Outbred laboratory rats. Medical search. Frequent questions

Other common strains are the Sprague Dawley, Fischer 344, Holtzman albino strains, Long-Evans, and Lister black hooded rats. (wikipedia.org)
Virus was transmissible to seronegative Sprague-Dawley rats, but transmission was spotty and magnitude and duration of infection were not robust. (cdc.gov)
Mice (around 280 strains which include inbred, out bred and genetically engineered lines), Rats (out bred stocks like Wistar, Sprague Dawley, Long Evans and several transgenic rat strains), Xenopus laevis and Zebra fish . (ncbs.res.in)
Dorsoventral radiographic view of a 2-month-old Sprague-Dawley outbred male rat included in a biomedical research project involving surgical placement of an intramedullary pin in a femur. (avma.org)
differential effects in Sprague Dawley and Brown Norway rats. (cdc.gov)
Both the inbred Brown Norway and the outbred Sprague Dawley rat strains were included to study the influence of strain on the detection of toxicity. (cdc.gov)
GMA-SS exposure lowered daily sperm production compared to air controls in Sprague Dawley rats, but only in GMA-SS Brown Norway rats also fed the HF diet. (cdc.gov)
At week 24, bronchoalveolar lavage cell counts had returned to background levels for GMA-SS exposed Sprague Dawley rats but remained elevated in Brown Norway rats. (cdc.gov)
GMA-SS did not affect daily sperm production statistically significantly at this time point, but testicular weights were lowered in GMA-SS Sprague Dawley rats. (cdc.gov)
Serum testosterone remained lowered in Sprague Dawley rats fed the HF diet. (cdc.gov)
Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats. (conzort.com)
Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)

While less commonly used for research than laboratory mice, rats have served as an important animal model for research in psychology and biomedical science. (wikipedia.org)
The historical importance of this species to scientific research is reflected by the amount of literature on it: roughly 50% more than that on laboratory mice. (wikipedia.org)
This was the first in a series of developments that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
Many investigators who wish to trace observations on behavior and physiology to underlying genes regard aspects of these in rats as more relevant to humans and easier to observe than in mice, giving impetus to the development of genetic research techniques applicable to rats. (wikipedia.org)
316 Chong-yang Rd., Taipei, 115 Taiwan BioLASCO Taiwan is a technology licensee of Charles River to produce the international standardized SPF Laboratory rats and mice in Taiwan. (contractresearchmap.com)
Up to date, there are 16 strains of laboratory rats and mice, including outbreed stocks, inbreed strains, and immunedeficient models have been breeding. (contractresearchmap.com)
This important part of their business includes research animal models such as inbred, outbred, disease and immunodeficiency models, including mice, rats, hamsters, guinea pigs and rabbits to name a few examples. (citeab.com)
It is worth noting that The Jackson Laboratory and Charles River have a cooperative agreement concerning local supplies of JAX™ Mice, including the ApoE knockout mice. (citeab.com)
Response to 30 generations of selection for open-field activity in laboratory mice. (springer.com)
Quantitative genetics of sprint running speed and swimming endurance in laboratory house mice ( Mus domesticus ). (springer.com)
Exercise physiology of wild and random-bred laboratory house mice and their reciprocal hybrids. (springer.com)
The DBA/2JRccHsd mice originate from Jackson Laboratory, Bar Harbor, Maine and were moved in 1974 to RCC Ltd. (formerly Ibm and BRL) in Füllinsdorf, Switzerland. (inotivco.com)
Timed mated rats and mice are determined by observation of a vaginal plug. (inotivco.com)
For models fulfilled from Envigo Affiliates in Europe, the last stage of gestation for mice is over 17 days and for rats is over 18 days, each at shipping. (inotivco.com)
To avoid charges, cancellations for timed mated rats, mice, guinea pigs, and hamsters must be received one week prior to mating date, however, cancelled orders for timed mated rabbits will be charged at full price regardless of the amount of notice supplied. (inotivco.com)
If customer's research project requires such litters, Envigo recommends ordering timed mated pregnant rats and mice which can litter at customer's facility. (inotivco.com)
C57BL/6J mice were introduced from the Jackson Laboratory to NIH and were maintained as C57BL6N. (nomura-siam.com)
In addition, C57BL/6J mice at F166 were introduced from the Jackson Laboratory to CLEA Japan, Inc., in 1989, at which time their production and supply was started. (nomura-siam.com)
This substrain is at least (a number>20 by definition) generations removed from the originating JAXR Mice strain and has NOT been re-infused with pedigreed stock from The Jackson Laboratory. (nomura-siam.com)
CBi is an inbred mouse strain derived from an outbred population generated by crossing BALB/c, Rockland, NIH and Swiss mice. (biomedcentral.com)
These mice have both BALB/c inbred and NIH(S) outbred stock in their genetic background. (vivobio.com)

