AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
OsteoblastsCell DifferentiationAlkaline PhosphataseOsteocalcinCalcification, PhysiologicCells, CulturedOsteogenesisCell LineCore Binding Factor Alpha 1 SubunitSkullRNA, MessengerBone and BonesSignal TransductionCalcitriolParathyroid HormoneOsteoclastsOsteosarcomaGene Expression RegulationTranscription FactorsIntegrin-Binding SialoproteinBone Morphogenetic Protein 2Cell DivisionStem CellsCell ProliferationOsteopontinBone Morphogenetic ProteinsRANK LigandOsteocytesMolecular Sequence DataBase Sequence3T3 CellsGene Expression Regulation, DevelopmentalBone ResorptionReverse Transcriptase Polymerase Chain ReactionOsteoprotegerinSex DifferentiationGene ExpressionPromoter Regions, GeneticSialoglycoproteinsTranscription, GeneticDNA-Binding ProteinsMice, Inbred C57BLEmbryonic Stem CellsBone Marrow CellsFibrous Dysplasia, MonostoticCell LineageReceptor Activator of Nuclear Factor-kappa BMesenchymal Stromal CellsTransforming Growth Factor betaTransfectionBone MatrixBone DevelopmentPhenotypeMice, TransgenicReceptor, Parathyroid Hormone, Type 1Tumor Cells, CulturedBlotting, WesternTretinoinTitaniumCollagen Type ITime FactorsImmunohistochemistryBlotting, NorthernUp-RegulationMice, KnockoutCell Culture TechniquesDexamethasoneConnexin 43Trans-ActivatorsDown-RegulationAntigens, DifferentiationCollagenHomeodomain ProteinsCell CommunicationApoptosisFlow CytometryModels, BiologicalDermotoxinsReceptors, Parathyroid HormoneAdipogenesisCoculture TechniquesBiological MarkersCell Line, TumorProtein BindingCell SurvivalPhosphorylationNuclear ProteinsStromal CellsAmino Acid SequenceMatrix Metalloproteinase 13Parietal BoneDose-Response Relationship, DrugRecombinant ProteinsMyoblastsDNA PrimersGlycoproteinsCarrier ProteinsNeuronsMembrane GlycoproteinsMutation
ProliferationExtracellularAlkaline phosphataseLineagesTissueChondrocytesMSCsStimulatesVitroProgenitor cellsInappropriate differentiationRegulatorGenesPathwaysLineageInhibitionInduceChondrogenicMaturationHematopoieticBMSCsRunx2UndergoOsteoprogenitor cellsInhibitorStimuliEmbryonic stemBone cellsOsteogenic cellsIncubationCytokineStem CellScaffoldsAdipocytesOsteocytesApoptosisHomeostasisTranscriptionQuantificationSurvivalMurineCorticalOsteocalcinSecretionMarkerPromotesHSCsAbnormalTumorProstate
Proliferation27
  • TGF-β is important for cell proliferation and differentiation during skeletogenesis. (wikipedia.org)
  • This study was therefore aimed at establishing the dose-response effect of EPO stimulation on rat BMSCs and investigating the effects of mechanical stretch combined with EPO on the proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
  • The proliferation and osteogenic differentiation of rat BMSCs were examined and compared using EPO with different concentrations. (hindawi.com)
  • Mechanical stretch combined with 20 IU/ml EPO promoted proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
  • EPO was able to promote the proliferation and osteogenic differentiation of BMSCs, and these effects were enhanced when combined with mechanical stretch. (hindawi.com)
  • This study was therefore aimed at addressing three key issues: First, is there a dose-dependent effect of EPO on the proliferation and osteogenic differentiation of BMSCs? (hindawi.com)
  • Depending on these effects, we propose that COX might possibly perform a function while in the Akt mediated regulation of osteoblasts proliferation. (mirnasynthesis.com)
  • And TGF-β, just going back to that, is specific to cellular function in terms of cell growth, proliferation, differentiation. (chiroeco.com)
  • Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells. (stepsofchange.org)
  • Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
  • In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
  • M-CSF binds to the M-CSF receptor, which is promote the proliferation and differentiation of OC and the continuous expression of RANK. (frontiersin.org)
  • Multiple signaling pathways stimulate the differentiation and proliferation of OC. (frontiersin.org)
  • The influcence of cytomechanical forces in cellular migration, proliferation and differentation of mesenchymal stem cells (MSCs) is still poorly understood in detail. (biomedcentral.com)
  • Because of their capacity for ex vivo proliferation and differentiation they provide a good source of osteoprogenitor cells within custom-shaped scaffolds for implantable autologous bone tissue thus allowing the generation of a large transplantable cell population from a small biopsy [ 5 - 11 ]. (biomedcentral.com)
