonatal renal function, invasive procedures such as exchange transfusion or dialysis were required. (medlineplus.gov)
  • Graft transplantation of embryonic cortical neurons may thus hold therapeutic potential and warrants further detailed analysis of its translational value. (jneurosci.org)
  • Determination of the optimal therapeutic window for transplantation is of paramount importance for allowing effective translation to the clinic, in part because a delay between injury and transplantation is inevitable in a clinical setting. (jneurosci.org)
  • This phase might provide an optimal therapeutic window for transplantation because it may increase functional integration of the graft into the host tissue. (jneurosci.org)
  • sought to identify the optimal time for transplantation by comparing the effect of immediate and delayed transplantation of E14 motor cortical neurons on graft vascularization, survival, and contribution to long-term motor outcome. (jneurosci.org)
  • In a pilot study, transplanting the graft 4, 7, or 30 d after lesion induction indicated that a delay of 7 d was the optimal time for transplantation. (jneurosci.org)
  • The results thus demonstrated that delaying transplantation within a specific time window increased graft survival and integration into host brain tissue. (jneurosci.org)
  • The improved transplantation efficiency in the delay condition could be explained by the fact that the acute inflammatory reaction that occurs after injury decreases within a few days following the insult, thus leading to an environment more receptive for grafting. (jneurosci.org)
  • Together, their data suggest the existence of a temporal window after injury induction, when there is an optimal balance between inflammation and prorepair factors, which improve transplantation outcome. (jneurosci.org)
  • It would be valuable for future studies to investigate the molecular mechanisms underlying the enhanced graft survival rate after delayed transplantation. (jneurosci.org)
  • performed additional studies to compare the effect of 7 d delay and immediate transplantation on survival and integration of grafted cells into host brain tissue at 4, 7, and 14 d after transplantation. (jneurosci.org)
  • Their results showed that delaying transplantation increased cell proliferation, without increasing apoptosis, consequently leading to increased graft size in the delayed condition. (jneurosci.org)
  • Delayed graft transplantation also led to an increase in donor-derived blood vessels, resulting in a transient improvement of graft vascularization at 4 d after transplantation. (jneurosci.org)
  • The host vessels were more swollen 7 d after transplantation in the no-delay group than in the delayed transplantation group, suggesting that ongoing inflammation was present in the no-delay group. (jneurosci.org)
  • There are four main types of pancreas transplantation: Pancreas transplant alone, for the patient with type 1 diabetes who usually has severe, frequent hypoglycemia, but adequate kidney function. (wikipedia.org)
  • The aim of their study was to determine whether mismatching weight is an independent risk factor for poor outcome following deceased donor renal transplantation. (tts.org)
  • This study sheds further light on the factors influencing outcome in adult kidney transplantation. (tts.org)
  • In liver transplantation, it is important to assess both the condition of the donor's liver and the urgency of the need for transplantation in the recipient - the LiMAx test can answer both these questions by determining the real-time liver function capacity of the donor and the recipient. (humedics.eu)
  • How to define initial poor graft function after liver transplantation? (humedics.eu)
  • By protecting kidney grafts adequately from the initial ischemic and subsequent reperfusion injury occurring during transplantation, both the number and quality of kidney grafts could be improved. (mysciencework.com)
  • The impact of cold ischaemia time on outcomes of living donor kidney transplantation: a systematic review and meta-analy. (mysciencework.com)
  • Studies have been carried out to investigate the effect of a prolonged cold ischaemia time (CIT) on the outcomes of living donor kidney transplantation (LDKT). (mysciencework.com)
  • To evaluate functional results, graft survival and late complications in patients who underwent robot-assisted kidney transplantation (RAKT) and who had a minimum of 1 year of follow-up data, and to analyse the correlations between surgical data and functional results at a minimum of 1-year postoperatively and between renal function in the immediat. (mysciencework.com)
  • Kidney transplantation (KT) is often delayed in small children because of fear of postoperative complications. (mysciencework.com)
  • The ultimate goal for any renal transplantation patient is to have an optimally functioning graft as early as possible after completion of surgery. (intechopen.com)
  • One of the reasons for graft failure after renal transplantation is inadequate graft perfusion caused by mis-management of perioperative hydration policy. (intechopen.com)
  • Renal transplantation outcomes: has delayed graft function any impact? (spnefro.pt)
  • Conclusions: This systematic review and meta-analysis suggested that the use of mannitol during kidney transplantation leads to lower incidence of acute renal failure and delayed graft function. (eur.nl)
  • A regression analysis adjusted for these variables was used to estimate the risk of graft failure within the first year and more than one year after transplantation. (nih.gov)
