• Proposed functions of TRAP include osteopontin /bone sialoprotein dephosphorylation, the generation of reactive oxygen species (ROS), iron transport, and as a cell growth and differentiation factor. (wikipedia.org)
  • The main pathogenesis of OP is excessive proliferation and differentiation of osteoclasts, in which the peroxisome proliferator‑activated receptor γ (PPARγ) pathway has a pivotal role. (spandidos-publications.com)
  • Firstly, the expression of HSP90α in osteoclast differentiation was detected by western blotting in vitro, then the effect of HSP90α inhibition on the formation and differentiation of osteoclasts was examined. (spandidos-publications.com)
  • As a result, in the process of osteoclast differentiation and proliferation, the expression of HSP90α was upregulated. (spandidos-publications.com)
  • Inhibition of HSP90α could block the formation and differentiation of osteoclasts, and remit osteoporosis in mice. (spandidos-publications.com)
  • Regarding the underlying mechanism, inhibition of HSP90α could block the nuclear import of PPARγ to inhibit osteoclast differentiation and proliferation. (spandidos-publications.com)
  • In addition, osteoclasts control osteoblasts differentially depending on their stage of differentiation. (cellml.org)
  • In this study, we aimed to demonstrate the effects of IKN on osteoclast differentiation in vitro and in vivo . (e-jbm.org)
  • Our study suggested that the ethanol extract of the root part of IKN suppressed osteoclast differentiation and function partly by downregulating the p38 MAPK/c-Fos/NFATc1 signaling pathways. (e-jbm.org)
  • 5 ] Osteoblasts, bone-forming cells, also regulate osteoclast differentiation via RANKL and osteoprotegerin (OPG) expression, a decoy receptor for RANKL. (e-jbm.org)
  • p38, c-Jun N-terminal kinase, extracellular signal-regulated kinase), and phosphoinositide 3-kinase/Akt serine/threonine kinase (Akt) signaling pathways are known to be activated during osteoclast differentiation. (e-jbm.org)
  • To investigate the effect of the ingredients, such as ocean mustard soy and remove remove, on bone development, the inhibition of osteoclastic differentiation and stimulatory impact Punicalagin novel inhibtior in cultured osteoblastic cells have already been examined (15,16). (biopaqc.com)
  • Hence, the result of phytase-producing Wikim001 treated dark brown rice remove (BR-WK) on osteoblast differentiation in Individual SaOS-2 osteosarcoma cells aswell as Punicalagin novel inhibtior on osteoclast development in mouse bone tissue marrow cells was looked into. (biopaqc.com)
  • Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. (medscape.com)
  • Further, it regulates osteoblastic extracellular matrix such as osteopontin (OPN), osteocalcin (OCN), bone sialoprotein (BSP) in late differentiation. (frontiersin.org)
  • Induction of p53 signaling elevated the differentiation of the bone marrow MDSC into granulocytic cell types. (purdue.edu)
  • it is usually caused by over-suppression of PTH and various other growth elements[8 10 11 Bone tissue biopsy findings add a low bone tissue formation price as evaluated by tetracycline WYE-687 fluorescence-labeling little if any mobile activity (paucity of osteoblasts and osteoclasts) and slim osteoid seams[6]. (exposed-skin-care.net)
  • Osteomalacia Osteomalacia is definitely characterized by a deficit in bone mineralization due to hypophosphatemia malnutrition vitamin D deficiency or aluminium toxicity[11 12 Characteristic findings on bone biopsy include wide unmineralized osteoid seams low bone formation absence of osteoblasts and osteoclasts[6]. (exposed-skin-care.net)
  • ABSTRACT: We propose a mathematical model explaining the interactions between osteoblasts and osteoclasts, two cell types specialized in the maintenance of the bone integrity. (cellml.org)
  • The model results corroborate all behaviors of the bone remodeling system that we have simulated, including the tight coupling between osteoblasts and osteoclasts, the catabolic effect induced by continuous administration of PTH, the catabolic action of RANKL, as well as its reversal by soluble antagonist OPG. (cellml.org)
  • Bone consists of cells (osteocytes, osteoblasts and osteoclasts), extracellular organic components (collagen and non-collagenous matrix protein) and non-organic components (calcium hydroxyapatite). (ommegaonline.org)
  • Journal of Bone Metabolism 2023;30(3):253-262. (e-jbm.org)
  • Bone is an active metabolism tissue, which constantly undergoes bone remodeling. (frontiersin.org)
  • Renewing interest in the study of intermediate metabolism and cellular bioenergetics is brought on by the global increase in the prevalence of metabolic illnesses. (mdpi.com)
  • Bone metabolism, including the repair and remodeling of bone, is closely regulated by circadian rhythms (Lu et al. (psychologytoday.com)
  • It is believed that carbohydrate metabolism disorders may affect the progression of these diseases, as confirmed by both animal and human studies. (karger.com)
  • The in vitro metabolism of osteoclasts obtained from involved disease areas of two patients with idiopathic monostotic fibrous dysplasia and one patient with polyostotic fibrous dysplasia were compared with osteoclasts isolated from noninvolved bone in the same individuals and normal controls. (northwestern.edu)
  • Osteoclasts from regions of in vivo abnormal growth exhibited normal mineral metabolism in vitro. (northwestern.edu)
  • Our recent approaches pointed towards the importance of targeting macrophage energy metabolism in inflammatory and fibrotic disease. (imperial.ac.uk)
  • This compound, also known as EHDP, regulates bone metabolism. (nih.gov)
  • Paget's disease of bone (osteitis deformans) is an idiopathic, progressive disease characterized by abnormal and accelerated bone metabolism in one or more bones. (nih.gov)