  • It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
  • Cell proliferation analysis revealed that the CHO-k1 and mesenchymal stem cells behaved differently. (biomedcentral.com)
  • The laser-processed titanium surface increased the proliferation of CHO-k1 cells, reduced the proliferation of mesenchymal stem cells, upregulated the expression of the osteogenic markers, and enhanced alkaline phosphatase activity. (biomedcentral.com)
  • Moreover, pathological processes, such as neuroinflammation, stroke or epilepsy, are able to induce proliferation and differentiation of NSCs and NPCs. (jneurology.com)
  • Multiple myeloma (MM) is an incurable malignancy characterized by clonal proliferation of plasma cells in the bone marrow microenvironment. (snmjournals.org)
  • The authors of the study have clarified the effect of CoQ10 on osteoblastic cell proliferation and differentiation, and its impact on osteoporosis. (saveourbones.com)
  • For the BMSCs they measured cell proliferation and differentiation, as well as signs of osteoblast creation. (saveourbones.com)
  • Currently, 17 murine and human KLFs are known to play crucial roles in the regulation of transcription, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. (mdpi.com)
  • Local factors, including transcription factors such as SRY-box 9 protein (SOX9), Runt-related transcription factor 2 (RUNX2), and bone morphogenetic proteins (BMPs), along with signaling pathways such as the Wnt pathway, play critical roles in chondrocyte proliferation and differentiation. (pfmjournal.org)
  • Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • Low-level laser therapy has been investigated as a possible stimulus for enhancement of proliferation and differentiation of various cell types, but few reports relate undifferentiated mouse pulp cells (OD-21) response to irradiation in in vitro models. (bvsalud.org)
  • Irradiation time of group I influenced positively the proliferation and viability of OD-21 cells in late cell culture period. (bvsalud.org)
Extracellular6
Alkaline phosphatase4
Lineages5
  • TGF-β determines and regulates cell lineages during endochondral ossification through Sox9 and Runx2 signalling pathways. (wikipedia.org)
  • It is thought that through a combination of biochemical and biophysical stimuli, the uncommitted stem cells of the embryo will undergo differentiation into certain cell lineages. (wikipedia.org)
  • Despite the fact that a preceding research noticed that both COX and COX levels are enhanced following mechanical stimuli inside the osteoblastic and osteoclastic lineages , the physiological part of constitutively expressed COX in osteoblasts hasn't been reported. (mirnasynthesis.com)
  • This article provides an overview of what is currently known about cell death in the osteoclast and osteoblast lineages and how the death of these cells may be related to clinically important bone diseases. (biomedcentral.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Tissue14
  • However, female mice with reduced osteoblastic Nrp2 expression display a reduced cross-sectional tissue area but have a normal trabecular bone mass. (bvsalud.org)
  • [ 9 ] Consequently, the osteoblastic cells will elaborate a fibrous tissue in the bone marrow instead of normal bone. (medscape.com)
  • This is explained with the limited soft tissue contrast, so that the differentiation of the gland itself from the bladder wall and sometimes the Levator ani muscles is not easily possible. (ispub.com)
  • Appropriately, cell therapy with autologous bone tissue marrow concentrates or aspirates, which includes both hematopoietic and mesenchymal stromal cells (BM-MSCs) furthermore to various other cell types that may are likely involved in tissues regeneration, represents a practical choice for osteonecrosis in SCD [6, 7]. (azd1152.com)
  • In most scientific studies for bone tissue regeneration, the efficacy of BM aspirates or concentrates depends upon the product quality and level of implanted BM-MSCs. (azd1152.com)
  • Today's webinar, "Breakthrough in Stem Cell Activation: The First Oral Protein Complex for Tissue Regeneration. (chiroeco.com)
  • Dr. Patterson, thank you for taking the time to participate in our webinar, and for sharing your expertise in stem cells, and helping our audience get a better understanding of stem cells and tissue regeneration. (chiroeco.com)
  • So one is to activate stem cells and the second is to regenerate tissue. (chiroeco.com)
