Otx gene otx transcription factors. Medical search. Frequent questions

It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. (nih.gov)
It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. (nih.gov)
Our observations indicate that the SCL transcription factor, a member of the basic helix-loop-helix family of proteins, is important for the long-term maintenance of hematopoietic stem cells. (umontreal.ca)
Interestingly, the genes coding for these three proteins are often activated in childhood T cell leukemias. (umontreal.ca)
These proteins are transcription factors that control developmental pathways. (nih.gov)
Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. (ouhsc.edu)
In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
This graph shows the total number of publications written about "Nuclear Factor 90 Proteins" by people in this website by year, and whether "Nuclear Factor 90 Proteins" was a major or minor topic of these publications. (ouhsc.edu)
Below are the most recent publications written about "Nuclear Factor 90 Proteins" by people in Profiles. (ouhsc.edu)
In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)

OTX2 is a 289 amino acid containing protein encoding a member of the bicoid sub-family of homeodomain-containing transcription factors. (thermofisher.com)
The Otx1 and Otx2 genes are two murine orthologues of the Orthodenticle ( Otd ) gene in Drosophila . (biologists.com)
In this study, we examined, at different developmental stages, the inner ears of mice lacking both Otx1 and Otx2 genes. (biologists.com)
In mutant mice in which both copies of the Otx1 gene were replaced with a human Otx2 cDNA ( hOtx2 1 / hOtx2 1 ) , most of the defects associated with Otx1 −/ − mutants were rescued. (biologists.com)
Role of Otx1 and Otx2 in brain evolution: functional equivalence between the invertebrate Orthodenticle and the murine OTX1 and OTX2 gene products supports a conserved genetic program of brain development between insects and mammals. (cnr.it)
Using these devices, Otx2 and other head organizer TFs (for example, Lim1/Lhx1 (activator) or Goosecoid (repressor)) are able to upregulate or downregulate a large battery of target genes in the head organizer . (xenbase.org)
This analysis indicates that each Otx class is characterized by highly specific and conserved expression features in the presumptive RPE, where Otx1 and Otx2, but not Otx5, are transcribed at optic vesicle stages, in the differentiating neural retina, where Otx2 and Otx5 show a conserved dynamic expression pattern, and in the forming ciliary process, a major site of Otx1 expression. (ox.ac.uk)

Head specification by the head -selector gene, orthodenticle (otx), is highly conserved among bilaterian lineages. (xenbase.org)
The mammalian Crx genes are highly divergent representatives of the Otx5 gene family, a gnathostome orthology class of orthodenticle-related homeogenes involved in the differentiation of retinal photoreceptors and circadian entrainment. (ox.ac.uk)
The mammalian Crx genes are highly divergent orthodenticle (otd)-related homeogenes that play important roles in the differentiation of retinal photoreceptors and the circadian entrainment. (ox.ac.uk)

Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene . (en-academic.com)
1992). "A conserved retina-specific gene encodes a basic motif/leucine zipper domain" . (en-academic.com)

It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE. (rush.edu)

An orthology relationship of these genes with the highly conserved Otx5 genes identified in fish and amphibians, and also expressed in the eye and epiphysis, has been proposed previously but remains controversial. (ox.ac.uk)

Cone-rod homeobox protein is a protein that in humans is encoded by the CRX gene. (wikipedia.org)
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. (wikipedia.org)
The whole mitogenome of O. conispadiceus is 16,027 basepairs (bp) in length with a base composition of 41.4% A, 34.8% T, 16.1% C, 7.7% G and contains 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a major non-coding region (MNR). (tonmo.com)
The molecular mechanism underlying TAZ-AS202 function does not involve change of TAZ expression or activity, but increases the protein level of the transcription factor E2F1, which in turn regulates the expression of a large set of target genes, including the EPHB2 receptor. (bvsalud.org)

They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)

These data indicate that specific functions selectively involving each Otx orthology class were fixed prior to the gnathostome radiation and highlight the prominent role of regulatory changes in the functional diversification of the multigene family. (ox.ac.uk)