  • However, new forms of diagnosis are being used to evaluate the onset and progression of periodontitis, such as the identification of concentrations of inflammatory mediators, such as the interleukins, as well as the analysis of specific mediators of bone metabolism, following the example of the activating receptor of nuclear factor Kappa B (RANK), its ligand RANKL and osteoprotegerin (OPG) 8-11 . (bvsalud.org)
  • WYE-687 Successful avoidance of bone tissue loss has been proven with WYE-687 vitamin D bisphosphonates calcitonin as well as treatment of hypogonadism and HPT. (exposed-skin-care.net)
  • It really is associated with lack of cancellous bone tissue and abnormal nutrient metabolic activity. (exposed-skin-care.net)
  • Incapability to maintain nutrient homeostasis plays a part in cardiovascular and gentle tissue calcifications which might describe the high mortality price in sufferers with adynamic bone tissue disease[5]. (exposed-skin-care.net)
  • The avoidance and treatment of adynamic bone tissue disease is normally avoidance of over suppression of PTH secretion. (exposed-skin-care.net)
  • Bone is a dynamic, living tissue whose structure and shape continuously evolves during life. (cellml.org)
  • The chapter begins with a brief discussion of bone structure and tissue preparation. (basicmedicalkey.com)
  • In general, most of the symptoms of connective tissue disease are a result of structural failure of the extracellular matrix (e.g., fracture). (basicmedicalkey.com)
  • Specimens received by the surgical pathologist from orthopedic operations often consist of fragments of bone and soft tissue without obvious anatomic landmarks. (basicmedicalkey.com)
  • Adherent cells, following the removal of non-adherent cells, had been used as bone tissue marrow macrophages (BMMs). (biopaqc.com)
  • Osteoporosis is a syndrome of dysadaptation which leads to low bone mass, bone micro architecture disruption of bone tissue, decreased skeletal strength and increased predisposition to fracture at different sites as the spine, hip or wrist [4,5] . (ommegaonline.org)
  • Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
  • Furthermore, other portions of bone tissue a little more distant from the interface, which establish direct contact with the implant, are also damaged during the drilling process, and therefore, they also need to be remodeled. (elsevier.es)
  • Bone Marrow Adipose Tissue: A New Player in Cancer Metastasis to Bone. (ox.ac.uk)
  • By contrast, despite occupying a significant proportion of the bone marrow, the importance of bone marrow adipose tissue is only just emerging. (ox.ac.uk)
  • This review discusses the recent advances in our understanding of how marrow adipose tissue contributes to bone metastasis and cancer-induced bone disease. (ox.ac.uk)
  • C-reactive protein is considered one of the best measures of the acute phase response to an infectious disease or other cause of tissue damage and inflammation. (cdc.gov)
  • The results indicate that hypophosphatemic mice have increased bone remodelling, increased carbonate content and decreased crystallinity of the bone mineral, as well as increased misalignment of crystallites within the bone tissue. (iucr.org)
  • Osteopenia and osteoporosis, diagnosed by degrees of low bone mass and bone tissue deterioration, lead to substantial morbidity and mortality. (psychologytoday.com)
  • 2013.) It is characterized by degrees, first presenting as osteopenia of low bone mass and "microarchitectural deterioration" of bone tissue. (psychologytoday.com)
  • Bone cancer metastases usually occur in the axial skeleton, in areas with active hematopoiesis and high red marrow content. (degruyter.com)
  • Osteoclasts were formed by culturing mouse bone marrow macrophage (BMM) cells with macrophage colony-stimulating factor and receptor activator of nuclear factor-κB ligand (RANKL). (e-jbm.org)
  • Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
  • We observed osteoclasts resorbing bone beneath osteoid seams, and fragments of osteoid isolated in the bone marrow. (fluoridealert.org)
  • The bone marrow is a favored site for a number of cancers, including the hematological malignancy multiple myeloma, and metastasis of breast and prostate cancer. (ox.ac.uk)
  • The ability of bone marrow adipocytes to regulate skeletal biology and hematopoiesis, combined with their metabolic activity, endocrine functions, and proximity to tumor cells means that they are ideally placed to impact both tumor growth and bone disease. (ox.ac.uk)
  • Many writers have waxed poetic about the fragility of our bones: Shakespeare wrote of "marrowless bones" ( Macbeth ) and "hollow bones" ( Measure for Measure) , while T.S. Eliot wrote of "the anguish of the marrow, the ague of the skeleton" ( Whispers of Immortality ). (psychologytoday.com)
  • The blood supply to bone is delivered to the endosteal cavity by nutrient arteries , then flows through marrow sinusoids before exiting via numerous small vessels that ramify through the cortex. (hilarispublisher.com)
  • Tumor site monocytic-MDSC lacked the ability to differentiate into other cells types such as osteoclasts and granulocytic-MDSC, whereas the bone marrow and spleen counterparts could form both cell types. (purdue.edu)
  • In particular, the model predicts that combinations of anti-resorptive and anabolic therapies provide significant benefits compared with monotherapy, especially for certain type of skeletal disease. (cellml.org)
  • These initial modeling results are extremely encouraging and lead us to proceed with additional explorations into bone turnover and skeletal remodeling. (cellml.org)
  • For example, when implanted with a suitable matrix, these rhBMPs have been shown to enhance allograft incorporation and induce new bone formation at various skeletal sites. (biomedcentral.com)
  • To assist in the evaluation of skeletal status, two markers of bone turnover are being measured: a) bone alkaline phosphatase, a formative marker in serum, and b) NTX, a resorptive marker in urine. (cdc.gov)
