• We studied the relationship between osteolysis and polyethylene wear, age at surgery, body mass index and height in 463 subjects (180 osteolysis and 283 controls) after cemented Charnley total hip arthroplasty (THA), in order to develop a kernel-based Bayesian model to quantitate risk of osteolysis. (royalsocietypublishing.org)
  • Osteolysis, resulting in aseptic loosening, is the most common factor limiting the survival of modern total hip arthroplasty (THA). (royalsocietypublishing.org)
  • However, much research remains to be done to completely understand the role of UHMWPE particles in osteolysis resulting from total hip arthroplasty. (kon.org)
  • 1) glenoid component wear was associated with humeral osteolysis, (2) stress shielding was associated with press-fit humeral implants, (3) there was a high rate of failure of glenoid components, especially those that were metal-backed and uncemented, (4) the revision rate for hemiarthroplasty was lower that that for total shoulder arthroplasty. (clinicadehombro.com.mx)
  • In total hip replacement, the generally accepted explanation for osteolysis involves wear particles (worn off the contact surface of the artificial ball and socket joint). (wikipedia.org)
  • An adenosine A 2A receptor agonist prevents osteolysis caused by polymeric wear particles in mouse calvaria. (sciencemag.org)
  • Aperiprosthetic osteolysis model in mouse was established by implanting 30 mg of TCP wear particles onto the surface of bilateral parietal bones following removal of the periosteum. (bvsalud.org)
  • 4) The observation that osteolysis only occurred in total shoulder replacements, supports the hypothesis that wear particles from polyethylene are likely to be responsible for osteolysis than are cement particles. (clinicadehombro.com.mx)
  • Our results demonstrated that the majority of wear particles within osteolytic interface membrane was in the 30-60 nm range, and that macrophage apoptotic ratio increased along with osteolysis progression. (ingentaconnect.com)
  • Thus, our findings suggested that wear particles generated at implant interface can accelerate macrophage apoptosis through changes in apoptotic pathways and ultimately aggravate the symptom of osteolysis. (ingentaconnect.com)
  • Osteolysis can also be associated with the radiographic changes seen in those with bisphosphonate-related osteonecrosis of the jaw. (wikipedia.org)
  • This retrospective study was aimed to evaluate the radiographic and clinical results of polyaxial locking compression osteosynthesis system and bone grafting for the Extended Trochanteric Osteotomy (ETO) in artificial femoral component revision with severe osteolysis of greater trochanter. (alliedacademies.org)
  • Patients with examination and radiographic signs of osteolysis who have trialed conservative management with continued symptoms or those patients unwilling to modify their activity level with continued symptoms are indicated for surgery. (thecardiologyadvisor.com)
  • This study examines the levels of osteoclastogenesis-related cytokines in serum and synovial fluid samples obtained from patients at the time of revision metal-on-metal total hip replacement and compares between patients with and without radiographic evidence of peri-prosthetic osteolysis. (hip-int.com)
  • Raghuveer HP, Jayalekshmy R. Gorham's massive osteolysis of the mandible - a progressive radiographic presentation. (sciencepublishinggroup.com)
  • Moreover, maintaining a healthy body weight via exercise or eating healthy can help maintain skeletal in integrity and thus decrease the rate of osteolysis. (healthguideinfo.com)
  • citation needed] Although osteolysis itself is clinically asymptomatic, it can lead to implant loosening or bone breakage, which in turn causes serious medical problems. (wikipedia.org)
  • Osteolysis eventually leads to the loosening of an implant and inevitably leads to the surgical removal of the implant. (kon.org)
  • The surgeon may be faced with limited proximal osteolysis in a well-fixed femoral component during revision of a failed acetabular component. (pubmedcentralcanada.ca)
  • When inflammation occurs in the vicinity of bone, such as in RA, PsA, orthopedic implant-associated osteolysis, and osteomyelitis, it induces focal erosion that is often devastating. (jci.org)
  • Traditionally, osteolysis around total knee replacements (TKRs) is treated with complete revision. (hindawi.com)
  • This study reports the clinical outcomes for selective bone grafting in patients with osteolysis without complete revision of the TKR. (hindawi.com)
  • We investigated whether the curetted proximal osteolysis around an unrevised femoral component progressed in size and whether this lesion would have a deleterious effect on fixation of the femoral component in patients with isolated acetabular revision. (pubmedcentralcanada.ca)
  • We prospectively followed 21 patients (24 hips) who underwent acetabular revision and curetting of femoral osteolysis. (pubmedcentralcanada.ca)
  • Although it is obvious revision generally should be performed when the osteolytic lesion is associated with a loose femoral component, the controversy arises when femoral osteolysis is accompanied by a well-fixed stem. (pubmedcentralcanada.ca)
  • However, it would be reasonable to be concerned about grafted bone escaping into the joint if the defect was not contained, and these studies do not describe femoral osteolysis treated by simple débridement without bone grafting after isolated acetabular revision. (pubmedcentralcanada.ca)