In the developing mouse embryo, both Otx genes are expressed in the rostral head region and in certain sense organs such as the inner ear. (biologists.com)
Here, we use mathematical modeling to demonstrate that geometry dictates the neural-epidermal cell fate choice in the 32-cell stage ascidian embryo by a two-step process involving first the modulation of ERK signaling and second, the expression of the neural marker gene, Otx. (bvsalud.org)
In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described cytokeratin 5 (K5)-Cre gene construct is expressed in early embryo development. (shengsci.com)
Cleavage asynchrony in the Tubifex embryo: involvement of cytoplasmic and nucleus-associated factors. (shengsci.com)

Simulations also predict in which conditions the dual control of gene expression by an activator and a repressor that are both under the control of ERK can induce a robust ON/OFF control of neural fate induction. (bvsalud.org)
The splicing co-factor Barricade/Tat-SF1, is required for cell cycle and lineage progression in Drosophila neural stem cells. (unibas.ch)
The identification of neural crest specification genes expressed in the neural plate of basal chordates, in addition to the discovery of pigmented migratory cells in ascidians, has challenged this hypothesis. (biomedcentral.com)
To determine the origin of neural crest genes, we analyzed Phenotype Ontology annotations to select genes that control the development of this tissue. (biomedcentral.com)
Of neural crest genes, 9% are vertebrate innovations. (biomedcentral.com)
Our comparative analyses show that, among different tissues, the neural crest exhibits a particularly high rate of gene emergence during vertebrate evolution. (biomedcentral.com)
A remarkable proportion of the new neural crest genes encode soluble ligands that control neural crest precursor specification into each cell lineage, including pigmented, neural, glial, and skeletal derivatives. (biomedcentral.com)
We propose that the evolution of the neural crest is linked not only to the recruitment of ancestral regulatory genes but also to the emergence of signaling peptides that control the increasingly complex lineage diversification of this plastic cell population. (biomedcentral.com)
Secreted from neighboring tissues, signaling molecules of the Wnt, Fgf, and Bmp families cooperate to activate a distinct combination of transcription factors at the neural plate border. (biomedcentral.com)
A conserved role in neural development has also been reported from NK2.2 , suggesting that the NKL genes might have been primarily involved in neural development in the last common ancestor of bilaterians or at least nephrozoans (all bilaterians excluding xenacoelomorphs). (biomedcentral.com)

TAZ-AS202 regulates the expression of a set of genes belonging to cancer-associated pathways, including WNT and EPH-Ephrin signaling. (bvsalud.org)
NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. (biomedcentral.com)

Role of unequal crossing-over in the evolution of ribosomal genes. (cnr.it)
Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)

MYC is a master transcription factor that regulates cell proliferation, differentiation and apoptosis and plays a significant role in more than 50% of all human cancers. (omegatherapeutics.com)
It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES . (nih.gov)

Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development. (cnr.it)
Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)
NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. (ouhsc.edu)

CRX is a divergent duplicate of OTX produced during the 2 rounds of vertebrate whole genome duplication. (wikipedia.org)

Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
However, the molecular mechanisms by which Otx and other transcription factors (TFs) interact with the genome to direct head formation are largely unknown. (xenbase.org)

Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. (nih.gov)
Expression analysis of several Hox genes in human embryos. (cnr.it)
Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)
Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities. (cnr.it)
Co-expression of these genes in X. tropicalis early gastrula embryos was shown with in situ hybridization using hemisections. (xenbase.org)
Comparative analysis of gnathostome Otx gene expression patterns in the developing eye: implications for the functional evolution of the multigene family. (ox.ac.uk)
We have performed a detailed analysis of the expression pattern of the three gnathostome Otx classes in order to gain new insights into their functional evolution. (ox.ac.uk)
The model describes signal transduction by the ERK pathway that is stimulated by FGF and attenuated by ephrin, and ERK-mediated control of Otx gene expression, which involves both an activator and a repressor of ETS-family transcription factors. (bvsalud.org)
Considering the measured area of cell surface contacts with FGF- or ephrin-expressing cells as inputs, the solutions of the model reproduce the experimental observations about ERK activation and Otx expression in the different cells under normal and perturbed conditions. (bvsalud.org)
Some recent studies revealed that MSCs from myeloma patients (MM-hMSCs) show an enhanced spontaneous and myeloma cell-induced production of cytokines and a distinctive gene expression profile, when compared to MSCs from normal donors (ND-hMSCs). (vub.be)
In this study, we observed that MM-hMSCs, especially for those from MM patients with bone lesions, exhibited in the presence of osteogenic differentiation (OD) medium, significantly decreased alkaline phosphatase (ALP) activity, reduced expression of specific osteogenic markers (OPN, BMP2, OTX and BSP) and impaired matrix mineralization, compared to ND-hMSCs. (vub.be)
When the NOTCH signalling inhibitor DAPT was added to MM-hMSCs in OD medium, we found that hes1 expression was suppressed while, RUNX2 expression, a key transcription factor for osteoblastogenesis, as well as ALP activity, osteogenic genes expression and mineralization deposition were all increased. (vub.be)
Our results, along with those on Otx - and Hox -gene expression, demonstrate that the cephalopod condition is similar to that in mouse and fruit fly, with Otx being expressed in the anterior-most brain region (except for the vertical lobe) and a Pax2/5/8 expression domain separating the Otx -domain from a Hox -gene-expressing posterior brain region. (biomedcentral.com)
A coordinated tempo-spatial expression of transcription factors is required for cell type specification and the differentiation of the three germ layers into distinct organ systems during bilaterian ontogeny [ 1 ]. (biomedcentral.com)
For inferences concerning the evolutionary conservation versus plasticity of transcription factor expression patterns and their putative roles, a broad comparative approach is imperative. (biomedcentral.com)
OTX-2002 is an mRNA therapeutic delivered via lipid nanoparticles (LNPs) designed to downregulate MYC expression pre-transcriptionally through epigenetic modulation while potentially overcoming MYC autoregulation. (omegatherapeutics.com)
OTX-2002 has demonstrated the ability to control MYC expression pre-transcriptionally in multiple preclinical studies, including the successful downregulation of MYC in non-human primates. (omegatherapeutics.com)
By pre-transcriptionally modulating gene expression, Omega's approach enables controlled epigenomic modulation of nearly all human genes, including historically undruggable and difficult-to-treat targets, without altering native nucleic acid sequences. (omegatherapeutics.com)
To further investigate the ancestral roles of NK family genes, we analyzed the expression patterns of NKL genes in the onychophoran Euperipatoides rowelli . (biomedcentral.com)
Our data for the remaining seven NKL genes revealed expression in different structures associated with the developing nervous system in embryos of E. rowelli . (biomedcentral.com)
Hence, future studies should focus on the expression of these genes in other bilaterians, which would provide a basis for comparative studies and might help to better understand the role of NK genes in the diversification of bilaterians. (biomedcentral.com)
On reception of a differentiation signal, the stochiometry tips in favor of SCL, thus overriding the repressive effect of ETO2 and allowing for activation of a gene expression program controlled by the SCL complex, i.e. erythroid genes and antiproliferative genes (p21Cdkn1a, Gfi-1b). (umontreal.ca)
By contrast, the development of the midbrain and forebrain, which lie within the Otx expression domain, is regulated by signalling centres generating graded patterning cues. (biomedcentral.com)
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. (harvard.edu)

Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex). (cnr.it)
They also indicate that a duplication event has taken place in actinopterygians, after the splitting of the Cladistia, and that a relaxation of the structural constraints acting on the gene coding region has occurred early in the mammalian lineage. (ox.ac.uk)

We observe that SCL blocks thymocyte differentiation and induces leukemia in transgenic mice by disrupting a combinatorial code between the E2A, HEB transcription factors and signalling by the pre-TCR. (umontreal.ca)
Finally, our recent work indicates that myeloid differentiation is controlled by a distinct transcriptional complex which implicates the PU.1, c-Jun and C/EBPb transcription factors. (umontreal.ca)

Sequence-specific transcription factor that binds gene promoters and activates their transcription. (affbiotech.com)

Mice carrying floxed alleles of the nonmuscle myosin II heavy chain gene (NMHC IIA(flox. (shengsci.com)

In the eutherian mammals, CRX has again duplicated by tandem gene duplication, with six ancestral duplicates, which are collectively referred to as ETCHbox genes. (wikipedia.org)

The lack of comparative data for many of the remaining NKL genes, including Bari , Hhex and Nedx currently hampers further evolutionary conclusions. (biomedcentral.com)

Previous studies have demonstrated that transcription factors such as Pax genes play important roles during their development. (biomedcentral.com)

However, their evolutionary origin and orthological relationships with other otd-related genes remain unclear. (ox.ac.uk)

Mutations in this gene are associated with photoreceptor degeneration, Leber's congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. (wikipedia.org)