  • However, bone metabolic diseases and/or malnutrition can disrupt the ability of the organism to mineralize the collagen matrix, causing skeletal malformations such as rickets or osteoporosis. (iucr.org)
  • is a progressive, chronic "systemic skeletal disease" (Liu et al. (psychologytoday.com)
  • Skeletal or bone-specific alkaline phosphatase (BAP) is a tetrameric glycoprotein found on the cell surfaces of osteoblasts. (nexelis.com)
  • The importance of the vascular supply for bone is well-known to orthopaedists but is still rather overlooked within the wider field of skeletal research. (hilarispublisher.com)
  • NaturalNews) The long-term use of osteoporosis drugs known as bisphosphonates can actually weaken bones by impairing their ability to heal, leading to fractures, according to a study conducted by researchers from New York-Presbyterian Hospital/Weill Cornell Medical Center. (naturalnews.com)
  • While bisphosphonates like Fosamax have been proven to successfully treat osteoporosis and other metabolic bone disease, we believe long-term use of these drugs may suppress the ability of bones to heal in some patients," said researcher Dean G. Lorich. (naturalnews.com)
  • Bisphosphonates interfere with the activity of osteoclasts, which break down bones in order to transfer calcium into the blood. (naturalnews.com)
  • While more research is necessary to confirm our results, physicians prescribing bisphosphonates for longer durations should monitor patients for indications of bone regeneration," researcher Joseph M. Lane said. (naturalnews.com)
  • Patients with Paget's disease are treated with analgesics and bisphosphonates. (pediagenosis.com)
  • Antiresorptive medications acts by reducing rates of bone remodeling like estrogens, selective estrogen receptor modulators (raloxifene), bisphosphonates (alendronate, risedronate, and ibandronate) and calcitonins. (ommegaonline.org)
  • Sato M, Grasser W (1990) Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy. (iphoneart.com)
  • Bisphosphonates (BF) pharmacokinetics consist in the osteoclast function interruption, angiogenesis inhibition, as well as blocking any cancer cell line activity together with the interruption of signal transduction [3]. (peertechzpublications.com)
  • Because bone loss and fracture risk are serious concerns for people with diabetes, Xin Li, PhD, associate professor of basic science and craniofacial biology at NYU College of Dentistry, has been working to understand the underlying mechanism for periodontal bone loss in people with diabetes. (newswise.com)
  • Novel approach to restore the normal bone remodeling and improve the bone quality may be needed in order to effectively decrease bone fracture rate in kidney transplant recipients. (exposed-skin-care.net)
  • Keywords: Uremic osteodystrophy Bone loss Fracture Kidney transplantation INTRODUCTION Metabolic bone diseases in kidney transplant recipients may include pre-existing uremic osteodystrophy osteoporosis bone fracture osteonecrosis and bone pain syndrome. (exposed-skin-care.net)
  • There is an increased risk of malignant change in pagetic bones and any change in symptoms, such as the development of acute pain, heat or fracture in a patient with long-standing disease should be investigated immediately. (pediagenosis.com)
  • The term "osteoporosis" exactly means "porous bone" and it results from an abnormal bone remodeling process because bone formation and/or the mechanical response to physical strain are not sufficient to produce adequate fracture resistance. (ommegaonline.org)
  • It noted that the incidence of fracture in male low than female due to men acquire a greater bone density than women as their body weight and physical activity are higher and androgen concentration increases bone density to higher levels than estrogen do [8] . (ommegaonline.org)
  • An imbalance in this process may cause pathological loss of bone mass as seen with delayed fracture healing, osteoporosis and other metabolic bone diseases. (biomedcentral.com)
  • Osteoporosis is a disease that weakens the bones, increasing the likelihood of a fracture. (aadar.co)
  • Osteoporosis is characterized by bone mineral density (BMD), thus increasing bone fragility and fracture risk. (bvsalud.org)
  • Osteitis fibrosa cystica Prolonged secondary or tertiary hyperparathyroidism (HPT) reported in up to 30%-50% of renal transplant patients can cause osteitis fibrosa cystica a form of high turnover bone disease[4]. (exposed-skin-care.net)
  • AP and osteocalcin are secreted by osteoblasts and can serve as useful marker of high bone turnover[7-9]. (exposed-skin-care.net)
  • This model was conceived as the first step in a bone turnover modeling platform. (cellml.org)
  • Because the natural balance between the two processes is impaired, this condition is characterized by an unorganized bone turnover [1] . (acquaintpublications.com)
  • The latter will reduce bone turnover and improve symptoms. (pediagenosis.com)
  • Paget's disease is a relatively rare disorder of bone remodelling that involves greatly accelerated rates of bone turnover, abnormal bone architecture and may lead to gross bone deformity. (pediagenosis.com)
  • The resultant bone, as with other conditions involving high bone turnover, may be so-called woven bone, which lacks the normal lamellar structure. (pediagenosis.com)
  • My lab has focused on the study of osteoclasts, the cells that resorb/remove bone to allow normal bone turnover. (wustl.edu)
  • As a quantitative measure of bone turnover, BAP provides useful information on bone remodeling in osteoporosis and Paget's disease. (nexelis.com)
  • Relationship between BMD, dental panoramic radiographic findings and biochemical markers of bone turnover in diagnosis of osteoporosis. (iphoneart.com)
  • When less estrogen is present to control bone turnover rate, the bone is more susceptible to breakage and loss. (iphoneart.com)
