Osteoblasts regulates expression. Medical search. Frequent questions

We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
This study confirms that alterations in the expression of exosomal miRNAs can promote osteogenic differentiation of ADSCs, which also provides the foundation for further research on the regulatory functions of exosomal miRNAs in the context of ADSC osteogenesis. (hindawi.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. (lu.se)
The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. (lu.se)
The study uses IDG-SW3 cells as a model for the differentiation from osteoblasts to osteocytes. (lu.se)
Among the major cyclin-dependent kinases (Cdks), Cdk1 is most abundantly expressed in IDG-SW3 cells, and its expression is down-regulated during differentiation into osteocytes. (lu.se)
Pthlh expression increases during differentiation, but inhibiting CDK1 activity reduces Pthlh expression. (lu.se)
These results demonstrate that Cdk1 plays an essential role in the differentiation from osteoblast to osteocyte and the acquisition and maintenance of bone mass. (lu.se)
Runx2 is known to mediate activation of osteoclast activity and inhibition of osteoblast differentiation by metastatic breast cancer cells. (biomedcentral.com)
The function of Runx2/CBFβ-regulated genes in mediating the ability of MDA-MB-231 to inhibit osteoblast differentiation was subsequently established in primary bone marrow stromal cell cultures and MC-3T3 osteoblast cells. (biomedcentral.com)
We show that Runx2/CBFβ mediates inhibition of osteoblast differentiation by MDA-MB-231 cells through induction of the Wnt signaling antagonist, sclerostin. (biomedcentral.com)
We also show that Runx2-dependent inhibition of osteoblast differentiation by breast cancer cells is mediated through the Wnt antagonist, sclerostin. (biomedcentral.com)
Members of the transforming growth factor beta (TGFβ) family also contribute to inhibition of osteoblast differentiation by metastatic breast cancer cells [ 6 , 7 ]. (biomedcentral.com)
Runt-related transcription factor 2 (RUNX2), a member of the RUNX family, functions as a critical regulator for osteoblast differentiation ( 14 ). (spandidos-publications.com)
Osteotesticular PTP (OST) is the only characterized member of this superfamily whose expression is regulated in osteoblasts and critical for their in vitro differentiation. (umn.edu)
In an effort to examine the molecular mechanisms involved in the cellular regulation of OST, we have characterized its expression in MC3T3 osteoblasts during differentiation. (umn.edu)
This expression pattern is unique to this phosphatase since, in comparison, the structurally similar receptor PTP, LAR, and the intracellular PTP1B show little change during differentiation. (umn.edu)
These results show that the murine OST gene is regulated at the transcriptional level in an osteoblast-specific, differentiation-dependent manner during the differentiation of MC3T3 osteoblasts. (umn.edu)
Expression of DKK1 inhibited the Wnt/β-catenin signaling pathway and partially rescued osteogenic differentiation of MSCs. (aging-us.com)
To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
The results showed that MSC did not alter their osteogenic differentiation capacity, surface marker profile, and the expression profiles of MSC during expansion. (biomedcentral.com)
Additionally, we were able to reconstruct the three developmental phases during osteoblast differentiation: proliferation, matrix maturation, and mineralization, and illustrate the activation of the SMAD signaling pathways by TGF-β2 and BMPs. (biomedcentral.com)
Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)
This differentiation was accompanied by expression of the osteoblastic transcription factor Runx2, which results in earlier initiation of the osteoblast differentiation programme. (adenosine-receptor.com)
Since Sirt-1 inhibits the adipogenic transcription factor PPAR-c, it also stimulates mechanisms regulating osteoblast differentiation. (adenosine-receptor.com)
11753686 " The mechanisms by which resveratrol and Sirt-1 mediate differentiation of MSCs to osteoblasts and inhibit adipogenesis, appear to involve, at least in part, the inhibition of PPAR-c and activation of Runx2. (adenosine-receptor.com)
The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. (biomedcentral.com)
Therefore, a sustainable drug is desirable to identify better and safe anabolic agents with low toxicity that act by either increasing the osteoblasts proliferation or inducing osteoblasts differentiation to enhance bone formation [ 8 ]. (biomedcentral.com)
Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. (medscape.com)
Conclusions Over-expression of miR-217 can inhibit the expression of EZH2 and promote the osteogenic differentiation of BM-MSCs in OP mice, which could provide a new strategy for clinical prevention and treatment of OP. (magtechjournal.com)