Most are derived from the albino Wistar rat, which is still widely used. (wikipedia.org)
Twenty-four Wistar albino rats were divided into three groups. (archivesofmedicalscience.com)
Twenty-four Wistar albino outbred female rats (mean weight, 250 ±30 g, mean age 7 months) were divided into 3 groups [ 13 ]. (archivesofmedicalscience.com)
RHODIXAN A-1 was tested for acute oral toxicity in Wistar rats, according to O.E.C.D. guideline N° 423/EEC method B.1ter, and in compliance with Good Laboratory Practice. (europa.eu)
Twenty four Wistar rats obtained from the same commercial supplier in two separate shipment batches underwent either subtotal nephrectomy or sham procedures. (biomedcentral.com)
We obtained 24 wild-type outbred Wistar International Genetic Standard (IGS) rats in two shipment batches, 3 weeks apart, from the same supplier (Charles Rivers, Kent, UK). (biomedcentral.com)
Female Wistar rats were exposed orally to 200 and 400 ppm propineb (Zn-containing dithiocarbamate) and 250 ppm maneb (Mn-containing dithiocarbamate), from the 6th day of gestation up to birth. (go.jp)
This study established a low incidence hydronephrosis Wistar rat (Mlac:WR) colony at the National Laboratory Animal Center, Mahidol University, Thailand. (mahidol.ac.th)

However, an HEV strain recently isolated from rats was unique and only distantly related to known strains ( 11 ). (cdc.gov)
Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. (conzort.com)
Two inbred mouse strains (BALB/c and A/J) and one outbred strain (ICR) were subcutaneously injected with saline solutions containing penicillin G (1.25, 2.5 and 5 mg/mouse), D-penicillamine (0.5, 1 and 2 mg/mouse), or barbital (2 mg/mouse) into one hind footpad and saline only was injected into the contralateral footpad. (go.jp)
C57BL/6, was introduced to the Jackson Laboratory to form the C57BL/6J strain. (nomura-siam.com)

Laboratory rats or lab rats are strains of the subspecies Rattus norvegicus domestica which are bred and kept for scientific research. (wikipedia.org)
Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012 showed that the albinos descended from hooded rats and all the albinos descended from a single ancestor. (wikipedia.org)
Scientists have bred many strains or "lines" of rats specifically for experimentation. (wikipedia.org)
Subsequently, in collaborations with the County of Los Angeles Department of Health (Los Angeles, CA, USA) Vector Management Program, we succeeded in transmitting to laboratory rats 2 strains of HEV from rats from Los Angeles but were again unable to obtain genomic sequence ( 14 ). (cdc.gov)
Conclusion: Exposure to GMA-SS welding fumes lowered sperm production in two strains of rats, whereas high fat diet lowered serum testosterone. (cdc.gov)

I learned about outbred heterogeneous stock rats for genetic fine-mapping during my first post-doctoral fellowship with Dr. Jonathan Flint at Oxford University. (wakehealth.edu)
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. (euratrans.eu)
Dr. Palmer gave a talk titled "Overview of the NIDA center for genetic studies of drug abuse in outbred rats", at the Genetic studies of drug addiction-related traits in outbred rats symposium, which was chaired by Dr. Polesskaya. (palmerlab.org)
Here, we show that absence seizures in Genetic Absence Epilepsy Rats from Strasbourg, a well established genetic model of this disease, arise from the facial somatosensory cortex. (moam.info)
Advances in genetic engineering and genome editing technologies resulted in the generation of thousands of genetically engineered mouse and rat models. (taconic.com)

Rat-catchers would not only make money by trapping the rodents, but also by selling them for food or, more commonly, for rat-baiting. (wikipedia.org)