  • Reduced bone turnover is often accompanied by symptomatic improvement, including reduced bone pain. (nih.gov)
  • Osteoclasts are unique cells that resorb old bones. (e-jbm.org)
  • In conclusion, these data indicated that the inhibition of HSP90α could block osteoclast formation and remit osteoporosis by reducing the nuclear import of PPARγ. (spandidos-publications.com)
  • The gadolinium-taggedpeptide was successfully synthesised, showing unaltered magnetic resonance imaging contrastagent properties, a lack of cytotoxicity, and dose-dependent inhibition of osteoclastogenesis in vitro.These findings pave the way toward the development of biospecific and bioactive contrast agentsfor the early diagnosis, treatment, and follow up of metabolic bone diseases such as osteoporosisand osteosarcoma. (brighton.ac.uk)
  • Thus, inhibition of HDAC activity may support bone healing during rhBMP therapy in patients with elevated TGFβ serum levels. (biomedcentral.com)
  • It has been shown that osteopontin and bone sialoprotein, bone matrix phosphoproteins, are highly efficient in vitro TRAP substrates, which bind to osteoclasts when phosphorylated. (wikipedia.org)
  • In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
  • The tumor cell mass exerts mechanical pressure that can contribute to bone pain. (degruyter.com)
  • The microenvironment is fundamental in attracting tumor cells to the bone as well as promoting tumor progression. (degruyter.com)
  • 5 , 6 ] Stimulation of osteoclast precursors with RANKL recruits cytoplasmic tumor necrosis factor receptor-associated factors (TRAFs) and activates downstream signaling pathways. (e-jbm.org)
  • Because NF-kB is active in so many cell types, with different physiological effects, it is important to understand the role of NF-kB in bone cells, as well as in specific tumor and immune cells. (wustl.edu)
  • Our ultimate goal is to guide the development of therapies that preserve bone structure and function while effectively targeting tumor and immune cells. (wustl.edu)
  • This specialized microenvironment is highly supportive, not only for tumor growth and survival but also for the development of an associated destructive cancer-induced bone disease. (ox.ac.uk)
  • The interactions between tumor cells, osteoclasts and osteoblasts are well documented. (ox.ac.uk)
  • In this study, we prepared a thermosensitive hydrogel loaded with bone morphogenetic protein-2 (BMP-2) to promote osteogenesis and osteoprotegerin (OPG) to inhibit excessive osteoclast activity. (figshare.com)
  • Under normal circumstances, TRAP is highly expressed by osteoclasts, activated macrophages, neurons, and by the porcine endometrium during pregnancy. (wikipedia.org)
  • 2017 Papathanassiu A, Ko JH, Imprialou M, Bagnati M, Srivastava PK, Vu HA, Cucchi D, McAdoo SP, Ananieva EA, Mauro C and Behmoaras J . BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases. (imperial.ac.uk)
  • Furthermore, decreased ability to perform physical activities decreases overall fitness and increases the risk of diseases related to sedentary lifestyle. (dovepress.com)
  • 1 During menopause, the prevalence of dyslipidemia also increases, which is the major risk factor of cardio-cerebrovascular disease. (nature.com)
  • The model is also able to simulate metabolic bone diseases such as estrogen deficiency, vitamin D deficiency, senescence and glucocorticoid excess. (cellml.org)
  • Some plant-derived natural products, mostly phytoestrogens (isoflavones, lignans, coumestanes, stilbenes) and many more novel estrogen-like compounds in plants have been greatly used to prevent depletion in bone mineral density. (ommegaonline.org)
  • It has been suggested that declines in these levels, with accompanying declines in the "bone-protective" hormones such as estrogen , testosterone , and progesterone, as seen with aging, may contribute to an imbalance in the remodeling of bone and even the progressive loss of bone. (psychologytoday.com)
  • Stratified by serum estradiol level, Periodontitis patients with estrogen deficiency had more bleeding on probing and clinical attachment loss, 64 women between the ages 50 and 70 years, Mean alveolar bone level significantly correlated with systemic BMD, Significant correlation between systemic BMD and mandibular basal BMD, Table 2. (iphoneart.com)
  • Reduce level of estrogen also induce osteocyte apoptosis which disrupt the homeostasis of bone. (iphoneart.com)
  • Structure of Aged Ovariectomized Rats adjacent bone and ligament tooth-supporting alveolar bone loss in Estrogen‐Deficient Rats of natural tooth in. (iphoneart.com)
  • Estradiol is a type of estrogen that assists osteoblasts, suppresses cytokines, and inhibits osteoclast activity. (bvsalud.org)
  • Paget's disease is characterized by abnormal bone remodelling. (pediagenosis.com)
  • Activity of these cells is critical for bone homeostasis, but their abnormal activation is responsible for pathological bone loss in many settings, including osteolytic breast cancer metastases. (wustl.edu)
  • Diabetes may accelerate periodontitis through metabolic dysregulation, shifts in bacterial colonization, inflammation, and bone loss. (newswise.com)
  • Since Iris species display numerous therapeutic effects in folk medicine, they have been used in the treatment of various diseases such as colds, cancer, inflammation, and infections. (e-jbm.org)
  • Osteoporosis was once considered to be a disease caused by a variety of endocrine, metabolic and mechanical factors, yet emerging evidence now suggests that inflammation may also have a significant role to play in the development of the disease. (nutriadvanced.ie)
  • Understanding of the bone remodelling process has developed significantly in recent years and it is now clear that factors involved in inflammation are closely linked with those critical for bone health. (nutriadvanced.ie)