  • After incubation, cell cultures were transfered to the different cutures systems: regular static tissue flasks (group I), spinner flasks (group II) and rotating wall vessels (group III). (biomedcentral.com)
  • During the last years tissue engineering based treatment concepts and cell therapeutics showed promising results in vitro . (biomedcentral.com)
  • These alterations may be inherited at conception, affecting every cell of the body, but are more commonly acquired by accident in a small number of cells in one or another tissue. (bbvaopenmind.com)
  • Mutations that increase the ability of these cells to proliferate generate small pre-malignant tissue masses. (bbvaopenmind.com)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
Chondrocytes7
  • They have the ability to differentiate into osteoblasts or chondrocytes depending on the signalling molecules they are exposed to, giving rise to either bone or cartilage respectively. (wikipedia.org)
  • β-catenin of the canonical Wnt signalling pathway plays a role in cell fate determination, as it is critical for osteoblastogenesis, and the differentiation of chondrocytes into osteoblasts. (wikipedia.org)
  • During this process, TGF-β can stimulate differentiation into either chondrocytes or osteoblasts via FGF, Msx1, and Ctgf signalling pathways. (wikipedia.org)
  • Sox9 stimulates differentiation into chondrocytes. (wikipedia.org)
  • Mesenchymal stem cells (MSCs) show trilineage differentiation because these cells differentiate into osteocytes, chondrocytes and adipocytes. (nature.com)
  • Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways. (pfmjournal.org)
  • The resting zone, a source of stemlike progenitor cells that restores the reservoir of proliferative chondrocytes, is located farthest from the primary ossification center and assumes responsibility for preserving the architectural integrity of the growth plate [ 4 ]. (pfmjournal.org)
MSCs14
  • With extensive experience in embryonic stem cells (ESCs), mesenchymal stromal/stem cells (MSCs), and osteosarcoma (OS), we collaborate with intramural and extramural colleagues to study breast cancer. (nih.gov)
  • Previously, we investigated osteosarcomagenesis using mesenchymal stromal/stem cells (MSCs) as a model. (nih.gov)
  • MSCs are thought to be one of the cells that contribute to the development of osteosarcoma. (nih.gov)
  • We and others showed that p53 represses osteoblastic differentiation of MSCs, and p53 loss in osteosarcoma cells correlates with the up-regulation of RUNX2, a master regulator of osteoblastic differentiation (He et al. (nih.gov)
  • In addition, our team has found that human osteosarcoma cells depend on RUNX2 for survival, but MSCs are not (Shin et al. (nih.gov)
  • As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. (nature.com)
  • Typically, BM-MSCs could be discovered by their plastic material adherence and capability to type colony-forming device fibroblasts (CFU-Fs) = 32) and from nonsickle cell disease sufferers (NS group, = 19), going through orthopedic medical procedures for principal osteoarticular problems. (azd1152.com)
  • Mesenchymal stem cells (MSCs) can easily be isolated and expanded from bone marrow (BM) aspirates. (biomedcentral.com)
  • For the quantification of cellular differentiation at the molecular level, osteogenic differentiation of MSCs is controlled by the interaction of hormones and transcription factors: runt-related transcription factor-2 (RUNX2) effectuates the expression of bone-specific genes, e.g. osterix (OSX), collagen type 1 alpha-1 (COL1A1), osteocalcin (OC), and bone sialoprotein (BSP) by binding to the promoters of these genes. (biomedcentral.com)
  • Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
  • Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
  • The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • Human bone marrow mesenchymal stem cells (hBM-MSCs) are the most commonly used cells. (biomedcentral.com)
Stimulates2
  • In our previous study, we demonstrated that an agonist of the perioxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipocyte differentiation, stimulates osteoblastic differentiation of cultured human periosteum-derived cells. (medsci.org)
  • Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
Vitro7
  • We developed an in vitro model of lipopolysaccharide (LPS)-induced inflammation and showed that Nampt and Sirt1 were significantly upregulated in LPS-treated MC3T3-E1 cells. (aging-us.com)
  • Deleting Nrp2 from the osteoclast lineage did not result in a bone phenotype, even though in vitro osteoclastogenesis of hematopoietic cells derived from mutant mice was significantly increased. (bvsalud.org)