  • INTRODUCTION: Dual kidney transplantation (DKT), using extended criteria donor (ECD) grafts not suitable for single kidney transplantation (SKT), has been suggested to expand the kidney donor pool. (uniba.it)
  • Here, we report that p53 in kidney proximal tubules plays a critical role in cold storage/transplantation kidney injury and inhibition of p53 can effectively improve the histology and function of transplanted kidneys. (elsevierpure.com)
  • Delayed graft function adversely affects outcomes following deceased donor kidney transplantation and is a significant problem for which there is currently no approved treatment. (rdworldonline.com)
  • ABSTRACT Ischemia-reperfusion injury is a pathophysiological event occuring after abdominal organ transplantation, and has a significant influence on prognosis and survival of the graft. (scielo.org)
  • It is a rare complication of kidney transplantation associated with a high rate of graft loss. (edu.au)
  • Conclusions: Recipient outcome is not compromised and excellent results can be achieved with living donor kidney transplantation using laparoscopically procured kidneys. (elsevierpure.com)
  • The aim of this study was to quantify renal microcirculatory perfusion in braindead donors using contrast-enhanced ultrasonography (CEUS), and to establish an accurate, noninvasive, and convenient index for predicting delayed graft function (DGF) post-transplantation. (e-ultrasonography.org)
  • Without modern pharmacologic recipient management, kidney transplantation outcome as we know it would not be possible. (5dok.net)
  • However, the studies in this thesis illustrate that various donor, donor management, and organ preservation related factors have a profound impact on outcome after renal transplantation. (5dok.net)
  • The American Organ Procurement and Transplantation Network (OPTN) database can be utilized to obtain additional detailed information on the association beween cold ischemic time and posttransplant outcome. (5dok.net)
  • The retrospective study presented in chapter 3 shows that donor age has a large impact on delayed graft function and graft survival after kidney transplantation. (5dok.net)
  • The Food and Drug Administration (FDA) is announcing a public workshop to discuss the effects of ischemia/ reperfusion injury ( IRI ) on outcomes in kidney transplantation. (myast.org)
  • A randomized, parallel-group, double-blind, placebo-controlled, multi-center study of eculizumab for the prevention of delayed graft function after kidney transplantation in adult subjects at increased risk of delayed graft function. (columbiasurgery.org)
  • The results obtained in the Lund transplantation program have provided proof-of-principle that human fetal midbrain dopamine neurons can survive and function for many years (more than a decade) after transplantation to the striatum in patients with advanced Parkinson´s disease ( publications 4 below ). (lu.se)
  • The brains from four of the grafted patients in the Lund program, who died 13-24 years after transplantation, have come to autopsy. (lu.se)
  • Martin explained that, in the general population, while transplantation extends survival, nutritional problems in both pre- and post-transplant patients present a threat to patient and graft survival as well as a patient's quality of life. (ukzn.ac.za)
  • Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain. (lu.se)
  • In this population-cohort study, Arshad and coworkers analyzed deceased-donor kidney transplant outcomes stratified by donor-to-recipient size ratios in 11720 adult patients that were transplanted in the UK between 2013 and 2015. (tts.org)
  • Adding the LiMAx test before and after hepatectomy improves treatment outcome and helps to identify patients with low risk of postoperative complications who can be safely managed without intensive care (figure 3) . (humedics.eu)
  • The test has been applied in studies to examine the variation of liver function capacity in patients with liver disorders, including cirrhosis, alcoholic liver disease, viral hepatitis, or non-alcoholic fatty liver disease (NAFLD). (humedics.eu)
  • The LiMAx test has also been applied in patients receiving bariatric surgery to evaluate the improvement of liver function capacity and treatment efficacy. (humedics.eu)
  • The increasing number of patients on the kidney transplant waiting list underlines the need to expand the donor pool and improve kidney graft utilization. (mysciencework.com)
  • BACKGROUND: Delayed graft function (DGF) remains a clinically relevant problem in the post-transplant period, especially in patients with a renal graft from a "donation after cardiac death" (DCD) donor. (mysciencework.com)
  • After censoring of data for patients who died with functioning grafts, the half-life for grafts from living donors increased from 16.9 years to 35.9 years, and that for cadaveric grafts increased from 11.0 years to 19.5 years. (nih.gov)
  • Data was extracted regarding the clinical presentation, investigation, findings on surgical exploration, and treatment outcomes of patients with torsion of kidney transplant. (edu.au)
  • Of the 16 published cases of torsion, seven (44%) grafts were detorted and salvaged, three (19%) grafts were detorted but subsequently lost and six (38%) patients underwent immediate nephrectomy. (edu.au)
  • Two patients died with functioning grafts and four patients lost the graft (three thrombosis, one anastomotic rupture). (elsevierpure.com)