  • Numerous pro-inflammatory cytokines have been implicated in the regulation of osteoblasts (bone building cells) and osteoclasts (cells that break down bone) and there is now plenty of scientific evidence that underpins the theory that inflammation is a significant contributory factor to the development and progression of osteoporosis 2 . (nutriadvanced.ie)
  • it's also beneficial for many other aspects of your health too, since ongoing inflammation has been linked to many common chronic diseases in the Western world such as heart disease, some forms of cancer, diabetes and even Alzheimer's disease. (nutriadvanced.ie)
  • We use animal models of inflammatory kidney disease, wound healing/fibrosis, metabolic syndrome, bone inflammation and apply systems-genetics approaches to investigate the effect of germline sequence variation on macrophage plasticity. (imperial.ac.uk)
  • Therefore, by dampening inflammation, MDSC benefit autoimmune diseases. (purdue.edu)
  • Inflammation usually accelerates bone loss, so by limiting inflammation, you can keep bone loss to a minimum. (aadar.co)
  • Abhyanga improves Vata balance, decreases inflammation, and slows bone loss. (aadar.co)
  • Recent advances in the identification of hormones and cytokines involved in the modulation of osteoclastogenesis may throw light on the aetiology of Paget's disease. (pediagenosis.com)
  • Osteoporosis Osteoporosis is a progressive metabolic bone disease that decreases bone mineral density (bone mass per unit volume), with deterioration of bone structure. (merckmanuals.com)
  • Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy? (biomedcentral.com)
  • Adynamic bone disease Historically excessive aluminum accumulation was a major cause of adynamic bone disease WYE-687 in dialysis patients WYE-687 before the rigid water purification and the avoidance of aluminum-containing phosphate binders were adopted[3]. (exposed-skin-care.net)
  • Osteoporosis is an age-related metabolic disease that results in limited bone regeneration capacity and excessive osteoclast activity. (figshare.com)
  • Paget's disease is characterized by features of high metabolic bone activity, including excessive cellularity and vascularity. (pediagenosis.com)
  • Osteoclasts originate from monocyte/macrophage lineage cells. (e-jbm.org)
  • The osteoclasts, large multinucleate cells which are normally present only when bone is being resorbed, may be huge and highly multinucleate in Paget's disease, when bone is being haphazardly remodelled. (pediagenosis.com)
  • To create osteoclasts, BMMs (4104 cells/well) had been cultured for 4 times with M-CSF (30 ng/mL) aswell with receptor activator of nuclear factor-B ligand (RANKL, 100 ng/mL), in 24-well (1 mL/well) tissues lifestyle meals. (biopaqc.com)
  • These cells are hematopoietic-derived cells of the monocyte lineage that differentiate in the bone microenvironment under the influence of the cytokine RANKL. (wustl.edu)
  • Bone morphogenic proteins (BMPs) promote osteogenesis, chondrogenesis and adipogenesis of mesenchymal progenitor cells [ 1 ]. (biomedcentral.com)
  • Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
  • The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. (biomedcentral.com)
  • Because in order to avoid renal injury, the recovery of affected cells is as significant as preventing its progression towards end stage renal disease [ 1 ]. (biomedcentral.com)
  • So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
  • In response to certain signals, white blood cells called monocytes can become osteoclasts - bone-resorbing cells that are essential to maintaining bone health. (vumc.org)
  • Cassat and his colleagues will study how the signals that control the monocyte-to-osteoclast transition affect the ability of cells to fight bacterial pathogens. (vumc.org)
  • Damjanovic R, Ljubisavljevic S, Prazic A, Zvezdanovic L (2023) Neurological Face of The Paget's Disease of Bone: A Case Report and Literature Review. (acquaintpublications.com)
  • This is a case of Paget's disease of bone (PDB) with a quick, progressive clinical course, initially presented with neurological symptoms, which is rare in previously shown literature. (acquaintpublications.com)
  • Complications of Paget's disease reflect the implications of bone deformity on associated soft tissues, and may be neoplastic, rheumatological, neurological and, rarely, cardiac. (pediagenosis.com)
  • Spinal stenosis (narrowing) may occur in vertebral Paget's disease, and peripheral nerve entrapment may cause, for example, carpal tunnel syndrome. (pediagenosis.com)
  • Osteoarthritis is a common complication of Paget's disease and bone sarcoma may develop. (pediagenosis.com)
  • Bone fractures are common in patients with Paget's disease. (nih.gov)
  • Etidronate disodium tablets, USP are indicated for the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury. (nih.gov)
  • Several diseases can result in disorders of bone mineralization, which can be defined as the process by which osteoid becomes calcified. (medscape.com)
  • OB release bone matrix rich in collagen type I and participate in the hydroxyapatite crystal formation in collagen fiber deposition process, namely bone mineralization process, eventually forming new bone. (frontiersin.org)
  • 1994). Bone mineralization and histomorphometry in biopsies of osteoporotic patients treated with fluoride. (fluoridealert.org)
  • This makes probing the effect of bone-mineralization-related diseases a complicated task. (iucr.org)
  • Therefore, probing the consequences of changes in bone mineral chemistry is an important area of research to understand the impact of altered mineralization on bone functionality. (iucr.org)
  • 1 ] Osteoclasts play critical roles in many bone-destructive diseases such as osteoporosis, osteomyelitis, rheumatoid arthritis, and periodontitis. (e-jbm.org)
  • Initial changes in alveolar bone volume for sham-operated and ovariectomized rats in ligature-induced experimental periodontitis. (iphoneart.com)
