Chemicals and DrugsPhenomena and ProcessesDisciplines and OccupationsInformation Science
OsteopontinSialoglycoproteinsEncyclopedias as TopicMoonChemotaxisNeurobiologyMedlinePlus
Spp1Differentially expressed genesOsteocalcinExtracellular matrixRole for osteopontinVariantsPolymorphismsBoneMineral depositionGlycoproteinAlkalineExonsSusceptibilityCytokineInducesEncodesAntigenPromoterCol1SNPsMiceInflammatoryReceptorsRenalProgressionDifferentiationVascularProteinsSynthesisTissuesMarkerMultiple sclerosisEnzymeConcentrationsBiologyTumorigenesisExpression patternsMutationsPathwaysTissueGeneticFunctionalCellsHumanReceptorContributesMicroarraySarcoidosisClinical data
Spp15
  • Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). (wikipedia.org)
  • Osteopontin (SPP1, OPN) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases. (iucc.ac.il)
  • Osteopontin (SPP1) upregulation increased from 30-fold at Day 30 to 45-fold at Day 14. (thejns.org)
  • OPN is encoded by the SPP1 gene , which is comprised of 7 exons and is located on the long arm of chromosome 4 near four other SIBLING (small integrin-binding N-linked glycoproteins) that are contained in bine and dentin - bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE). (shu.edu)
  • It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
Differentially expressed genes2
  • Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
  • Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
Osteocalcin5
  • The expression of gene transcripts for Runx2, Bmp2, Fgfr1, collagen type 1 (Col1), osteocalcin (Oc), and osteopontin (Op) were evaluated by real-time RT-PCR. (techscience.com)
  • Osteoblast cultures of neonates exposed to maternal hyperthyroidism also showed a larger total area of mineralized matrix and greater expression of gene transcripts for Oc and Op. Maternal hyperthyroidism increases the activity of matrix synthesis, alkaline phosphatase activity, and expression of gene transcripts for osteocalcin and osteopontin in the osteoblasts, extracted from the calvaria of the offspring, which may be one of the mechanisms of premature fusion of cranial sutures. (techscience.com)
  • Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
  • Results published online in the Journal of Clinical Endocrinology and Metabolism showed the additive-enhanced diet significantly increased circulating fibroblast growth factor 23 (FGF-23), osteopontin, and osteocalcin concentrations by 23%, 10%, and 11%, respectively, and decreased sclerostin. (renalandurologynews.com)
  • The investigators performed a parallel study in animals and found similar results: FGF-23, osteopontin and osteocalcin increased, whereas sclerostin decreased. (renalandurologynews.com)
Extracellular matrix3
  • Osteopontin-c has been suggested to facilitate the anchorage-independent phenotype of some human breast cancer cells due to its inability to associate with the extracellular matrix. (wikipedia.org)
  • The lists of up- and downregulated genes were cross-matched with lists of genes known to be associated with cytokines or the extracellular matrix. (thejns.org)
  • The effects of MAGP-1 in the expression of genes involved in the extracellular matrix (ECM) remodelling and tumorigenesis in HT-29 cells was also explored. (cun.es)
Role for osteopontin1
  • The data support an important role for osteopontin in bladder cancer, and identify several pathways worthy of further investigation. (urotoday.com)
Variants6
  • The cancer-specific splice variants are osteopontin-a, osteopontin-b, and osteopontin-c. (wikipedia.org)
  • Objective To determine whether plasma OPN levels are elevated in patients with sarcoidosis and compare the frequency of four single nucleotide polymorphism (SNPs) variants in the OPN gene in sarcoidosis patients compared to healthy controls. (iucc.ac.il)
  • Several transcript variants encoding different isoforms have been found for this gene. (origene.com)
  • Splice variants of osteopontin (OPN). (shu.edu)
  • Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. (antibodies-online.com)
  • Study the impact of common variants in the genes encoding for GIP, the GIP degrading enzymes dipeptidyl peptidases (DPPs), and OPN on diabetic complications. (lu.se)