Enpp1-3 gene expression was assayed by real-time PCR in human periodontal ligament (PDL) cells and murine cementoblasts (OCCM-30) under osteogenic conditions. (umich.edu)
We have previously demonstrated that Runx2 requires the co-activator core binding factor beta (CBFβ) to regulate gene expression in breast cancer cells. (biomedcentral.com)
MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
Sommerer, C. & Giese, T. Nuclear Factor of Activated T Cells-Regulated Gene Expression as Predictive Biomarker of Personal Response to Calcineurin Inhibitors. (uni-heidelberg.de)
MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
Chronic administration effects were evaluated by histology and gene expression analysis in adipose tissue and liver samples. (bvsalud.org)
This activation appears to be specific to osteoblasts, since progression to a myoblast phenotype results in no change in reporter gene activity. (umn.edu)
Moreover, the gene expression profile of inflammatory modulators such as IL10, IL6, and TNF-α was also investigated to verify the macrophage phenotype induced by treatment. (mdpi.com)
X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)
This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. (lu.se)

Breast cancers frequently metastasise to the skeleton where they cause osteolytic bone destruction by stimulating osteoclasts to resorb bone and by preventing osteoblasts from producing new bone. (biomedcentral.com)
These metastatic tumours interfere with normal bone remodelling by stimulating osteoclasts to resorb bone and preventing new bone growth by inhibiting osteoblasts. (biomedcentral.com)
Thus, bone degradation is due to both increased activation of osteoclasts and suppression of osteoblasts. (biomedcentral.com)
It was detected in the periosteum which contains mesenchymal pre-osteoblasts of the ulna and radius, in osteocytes and osteoclasts. (cdc.gov)
In this study, we observed increased 11β-HSD1 expression in osteoclasts within an osteoporotic mice model (ovariectomized mice). (ijbs.com)
Then, by suppression of YAP expression in Hippo signaling, we observed the redundant of osteoclasts formation even in 11β-HSD1 high expression conditions. (ijbs.com)
Bone is a unique connective tissue which constantly undergoes remodeling, which involves bone formation by osteoblasts and bone resorption by osteoclasts[ 3 ]. (ijbs.com)
Previous studies showed that different plant-derived flavonoid compounds could stimulate osteoblasts function, and inhibit osteoclasts functions either alone or in combination. (biomedcentral.com)
Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. (ebi.ac.uk)
Osteoblasts (cells that make the organic matrix of bone and then mineralize bone) and osteoclasts (cells that resorb bone) are regulated by parathyroid hormone (PTH), calcitonin , estrogen , vitamin D, various cytokines, and other local factors such as prostaglandins. (msdmanuals.com)

Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
In the presence of resveratrol or/and nicotinamide, MSCs differentiate into osteoblasts and adipocytes in highdensity cultures. (adenosine-receptor.com)
In contrast to MSCs, pre-osteoblast cells were programmed to differentiate into their committed target osteoblast cells, as they were unable to differentiate into adipocytes. (adenosine-receptor.com)

The in-vivo use of alpha-CGRP, which leads to down-regulated RANKL in-vitro, might inhibit the catabolic effect of particles in conditions of particle induced osteolysis. (nih.gov)

The purpose of this study was to investigate the effects of extra corporeal shock waves (ESW) therapy on the metabolism of healthy and osteoarthritic human chondrocytes, and particularly on the expression of IL-10, TNF-alpha and beta1 integrin. (biomedcentral.com)
After that, chondrocytes were cultured in 24-well plate in DMEM supplemented with 10% FCS for 48 hours and then beta 1 integrin surface expression and intracellular IL-10 and TNF-alpha levels were evaluated by flow-cytometry. (biomedcentral.com)
Following ESW application, while beta1 integrin expression remain unchanged, a significant decrease of IL-10 and TNF-alpha intracellular levels was observed both in osteoarthritic and healthy chondrocytes. (biomedcentral.com)
Nonetheless, ESW treatment application down-regulate the intracellular levels of TNF-alpha and IL-10 by chondrocytes, suggesting that ESW might restore TNF-alpha and IL-10 production by osteoarthritic chondrocytes at normal levels. (biomedcentral.com)
TNF-alpha is produced by inflamed synovial membrane, chondrocytes and osteoblasts, and act in an autocrine-paracrine manner. (biomedcentral.com)