  • 1 , 2 ] Therefore, many researchers consider osteoclasts clinically important and have attempted to develop new drugs targeting osteoclasts to treat osteolytic diseases. (e-jbm.org)
  • It is associated with cortical bone loss and weakening its mechanical function[5]. (exposed-skin-care.net)
  • The diagram highlights the osseous target for periodontal disease (alveolar cortical bone) and osteoporosis (trabecular bone). (iphoneart.com)
  • Our work has centered on the role of NF-kB signaling in osteoclasts, particularly in the context of cancer metastasis to bone and inflammatory arthritis. (wustl.edu)
  • Osteoporosis (OP) is a systemic metabolic bone disease that occurs most frequently in the elderly. (spandidos-publications.com)
  • These adverse drug reactions have a broad spectrum of clinical manifestations that can mimic those of other disease states, including both local and systemic conditions. (medscape.com)
  • An obvious increase or decrease in bone density should be sought, as should localized lesions. (basicmedicalkey.com)
  • Also IOF reported that Egyptian women have lower bone mineral density compared to western women and 28.4% of postmenopausal women in Egypt are expected to have osteoporosis [7] . (ommegaonline.org)
  • Osteoporosis is a common metabolic bone condition in which bones become less dense due to lack of mineral density and increased bodily breakdown. (iphoneart.com)
  • Since the … Low Bone Mineral Density Is Associated with Tooth Loss in Postmenopausal Women: A Nationwide Representative Study in Korea. (iphoneart.com)
  • The main finding of the study was a significant link between bone density and dietary inflammatory index score (DII) - a measure of how inflammatory a diet is. (nutriadvanced.ie)
  • Results showed that women with the least inflammatory diets (low DII score) lost less bone density during a six year follow up period than women with the most inflammatory diets (high DII score). (nutriadvanced.ie)
  • Blocking FSH reduced body fat levels and increased bone density in menopause. (nature.com)
  • As a result, bone density can drop by more than 4% over the next 5-8 years. (aadar.co)
  • To analyze the impact of basketball practice on bone mineral density of male adolescents. (bvsalud.org)
  • Bone mineral density was measured in different body segments (upper limbs, lower limbs, spine, and total) using the dual energy X-ray absorptiometry technique. (bvsalud.org)
  • The practice of basketball seems to affect bone mineral density gains in adolescents, mainly when the practice is prolonged. (bvsalud.org)
  • Jim Cassat , MD, PhD, associate professor of Pediatrics, Pathology, Microbiology and Immunology, and Biomedical Engineering, has received a three-year, $750,000 award from the G. Harold and Leila Y. Mathers Foundation to support research exploring the interplay between bone homeostasis and infectious disease. (vumc.org)
  • With the Mathers Foundation award, the team will investigate how signals that regulate bone homeostasis impact antibacterial responses outside of the skeleton. (vumc.org)
  • As pagetic bone is more vascular, less compact, and enlarged, it is more prone to deformities and fractures. (acquaintpublications.com)
  • The aetiology is poorly understood but may involve a chronic viral infection since inclusion bodies resembling paramyxovirus have been found in pagetic osteoclasts. (pediagenosis.com)
  • The pathogenesis probably includes a defect in bone reabsorption as well as immune dysregulation because of impaired dephosphorylation of osteopontin, but may be more complex and needs to be elucidated further. (wikipedia.org)
  • An osteoclast defect causes more significant bone destruction, prompting osteoblastic new bone production. (acquaintpublications.com)
  • Therefore, in order to design an improved second-generation therapy, it is necessary to fully understand the molecular mechanisms of the activity of rhBMPs in the setting of bone defect therapy. (biomedcentral.com)
  • Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. (degruyter.com)
  • A total of 61 DEGs, included 27 down-regulated and 34 up-regulated, were found to be significant in breast cancer bone metastasis. (degruyter.com)
  • DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
  • Metastasis to bone typically results in a poor prognosis, reducing life expectancy to 2-3 years post-diagnosis. (degruyter.com)
  • Anamnesis referred breast cancer with bone metastasis diagnosed in 2013 treated by bilateral mastectomy and adjuvant chemotherapy. (peertechzpublications.com)
  • In BMM cultures, an ethanol extract of the root part of IKN suppressed RANKL-induced osteoclast formation and bone resorptive activity. (e-jbm.org)
  • In contrast, an ethanol extract of the aerial parts of IKN had a minor effect on RANKL-induced osteoclast formation. (e-jbm.org)
  • Most commonly patients present with bone pain or deformity - these are characteristic of the disorder and include bowing of the long bones, skull enlargement with frontal bossing and, less commonly, pathological fractures (Fig. 53a, b and c). (pediagenosis.com)
  • It is not strictly a metabolic disorder since the disease is focal to bone. (pediagenosis.com)
  • 200 million person the all over the world affected by osteoporosis as it is most common metabolic bone disorder. (ommegaonline.org)
  • Osteoporosis (OP) is a metabolic disorder, which is characterized by the decrease of bone mass, and the increase of bone brittleness ( 1 ). (frontiersin.org)
  • Conditions like rheumatoid arthritis and chronic kidney disease can also raise your risk. (aadar.co)
  • Rheumatoid arthritis, diabetes, breast or prostate cancer, and certain digestive diseases are all linked to osteoporosis. (aadar.co)
  • In TRAP overexpressing transgenic mice, mild osteoporosis occurs along with increased osteoblast activity and bone synthesis. (wikipedia.org)
  • It is well established that fluoride exposure can increase bone formation by increasing the proliferation of osteoblasts . (fluoridealert.org)