Phylogenetic analyses of the coding sequences show that the mammalian Crx genes are orthologous to the Otx5-related genes isolated in other gnathostomes. (ox.ac.uk)

There are currently 20 retinal genes whose mutations cause the phenotype of LCA, accounting for about 70% of the cases, while the genes underlying the remaining 30% of patients await discovery. (aao.org)
Visual acuity (VA) in children with LCA varies significantly among patients with differing gene mutations and can be as low as no light perception (NLP). (aao.org)
Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. (en-academic.com)

Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. (wikipedia.org)

We found by quantitative real time PCR that NOTCH1, NOTCH2, Dll-1, Jagged-1, and NOTCH pathway downstream genes hes1, hey1, hey2, heyL were considerably decreased in ND-hMSCs after shifting them from normal culture medium to OD medium, indicating that NOTCH signalling was gradually suppressed during MSC osteogenesis. (vub.be)
Pharmacological disruption of the Notch transcription factor complex. (harvard.edu)

An underlying principle is that Otx marks target genes for head specification to be regulated positively or negatively by partner TFs through specific types of CRMs. (xenbase.org)

They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (childrensmercy.org)

To test this hypothesis, we have identified Crx genes in a wide range of mammals, including three marsupials, and Otx5-related genes in a lizard, a turtle, and two archosaurs (crocodile and chick), as well as in the pufferfish. (ox.ac.uk)

A multimeric complex that functions as a ligand-dependent transcription factor. (nih.gov)

Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer. (cnr.it)

Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. (zfin.org)
Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
Real-World Study of Regional Differences in Patient Demographics, Clinical Characteristics, and BRCA1/2 Mutation Testing in Patients with Human Epidermal Growth Factor Receptor?2-Negative Advanced Breast Cancer in the United States, Europe, and Israel. (jefferson.edu)
Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)

A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG. (ucdenver.edu)

The prototype of this family is the mouse Brachyury (or T) gene product. (nih.gov)
Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)

p300-CBP Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Host Cell Factor C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)

Although these genes are found in various metazoans, plants, fungi and even unicellular eukaryotes, bilaterians have evolved the largest diversity of homeobox genes that arose predominantly due to extensive tandem duplications [ 2 , 4 , 5 ]. (biomedcentral.com)

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (zfin.org)

Isolation and characterization of alternative messenger RNAs coding class I HLA genes. (cnr.it)
CAMBRIDGE, Mass., Sept. 25, 2023 (GLOBE NEWSWIRE) -- Omega Therapeutics, Inc. (Nasdaq: OMGA) ("Omega"), a clinical-stage biotechnology company pioneering the development of a new class of programmable epigenomic mRNA medicines, today announced that management will host a conference call and webcast to discuss preliminary clinical data from the ongoing Phase 1/2 MYCHELANGELO™ I trial of OTX-2002 on Tuesday, September 26, 2023, at 8:00 a.m. (omegatherapeutics.com)
The homeobox genes of animals are categorized into eleven classes, with the Antennapedia class (ANTP) being one of the largest, comprising the Hox, ParaHox and NK gene families [ 5 , 9 ]. (biomedcentral.com)

Additionally, OTX-2002 has shown robust anti-tumor activity alone and in combination with standard of care therapies in vivo in multiple preclinical models of HCC. (omegatherapeutics.com)
MYCHELANGELO I ( NCT05497453 ) is a Phase 1/2 open label trial evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of OTX-2002 as a monotherapy (Part 1) and in combination with standard of care therapies (Part 2) in patients with relapsed or refractory HCC and other solid tumor types known for association with the MYC oncogene. (omegatherapeutics.com)

Anatomy4

Organisms3

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes24

Information Science3

Proteins11

Otx27

Orthodenticle3

Retina2

GENETIC TRANSCRIPTION2

Highly conserved1

Protein4

Cell Differentiation1

Orthology1

Embryo4

Neural10

Pathways2

Ribosomal2

Regulates2

Murine3

Divergent1

Molecular2

Expression24

Structural2

Differentiation2

Binds1

Mice1

Ancestral1

Comparative1

Play important roles1

Evolutionary1

Photoreceptor1

Orthologous1

Mutations3

Variants1

NOTCH2

Specification1

Basal1

Mammals1

Complex1

Identification1

Human4

Primarily1

Family2

Descriptor3

Tandem1

Sequence1

Class3

Activity2