However, while Runx2-regulated genes that mediate osteoclast activation have been identified, how Runx2 determines inhibition of osteoblasts is unknown. (biomedcentral.com)
We, therefore, performed independent microarray analyses to identify target genes whose expression is dependent upon both Runx2 and CBFβ. (biomedcentral.com)
We demonstrate that MDA-MB-231 cells secrete sclerostin and that sclerostin-expression is critically dependent on both Runx2 and CBFβ. (biomedcentral.com)
This study demonstrates that Runx2 and CBFβ are required for the expression of genes that mediate the ability of metastatic breast cancer cells to directly modulate both osteoclast and osteoblast function. (biomedcentral.com)
Using bioinformatics, a luciferase reporter assay and western blot analyses, the current study identified that runt‑related transcription factor 2 (RUNX2) was a target of miR‑205 in PC and overexpression of miR‑205 suppressed the expression of RUNX2. (spandidos-publications.com)
In addition, Kayed et al ( 15 ) demonstrated that RUNX2 was overexpressed in PC and could be regulated by certain cytokines, including transforming growth factor β1 and bone morphogenetic protein 2. (spandidos-publications.com)
However, to the best of our knowledge, the miRs that regulate RUNX2 expression in tumors are unknown. (spandidos-publications.com)
The current study demonstrated that miR-205 was a tumor suppressor in PC and a regulator of RUNX2 expression. (spandidos-publications.com)
Runx2 is responsible for expression of osteogenic marker genes, including osteopontin, osteocalcin and ALP. (adenosine-receptor.com)
The expression level of miR-217 in BM-MSCs, the expression levels of OCN, Runx2, collagen Ⅰ mRNAs and proteins, and the ALP activity in the miR-217 mimics group were higher than those in the control group and in miR-NC group ( P ＜0.05). (magtechjournal.com)

We previously showed that prostaglandin E1 (PGE1) induces the synthesis of IL-6 by activating p44/p42 mitogen-activated protein kinase (MAPK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 MAPK in osteoblast-like MC3T3-E1 cells. (iasp-pain.org)
The osteoblast-like MC3T3-E1 cells were treated with HSP70 inhibitors-VER-155008 and YM-08-, PD98059, SB203580 or SP600125 and then stimulated with PGE1. (iasp-pain.org)
cells, but pre-osteoblastic cells from the osteoblast progenitor MC3T3-E1 are not. (adenosine-receptor.com)

In PDL cells, Enpp2 and Enpp3 were significantly increased at later stages of mineralization (about 4-fold), while Enpp1 expression was unaltered by osteogenic conditions. (umich.edu)

MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. (nih.gov)

EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer. (uni-heidelberg.de)
Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)

By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
In contrast, few studies have identified mechanisms by which breast cancer cells suppress bone synthesis by osteoblasts. (biomedcentral.com)
Zhang et al ( 9 ) revealed that expression of miR-205 was significantly decreased in radioresistant subpopulations of breast cancer cells and loss of miR-205 expression was associated with poor distant relapse-free survival in patients with breast cancer. (spandidos-publications.com)
EMT is an embryologically conserved genetic program by which epithelial cells down regulate intercellular tight junctions, loose polarity, express mesenchymal markers, and manifest a migratory phenotype [ 1 ]. (intechopen.com)
c) HTR-8/SVneo cells were transfected with MTA1 siRNA or scramble siRNA (Scr) in the presence or absence of 200 ng/ml leptin for 24 h, and Western blot analysis was performed to detect the expression of MTA1, WNT1, p-GSK3 β (Ser9), and nuclear β -catenin. (bioz.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
We also showed that miR-96-transfected cells had increased cell-cell adhesion to both each other and osteoblasts, and an increased colony formation potential. (lu.se)

In vitro experiments showed the endogenous high expression of 11β-HSD1 lead to osteoclast formation and maturation. (ijbs.com)

MicroRNAs function to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
Exploration of genes that cause SBD has significantly improved our understanding of the mechanisms that regulate bone formation. (nature.com)
Expression of the estrogen receptor and estrogen-induced genes was studied at the mRNA level by RT-PCR and at the protein level by immunohistochemistry and western blot analysis. (biomedcentral.com)

However, the mechanism by which nuclear translocation is regulated remains unclear. (nature.com)

Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. (ebi.ac.uk)

HSP70 inhibitors upregulate prostaglandin E1-induced synthesis of interleukin-6 in osteoblasts. (iasp-pain.org)
Our results suggest that HSP70 inhibitors upregulate the PGE1-stimulated IL-6 synthesis through p38 MAPK in osteoblasts and therefore affect bone remodeling. (iasp-pain.org)
It increases the synthesis of MMPs and plasminogen activator, essential to convert the pro-MMPs in MMPs, and regulate the organization of ECM by enhancing the synthesis of minor collagens, normally not present in cartilage, such as collagen types I and III, and decreasing the production of proteoglycans and collagen types II and IX, which represent the optimal scaffolding of cartilage [ 3 ]. (biomedcentral.com)

miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. (nih.gov)