  • Consistency in diagnostic evaluation with respect to both terminology and report content facilitates liaison at multidisciplinary bone tumour meetings and collaboration between cancer units and networks, as well as providing a common database for audit of the clinical, radiological and pathological aspects of bone tumours. (biomedcentral.com)
  • Primary benign and malignant bone tumours vary widely in their clinical behaviour and pathological features. (biomedcentral.com)
  • The quality of vascular supply to bone tends to decline with age and may be compromised in common pathological settings, including diabetes, anaemias, chronic airway diseases and immobility, as well as by tumours. (hilarispublisher.com)
  • The most common complications are: nerves involvement, abscesses in the nasal cavity or in paranasal sinuses and pathological bones fractures. (peertechzpublications.com)
  • There is nothing poetic, though, about osteoporosis, "the most common metabolic disease of bone" (Sandyk et al. (psychologytoday.com)
  • Osteoporosis is a common metabolic bone disease which frequently occurs in postmenopausal women, and occurs less frequently in men. (iphoneart.com)
  • Among the rare studies found in the literature about bone remodeling after osseointegration, there were no verified studies on the possible influence of implant surface treatments on bone remodeling that occurs after osseointegration. (elsevier.es)
  • Researchers, for example, found melatonin levels in postmenopausal women with osteoporosis were significantly lower than in young women with normal bone mass and suggested that melatonin levels could serve as an "auxiliary diagnostic index" for osteoporosis (Cao et al. (psychologytoday.com)
  • 2007) The association between postmenopausal osteoporosis and periodontal disease. (iphoneart.com)
  • Thus, the root part of IKN could be useful in the prevention and treatment of osteoclast-related diseases. (e-jbm.org)
  • Bone or joint pain, fractures, bone abnormalities and enlargement, and even malignant transformation are common symptoms and manifestations [2] . (acquaintpublications.com)
  • This review is intended to provide histopathologists with guidelines for clinical assessment, specimen handling and diagnostic reporting of benign and malignant primary bone tumours. (biomedcentral.com)
  • All primary malignant bone tumour cases should be discussed at a properly constituted sarcoma multidisciplinary team (MDT) meeting. (biomedcentral.com)
  • Heterotopic ossification has also been observed in non-traumatic conditions (e.g., infections of the central nervous system, peripheral neuropathy, tetanus, biliary cirrhosis, Peyronie's disease, as well as in association with a variety of benign and malignant neoplasms). (nih.gov)
  • We hypothesize that targeting succinate signaling will prevent the acceleration of periodontal disease. (newswise.com)
  • The new NIDCR grant will fund research to determine whether elevated levels of succinate accelerate the progression of periodontal disease. (newswise.com)
  • Because we've found that succinate has significant implications for periodontal disease, we hope that by understanding this novel mechanism, we can help prevent periodontal bone loss in those with diabetes," said Deepak Saxena, PhD, associate professor of basic science and craniofacial biology at NYU College of Dentistry and one of the project's principal investigators. (newswise.com)
  • Many studies have explored and identified a connection between periodontal disease and osteoporosis. (iphoneart.com)
  • Etiology and Pathogenesis of Periodontal Disease. (iphoneart.com)
  • To enhance the usability and experience for persons with osteoporosis in periodontics million ( 54 % ) older US adults in M... Clinical Diagnostics and patient Stratification for use in the understanding of periodontal disease and osteoporosis.2 ) osteoporosis in women! (iphoneart.com)
  • Management of patients on bisphosphonate therapy: a bibliographic review looking into a person ' S.... Efficacy of periodontal disease and osteoporosis.2 ) osteoporosis effect on periodontal Wound Healing and Regeneration in an Osteoporotic Model ligature-induced. (iphoneart.com)
  • And on Induced periodontal disease, tooth loss among adults in the meta-analysis for osteoporosis and risk of developing. (iphoneart.com)
  • A number of studies that have been carried out believe that diabetes has a big influence on the onset and progression of periodontal disease which, in turn, also influences glycemic control and that there exists, therefore, a bidirectional relationship between the two diseases in which diabetes predisposes the establishment of periodontal disease and the latter has a negative influence on the metabolic control of diabetes 1-2 . (bvsalud.org)
  • The prevalence and severity of periodontal disease in diabetics has been shown to be greater than that of the population as a whole 3-4 , where the effects of periodontal disease in these individuals are aggravated by metabolic and histopathological changes, characteristics of diabetes, as well as vascular changes, defective immunological responses and a delayed process of healing 1,5-7 . (bvsalud.org)
  • Newswise - The National Institute of Dental & Craniofacial Research, part of the National Institutes of Health, has awarded a grant to researchers at New York University College of Dentistry (NYU Dentistry) to explore the biological mechanisms that contribute to poor oral health and related bone loss among people with diabetes. (newswise.com)
  • Using mouse models, the researchers will investigate whether succinate signaling alters the oral microbiome, study the role of succinate as an inflammatory and immune mediator, and determine whether blocking succinate signaling can thwart diabetes-related periodontal bone loss. (newswise.com)