  • We asked whether the proximal osteolysis around an unrevised femoral component could be halted by revision of the acetabular component and débridement of the femoral osteolytic lesion without bone grafting in a well-fixed femoral stem. (pubmedcentralcanada.ca)
  • 200 patients undergoing revision THA/TKA for culture negative osteolysis. (mayo.edu)
  • We found the incidence of osteolysis, rate of revision, and implant survivorship were similar between fixed-bearing and mobile-bearing TKAs in younger patients. (springermedizin.de)
  • This retrospective study analyzes 10 TKRs (9 patients, 66.5 ± 6.1 years old) presenting with osteolysis and revised after 8.7 ± 1.9 years of in vivo function. (hindawi.com)
  • These findings suggest that LCS may be a promising biomaterial for suppressing osteolysis, thus paving the way for the treatment of osteoporosis using bioactive inorganic materials. (rsc.org)
  • Thus, the impact of inflammatory cytokines on osteoclast formation and function was among the most important discoveries advancing the treatment of focal osteolysis, leading to development of therapeutic agents that either directly block the bone-resorptive cell or do so indirectly via cytokine arrest. (jci.org)
  • At age 4 years, high doses of phosphate resulted in increased serum phosphate levels, decreased neopterin and cytokines, decreased FGF23, and stabilization of osteolysis. (elsevier.com)
  • Thus, the non-depleting mAb H27K15 is a promising anti-tumor candidate, able to inhibit osteoclast differentiation, likely decreasing metastasis-induced osteolysis, and able to prevent M2 polarization of TAMs while inducing DCs, hence contributing to the creation of more efficient anti-tumor immune responses. (ovid.com)
  • IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis. (viraquest.com)
  • Osteolysis can be caused by diseases, such as psoriasis and rheumatoid arthritis. (drugs.com)
  • The differential diagnosis includes cervical spine pathology in addition to systemic disorders such as gout and rheumatoid arthritis that may cause symptoms similar to osteolysis. (thecardiologyadvisor.com)
  • Periarticular osteolysis, a crippling complication of rheumatoid arthritis, is the product of enhanced osteoclast recruitment and activation. (biomedcentral.com)
  • Patients have not exhibited any further complications associated with osteolysis after 5.1 ± 2.4 years of followup. (hindawi.com)
  • This case series shows complete resolution of osteolysis in all patients with no complications. (hindawi.com)
  • Interestingly, we have observed this in other patients as well and the talar component is much more frequently unstable when osteolysis occurs. (podiatrytoday.com)
  • We followed these patients prospectively at the time of scheduled visits to evaluate femoral osteolysis. (pubmedcentralcanada.ca)
  • While these methods give useful information on the epidemiological association between wear and osteolysis, they do not provide risk data that would be directly clinically applicable to individual patients, and they also do not predict risk of osteolysis in the setting of other clinical risk factors, such as age and sex. (royalsocietypublishing.org)
  • While many liver transplant patients suffer osteolysis, bone loss can be prevented. (healthguideinfo.com)
  • We asked whether the prevalence of osteolysis would be less in well-functioning mobile-bearing TKAs than in well-functioning contemporary fixed-bearing TKAs in young patients. (springermedizin.de)
  • While commonly associated with weightlifters, osteolysis can also occur in patients performing repetitive overhead lifting and carrying. (thecardiologyadvisor.com)
  • Samples from 36 patients (18 with osteolysis, 18 without osteolysis) were analysed. (hip-int.com)
  • No significant differences were found between patients with and without osteolysis in mean synovial fluid levels of IL-6 (p = 0.863), IL-18 (p = 0.324), M-CSF (p = 0.508), sRANKL (p = 0.884), OPG (p = 0.776) or mean serum levels of OPG (p = 0.993) or sRANKL (p = 0.565) (insufficient detection of IL-6, IL-18 or M-CSF in serum samples). (hip-int.com)
  • Interleukin-6: a potential mediator of the massive osteolysis in patients with Gorham-Stout disease. (sciencepublishinggroup.com)
  • Beginning in the 1990s there were reports of elevated levels of a protein called interleukin-6 (IL-6) being detected in patients with the disease, leading some to suggest that increased levels of IL-6 and vascular endothelial growth factor (VEGF) may contribute to the chemical changes Gorham and others believed were the cause of this type of osteolysis. (wikipedia.org)
  • Osteolysis around the femoral stem is a well-recognized complication and one of the most frequent causes of failure in THA [ 5 , 24 , 26 ]. (pubmedcentralcanada.ca)
  • Many surgeons treat progressive femoral osteolysis in association with a well-fixed stem with bone grafting but in uncontained proximal defects the graft could get into the joint, raising a question regarding whether the osteolysis can be treated by simple débridement without bone grafting. (pubmedcentralcanada.ca)
  • All shoulders with wear of the glenoid insert had osteolysis of the proximal humerus. (clinicadehombro.com.mx)
  • Publications] Kenji Kaneko, Miho Iwase, Tatsuo Itoh, Kang Jung Kim: 'Therapeutic effects of Osteoprotegerin on a rat osteolysis model. (nii.ac.jp)