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  • apoptotic
  • Histologic sections of the midshaft showed increased apoptotic osteocytes in Δ130-136, but not in WT and R76W, mice which correlated with altered biomechanical and estimated bone material properties. (nih.gov)
  • phenotype
  • None of these osteocyte abnormalities were observed in another model of osteomalacia, the vitamin D receptor knockout, nor could the DMP1 null phenotype be rescued by a high calcium, phosphate diet suggesting that the defect is not systemic. (grantome.com)
  • CX43
  • Two transgenic mouse models driven by a DMP1 promoter with the overexpression of dominant negative Cx43 mutants were generated to dissect the functional contribution of Cx43 gap junction channels and hemichannels in osteocytes. (nih.gov)
  • Fig. 1 L2O2 induce cell loss of life and lowers Cx43 phrase in osteocyte cell range. (techblessing.com)
  • We showed that OS induced by H2O2 not only caused decrease manifestation of Cx43 but also resulted in decreased gap junctional coupling and death of the osteocytes. (techblessing.com)
  • sclerostin
  • Confirming a direct androgen receptor-mediated effect on sclerostin production, flutamide coincubation and silencing of androgen receptor gene in osteocytes abolished the DHT effects. (ovid.com)
  • Sclerostin is a 190 amino acid protein secreted primarily by osteocytes. (readbyqxmd.com)
  • FGF23
  • We therefore utilized chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) data from an osteocyte cell line to identify potential regulatory regions of the Fgf23 gene. (readbyqxmd.com)
  • Complete neutralization of FGF23 has adverse effects, but neutralization of FGF23 excess may be practical, or in the future, suppression of excess FGF23 biosynthesis by osteocytes. (careacross.com)
  • myeloma
  • The investigators data point to a central role of the osteocyte to induce heparanase, a multifunctional mediator of myeloma bone disease. (careacross.com)
  • There were six specimens in this dataset, including three HOB-01 (osteocyte cell line) control samples and three HOB-01 samples co-cultured with JJN3 (human myeloma cell line). (biomedcentral.com)
  • calcium
  • His work has shown how in many cell types including now osteocytes, the load causes the tears which allows calcium to rush in to both rapidly heal tears and to set in motion inside a host of actions that, in this case, remodels bone. (medicalxpress.com)
  • In cell cultures, they watched as increased calcium levels inside osteocytes triggered an increase in the production of the protein c-fos. (medicalxpress.com)
  • Osteocytes use their micron-thin tentacles to communicate with each other and the scientists also learned that when one osteocyte gets tears, it appears to communicate its load to neighboring osteocytes so the calcium level goes up in those as well even without a tear. (medicalxpress.com)
  • Intracellular ALP was found to peak earlier and there was greater calcium deposition when MSCs were co-cultured with osteocytes rather than osteoblasts, suggesting that osteocytes are more influential than osteoblasts in stimulating osteogenesis in MSCs. (nuigalway.ie)
  • gene expression
  • GSE27372 was downloaded from Gene Expression Omnibus, including three HOB-01 (osteocyte cell line) control samples and three HOB-01 samples co-cultured with JJN3 (human MM cell line). (biomedcentral.com)
  • In our study, in order to investigate the molecular mechanism of osteocyte death in MM patients, we reanalyzed the gene expression profile in Giuliani et al. (biomedcentral.com)
  • projections
  • They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi. (zfin.org)
  • membrane
  • Osteocytes within osteoid show a loss of the lamina limitans with a concomitant obliteration of the canalicular space and abnormal """"""""buckling"""""""" of the membrane surface of dendrites. (grantome.com)
  • estrogen
  • Deepak, V., Kayastha, P., McNamara, L. M. Estrogen deficiency attenuates fluid flow induced [Ca2+](i) oscillations and mechanoresponsiveness of MLO-Y4 osteocytes. (nuigalway.ie)