  • To evaluate the effects of applied cytomechanical forces towards cellular differentiation distinct parameters were measured (morphology, antigen and antigen expression) after a total cultivation period of 21 days in vitro. (biomedcentral.com)
  • Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
  • In vitro studies using infra-/red light have not shown any useful impact on wound healing by activating cells located in deeper skin layers such as fibroblasts or stem cells [2] . (researchgate.net)
  • Her research interests include the preparation and design of materials and scaffolds for in vitro and in vivo fundamental studies, and a further focus is the provision of useful tools to assess mechanisms that govern cell behavior in regenerative medicine. (ibecbarcelona.eu)
  • In vitro experiments withcardiac fibroblasts and H9c2 cells confirmed the exceptional biocompatibilityof BC-Ppy composites. (ibecbarcelona.eu)
Progenitor cells4
  • Osteochondroprogenitor cells are progenitor cells that arise from mesenchymal stem cells (MSC) in the bone marrow. (wikipedia.org)
  • The transcription factor Sox9 can be found in multiple sites in the body (pancreas, central nervous system, intestines) and it is also found in all chondrocyte progenitor cells, suggesting that they are important in chondrogenesis. (wikipedia.org)
  • In these regions, neural stem cells (NSCs) and neural progenitor cells (NPCs) have been reported to proliferate and produce postmitotic neurons. (jneurology.com)
  • In the last decade, cortical adult neurogenesis and its neural stem cells (NSCs), which are self-renewing and can generate neurons, astrocytes and oligodendrocytes, and neural progenitor cells (NPCs), which have a tendency to differentiate into certain types of neurons, have been found in the cerebral cortex of adult mammals 3 . (jneurology.com)
Inappropriate differentiation2
  • The growth of these cells is faster, leading to an inappropriate differentiation of mesenchymal cells. (medscape.com)
  • The osteoblastic cell responsible for HO is believed to result from inappropriate differentiation of pluripotent mesenchymal stem cells. (postgraduateorthopaedics.co.uk)
Regulator1
  • We conclude that similar to those TFs mentioned above, Ebf1 is also an essential regulator of podocyte differentiation and glomerular maturation. (biodiversityhotspot.org)
Genes5
  • Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the osteoblastic lineage. (wikipedia.org)
  • Our research has shown that p53 plays an essential role in regulating ESC differentiation after DNA damage by down-regulating the transcription of many ES cell critical genes (Li et al. (nih.gov)
  • The increase in ALP, mineral deposition, and osteoblastic genes induced by the mechanical stretch-EPO combination was inhibited by U0126, an ERK1/2 inhibitor. (hindawi.com)
  • Composed of multiple constituent enhancers, super enhancers (SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. (nature.com)
  • First identified in embryonic stem cells, SEs mediate pluripotent state maintenance by promoting the expression of pluripotent identity genes, including Oct4 , Sox2 , Nanog and Klf4 . (nature.com)
Pathways4
  • The differentiation of mesenchymal stem cells towards an osteoblastic fate depends on numerous signaling pathways, including activation of bone morphogenetic protein (BMP) signaling components. (medsci.org)
  • [ 10 ] Although the mutation is known, the actual pathways that lead to abnormal osteoblast differentiation and function remain to be fully elucidated. (medscape.com)
  • Cell death occurs under physiological and pathological conditions and mediates through three pathways as follows: apoptosis, autophagic cell death, and necrosis. (biomedcentral.com)
  • For a previously unpublished BMP6 study, GAGE predicted novel regulatory mechanisms for BMP6 induced osteoblast differentiation, including the canonical BMP-TGF beta signaling, JAK-STAT signaling, Wnt signaling, and estrogen signaling pathways-all of which are supported by the experimental literature. (biomedcentral.com)
Lineage10
  • BMP signaling also has a critical role in the processes by which mesenchymal stem cells undergo commitment to the adipocyte lineage. (medsci.org)
  • Runx2 (which may also be known as Cbfa1), and Osx (a zinc finger containing transcription factor) are necessary for osteochondroprogenitor cells to differentiate into the osteoblast cell lineage. (wikipedia.org)