  • We hypothesized that AA patients receiving alemtuzumab would experience worse outcomes than White patients. (ectrx.org)
  • However, this practice leads to an increase in the incidence of delayed graft function (DGF) or graft primary non-function, and affects patients' long-term survival [ 3 ]. (e-ultrasonography.org)
  • To answer questions about the safety and durability of endoscopic vein-graft harvesting during CABG surgery, Williams and co-workers performed an observational study in 235,394 Medicare patients undergoing isolated first-time CABG surgery between 2003 and 2008 at 934 surgical centers participating in the STS national database.6 The STS records were linked to Medicare files to allow longitudinal assessment (median 3-year follow-up) through December 31, 2008. (hcplive.com)
  • Association between endoscopic vs. open vein graft harvesting and mortality, wound complications and cardiovascular effects in patients undergoing CABG surgery. (hcplive.com)
  • Although the clinical outcome so far has been highly variable, the trials have provided evidence that grafted dopamine neurons can restore regulated dopamine release and movement-related frontal cortical activation in the transplanted patients, and - at least in some cases - give rise to significant symptomatic relief ( publications 5 below ). (lu.se)
  • The study recommends that patients identified as at risk of clinical complications seek appropriate help based on the outcome of the assessments, in order to improve their health and quality of life. (ukzn.ac.za)
  • In transplanted patients the incidence of this opportunistic agent is even more frequent, with 512 cases/100.000 inhabitants/year and it is often linked to adverse outcomes [ 1 - 3 ]. (hindawi.com)
  • Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (medscape.com)
  • HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
  • The incidence of endoscopic harvesting increased over time such that in 2008, 70% of the vein-graft harvests were performed endoscopically. (hcplive.com)
  • En-bloc resection of the tumor was carried out, included the fourth portion of the duodenum and the transverse and descending colon, without postoperative complications. (scielo.org)
  • Secondary outcomes included wound complications, and the composite end point of death, MI, and the need for repeat revascularization. (hcplive.com)
  • Complications of prolonged oligohydramnios may include limb contractures and delayed lung maturation. (medlineplus.gov)
  • Expression of heat shock proteins is associated with inflammatory manifestations and ischemia-reperfusion injuries in abdominal organ transplantations and may influence graft outcomes. (scielo.org)
  • Since nutritional health is a modifiable factor, improving nutritional status can positively influence graft and patient outcomes. (ukzn.ac.za)
  • Studies involving heat shock proteins enhance knowledge on ischemia-reperfusion injury mitigation processes and the mechanisms involved in the survival of abdominal grafts, and open space to support therapeutic future clinical studies, minimizing ischemia and reperfusion injuries in abdominal organ transplantations. (scielo.org)
  • Notably, pifithrin-α also ameliorated kidney injury and improved the function of transplanted kidneys in 6 days when it became the sole life-supporting kidney in recipient mice. (elsevierpure.com)
  • We hope that QPI-1002 could improve outcomes and encourage greater utilization of deceased donor kidneys allowing the use of additional kidneys and shortening the transplant waiting list. (rdworldonline.com)
  • Deceased donor kidneys should always be transplanted as soon as possible, for a few hours reduction in cold ischemic time will result in a significant and clinically relevant improvement in outcome. (5dok.net)
  • Kaplan-Meier survival analyses showed no difference between the two induction agents for graft or patient survival. (atcmeetingabstracts.com)
  • A reliable and valid pre-transplant organ quality assessment to minimize unnecessary discards and maximize graft and patient survival has thus become an urgent priority. (e-ultrasonography.org)
  • We present our initial surgical experience and early outcomes with KT at a Nigerian transplant center over 2 years. (lidsen.com)
  • Extracted information included demographic characteristics, side of open donor nephrectomy (ODN), recipient anatomy, surgical techniques and postoperative outcomes. (lidsen.com)
  • Clinical presentation and diagnostic imaging modalities are non-specific, and surgical exploration is therefore often delayed. (edu.au)
  • Conclusions: A prompt consideration of the diagnosis of torsion of kidney transplant is required to prevent delay in surgical intervention. (edu.au)
  • 1) Establishing a prospective outcome registry to identify variables associated with graft dysfunction, 2) Training in advanced basic science methodologies of quantifying fibrinolysis, 3) Integration of clinical and translation data to form a mechanistic hypothesis for factors driving low fibrinolysis 4) Concurrent success in clinical training with maturation as a physician scientist. (ucdenver.edu)
  • Analytical study revealed an elevated C-reactive protein (CRP = 70 mg/L), no anemia or leukocytosis, acute graft dysfunction, or other abnormalities. (hindawi.com)
  • After clinical and perienced delayed graft function. (cdc.gov)
  • Moreover, a functional classification can be more effective than conventional histological grading, improving clinical management and patient outcome. (humedics.eu)