11β-HSD1 has been observed to regulate skeletal metabolism, specifically within osteoblasts. (ijbs.com)

This research aimed to map NPP1,2, and 3 expression in the developing periodontium in wild-type (WT) mice, as well as in PP i -deficient progressive ankylosis protein ( Ank ) and Enpp1 KO mice, to explore their roles in periodontal homeostasis. (umich.edu)
Results: In WT mice, NPP1 staining was observed in cementoblasts, osteoblasts, and odontoblasts, whereas NPP2 and NPP3 were localized to pulp and PDL tissues. (umich.edu)
In Enpp1 KO mice, NPP2/3 expression was similar to WT. (umich.edu)
The remaining mice were assessed for tolerance to THC‐induced hypothermia, and whole‐brain CB1R expression was assessed in all mice. (iupui.edu)
Bone formation-related indices like osteoblast number, osteoblast surface, bone volume, mineralizing surface, mineral apposition rate and bone formation rate were significantly increased in the TPF-treated mice compared to the control mice. (biomedcentral.com)
Downregulation of miR-379 enhanced incidence of bone metastasis in mice, increased colony formation potential in osteoblast-conditioned media, and increased cell growth. (lu.se)

Such crosstalk between Mφs and MSCs further strengthens the effect of paracrine mediators from MSCs to regulate Mφs phenotypic alteration. (frontiersin.org)
Results The expression level of miR-217 in the bone tissue and BM-MSCs of the OP group was lower than that of the sham group ( P ＜0.05), and the expression level of EZH2 mRNA was higher than that of the sham group( P ＜0.05). (magtechjournal.com)
The expression levels of EZH2 mRNA and protein in BM-MSCs in the miR-217 mimics+pcDNA 3.1-EZH2 group were higher than those in the miR-217 mimics group and miR-217 mimics+pcDNA 3.1 group ( P ＜0.05). (magtechjournal.com)

3) The expressions of Cbfa1 and OCN in osteoblasts treated with the same experimental conditions as the fibroblasts were up-regulated by fluoride following the same trend as in the fibroblasts. (fluoridealert.org)
Our results showed an increase in the expression of Cbfa1 and OCN in fibroblasts and osteoblasts exposed to fluoride and suggested that the osteogenic function of fibroblasts induced by fluoride could play an important role in the development of extraperiosteal ossification during skeletal fluorosis. (fluoridealert.org)

Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. (ebi.ac.uk)

Bone formation represents a heritable trait regulated by many signals and complex mechanisms. (nature.com)

To investigate the expression of pro-inflammatory cytokines ELISA assay was done on the bone of performing and control animals. (cdc.gov)
The over-expression of MMPs is induced by several cytokines, such as IL-1, TNF-alpha, IL-17, IL-10, and many others, which have been detected increased in OA cartilage. (biomedcentral.com)

In the present study, polysaccharides composed mainly by β-glucans, produced by the mushroom Gymnopilus imperialis (from Atlantic Forest in Brazil), were evaluated in terms of in vitro immunomodulatory potential, iNOS expression levels, and NO production. (mdpi.com)

Primary human osteoblasts were stimulated by UHMWPE particles (cell/particle ratios 1:100 and 1:500) and different doses of alpha-CGRP (10(-7 )M, 10(-9 )M, 10(-11 )M). Receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) mRNA expression and protein levels were measured by RT-PCR and Western blot. (nih.gov)
Although various studies have assessed OPN protein levels in several tumor types, a broad survey of OPN expression in human neoplasia under the same experimental conditions has not been carried out. (aacrjournals.org)
PLF protein was markedly up regulated in the bone of the performing limb of animals exposed to high force and repetitive motion, and the spatial pattern of PLF expression varied over the course of remodeling. (cdc.gov)
The expression level of EZH2 mRNA and protein were lower than those of the control group and miR-NC group ( P ＜0.05). (magtechjournal.com)
Osteonectin expression was evaluated using immunohistochemistry with anti-secreted protein acidic and rich in cystein (anti-SPARC) antibody. (bvsalud.org)
In Paper I, we showed that miR-96 can upregulate the mRNA and protein expression of adhesion proteins E-Cadherin and EpCAM through direct interaction with target sites in the mRNA coding sequence. (lu.se)

Alpha-CGRP in all tested concentrations showed a significant depressive effect on the expression of RANKL mRNA in primary human osteoblasts under particle stimulation. (nih.gov)
In cell-particle ratios of 1:100 after 24 hours the osteoprotective influence of alpha-CGRP reversed the catabolic effects of particles on the RANKL expression. (nih.gov)