  • Once Sox9 activity is lost, differentiation into the osteoblastic lineage dominates. (wikipedia.org)
  • citation needed] The positioning of the osteoprogenitor cell condensations determines the cell lineage before the signalling molecules can. (wikipedia.org)
  • Their distance in relation to the nearest epithelial surface will determine the cell lineage. (wikipedia.org)
  • As ESCs have the potential to differentiate into many different cell types and are a promising source for cell therapy, maintaining genomic stability and homeostasis is crucial for proper lineage choice. (nih.gov)
  • We next generated mice with a conditional deletion of Nrp2 in the osteoblast cell lineage under control of the paired related homeobox 1 promoter and mice with a conditional Nrp2 knockdown in osteoclasts under control of the Lysozyme promoter. (bvsalud.org)
  • Analyses of the molecular pathophysiology using the primary cells from the Tmem53 -/- mice and the TMEM53 knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2-activated Smad proteins. (nature.com)
  • Osteoclast, derived from macrophage-mononuclear lineage, is a special myeloid cell. (frontiersin.org)
  • Following standard protocols cells were stimulated lineage specific towards the osteogenic and chondrogenic lines. (biomedcentral.com)
Inhibition2
  • Overexpression of Nampt overrode the effect of LPS and rescued LPS-induced inhibition on osteogenic differentiation. (aging-us.com)
  • MM bone loss is due to complex interactions between the tumor and the bone marrow microenvironment leading to both osteoclastic stimulation and inhibition of osteoblastic function. (snmjournals.org)
Induce2
  • Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)
  • While serum Ocn of mice was twice that of their littermates (Fig. 1A) the mice had low bone mineral density (6, 17), and their osteoblasts displayed a markedly reduced ability to induce Ocn mRNA during differentiation (Fig. 1B) and (Fig. 1C). (biodiversityhotspot.org)
Chondrogenic2
  • Osteoblastic and chondrogenic condensations differ in their biophysical parameters within the embryo. (wikipedia.org)
  • Cytomechanical forces with rotational components strongly influence the osteogenic and chondrogenic differentiation. (biomedcentral.com)
Maturation2
  • Originally, Ebf1 was found Mocetinostat to be necessary for B cell maturation as progenitors deficient in its expression arrested at the pre-pro-B cell stage (2). (biodiversityhotspot.org)
  • Runx2 is a critical regulatory factor promoting OB maturation in early differentiation. (frontiersin.org)
Hematopoietic5
  • Vertebrate Hematopoietic Stem Cells (HSCs) are responsible for lifelong maintenance of blood cells. (stemcells-live.fr)
  • The discovery of the Posterior Signaling Center (PSC), a group of cells controlling blood cell differentiation in the larval Drosophila hematopoietic organ, the lymph gland (LG), has made Drosophila a model to investigate the interaction between hematopoietic progenitors and their microenvironment. (stemcells-live.fr)
  • The larval LG contains hematopoietic progenitors (pro-hemocytes) for three types of differentiated hemocytes: the plasmatocytes which are monocyte-like cells involved in phagocytosis, the crystal cells which are required for melanisation, an insect-specific immune and wound-healing response, and the lamellocytes which are devoted to encapsulation of foreign bodies too large to be phagocytosed. (stemcells-live.fr)
  • The overall goal is to integrate the different communications between the vascular niche and the LG, and between the PSC and hemocyte progenitors, in order to have a global view of hematopoietic stems cells maintenance of and the control of Drosophila hematopoiesis in normal conditions and upon parasitsism. (stemcells-live.fr)
  • The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
BMSCs3
  • The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
  • Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
  • The researchers examined the effects of different amounts of CoQ10 on isolated rat bone marrow stromal cells (BMSCs, stem-cell-like cells that can differentiate into many types of cells, including bone cells) and in rats with induced osteoporosis. (saveourbones.com)
Runx22
  • TGF-β will act as a stimulator of chondrogenesis, and an inhibitor of osteoblastic differentiation, by blocking the Runx2 factor through Smad3 activation. (wikipedia.org)
  • These findings suggest that the RUNX2 signaling pathway may be an actionable vulnerability in osteosarcoma cells, and targeting CBFB, a transcription co-factor of RUNX2, may be a promising strategy. (nih.gov)
