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  • remotely
  • 6 ) report that osteoblasts, which reside in the bone, can be remotely activated by secreted factors from lung adenocarcinoma, which in turn mobilize a specific subset of BMDCs-neutrophils-to foster tumor growth. (sciencemag.org)
  • assay
  • Next the Gilead team developed a primary osteoblast cell growth assay and evaluated TFV-DP levels after single and multiple TAF pulses. (natap.org)
  • calcium
  • Osteoblast activity serves this function of maintaining appropriate calcium levels by depositing calcium in bones when blood calcium levels are above normal. (wikipedia.org)
  • activity
  • Human cultured female osteoblasts (Obs) respond age-dependently to estradiol-17β (E2) and to phytoestrogens by increased DNA synthesis (DNA) and creatine kinase specific activity (CK). (omicsonline.org)
  • tissue
  • Osteoblast quantity is understood to be inversely proportional to that of marrow adipocytes which comprise marrow adipose tissue (MAT). (wikipedia.org)
  • Primary
  • They then evaluated similar TAF concentrations in primary osteoblasts. (natap.org)
  • They assessed cell viability after treating primary osteoblasts with TAF for 3 days. (natap.org)
  • In primary osteoblasts, a single 2-hour pulse of the same TAF concentrations yielded TFV-DP levels comparable to those reached in PBMCs. (natap.org)
  • The Gilead team saw no change in cell viability of primary osteoblasts exposed to clinically relevant TAF concentrations. (natap.org)
  • The investigators concluded that "primary osteoblasts were not preferentially loaded by TAF relative to PBMCs. (natap.org)