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  • Otx1
  • Cell culture experiments indicate that Otx1 may activate transcription of the growth hormone (GH), follicle-stimulating hormone (betaFSH), luteinizing hormone (betaLH) and (alpha)-glycoprotein subunit ([alpha]GSU) genes. (sdbonline.org)
  • These data indicate that Otx1 is a new pituitary transcription factor involved at the prepubescent stage in the control of GH, FSH and LH hormone levels and suggest that a complex regulatory mechanism might exist to control the physiological need for pituitary hormones at specific postnatal stages (Acampora, 1998a). (sdbonline.org)
  • neurons
  • Here we describe a role of the highly conserved HMG‐box transcription factor SOX‐2 in postmitotic specification and alternative differentiation of the Caenorhabditis elegans AWC and AWB olfactory neurons. (embopress.org)
  • In an effort to identify genes that specify the mammalian forebrain, we used a comparative approach to identify mouse homologs of transcription factors expressed in developing Caenorhabditis elegans GABAergic neurons. (biomedcentral.com)
  • A cell-specific microarray profiling study revealed a set of transcription factors that are highly expressed in embryonic C. elegans GABAergic neurons. (biomedcentral.com)
  • cytokines
  • In retinal detachment, a full-thickness retinal break exposes cells, allowing macrophages, retinal pigment epithelial cells, glial cells, and fibroblasts to migrate into the vitreous, a rich source of growth factors and cytokines correlated to PVR activity [ 4 - 6 ]. (hindawi.com)
  • Function
  • Given its important role as mediator of glucocorticoid function in a wide variety of brain processes, including neuroprotection, apoptosis, and control of the neuroendocrine system, the results add ANXA1 to the growing list of rare candidate genetic etiological factors for ASD. (biomedcentral.com)
  • known
  • However, very little is known about the role of Otx genes in further decisions involving the allocation of midbrain neuronal fates under the influence of Fgf8 and Shh induction. (biologists.org)
  • functions
  • SOX‐2 functions cooperatively with the OTX/OTD transcription factor CEH‐36 to specify an AWC "ground state," and functions with the LIM homeodomain factor LIM‐4 to suppress this ground state and drive an AWB identity instead. (embopress.org)
  • Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs (Szeto, 1996). (sdbonline.org)