• The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (nih.gov)
  • The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (0.625 mg) alone, relative to placebo. (ziprx.ca)
  • The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years and older during 5.2 years of treatment with daily conjugated estrogens (0.625 mg) alone, relative to placebo. (ziprx.ca)
  • The suppression of bone turnover markers was evident by months and persisted throughout the 36-month and 24-month observation periods.In 31-week, open-label, radiocalcium kinetics study, 33 early postmenopausal women were randomized to treatment with once-daily raloxifene hydrochloride tablets 60 mg, cyclic estrogen/progestin (0.625 mg conjugated estrogens daily with mg medroxyprogesterone acetate daily for the first weeks of each month [hormone therapy]), or no treatment. (drugcentral.org)
  • A dosage of 50 mg once every 2 to 4 weeks by intramuscular injection is used in the prevention and treatment of postmenopausal osteoporosis and in the palliative treatment of inoperative breast cancer. (wikipedia.org)
  • Nursing Mothers: Estrogen administration to nursing women has been Prevention of postmenopausal osteoporosis shown to decrease the quantity and quality of breast milk. (gotomydoctor.com)
  • Women taking conjugated estrogens/bazedoxifene should not take additional estrogens. (ziprx.ca)
  • Estradiol Tablets USP for oral administration contains 0.5, 1 or 2 mg of micronized estradiol, USP per tablet. (nih.gov)
  • Bazedoxifene is a selective estrogen receptor modulator (SERM) that acts as a partial estrogen receptor agonist and helps maintain bone mineral density while at the same time acting as an estrogen receptor antagonist in breast tissue and the uterus. (ziprx.ca)
  • Raloxifene is an estrogen agonist/antagonist, commonly referred to as selective estrogen receptor modulator (SERM). (drugcentral.org)
  • Conjugated estrogens/bazedoxifene has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. (ziprx.ca)
  • Bazedoxifene+Conjugated Equine Estrogens, Duavive/Duavee is officially indicated for vasomotor symptoms associated with menopause and osteoporosis prevention in women with a uterus. (ziprx.ca)
  • Eenclomiphene is a non-steroidal estrogen receptor antagonist in development for secondary hypogonadism in overweight men wishing to restore normal testicular function. (fr.nf)
  • It is used to prevent osteoporosis (weak bones) after menopause in certain patients. (globaldiscountpill.com)
  • Generic Evista is used for treating and preventing osteoporosis (bone thinning) in women who are past menopause. (healthylifemeds.com)
  • Generic Femara - hormonal remedy, with Letrozole as an active ingredient, which lowers estrogen level in woman after menopause. (healthylifemeds.com)
  • After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. (nih.gov)
  • No adequate evidence supports that estrogens are effective for nervous symptoms or depression that might occur during menopause, and they should not be used to treat these conditions. (medscape.com)
  • Decreases in estrogen levels after oophorectomy or menopause lead to increases in bone resorption and accelerated bone loss. (drugcentral.org)
  • Treatment of moderate to severe vasomotor symptoms due to menopause )  Treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to Limitation of Use: When prescribing solely for the treatment of moderate to severe Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism. (gotomydoctor.com)
  • Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. (nih.gov)
  • To date, two estrogen receptors have been identified. (nih.gov)
  • The biological actions of raloxifene are largely mediated through binding to estrogen receptors. (drugcentral.org)
  • Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through a negative feedback mechanism. (nih.gov)
  • Estrogens are intricately involved with other hormones, especially progesterone, in the processes of ovulatory menstrual cycle and pregnancy and affect release of pituitary gonadotrophins. (medscape.com)
  • Estradiol is the principal female estrogen and inhibits the pituitary release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) thereby inhibiting ovulation through a negative feedback system. (ziprx.ca)
  • FOSAMAX is indicated for the treatment and prevention of osteoporosis in postmenopausal women. (merck.com)
  • ACTONEL is indicated for the treatment and prevention of osteoporosis in postmenopausal women. (guidelinecentral.com)
  • Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. (oncology-drugs.net)
  • Estrogens with or without progestins should not be used for the prevention of cardiovascular disease. (nih.gov)
  • Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. (nih.gov)
  • CONJUGATED ESTROGENS are mostly used as hormone replacement in menopausal women. (globaldiscountpill.com)
  • Nandrolone decanoate, sold under the brand name ROLON among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women. (wikipedia.org)
  • There is no evidence that the use of "natural" estrogens results in a different endometrial risk profile than "synthetic" estrogens at equivalent estrogen doses. (nih.gov)