Karina Cerda joined the Palmer Lab in April 2022 as a Laboratory Assistant. (palmerlab.org)

My laboratory uses outbred rats to study the genetics of obesity and other complex traits. (wakehealth.edu)
Incentive salience attribution, "sensation-seeking" and "novelty-seeking" are independent traits in a large sample of male and female heterogeneous stock rats. (wakehealth.edu)

There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in different laboratories. (wikipedia.org)
All but one of the testicular tumors occurred in the rats from a single supplier. (wikipedia.org)

Common experimental animals (rats, guinea pigs, chinchillas, cats) are outbred?their genomes contain an admixture of many genes. (cdc.gov)
After mouzes and rats Guinea pigs are easy in maintained laboratory animals. (heat-shock.com)

In 18th-century Europe, wild brown rats (Rattus norvegicus) ran rampant and this infestation fueled the industry of rat-catching. (wikipedia.org)

Food consumption: standard laboratory rodent diet ad libitum. (europa.eu)
Based on an assumption of metabolic similarity between experimental animals, we sought to investigate this 'gut-kidney axis' in a rodent model of uraemia, by demonstrating the effect of experimental uraemia on the urinary metabolome and gut microbiota of rats, purchased from the same supplier in two separate shipment batches for logistical reasons. (biomedcentral.com)
The most common format for cryopreserving laboratory rodent models is to preserve and store embryos or sperm in secure liquid nitrogen storage. (taconic.com)

Charles River Laboratories (NYSE:CRL) entered the S&P 500® around one year ago, marking their impressive success in the life science industry. (citeab.com)
American company Charles River Laboratories serves the Pharmaceutical, Biotechnology and Medical Industries. (citeab.com)
Demonstrating their success in this market, in May 2021 Charles River Laboratories joined the S&P 500®, replacing FLIR Systems Inc. This important index tracks the performance of 500 large, publicly traded companies in the US[2,3]. (citeab.com)
Available at: https://www.prnewswire.com/news-releases/charles-river-laboratories-international-set-to-join-sp-500-others-to-join-sp-midcap-400-and-sp-smallcap-600-301287994.html [Accessed 9 Jun. (citeab.com)

Overall, Charles River claim second position as most cited animal model supplier, just behind The Jackson Laboratory. (citeab.com)
The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
George D. Snell of The Jackson Laboratory won the 1980 Nobel Prize in Physiology or Medicine for "discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions. (jax.org)
In fact, 26 Nobel prizes are associated with Jackson Laboratory research, resources and educational programs. (jax.org)
The scid-beige Spontaneous mutant model was developed by Dr. Anne Croy et al of the University of Guelph in April 1993 by intercrossing C.B-17 from R. A. Phillips to C57BL/6-bg from the Jackson Laboratory. (vivobio.com)

Seventy-six, five-month-old outbred female rats were randomly subdivided into two groups and were subcutaneously injected with 0.2 ml of normal saline (controls, 32 rats) or with 5 micrograms/rat of the dipeptide L-Glu-L-Trp, dissolved in 0.2 ml of saline (44 rats), 5 times per week for 12 months. (nih.gov)

Viremia was higher in nude rats. (cdc.gov)

Domestic rats differ from wild rats (various spp. (wikipedia.org)

Neuronal specificity in the optogenetic experiments will be achieved through the use of transgenic rat lines that express Cre recombinase selectively in D1 dopamine receptor (D1DR)- or D2DR-expressing medium spiny neurons (MSNs) in the nucleus accumbens. (rutgers.edu)

The genetics of rats was studied by William Ernest Castle at the Bussey Institute of Harvard University until it closed in 1994. (wikipedia.org)

Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose. (wakehealth.edu)

Metal content in the testes was assessed in a limited number of samples in Brown Norway rats, but no increase was obsedrved. (cdc.gov)

Safety study for Singinatha choornam was done by treating rats orally with 18, 90 and 180 mg/kg b.wt. (ijpsonline.com)

Animal research has been based on the assumption that whilst experimental animals in different facilities may have differences at species level between their gut microbiota [ 3 ], at a population level, in healthy laboratory animals on identical diets, these diverse collections of microorganisms achieve a shared set of basic metabolic functions-an assumption supported by evidence of significant functional redundancy within gut microbial communities [ 4 ]. (biomedcentral.com)

