• citation needed] Distal clavicular osteolysis (DCO) is often associated with problems weightlifters have with their acromioclavicular joints due to high mechanical stresses put on the clavicle as it meets with the acromion. (wikipedia.org)
  • Distal clavicular osteolysis (DCO) is a rare condition that is more common among athletes and weight lifters, particularly those who engage in frequent overhead motions. (physio-pedia.com)
  • Any patient presenting with AC joint or superior shoulder pain should be evaluated for distal clavicular osteolysis. (physio-pedia.com)
  • Distal clavicular osteolysis is almost exclusively a diagnosis of young athletes and weight lifters, particularly those engaging in repetitive pressing or overhead activities. (physio-pedia.com)
  • Plain film X-ray of the AC joint is typically sufficient to evaluate for distal clavicular osteolysis. (physio-pedia.com)
  • Weight-lifter's shoulder, or Distal Clavicular Osteolysis, is a painful shoulder injury that occurs when the distal end of the Clavicle beings to deteriorate. (philamassages.com)
  • For Distal Clavicular Osteolysis, the areas affected are usually the distal part of the Clavicle and the AC joint, but other surrounding structures can be affected by the inflammation too. (philamassages.com)
  • The medical term for this condition is distal clavicular osteolysis, although weightlifters have coined the term weightlifter's shoulder to describe this shoulder problem. (cathe.com)
  • Wear debris is known to impact on a variety of cellular responses and genes in multiple pathways associated with the development of the periprosthetic osteolysis and chronic inflammation. (edu.au)
  • Fourteen studies reported periprosthetic osteolysis in a total of 46 patients with onset ranging from 15-96 months after the index procedure. (londonspine.com)
  • On the second day of ISASS23, Dr. Lanman reviewed the clinical and radiographic findings associated with periprosthetic osteolysis. (kajnews.com)
  • Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model. (rush.edu)
  • Green JM, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C. Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model. (rush.edu)
  • In order to understand osteolysis of the distal clavicle , sometimes called " Weightlifter's Shoulder ", it is important to understand the anatomy and function of the shoulder. (shoulderpaininfo.com)
  • Al-Mayouf SM, Majeed M, Hugosson C, Bahabri S. New form of idiopathic osteolysis: nodulosis, arthropathy and osteolysis (NAO) syndrome. (medlineplus.gov)
  • This is the 17th reported case of spinal involvement by this rare type of idiopathic osteolysis. (nih.gov)
  • I was also PI on an investigator initiated study of a biologic for prosthetic hip loosing and the first CT imaging algorithms to quantify peri-prosthetic osteolysis. (rochester.edu)
  • Acro-Osteolysis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • When acro-osteolysis is accompanied by generalized OSTEOPOROSIS and skull deformations, it is called HAJDU-CHENEY SYNDROME. (harvard.edu)
  • This graph shows the total number of publications written about "Acro-Osteolysis" by people in Harvard Catalyst Profiles by year, and whether "Acro-Osteolysis" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Acro-Osteolysis" by people in Profiles. (harvard.edu)
  • A 59 year old while female with striking carpal and tarsal osteolysis is reported. (nih.gov)
  • Idiopathic carpal tarsal osteolysis (ICTO) is a rare congenital disorder that results in the destruction and resorption of bone, leading to severe functional deficits and cosmetic deformities. (utmb.edu)
  • MONA includes a condition formerly called nodulosis-arthropathy-osteolysis (NAO) syndrome. (medlineplus.gov)
  • Pamidronate does not improve peripheral osteolysis in multicentric osteolysis and nodular arthropathy caused by a mutation in the matrix metalloproteinase 2 gene. (medscape.com)
  • The pertinent literature is reviewed and a simplified classification of idiopathic multicentric osteolysis is presented. (nih.gov)
  • Idiopathic multicentric osteolysis may be sporadic but can demonstrate either dominant or recessive inheritance. (nih.gov)
  • Gorham's disease, the Winchester syndrome, and other osteolytic conditions which may predominantly affect the tarsal and carpal bones most likely are totally different processes, unrelated to idiopathic multicentric osteolysis. (nih.gov)
  • Inherited multicentric osteolysis with arthritis: a variant resembling Torg syndrome in a Saudi family. (medlineplus.gov)
  • An additional cause of DCO was synovial invasion of the subchondral bone, leading to osteolysis. (physio-pedia.com)
  • Using the latest Next Generation Sequencing technologies, we are investigating miRNA expression profiles in human trabecular bone, synovial fluid and plasma sourced from TJR revision surgery where wear particle associated osteolysis was evident. (edu.au)
  • As reported in The Lancet Rheumatology, Dr. Wilkinson and colleagues conducted a phase-2 randomized, placebo-controlled, proof-of-concept study of patients scheduled for revision surgery for symptomatic osteolysis. (sense-studios.com)
  • On the other hand, osteolysis is less common, presenting more than a year post-operative and often accompanied by additional complications, leading to revision surgery. (londonspine.com)
  • However, several long-term complications of these procedures are well recognized, including polyethylene wear, osteolysis, metal debris synovitis, and fracture of the metal components [ 2 , 3 ]. (hindawi.com)
  • The review highlights the need for clear terminology to distinguish between bone loss and inflammatory osteolysis, as their clinical outcomes and treatment plans differ greatly. (londonspine.com)
  • Intensified symptoms of osteoporosis, including osteolysis of the carpal and tarsal bones, causes destructive changes in the joints of the hands and wrists, as well as in the joints of the tarsus and foot. (medscape.com)