Polymorphisms8
  • Nevertheless, the effects of the RAN and RANBP2 gene polymorphisms on the tumorigenesis of Wilms tumor remain unclarified. (jcancer.org)
  • The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. (medsci.org)
  • We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). (medsci.org)
  • A body of studies suggests the role of osteopontin (OPN) in onset and development of osteoarthritis (OA), however, the association between OPN polymorphisms and OA susceptibility as well as its clinical features has not been reported. (biomedcentral.com)
  • Three polymorphisms of OPN gene, namely, -156GG/G, -443C/T and -66T/G were determined. (biomedcentral.com)
  • Our findings suggest that certain OPN gene polymorphisms may be used as molecular markers for the susceptibility and severity of OA. (biomedcentral.com)
  • Several polymorphisms in the human OPN encoding gene have been identified in different populations, of which the -156 GG/G, -443C/T and -66T/G polymorphisms were mostly studied. (biomedcentral.com)
  • We carried out a case-control study to clarify whether the abovementioned genetic polymorphisms in the OPN gene are associated with the susceptibility and severity of OA in a Chinese cohort. (biomedcentral.com)
Bone11
  • Osteopontin is an extracellular structural protein and therefore an organic component of bone. (wikipedia.org)
  • The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells. (medlineplus.gov)
  • During bone remodeling, osteopontin is turned on (activated), allowing osteoclasts to attach (bind) to bones. (medlineplus.gov)
  • When the breakdown of bone is complete, TRAP5b turns off (inactivates) osteopontin, causing the osteoclasts to release themselves from bone. (medlineplus.gov)
  • Like TRAP5b in bone cells, the TRAP5a enzyme inactivates osteopontin in macrophages and dendritic cells when it is no longer needed. (medlineplus.gov)
  • As a result, osteopontin is abnormally active, prolonging bone breakdown by osteoclasts and triggering abnormal inflammation and immune responses by immune cells. (medlineplus.gov)
  • Bone mineralization and inflammation genes increase in muscles as a consequence of age and performance of a high repetition task. (cdc.gov)
  • Our purpose was to examine expression patterns of genes related to bone mineralization and inflammation in flexor forelimb muscles from young adult and aged (16 months) rats performing a repetitive reaching and grasping task. (cdc.gov)
  • A significant upregulation of Osteoactivin, a gene related to bone mineralization, was found in aged rats (both control and task), while alpha-2-HS-glycoprotein was significantly down-regulated in young adult 3 week HRLF task rats only. (cdc.gov)
  • These results show that a high repetition-low force reaching and grasping task induces genes related to both inflammation and bone mineralization in muscle tissues, suggesting that these molecules play a role in either inflammation or injury healing. (cdc.gov)
  • The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. (origene.com)
Mineral deposition1
  • The increase in ALP, mineral deposition, and osteoblastic genes induced by the mechanical stretch-EPO combination was inhibited by U0126, an ERK1/2 inhibitor. (hindawi.com)
Glycoprotein4
  • Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts. (wikipedia.org)
  • Background: The Osteopontin (OPN) is a highly phosphorylated glycoprotein in numbers of bovine tissues and milk. (ijbiotech.com)
  • Osteopontin is a highly phosphorylated glycoprotein and is expressed in several tissues (13). (ijbiotech.com)
  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (antibodies-online.com)
Alkaline1
  • GDF-5 also increased the gene expression and enzyme activity of alkaline phosphatase. (ispub.com)
Exons3
  • The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322.1). (wikipedia.org)
  • The OPN gene is composed of 7 exons, 6 of which containing coding sequence. (wikipedia.org)
  • The exons of the osteopontin gene are highlighted as boxes. (shu.edu)
Susceptibility1
  • The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis. (cdc.gov)
Cytokine3
  • Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS) plaques. (unict.it)