The effect of dipeptide on survival, life span and spontaneous tumor development was studied in female rats. (nih.gov)
Thus, treatment with L-Glu-L-Trp delayed aging rate and decreased spontaneous tumor incidence in rats. (nih.gov)

Spontaneous cholangiofibrosis adjacent to a dilated common bile duct with intestinal metaplasia in a Royal College of Surgeons rat. (kyoto-u.ac.jp)

Artemis Bioservices (formerly known as Artemis Bio-Support BV) was recently awarded the Good Laboratory Practice (GLP) endorsement . (artemisbioservices.com)

The reproductive function of rats was studied at the Institute for Experimental Biology at the University of California, Berkeley by Herbert McLean Evans and Joseph A. Long. (wikipedia.org)
Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. (kyoto-u.ac.jp)
This study was carried out at the Experimental Animal Laboratory of Uludağ University after the approval of the Animal Ethics Committee had been obtained by the researchers. (archivesofmedicalscience.com)
Under the experimental conditions of this study, the oral LD50 of the test item Rhodixan A-1 was between 500 and 2000 mg/kg in rats. (europa.eu)
Here, we set out to demonstrate the effect of experimental uraemia on the rat urinary metabolome and gut microbiome but found instead that the effect of vendor shipment batch was larger in both areas than that of uraemia. (biomedcentral.com)
White sexually mature outbred male rats in the amount of 64 individuals weighing 250-265 grams were used as experimental animals. (peertechzpublications.com)

This includes, but is not limited to, the acquisition and housing of laboratory animals, training researchers regarding proper animal care and use, providing state-of-the art facilities, and monitoring the safety of all personnel with laboratory animal contact. (ncbs.res.in)
The ACRC is dedicated to provide quality (healthy and non-stressed) laboratory animals for research and 24X7 caring of animals. (ncbs.res.in)
The ACRC handles breeding, maintenance and supply of healthy laboratory animals to support the ongoing research at the center. (ncbs.res.in)
All protocols were in accordance with the regulations concerning the care and use of laboratory animals as in the Declaration of Helsinki. (archivesofmedicalscience.com)
Many methodologies exist for polyclonal antibody production in laboratory animals. (wikidoc.org)
The primary goal of antibody production in laboratory animals is to obtain high titer , high affinity antisera for use in experimentation or diagnostic tests. (wikidoc.org)
The first series of rats were given light physical activity, for which they were placed in a bath with a water temperature of 29-32 degrees Celsius in which the animals were swimming for 15 minutes [9-11]. (peertechzpublications.com)
Drug Dosage in Laboratory Animals. (oldandelegant.com)
At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)

Positional cloning of rat mutant genes reveals new functions of these genes. (kyoto-u.ac.jp)
Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method. (kyoto-u.ac.jp)

High-fat diet negatively impacts both metabolic and behavioral health in outbred heterogeneous stock rats. (wakehealth.edu)
These conditions included treatments at concentrations equivalent to 5885 μg enzymes concentrate dry matter/mL with and without the rat liver metabolic activation system (S9), and using a treat and plate assay. (europa.eu)
These conditions included treatments at concentrations up to 16667 μg enzymes concentrate dry matter/mL), in the absence and in the presence of a rat liver metabolic activation system (S-9) using a modified Treat and Plate methodology. (europa.eu)
It was concluded that Deoxyribonuclease, PPW38822 did not induce biologically relevant increases micronuclei in cultured human peripheral blood lymphocytes following treatment in the absence and presence of a rat liver metabolic activation system (S-9). (europa.eu)
It was concluded that deoxyribonuclease batch PPW42035 induced micronuclei in cultured human peripheral blood lymphocytes following treatment in the absence and presence of an induced rat liver metabolic activation system (S-9) in two independently conducted experiments. (europa.eu)

This study aimed to validate Singinatha choornam as an effective drug against platelet activating factor-induced rhinosinusitis in rat model. (ijpsonline.com)
The study concludes Singinatha choornam has efficacy against rhinosinusitis in rat model but not so significant to standard treatment. (ijpsonline.com)
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. (kyoto-u.ac.jp)
The rat as a model for physical fitness studies. (springer.com)
Klarik Z, Tamas R, Toth E, Kiss F, Kovacs EL, Jäckel M, Furka I, Nemeth N. Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion. (scielo.br)
General multipurpose rat model for safety and efficacy tests also for infection research. (animalab.eu)
The subsequent characterization of the model is an even greater investment, often taking years' effort in the laboratory. (taconic.com)

