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  • atherosclerotic
  • Recent studies have investigated whether osteocalcin is associated with subclinical and clinical atherosclerotic coronary artery disease (CAD), but these studies have yielded inconsistent results. (biomedcentral.com)
  • regulates
  • Ferron M, Hinoi E, Karsenty G, Ducy P (2008) Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. (springer.com)
  • M. Ferron, E. Hinoi, G. Karsenty, and P. Ducy, "Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice," Proceedings of the National Academy of Sciences of the United States of America , vol. 105, no. 13, pp. 5266-5270, 2008. (hindawi.com)
  • role of osteocalcin
  • This study extends the endocrine role of osteocalcin to the developmental period and establishes osteocalcin/Gprc6a signaling as a major regulator of β-cell endowment that can become a potential target for β-cell proliferative therapies. (diabetesjournals.org)
  • Therefore, the aim of this review is to examine the evidence for a role of osteocalcin in atherosclerosis development and progression, and in particular endothelial dysfunction and vascular calcification. (mdpi.com)
  • marker osteocalcin
  • The current double-blind, randomized study was designed to test whether daily consumption of double-strength Ocean Spray light CJ (2 x 230 ml) over 4 months has beneficial effects on vascular function and on endothelial progenitor cells (EPCs) carrying the osteoblastic marker osteocalcin in particular. (uzh.ch)
  • phenotype
  • The observed nonspecificity of many osteocalcin antisera may compromise immunocytochemical studies of the osteoblast phenotype in studies in vitro when based solely on reactivity with inadequately characterized osteocalcin antisera. (ox.ac.uk)
  • bone-derived
  • However, the choice of skin cells as negative controls for osteocalcin synthesis yielded an unexpected positive staining pattern similar to that seen with the bone-derived cells over a range of antiserum dilutions. (ox.ac.uk)