  • In the absence of comparable data, these risks should be assumed to be similar for other doses of conjugated estrogens and other dosage forms of estrogens. (ziprx.ca)
  • Estrogens should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman. (ziprx.ca)
  • In any case, nandrolone decanoate has widely been used at low doses as a means of androgen replacement in postmenopausal women, for instance to maintain or increase bone mineral density and decrease the risk of osteoporosis. (wikipedia.org)
  • Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol at the receptor level. (nih.gov)
  • Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women. (nih.gov)
  • These results are consistent with findings in clinical trials, which suggest that raloxifene hydrochloride lacks estrogen-like effects on the uterus and breast tissue. (drugcentral.org)
  • It is metabolized mainly in the liver and excreted in the urine as sulfate and glucuronide conjugates. (drugs.com)
  • The liver is the primary site for estrogen clearance, an adequate level of vitamin B is also necessary for estrogen clearance from the body. (healingmoringatree.com)
  • Close clinical surveillance of all women taking estrogens is important. (nih.gov)
  • It is unknown whether this finding applies to younger postmenopausal women or to women taking estrogen alone therapy. (nih.gov)
  • The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. (nih.gov)
  • Nandrolone decanoate is approved in the United States specifically for the treatment of anemia of chronic kidney disease and in the United Kingdom specifically for the treatment of osteoporosis in postmenopausal women. (wikipedia.org)
  • In Australia, it is approved specifically for the treatment of kidney failure, chronic kidney disease, anemia of kidney failure, aplastic anemia, osteoporosis (in women in whom estrogens are contraindicated), inoperable breast cancer, and for patients on long-term corticosteroid therapy. (wikipedia.org)
  • Vertebral fractures are the most common type of osteoporotic fracture in postmenopausal women.In both the osteoporosis treatment and prevention trials, raloxifene hydrochloride tablets therapy resulted in consistent, statistically significant suppression of bone resorption and bone formation, as reflected by changes in serum and urine markers of bone turnover (e.g., bone-specific alkaline phosphatase, osteocalcin, and collagen breakdown products). (drugcentral.org)
  • Detectable Limitation of Use: When prescribing solely for the treatment of postmenopausal amounts of estrogens have been identified in the breast milk of women osteoporosis, therapy should only be considered for women at significant risk of receiving estrogens osteoporosis and non-estrogen medications should be carefully considered. (gotomydoctor.com)
  • ACTONEL is indicated for the treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoid treatment (daily dosage of greater than or equal to 7.5 mg of prednisone or equivalent) for chronic diseases. (guidelinecentral.com)
  • It is also used for estrogen replacement therapy after failure of the ovaries and to relieve the symptoms of breast cancer. (healthylifemeds.com)
  • Do not use estrogen therapy for the prevention of cardiovascular disease. (ziprx.ca)
  • Do not use estrogen therapy for the prevention of dementia. (ziprx.ca)
  • In New Zealand, it is approved for osteoporosis, inoperable breast cancer, and as an adjunct to therapy for conditions characterized by a negative nitrogen balance. (wikipedia.org)
  • In vitro and in vivo studies have shown that estrogens are metabolized partially by cytochrome P450 3A4 (CYP3A4). (pfizermedicalinformation.com)
  • Inducers of CYP3A4, such as St. John's Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. (pfizermedicalinformation.com)
  • Estrogens diffuse through cell membranes, distribute themselves throughout the cell, and bind to and activate the nuclear estrogen receptor, a DNA-binding protein found in estrogen-responsive tissues. (medscape.com)
  • Preclinical data demonstrate that raloxifene is an estrogen antagonist in uterine and breast tissues. (drugcentral.org)
  • The agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptor (ER) target gene promoters.Raloxifene appears to act as an estrogen agonist in bone. (drugcentral.org)
  • The activated estrogen receptor binds to specific DNA sequences or hormone-response elements, which enhances transcription of adjacent genes and, in turn, leads to the observed effects. (medscape.com)
  • Estrogen is a steroid hormone that supports the development and function of the female reproductive system, secondary sex characteristics and urogenital structures. (ziprx.ca)
  • Objective: To compare the efficacy of perioperative vaginal estrogen vs placebo cream on prolapse recurrence following native tissue surgical prolapse repair. (bvsalud.org)
  • Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. (nih.gov)
  • It is also used in certain patients to treat low estrogen levels, prostate cancer or breast cancer. (globaldiscountpill.com)
  • Clinicians may recommend vaginal estrogen in an effort to reduce prolapse recurrence, but the effects of intravaginal estrogen on surgical prolapse management are uncertain. (bvsalud.org)