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  • morphologic
  • This extensively folded or ruffled border facilitates bone removal by dramatically increasing the cell surface for secretion and uptake of the resorption compartment contents and is a morphologic characteristic of an osteoclast that is actively resorbing bone. (wikipedia.org)
  • macrophages
  • When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 µm in diameter occur. (wikipedia.org)
  • The size of the multinucleated assembled osteoclast allows it to focus the ion transport, protein secretory and vesicular transport capabilities of many macrophages on a localized area of bone. (wikipedia.org)
  • cells
  • These may have dozens of nuclei, and typically express major osteoclast proteins but have significant differences from cells in living bone because of the not-natural substrate. (wikipedia.org)
  • tartrate resistant a
  • This permits characterization of osteoclasts by their staining for high expression of tartrate resistant acid phosphatase (TRAP) and cathepsin K. Osteoclast rough endoplasmic reticulum is sparse, and the Golgi complex is extensive. (wikipedia.org)
  • Scale bar, 0.5 mm. ( f ) Histological sections of distal femurs of 5-week-old RANKLf/f and Prx1-Cre;RANKLf/f mice stained for tartrate-resistant acid phosphatase (TRAP) activity (osteoclasts stain red). (nih.gov)
  • Furthermore
  • Furthermore, the project focuses on using protein chemistry and proteomic analyses for identification of the unknown factor(s) secreted by the osteoclasts. (nordforsk.org)
  • Generation
  • Hence, the current paradigm holds that TRANCE-RANK interaction and subsequent signaling via TRAF6 are essential for the generation of functional osteoclasts. (nih.gov)
  • large
  • Light micrograph of an osteoclast displaying typical distinguishing characteristics: a large cell with multiple nuclei and a "foamy" cytosol. (wikipedia.org)
  • increase
  • Conclusions- Long-term alendronate treatment is associated with an increase in the number of osteoclasts, which include distinctive giant, hypernucleated, detached osteoclasts that are undergoing protracted apoptosis. (natap.org)
  • In early postmenopausal women, treatment with alendronate for 3 years decreased biochemical markers and histomorphometric indexes of bone turnover and simultaneously increased bone mineral density.3 Our study indicates that these changes were accompanied by a dose-dependent increase in the number of osteoclasts. (natap.org)