  • Accordingly, the CD44v7 ligand osteopontin, whose levels were elevated in Crohn's disease, specifically induced IL-6 in human monocytes, a cytokine also increased in these patients. (nature.com)
  • In these studies we explore the role of GIP, its receptor GIPR and their genetic variation, as well as their downstream target, the cytokine osteopontin (OPN) in the development of vascular complications of diabetes. (lu.se)
Induces1
  • OPN induces gene expression changes in a model of breast cancer that reflect the six hallmarks of cancer. (shu.edu)
Encodes1
  • Osteopontin gene (OPN) and PPARGC1A are located in the middle of chromosome 6 about 6 Mb apart, which is approximately 12 cM (6) and encodes osteopontin, the prime candidate among the six genes in the 420 Kb region (9). (ijbiotech.com)
Antigen1
  • Osteopontin (OPN) expression is modulated by Schistosoma mansoni egg antigen. (wikipedia.org)
Promoter2
  • This is due to the presence of a high-specificity vitamin D response element (VDRE) in the OPN gene promoter. (wikipedia.org)
  • They indicated that the Tn motif in OPN-3907, bears an osteopontin regulator element at further up to the gene promoter. (ijbiotech.com)
Col11
  • Runx2 (aka Cbfa1) and osterix (Osx) transcription factors are required for the expression of OPN Runx2 and Osx bind promoters of osteoblast-specific genes such as Col1α1, Bsp, and Opn and upregulate transcription. (wikipedia.org)
SNPs2
  • Blood samples were analyzed for SNPs of the OPN gene and for plasma OPN and CRP levels. (iucc.ac.il)
  • We found no evidence for an association between SNPs on the osteopontin gene and plasma OPN levels or the presence of sarcoidosis, however, an association between genotype and several phenotypic clinical parameters of disease was observed. (iucc.ac.il)
Mice1
Inflammatory3
  • Inflammatory MCP-1 and fibrosis (collagen, fibronectin, plasminogen activator inhibitor-1, and osteopontin) renal biomarkers were significantly reduced in the CXA-10 (2.5 mpk) group. (aspetjournals.org)
  • These animals developed the lung disease in three to four months, with certain inflammatory cells and genes proving crucial to the process. (doctorshealthpress.com)
  • These cells included the gene for "osteopontin," which promotes initiation of the inflammatory cascade that damages lungs. (doctorshealthpress.com)
Receptors3
  • Although most cells have vitamin D receptors, several key genes that encode proteins and peptides are modulated in part by vitamin D and thus affect musculoskeletal functions, mitochondrial respiration, cell growth, proliferation, differentiation, and apoptosis [13]. (vitamindwiki.com)
  • Investigators have demonstrated other substrates for factor XIIIa, including proteins such as osteopontin, factor V, thrombospondin, vinculin, and endothelial cell receptors α v β 3 integrin and VEGFR-2. (medscape.com)
  • Recent investigators have demonstrated other substrates for factor XIIIa, including proteins such as osteopontin, factor V, thrombospondin, vinculin, and endothelial cell receptors avb3 and VEGFR-2. (medscape.com)
Renal1
  • These results suggest that changes in dietary phosphorus consumption can influence gene expression in different tissues even with normal renal function," the investigators commented. (renalandurologynews.com)
Progression1
  • Interferon-induced transmembrane protein 1 (IFITM1) is essential for progression of laryngeal squamous cell carcinoma in an Osteopontin/NF-κB-dependent manner. (nih.gov)
Differentiation6
  • In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
  • Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
  • An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
  • The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
  • Microarray analysis of MSC during osteogenic differentiation identified three candidate genes for further examination and functional analysis: ID4, CRYAB, and SORT1. (biomedcentral.com)
  • Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)
Vascular1
  • Low shear stress up-regulates expression of vascular cell adhesion molecule 1 (VCAM-1), while increased shear stress can lead to increased gene expression of intercellular adhesion molecule 1 (ICAM-1). (medscape.com)
Proteins1