  • CLINICAL NEED: Although most fractures heal within a normal period, about 5% to 10% do not heal and are classified as delayed or nonunion fractures. (who.int)
  • We report early- and long-term outcomes in children transplanted at ≤15 kg in the two largest Belgian pediatric transplant centers. (mysciencework.com)
  • Currently, 1-year patient and graft survival rates exceed 90% in most transplant centers. (medscape.com)
  • The LiMAx test: a new liver function test for predicting postoperative outcome in liver surgery. (humedics.eu)
  • the psoas as a predictor of cardiac transplant outcomes. (tts.org)
  • Objectives: Grafts from extended criteria donors, donors after cardiac death, and elderly donors have an increased risk of delayed graft function, lower graft survival, longer hospital stay, higher costs, and increased medical sequelae. (psu.edu)
  • The primary outcome was allcause mortality. (hcplive.com)
  • This example illustrates that slightly speeding up organ transport, crossmatch, and operating room logistics might result in a similar improvement in outcome as a costly new immunosuppressive drug will achieve. (5dok.net)
  • CONCLUSIONS: ECD graft survival using DKT provided better results compared with SKT, despite the use of organs from higher-risk donors. (uniba.it)
  • Outcomes before (period 1) and since the introduction of basiliximab and mycophenolate-mofetil in 2000 (per. (mysciencework.com)
  • Describe interprofessional team strategies for improving care coordination and communication to advance mitral regurgitation and improve outcomes. (nih.gov)
  • We investigate the use of semi-automated, CT-based quantification of graft volume as a non-invasive, pre-operative predictor of 12 and 24 month graft function. (rsna.org)
  • DKV/RW ratio is a non-invasive, readily-obtained, reproducible parameter that is a predictor of 12 and 24 month renal transplant outcomes. (rsna.org)
  • The Influence of Donor to Recipient Size Matching in Kidney Transplant Outcomes. (tts.org)
  • Transplant outcomes can be improved by incorporating DKV/RW ratio into the renal donor/recipient selection process. (rsna.org)
  • IRD designation led to early diagnosis of recipient infection, and prompt implementation of therapy, likely reducing the risk of graft failure, liver disease and death. (cdc.gov)
  • We applied the RIFLE classification to evaluate renal function changes in our donor pool, in an attempt to know its influence in transplant outcome. (unican.es)
  • Histopathology of microbiological remission of the infection, dos- the graft showed organisms consistent with Crypto- age was adjusted on the basis of renal function coccus yeast cells, suggesting fungal pyelonephritis. (cdc.gov)
  • The goal of lymphedema therapy is to restore function, reduce physical and psychologic suffering, and prevent the development of infection. (medscape.com)
  • AIM: Conduct a large-volume cohort study with long-term follow-up to analyze specific and overall survival outcomes after surgery. (bvsalud.org)
  • Since 1988, there has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors. (nih.gov)
  • Herein, we reviewed the long-term outcomes of DKT to assess its results versus a control group of 179 ECD SKTs. (uniba.it)
  • Therefore, induction therapy is widely used in KT to improve both short- and long-term graft outcomes. (sciepub.com)
  • However, the outcome of treatment with implants is no longer measured exclusively in terms of implant survival, but also by the long-term esthetic and functional success of the prosthesis (2,3). (bvsalud.org)
  • The objective of this study was to provide information on heat shock protein mechanisms in ischemia-reperfusion injuries in abdominal organ transplantations, and to indicate the possible factors involved that may influence the graft outcome. (scielo.org)
  • Kidney delayed graft function (K-DGF) is a common post-kidney transplant complication associated with adverse outcomes. (umn.edu)
  • These adverse outcomes are seen, on average, after days to weeks of treatment, although oligohydramnios has been infrequently reported as soon as 48 hours after NSAID initiation. (medlineplus.gov)
  • Although >10% of brain-deceased donors can suffer AKI, these grafts can perform adequately. (unican.es)
  • The multivariate models in chapters 3 and 5 show that increased cold ischemic time is significantly and independently associated with an elevated risk of delayed graft function and graft failure. (5dok.net)
  • of the average cold ischemic time with just a few hours is likely to result in an improved postttansplant outcome which is in the same order as the effect that low-dose ciclosporin + daclizumab had versus standard-dose ciclosporin. (5dok.net)
  • From 1988 to 1996, the one-year survival rate for grafts from living donors increased from 88.8 to 93.9 percent, and the rate for cadaveric grafts increased from 75.7 to 87.7 percent. (nih.gov)
  • The half-life for grafts from living donors increased steadily from 12.7 to 21.6 years, and that for cadaveric grafts increased from 7.9 to 13.8 years. (nih.gov)
  • Further innovations, including anti-T cell antibodies (both monoclonal and polyclonal preparations), as well as other maintenance immunosuppressants (eg, tacrolimus, mycophenolate, sirolimus), have made a significant impact on both patient and graft survival. (medscape.com)
  • abstract = "Background: Torsion of kidney transplant refers to rotation of the kidney transplant graft around its vascular pedicle resulting in vascular compromise and infarction. (edu.au)