A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced. (cdc.gov)

Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat 1 1 Research performed at Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary. (scielo.br)

Rats are particularly interesting as a potential source of human infections because although they are not a human food, they have a high seroprevalence of antibodies against HEV ( 12 , 13 ) and they are ubiquitous and in close contact with humans everywhere. (cdc.gov)
Rats are used to make rat monoclonal anti mouse antibodies. (conzort.com)

Overall, HF diet rats had lower serum testosterone levels compared to rats on regular diet. (cdc.gov)

Rats were fed regular or high fat (HF) diet for 24 weeks and were exposed to 20 mg/m3 of gas metal arc-stainless steel (GMA-SS) welding fumes or filtered air for 3 h/day, 4 days/week for 5 weeks, during weeks 7-12. (cdc.gov)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)

Laboratory methods are used to make a diagnosis. (journalveterinariya.ru)

Over the next 30 years, rats were used for several more experiments and eventually the laboratory rat became the first animal domesticated for purely scientific reasons. (wikipedia.org)

The first rat colony in America used for nutrition research was started in January 1908 by Elmer McCollum and then, nutritive requirements of rats were used by Thomas Burr Osborne and Lafayette Mendel to determine the details of protein nutrition. (wikipedia.org)
Twenty Mlac:WR breeding pairs were randomized to determine the percentage of hydronephrosis in the original National Laboratory Animal Center colony. (mahidol.ac.th)

This grant is focused on enabling the NCBS/inStem/C-CAMP biocluster to build a unique shared state-of-the-art SPF mouse facility and a rat facility where the needs of researchers within our campus as well as nationwide are addressed. (ncbs.res.in)
There are less rat- than mouse clones however. (conzort.com)
The storm surge flooded the East River into the underground vivarium space of the New York University Medical School, leading to the loss of hundreds of unique genetically modified mouse and rat lines. (taconic.com)

The first time one of these albino mutants was brought into a laboratory for a study was in 1828 for an experiment on fasting. (wikipedia.org)
Laboratory rats are frequently subject to dissection or microdialysis to study internal effects on organs and the brain, such as for cancer or pharmacological research. (wikipedia.org)
After end of the study, rats were sacrificed and examined for nasal sinuses and lamina propria histology. (ijpsonline.com)
Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)

Envigo uses an impedance meter for determining the stage of estrus in rats. (inotivco.com)

In Japan, there was a widespread practice of keeping rats as a domesticated pet during the Edo period and in the 18th century guidebooks on keeping domestic rats were published by Youso Tamanokakehashi (1775) and Chingan Sodategusa (1787). (wikipedia.org)

In 2007, BioLASCO Taiwan Yi-Lan Breeding center has been awarded the Full Accreditation of AAALAC International, as the first one commercial laboratory animal breeding facility which is accredited by AAALAC International in Asia. (contractresearchmap.com)
However, the rabbit is the most commonly used laboratory animal for this purpose. (wikidoc.org)
National Laboratory Animal Center. (mahidol.ac.th)

Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats. (kyoto-u.ac.jp)

A phospholipid inflammatory mediator, 50 µl were applied intranasally in rats of test and standard groups while control groups intranasally treated with 50 µl of distilled water as single application. (ijpsonline.com)

To Harlan Laboratories through acquisition in 2004. (inotivco.com)

The rat Downunder (Du) coat color mutation is associated with eye anomalies and embryonic lethality and maps to a 3.9-Mb region on chromosome 3. (kyoto-u.ac.jp)

1 Laboratory of Carcinogenesis and Aging, N.N. Petrov Research Institute of Oncology, Pescony-2, St. Petersburg 189646, Russia. (nih.gov)

Three groups of rat were allotted (control - distilled water 2 ml/dose, test drug - Singinatha choornam 90 mg/kg and standard - chloropheniramine maleate 1 mg/kg) and treated for 3 days. (ijpsonline.com)

Longevity studies in rats. (avma.org)

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