Undergo1
  • Sox9, L-Sox5 and Sox6 are needed for the osteochondroprogenitor to undergo chondrocytic differentiation. (wikipedia.org)
Osteoprogenitor cells2
  • Alexander Friedenstein and his colleagues first identified osteoprogenitor cells in multiple mammalian tissues, before any genetic or morphological criteria were put in place for bone marrow or connective tissues. (wikipedia.org)
  • Osteoprogenitor cells can be identified by their associations with existing bone or cartilage structures, or their placement in the embryo, as the sites for osteogenesis and chondrogenesis are now known. (wikipedia.org)
Inhibitor2
  • In this study, we used dorsomorphin, a selective small molecule inhibitor of BMP signaling, to investigate whether BMP signaling is involved in the positive effects of PPARγ agonists on osteogenic phenotypes of cultured human periosteum-derived cells. (medsci.org)
  • We show that TMEM53 acts as an inhibitor of BMP-SMAD signaling by preventing SMAD accumulation in the cell nucleus and that its deficiency enhances osteogenic differentiation by overactivating the BMP signaling pathway. (nature.com)
Stimuli2
  • For example osteoblastic condensations are closer to epithelial surfaces so they will be exposed to more biophysical and biochemical stimuli due to the proximity and increased cell-epithelial interactions. (wikipedia.org)
  • These dormant mesenchymal stem cells differentiate into osteogenic cells under appropriate stimuli. (postgraduateorthopaedics.co.uk)
Embryonic stem1
Bone cells11
Osteogenic cells3
  • Bone grafting is a common procedure in orthopaedic surgery and the implantation of autologous bone grafts supplying osteoinductive growth factors, osteogenic cells, and a structural scaffold, has become the gold standard for the surgical treatment of bone defects caused by trauma, tumor, infection or congenital abnormalities. (biomedcentral.com)
  • Various preventive measures required to treat femoral head necrosis include revascularization, adequate supply of osteogenic cells and establishing enough strength to avoid collapse. (ijpsonline.com)
  • Although, a list of contributing factors such as sickle cell anaemia, use of steroids, femoral neck fractures are involved in the loss of osteogenic cells via obstructing blood supply especially in the greater trochanteric region[ 1 , 2 ]. (ijpsonline.com)
Incubation1
  • Incubation with NMN or SRT 1720 also counteract the inhibitory effect of LPS and rescued osteoblast differentiation. (aging-us.com)
Cytokine2
  • LPS induced secretion of the proinflammatory cytokine interleukin-6 (IL-6) and attenuated osteogenic differentiation. (aging-us.com)
  • We also compared expanded BM-MSC osteogenic differentiation, migration, and cytokine secretion potential between these organizations. (azd1152.com)
Stem Cell6
  • Specifically, my laboratory investigates the biological functions of transcription factors that play critical roles in both stem cell and cancer biology. (nih.gov)
  • Really excited today to talk about breakthrough in stem cell activation through an oral protein complex. (chiroeco.com)
  • I will go through these BMPs and their stem cell signaling pathway, and then we're going to talk about just principles of bone and cartilage. (chiroeco.com)
  • Even though the integration of stem cells was promising, neural stem cell studies still have many milestones to reach. (omicsonline.org)
  • Achievement of a complete response on 18 F-FDG PET before stem-cell transplantation correlates with a superior outcome. (snmjournals.org)
  • In recent years, with a combination of autologous stem-cell transplantation and modern chemotherapy, the 10-y survival of patients presenting at an age less than 60 y is approximately 30% ( 1 , 2 ). (snmjournals.org)
Scaffolds2
  • BC-Ppy scaffolds improved cell viability andattachment, promoting a desirable cardiomyoblast morphology. (ibecbarcelona.eu)
  • Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
Adipocytes1
Osteocytes1
  • Also, GJC forming by contacting two HC from adjacent cells present among osteoblasts, between dendritic process of osteocytes, osteocyte-osteoblast as well as osteocyte-osteoclast. (biomedcentral.com)
Apoptosis3
  • In contrast to necrosis (murdered cells), in apoptosis (commit suicide) and autophagy process, cytoplasmic membranes are maintained and cell body is completely removed without any inflammation. (biomedcentral.com)