  • These findings reveal a novel regulatory pathway in which NO functions as a negative regulator of metabolic abnormalities induced by diabetes. (californiaehealth.org)
  • The clinical phenotype involves the bone, the central nervous system, and the immune system. (wikipedia.org)
  • Another important anomaly is that exposure to pathogenic organisms does not necessarily result in development of clinical disease. (hindawi.com)
  • even so, exposure alone does not necessarily result in development of clinical disease. (hindawi.com)
  • The clinical patterns of adverse drug reactions of the oral cavity include xerostomia, swelling, nonspecific ulceration, vesiculobullous or ulcerative mucositis that mimics other disease states, nonspecific vesiculoulcerative mucositis, pigmentation, gingival enlargement, and medication-related osteonecrosis of the jaws. (medscape.com)
  • To optimally report these diseases, it is useful to be aware of the relevant clinical history, including which bones are involved, the location of the lesion within the bone, and the radiologic features. (basicmedicalkey.com)
  • She has served in the leadership of the American Society for Bone and Mineral Research and the American Society for Clinical Investigation. (wustl.edu)
  • My clinical research interests include analyzing bone biopsies for studies of metabolic bone diseases such as osteoporosis and hypophosphatasia, using both qualitative and quantitative histomorphometric approaches. (wustl.edu)
  • A growing body of evidence has identified fibrinogen as an important risk factor for cardiovascular disease, the major cause of death in the U.S. The objective of including this measure is to provide data on laboratory, clinical, and socio- demographic correlates of fibrinogen levels. (cdc.gov)
  • With unrivaled expertise in immunology, 4 operating sites in North America and Europe, and a translational offer of services covering the needs of the pharmaceutical industry from the lead selection to the late clinical stage, Nexelis, a Q² Solutions Company, is a leading provider of assay development and advanced laboratory testing services in the infectious, metabolic and oncologic fields. (nexelis.com)
  • Data was collected from the Women's Health Initiative (WHI) Observational Study and Clinical Trials and results were published recently in the Journal of Bone and Mineral Research 3 . (nutriadvanced.ie)
  • Information from radiology, surgical, oncology and other clinical colleagues involved in the diagnosis and treatment of primary bone tumours should be properly assessed before undertaking a structured approach to specimen handling and histological reporting. (biomedcentral.com)
  • Considering the pathogenesis and the clinical outcome, the therapeutic strategy is oriented to face the infective complications (antibiotic, antiseptic, antifungal) and to remove the necrotic bone (minimally-invasive surgery). (peertechzpublications.com)
  • Our model confirms that anti-resorptive therapies are unable to partially restore bone loss, whereas bone formation therapies yield better results. (cellml.org)
  • Finally, the model clearly indicates that increasing the size of the pool of preosteoblasts is an essential ingredient for the therapeutic manipulation of bone formation. (cellml.org)
  • In this study, we explore different signaling pathways and associated molecular mechanisms of underlying primary breast cancer development, along with the formation of metastases in the bone. (degruyter.com)
  • Lipopolysaccharide (LPS)-induced osteoclast formation was performed using a mouse calvarial model. (e-jbm.org)
  • IKN administration decreased LPS-induced osteoclast formation in a calvarial osteolysis model in vivo . (e-jbm.org)
  • Bone formation is involved with a large number of osteoblasts (OB) under the periosteum. (frontiersin.org)
  • OB mediates bone formation through runt-related transcription factor 2(Runx2). (frontiersin.org)
  • These form a complex network structure and precisely regulate bone formation ( 6 ). (frontiersin.org)
  • As an indicator of osteoblastic activity, BAP provides information on bone formation. (nexelis.com)
  • The latter conclusion infers that susceptibility to infectious disease can be modified by host-related factors. (hindawi.com)
  • Inherent in this technically accurate paradox is that while the former supports the well-established link between microbial pathogens and infectious diseases, the latter infers that disease susceptibility can be modified by extramicrobial factors [ 1 - 3 ]. (hindawi.com)
  • A plausible extension of this concept relates to the involvement of vitamin D in immunomodulation and the role the vitamin appears to have in a number of infectious diseases. (hindawi.com)
  • He came to Vanderbilt in 2008 for an accelerated two-year residency in pediatrics, followed by a fellowship in pediatric infectious diseases. (vumc.org)
  • Similarly, within the cancellous bone, the trabeculae are arranged along the principal lines of stress. (basicmedicalkey.com)
  • The cortex is thicker in the middle of the shaft of a long bone to resist bending forces, whereas the cancellous bone is concentrated at the ends of the long bones to resist the mainly compressive forces that are common at that site. (basicmedicalkey.com)
  • 2022.) As an anti-inflammatory and "free radical scavenger," melatonin may be therapeutic in preventing bone loss (Amstrup et al. (psychologytoday.com)
  • The efficacy on wound healing, blood circulation, immunological response, and microbicide power make this molecule an interesting therapeutic aid for many diseases, including BRONJ [28]. (peertechzpublications.com)
  • Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)
  • He and his colleagues developed animal models and unique imaging technologies to study these interactions, and they published a comprehensive evaluation of the metabolic pathways that support Staphylococcus aureus ("staph") growth during invasive bone infections. (vumc.org)