Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens. (nih.gov)
Secreted modular calcium binding protein 1 (SMOC1) is an osteonectin/SPARC associated matricellular protein, whose expression is regulated by miR-223. (ncbcs.org)
En el sinónimo glicoproteína SPARC, la abreviatura representa Secreted Protein, Acidic and Rich in Cysteine (proteína segregada, ácida y rica en cisteína). (bvsalud.org)
Osteonectin/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis. (cdc.gov)
Matricellular1
This indicates a means to redirect calcium to activities such as vitellogenesis when this ion is in high demand.INTRODUCTION: Osteonectin is a unique matricellular calcium-binding glycoprotein and a major noncollagenous constituent of higher eukaryote bone. (ualg.pt)
Protein3
Isolation and characterization of piscine osteonectin and downregulation of its expression by PTH-related protein. (ualg.pt)
Moreover, an in vitro bioassay with S. auratus scales was specifically developed for measuring the effect of PTHrP on osteonectin expression.RESULTS AND CONCLUSIONS: Phylogenetic analysis showed that S. auratus osteonectin is highly homologous with previously reported osteonectins, supporting the idea of a conserved function for this protein in the ECM. (ualg.pt)
More specifically, the localization of the osteonectin mRNA in the basement membrane that separates the epithelia from the underlying mineralized connective tissue supports a role for this protein in calcified matrix turnover. (ualg.pt)
MRNA2
UNLABELLED: The skeleton is the main source of osteonectin mRNA in adults of the seawater teleost sea bream Sparus auratus. (ualg.pt)
PTHrP induced downregulation of osteonectin mRNA in vitro in scales, a mineralizing tissue with bone-like metabolism. (ualg.pt)
Osteopontin1
BSP (as well as other glycoproteins such as osteonectin and osteopontin) plays a regulatory role in bone metabolism, e.g. the control of mineralisation in the formation of new bones and bone resorption. (immundiagnostik.com)
Bone metabolism1
We have analyzed the immunohistochemical expression of three molecules involved in bone metabolism, namely osteonectin, TGF-b1, and BMP2/4. (bvsalud.org)
Expression2
Its high expression by fish scales provides a unique in vitro bioassay with which to study regulation of osteonectin gene expression by the recently isolated piscine PTH-related peptide (PTHrP).MATERIALS AND METHODS: An intervertebral tissue cDNA library from S. auratus was the source of the full-length cDNA clone for osteonectin. (ualg.pt)
Furthermore, the recently identified piscine hypercalcemic factor PTHrP downregulates osteonectin expression in scales, suggesting a catabolic action for this hormone on these structures. (ualg.pt)
Results1
Results: Osteonectin and BMP2/4 antibodies were positive in all cases. (bvsalud.org)
Factor1
In skeleton biology, osteonectin has been described as a positive factor in the mineralization process as well as in osteoblastic cell lineage differentiation and is downregulated by the hypercalcemic hormone PTH. (ualg.pt)
Osteocalcin8
Histologic evaluations, changes in genes and proteins expression of osteoprotegerin (OPG), RANK, RANKL, osteonectin (ONC), osteocalcin (OCC), bone sialoprotein (BSP), osteopontin (OPN) and bone morphognetic protein-2 (BMP-2) will be evaluated along with the changes in body weight, water intake and maxillary suture expansion rates. (fapesp.br)
HA-PMMA composites can enhance the activity of proteins associated with osseointegration such as BMP-2/4/7, AP, osteocalcin, osteonectin, and osteopontin in silico . (jppres.com)
HA-PMMA composites are potential candidates for dental implant biomaterials with the osteointegration ability through binding with BMP-2/4/7, AP, osteocalcin, osteonectin, and osteopontin in silico . (jppres.com)
These cells may also be in charge of the mineralization from the matrix through secretion of specific molecules, such as for example Alkaline phosphatase (ALP), Osteonectin and Osteocalcin that binds inorganic nutrients [17,18]. (ablkinase.com)
The requirement for specifically indicated genes in LGX 818 biological activity osteoblasts (e.g. em col1, osteocalcin /em and em osteonectin /em ) and chondrocytes (e.g. em col2 /em and em col10 /em ) to initiate the formation of matrix or control the growth of hydroxyapatite crystals is definitely supported by several studies [18,20,21]. (ablkinase.com)
Osteopontin3
After the routine follow-up on tissues, immunostaining of osteopontin and osteonectin antibodies was applied to sections and observed under a light microscope. (viamedica.pl)
The control group exhibited osteopontin and osteonectin expression in fibroblasts and inflammatory cells at the end of the 4th week with an acceleration at the 8th week. (viamedica.pl)
SILAC-based quantitative proteomics disclosed intricate protein composition alterations in the activin A ECM, including changed expression of collagen XII, osteonectin and several cytoskeleton-binding proteins. (eur.nl)
Here we show that phenytoin also reduces pro-collagen I production in osteoblast-like cells, but does not appear to cause a decrease in osteonectin message or protein production. (keele.ac.uk)
aka osteonectin or BM-40) can be an evolutionarily conserved collagen-binding proteins within IVDs. (labsmart.net)
also known as BM-40 and osteonectin) was initially recognized by Termine et al [5] like a bone-specific phosphoprotein that binds to collagen fibrils and hydroxyapatite at unique sites. (cancer-ecosystem.com)
Proteins1
L-ascorbic-2-phosphate and Dexamethasone docked within the binding pockets of ALPL, RunX2, MMP13, and Osteonectin proteins, expressed in the bone cells. (als-journal.com)
Fibronectin1
The extracellular matrix (ECM) is an insoluble supra-structure comprised of a variety of matrix components including fibronectin, glycosaminoglycans, chrondronectin, osteonectin, collagens, laminin, proteoglycans, and growth factors [ 1 - 6 ]. (hindawi.com)
Antibodies1
Results: Osteonectin and BMP2/4 antibodies were positive in all cases. (bvsalud.org)
Involved in bone1
We have analyzed the immunohistochemical expression of three molecules involved in bone metabolism, namely osteonectin, TGF-b1, and BMP2/4. (bvsalud.org)
Transcription factors1
These results were generally consistent with what has been observed in conjunction with the overexpression of adipogenesis- and osteogenesis-related transcription factors, including RXR, osteonectin, AP, and PPAR-gamma, after Oct4 mediated cell reprogramming ( Fig . 5A). (manchester.ac.uk)
Markers1
Subsequently, the expression of both the odontoblast markers dentine sialoprotein (DSP) and osteonectin (OSN) was studied in human pulp cells under the same conditions. (univ-amu.fr)
Genes1
The effect of validated RGs was then verified by normalization of lineage-specific genes (fatty acid binding protein 4 [ FABP4 ] and osteonectin [ ON ]) expressions during differentiations of bBMMSCs or POU class 5 homeobox 1 ( OCT4 ) expression between bBMMSCs and dermal skins. (animbiosci.org)
Role1
Unexpectedly, Kaplan-Singer s summer studies indicated that osteonectin does not affect cell proliferation, a result, he says, that suggests the need for a new approach to studying osteonectin s role. (nih.gov)
Change1
Instead, a 24 h exposure to a clinically relevant concentration of phenytoin resulted in a dose-dependent change in electrophoretic mobility of osteonectin, which was suggestive of a change in post-translational modification status. (keele.ac.uk)