However, to the best of our knowledge, the association between miR‑205 expression and the progression of PC has rarely been investigated. (spandidos-publications.com)
miR-205 expression in humans was validated by Landgraf et al ( 8 ), however, its role in tumor progression is contradictory ( 9 - 12 ). (spandidos-publications.com)
Northern analysis revealed that murine OST mRNA is dramatically regulated during the preosteoblast to osteoblast progression, with predominant expression in differentiated and early mineralizing osteoblasts. (umn.edu)

Interleukin-6 (IL-6) is a pro-inflammatory and bone-resorptive cytokine that also regulates bone formation. (iasp-pain.org)

To study the effects and importance of fluoride on FBs in the development of extraperiosteal calcification and the ossification of skeletal fluorosis, the presence of the osteogenic phenotype, which is indicated by the expression of core-binding factor a1 (Cbfa1) and osteocalcin (OCN), in an FB cell line (L929) and in osteoblasts (OBs) exposed to fluoride was determined. (fluoridealert.org)
A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)
By contrast, miR-205 expression has been identified to be significantly increased in several human cancer types, including ovarian cancer, endometrial cancer and laryngeal squamous cell carcinoma, in which it was identified to function as an oncoprotein ( 10 , 11 , 13 ). (spandidos-publications.com)
Cell density contributes to this upregulated expression as confluent cultures display an increase in OST transcripts within 4 h post-plating. (umn.edu)

Cover: In zebrafish, osteoblasts are positioned distal to the mineralized matrix, allowing the simultaneous in vivo visualization of osteoblasts (red, osterix:mCherry) and calcified tissue (green, calcein staining). (biologists.com)

The suggested osteoprotective influence of alpha-CGRP on the catabolic effects of ultra-high molecular weight polyethylene (UHMWPE) particles is analyzed in this study in primary human osteoblasts. (nih.gov)
Osteosarcoma is a malignant primary bone tumor that is characterized by neoplastic osteoblasts that produce osteoid. (medscape.com)

Compared to WT, NPP1 expression was increased markedly in Ank KO cementoblasts lining the cervical root from 27 to 79 dpc, whereas NPP2 and NPP3 were increased at days 27, 33 and 60 in pulp and PDL tissues. (umich.edu)

Ectonucleotide Pyrophosphatase/Phosphodiesterase (NPP)1-3 May Regulate Periodontal Homeostasis. (umich.edu)

These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)

IL-6 mRNA expression was measured by real-time RT-PCR. (iasp-pain.org)
We found that VER-155008, an HSP70 inhibitor, enhanced the PGE1-stimulated IL-6 release and IL-6 mRNA expression. (iasp-pain.org)

In the current study, low miR‑205 expression was revealed in PC tumor tissues and indicated poor prognosis in patients with PC. (spandidos-publications.com)
When considering all sites, OPN expression significantly correlated with tumor stage (Spearman's correlation coefficient, P = 0.0002). (aacrjournals.org)

We also studied the role of A-to-I RNA editing in regulating miR-379 function. (lu.se)

PLF over expression by adenovirus in the bone marrow cavity of rats resulted in increased bone formation. (cdc.gov)
The expression of PLF in bones undergoing remodeling, recovery and repair suggests that PLF plays a significant role in formation and maintenance of bone tissue. (cdc.gov)
play a crucial role in bone formation, which process is regulated by many factors [ 1 ]. (biomedcentral.com)

However, while this approach reduces the bone lesions and improves the quality of patient life, therapies that restore osteoblast activity are required to achieve more complete repair of osteolytic lesions [ 1 ]. (biomedcentral.com)
Periostin-Like-Factor (PLF) is expressed in developing bone and is up regulated in adult bones that undergo remodeling due to fractures or repeated high force activity which leads to inflammation followed by injury of the bone. (cdc.gov)

Anatomy20

Organisms3

Diseases11

Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes26

Technology, Industry, Agriculture2

Differentiation32

Gene10

Osteoclasts10

Adipocytes4

Inhibit1

Chondrocytes5

Runx210

MC3T3-E13

Mineralization1

Proliferation1

Inhibits2

Cells8

Maturation1

Genes4

Remains unclear1

Osteocytes1

Synthesis3

Inhibition1

Metabolism1

Mice6

MSCs3

Fibroblasts2

Osteocyte1

Mechanisms1

Cytokines2

Vitro1

Protein6

RANKL2

Progression3

Cytokine1

Cell4

Vivo1

Primary2

Markedly1

Homeostasis1

Collagen1

MRNA expression2

Tumor2

Function1

Formation3

Activity2