  • However, if phagocytosis of the cell does not occur at the final stage of apoptosis or autophagic process, the cells are removed through secondary necrosis [ 12 ]. (biomedcentral.com)
  • Apoptosis was first described by Kerr and colleagues in 1972 [ 17 ] as a physiological situation characterized by distinguishable morphological features such as nuclear changes (nuclear chromatin condensation and nuclear fragmentation), cell contraction, and losing attachment with adjacent cells. (biomedcentral.com)
Homeostasis4
  • In conclusion, osteoblastic Nrp2 expression is suggested to regulate bone homeostasis in a sex-specific manner. (bvsalud.org)
  • Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. (stemcells-live.fr)
  • Two Independent Functions of Collier/Early B Cell Factor in the Control of Drosophila Blood Cell Homeostasis. (stemcells-live.fr)
  • The basic purpose of hormesis is maintaining a health condition of homeostasis or better in a cell, organ or entire organism. (anti-agingfirewalls.com)
Transcription2
Quantification1
  • However, easy BM-MSC quantification and practical home assays are essential factors for cell-based therapies yet to be optimized. (azd1152.com)
Survival3
  • However, CBM have several challenges with respect to intrinsic biological characteristics, such as viable cell sources, donor age at the time of graft harvest, and cell survival after transplantation, which may cause differences in expected outcomes due to different batches of the same product. (encyclopedia.pub)
  • They play a substantial role in survival and cell death, since pro-apoptotic signals can propagate through them. (biomedcentral.com)
  • The Neutrophil Gelatinase-Associated Lipocalin (NGAL), a NF-kB-regulated gene, is a survival factor for thyroid neoplastic cells. (uniud.it)
Murine2
  • Tomeglovir showed that BM-MNCs from SCD sufferers had been practical lately, proliferative highly, and in a position to differentiate into useful bone-forming osteoblastic cells in ectopic implantation murine versions [8]. (azd1152.com)
  • Immortalized murine pulp cells (OD-21)6 are considered as the major action mechanism of those lasers.11 undifferentiated mesenchymal stem cells derived from fetal Although this mechanism has not been fully clarified, the most molar papillae7. (bvsalud.org)
Cortical2
  • Moreover, certain drugs, such as antidepressants, can accelerate production of neurons from cortical NPCs, and increased neurons from cortical NPCs have the inhibitory effect on neuronal cell death, which is induced by global ischemia 4 . (jneurology.com)
  • Historically, the discovery of cortical adult neurogenesis is old, and identifying generation of new cells in the adult cerebral cortex was first reported in 1912 5 . (jneurology.com)
Osteocalcin3
Secretion2
  • He S , Zhang H , Lu Y , Zhang Z , Zhang X , Zhou N , Hu Z , . Nampt promotes osteogenic differentiation and lipopolysaccharide-induced interleukin-6 secretion in osteoblastic MC3T3-E1 cells. (aging-us.com)
  • Solid tumors such as carcinomas of the lung, colon, breast, or prostate start in epithelial cells that line the surface of the bronchia, the intestinal mucosa, or the alveoli of fl uid secretion in the breast and prostate. (bbvaopenmind.com)
Marker1
  • Wt1 is the earliest marker of the podocyte, and depending upon the degree of Wt1 deficiency a spectrum of kidney defects can arise from adult-onset nephrotic syndrome to complete renal agenesis in Wt1? (biodiversityhotspot.org)
Promotes1
  • The exact biological mechanism by which CoQ10 promotes the production of bone has been a matter of speculation, but a recent study has shed light on the interplay between CoQ10 and the cells responsible for the bone remodeling process. (saveourbones.com)
HSCs1
  • Maintaining HSCs depends on signals provided by a complex micro-environment, called the « niche », which is made of vascular and osteoblastic cells. (stemcells-live.fr)
Abnormal1
  • Other symptoms may be present depending on the site of cancer (eg, hoarseness in laryngeal cancer or abnormal vaginal bleeding in uterine cancer). (msdmanuals.com)
Tumor2
  • The prognosis for prostate cancer patients depends on the histologic grade, the tumor size, and the disease stage. (basicmedicalkey.com)
  • A further conversion of the malignant tumor leads to the formation of highly motile and invasive cancer cells, and the recruitment of normal cells that act as helpers in tumor dissemination. (bbvaopenmind.com)
Prostate1
  • Additionally, earlier in the month, the patient had been diagnosed with prostate cancer with osteoblastic metastatic disease in the ninth left rib, L2 and L5. (faoj.org)