  • Reuters Health - 20/01/2021 - Denosumab showed biological efficacy against osteolysis after total hip replacement in a proof-of-concept trial. (sense-studios.com)
  • There were 83% fewer osteoclasts at the osteolysis membrane-bone interface in the denosumab group: median 0.05 per mm versus 0.30 mm for placebo. (sense-studios.com)
  • The molecular approach of denosumab treatment--inhibition of osteoclast differentiation and activity via blockade of RANK ligand--hits the core pathological mechanism of wear-induced osteolysis," he said. (sense-studios.com)
  • That is, to our understanding, the first scientific trial assessment the efficiency of denosumab in reducing wear-induced osteolysis. (gasyblog.com)
  • Denosumab halts the osteolysis by. (koreamed.org)
  • Osteolysis will end up being thought as a demarcated non-linear osteolytic lesion 3?mm. (gasyblog.com)
  • Osteolysis often occurs in the proximity of a prosthesis that causes either an immunological response or changes in the bone's structural load. (wikipedia.org)
  • Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification. (wikipedia.org)
  • Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process. (wikipedia.org)
  • Morphine-induced osteolysis and hypersensitivity is mediated through toll-like receptor-4 in a murine model of metastatic breast cancer. (iasp-pain.org)
  • Using an immunocompetent murine model of metastatic breast cancer, we demonstrated that sustained morphine infusion induced a significant increase in osteolysis and hypersensitivity within the ipsilateral femur through the activation of toll-like receptor-4 (TLR4). (iasp-pain.org)
  • Pharmacological blockade with TAK242 (resatorvid) as well as the use of a TLR4 genetic knockout ameliorated the chronic morphine-induced osteolysis and hypersensitivity. (iasp-pain.org)
  • Together, these data indicate that morphine induces osteolysis and hypersensitivity that are mediated, in part, through a TLR4 receptor mechanism. (iasp-pain.org)
  • He noted by email that osteolysis is caused by wear particles, and is "a frequent complication of conventional polyethylene bearing surfaces. (sense-studios.com)
  • Treatment of glenoid loosening and bone loss due to osteolysis with glenoid bone grafting. (llu.edu)
  • In total hip replacement, the generally accepted explanation for osteolysis involves wear particles (worn off the contact surface of the artificial ball and socket joint). (wikipedia.org)
  • Macrophage phagocytosis of wear particles induces human biological/physiological responses which eventually lead to bone resorption and Osteolysis. (nist.gov)
  • Although wear remains a problematic issue in THA, its consequences-namely, osteolysis and prosthetic loosening-loom as larger issues. (medscape.com)
  • In vivo, 7E reduced tumor growth, suppressed tumor-mediated osteolysis, and protected bone mineral density after intratibial injection of prostate cancer cells. (tmu.edu.tw)
  • We conclude that IL-20 is involved in the cell migration, colony formation, and tumor-induced osteolysis of prostate cancer. (tmu.edu.tw)
  • Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. (nature.com)
  • Osteolysis can also be associated with the radiographic changes seen in those with bisphosphonate-related osteonecrosis of the jaw. (wikipedia.org)
  • While bone resorption is commonly associated with many diseases or joint problems, the term osteolysis generally refers to a problem common to artificial joint replacements such as total hip replacements, total knee replacements and total shoulder replacements. (wikipedia.org)
  • The word "osteolysis" refers to a softening, absorption, and dissolution of bone or the removal or loss of calcium in bone. (shoulderpaininfo.com)
  • We speculate that the primary causative factor of the fatigue fracture of the base plate due to loss of bony support most likely secondary to osteolysis was varus malalignment at primary implantation. (hindawi.com)
  • Osteolysis may also be caused by pathologies like bone tumors, cysts, or chronic inflammation. (wikipedia.org)
  • We therefore propose that novel correlations exist between the differentially expressed mRNAs and miRNAs expressions of multiple signalling pathways in osteolysis/chronic inflammation. (edu.au)
  • Osteolysis is one of the causes that lead to the failure of total joint replacement (TJR). (edu.au)
  • What can cause AC joint osteolysis? (shoulderpaininfo.com)
  • What other biologic and mechanical factors might contribute to osteolysis? (usuhs.edu)
  • Dive into the research topics of 'What other biologic and mechanical factors might contribute to osteolysis? (usuhs.edu)
  • citation needed] There are several biological mechanisms which may lead to osteolysis. (wikipedia.org)
  • Characterization of the gene expression signature specific to the TB interface in our model revealed signaling mechanisms operative in human breast cancer metastases and predicted a therapeutic inhibitor of cancer-mediated osteolysis. (biomedcentral.com)
  • Several animal models have been developed to study the mechanisms governing cancer-mediated osteolysis. (biomedcentral.com)
  • citation needed] Although osteolysis itself is clinically asymptomatic, it can lead to implant loosening or bone breakage, which in turn causes serious medical problems. (wikipedia.org)
  • Here we tested the drug in the setting of osteolysis after hip replacement, a condition that currently has no effective non-surgical treatment. (sense-studios.com)
  • Debate In vitro outcomes of both bisphosphonates and RANKL AMG 900 inhibitors have already been promising, showing decreased osteolysis with treatment. (gasyblog.com)
  • Osteolysis has been reported to occur as early as 12 months after implantation and is usually progressive. (wikipedia.org)
  • Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation. (bvsalud.org)