  • osteopontin and cystatin C. In an independent multivariate orthogonal projection to latent structures discriminant analysis (OPLS-DA), these proteins were also identified as major contributors to the separation between AD and non-AD in both cohorts. (lu.se)
Synthesis1
Tissues1
  • Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
Marker1
  • Odontoblast marker gene levels, on the other hand, were significantly elevated after seven days of culture in the presence of GDF-5. (ispub.com)
Multiple sclerosis2
  • Genetic variation in the transforming growth factor beta1 gene in multiple sclerosis. (cdc.gov)
  • Osteopontin gene and clinical severity of multiple sclerosis. (cdc.gov)
Enzyme2
  • The ACP5 gene provides instructions for making an enzyme called tartrate-resistant acid phosphatase type 5 (TRAP). (medlineplus.gov)
  • The ACP5 gene mutations that cause SPENCDI typically change single protein building blocks (amino acids) in the TRAP enzyme or result in the production of an abnormally short enzyme. (medlineplus.gov)
Concentrations1
  • Circulating concentrations of MAGP-1 and its gene expression levels (MFAP2) in VAT were analysed. (cun.es)
Biology1
  • Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity. (nih.gov)
Tumorigenesis2
  • Osteopontin (OPN) is an integrin-binding protein overexpressed in various experimental models of malignancy and appears to be involved in tumorigenesis and metastasis. (aacrjournals.org)
  • The decreased levels of MAGP-1 in patients with obesity and CC together with its capacity to modulate key genes involved in ECM remodelling and tumorigenesis suggest MAGP-1 as a link between AT excess and obesity-associated CC development. (cun.es)
Expression patterns1
  • Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
Mutations4
  • At least 10 mutations in the ACP5 gene have been found to cause spondyloenchondrodysplasia with immune dysregulation (SPENCDI). (medlineplus.gov)
  • These mutations affect both TRAP isoforms and impair or eliminate TRAP's ability to inactivate osteopontin. (medlineplus.gov)
  • BACKGROUND: Spinal muscular atrophy (SMA) is caused by bi-allelic, recessive mutations of the survival motor neuron 1 (SMN1) gene and reduced expression levels of the survival motor neuron (SMN) protein. (bvsalud.org)
  • Inherited factor XIII deficiency is usually due to mutations in the gene encoding the catalytic A subunit, located on chromosome 6. (medscape.com)
Pathways1
  • In this study, we aim to leverage these metabolic changes as potential biomarkers for assessing ovarian cancer.A functional module-based approach was utilized to identify key gene expression pathways that distinguish different stages of ovarian cancer (OC) within a tissue biopsy cohort. (stanford.edu)
Tissue1
  • Osteopontin was markedly overexpressed in invasive cancer compared to healthy tissue. (urotoday.com)
Genetic2
  • A point mutation in the DGAT1 gene, which is responsible for nearly 43% of the genetic variation of fat percentage was identified (8). (ijbiotech.com)
  • The first genetic defect was described in 1995 by the discovery of the FAS gene mutation. (medscape.com)
Functional1
  • The EASE analysis yielded eight functional classes of gene expression. (thejns.org)
Cells4
  • Osteopontin performs a variety of functions in these cells. (medlineplus.gov)
  • In the immune system, osteopontin is found primarily in cells called macrophages and dendritic cells. (medlineplus.gov)
  • 2002). It has also been reported that the GDF-5 gene is expressed in dental sac, periodontal ligament, dental pulp cells, and odontoblasts during tooth development (Morotome et al. (ispub.com)
  • Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. (elifesciences.org)
Human2
Receptor1
  • It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). (antibodies-online.com)
Contributes1
  • The present study contributes to a growing body of work on gene expression signatures in bladder cancer. (urotoday.com)
Microarray1
  • Complementary DNA microarray analysis was performed for gene expression profiling. (thejns.org)
Sarcoidosis1
Clinical data1
  • The gene expression and clinical data of patients with DLBCL were downloaded from the Gene Expression Omnibus database. (biomedcentral.com)