Osteoblast and bone marrow. Medical search. Frequent questions

Bone marrow adipocytes (BMAds) originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. (wikipedia.org)
In addition to WAT and BAT, adipocytes also exist in the bone marrow, and such marrow adipose tissue (MAT) has been estimated to account for over 10% of total adipose tissue mass in lean, healthy humans ( 3 ). (frontiersin.org)
MSCs have a lower ability to differentiate into osteoblasts but a higher ability to differentiate into adipocytes, which could be linked to myeloid malignancies ( Woods and Guezguez, 2021 ). (techscience.com)
Besides, they were able to differentiate into osteoblasts, chondrocytes and adipocytes. (scielo.br)
and (iii) MSCs maintains the differentiation potentials of adipocytes, osteoblasts, and chondroblasts in vitro [14]. (researchsquare.com)
These cells are multipotent, meaning they have the ability to differentiate into several different specialised cell types, such as cartilage cells (chondrocytes), bone cells (osteoblasts) and fat cells (adipocytes). (rvc.ac.uk)
The balance between osteoblasts and adipocytes is influenced by a reciprocal relationship. (ironmagazine.com)
Bone marrow mesenchymal stem cells (MSCs) give rise to osteoblasts and adipocytes, with an inverse relationship between the 2. (aetox.com)

Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is lacking. (nih.gov)
Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. (hindawi.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
The study also showed that the adult OCRs are distinct from mesenchymal stem cells (MSCs), which play a role in bone generation during development and adulthood. (sciencedaily.com)
Oct. 8, 2021 Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. (sciencedaily.com)
Jan. 29, 2020 Scientists used molecular motors to manipulate the protein matrix on which bone marrow-derived mesenchymal stem cells are grown. (sciencedaily.com)
The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)

Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
Of note, we define OCT identities as a state with some characteristics of both osteoblasts and chondrocytes, instead of cell-type plasticity between osteoblasts and chondrocytes. (nature.com)
Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. (hindawi.com)
MSCs have multilineage differentiation potential, allowing them to differentiate, for example, into chondrocytes and osteoblasts, the key cells from the two tissues that constitute the osteochondral unit. (hindawi.com)
Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes. (sciencedaily.com)
PLF was detectable in the cytoplasm of osteoblasts, osteocytes and osteoclasts, and matrix surrounding proliferating and hypertrophied chondrocytes, suggestive of secretion. (cdc.gov)

Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. (wikipedia.org)
Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT's thermogenic role. (wikipedia.org)
Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. (frontiersin.org)
MSCs could be derived from a series of tissues including but not limited to umbilical cord, placenta, adipose tissue, bone marrow, gingiva, and dental pulp [5-12]. (researchsquare.com)
MSCs were first found in bone marrow, but have since been detected in many different tissues, including adipose tissue (fat) and umbilical cord blood. (rvc.ac.uk)
The decrease in the bone mass associated with osteoporosis caused by ovariectomy, aging, and other conditions is accompanied by an increase in bone marrow adipose tissue. (ironmagazine.com)
The development of modalities to promote local/systemic bone formation by inhibiting bone marrow adipose tissue is important in the treatment of fractures or metabolic bone diseases such as osteoporosis. (ironmagazine.com)

Additionally, we were able to reconstruct the three developmental phases during osteoblast differentiation: proliferation, matrix maturation, and mineralization, and illustrate the activation of the SMAD signaling pathways by TGF-β2 and BMPs. (biomedcentral.com)
The pyrophosphate found outside of cells (extracellular pyrophosphate) helps control bone formation by preventing mineralization, the process by which minerals such as calcium and phosphorus are deposited in developing bones. (medlineplus.gov)
A shortage of extracellular pyrophosphate can increase bone mineralization, which may also contribute to the bone abnormalities. (medlineplus.gov)
Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia med. (emf-portal.org)
Histomorphometry findings were consistent with low bone turnover disease characterized by the decreased bone formation and resorption: increased mineralization lag time, increased osteoblasts apoptosis, decreased osteoblast surface, and resorptive surface. (medscape.com)

The purpose of this review is to bridge the gap in our understanding between the basic science knowledge on MSCs and BMA and the clinical and technical aspects of marrow stimulation-based cartilage repair by examining available data on the role and mechanisms of MSCs and BMA in osteochondral repair. (hindawi.com)
They were first isolated from the bone marrow, and the potency of MSCs is currently being employed in the techniques of marrow stimulation for symptomatic small chondral defects. (hindawi.com)
In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
Moreover, the bone marrow clot provides a three-dimensional (3D) environment which supports the chondrogenesis of MSCs. (hindawi.com)
Researchers presumed that MSCs were the origin of all bone, cartilage, and fat, but recent studies have shown that these cells do not generate young bone and cartilage. (sciencedaily.com)
The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults. (sciencedaily.com)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)

These hematopoietic cells are derived from hematopoietic stem cells (HSC) which give rise to diverse cells: cells of the blood, immune system, as well as cells that break down bone (osteoclasts). (wikipedia.org)
Estrogen inhibits bone resorption by directly +6inducing apoptosis of the bone-resorbing osteoclasts. (imsociety.org)
Furthermore, we found that exosomes derived from B cells inhibited the differentiation of osteoblasts and osteoclasts in vitro. (nih.gov)
The ANKH gene provides instructions for making a protein that plays a role in the development and function of cells that build bones (osteoblasts) and cells that break down bone (osteoclasts). (medlineplus.gov)
Osteoclasts are involved in bone remodeling, a normal process in which old bone is removed and new bone is created to replace it. (medlineplus.gov)
Mutations in the ANKH gene that cause autosomal dominant craniometaphyseal dysplasia impair the maturation (differentiation) of osteoclasts, which likely disrupts bone remodeling. (medlineplus.gov)
Bone-degrading osteoclasts and bone-building osteoblasts ensure a fine balance in the healthy organism. (medicalxpress.com)
So far, drugs are available that inhibit bone resorption by osteoclasts. (medicalxpress.com)
OPG binds RANKL as a decoy receptor, inhibiting the activation of RANK by RANKL and preventing the differentiation of bone marrow precursor (monocyte/macrophage) cells to osteoclasts - cells that are central in the process of bone resorption [ 2 ]. (biomedcentral.com)
Osteoclasts are specialized as the only bone-resorbing cell type and increased numbers are implicated in the development of bone loss-accompanied diseases such as osteoporosis, periodontitis, rheumatoid arthritis, osteosarcoma, and bone cancer metastases [ 2 - 4 ]. (biomedcentral.com)

HSC renewal occurs in the marrow stem cell niche, a microenvironment that contains cells and secreted factors that promote appropriate renewal and differentiation of HSC. (wikipedia.org)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
Thus, maintaining low B cell levels in the bone marrow microenvironment promotes fracture healing. (nih.gov)
The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. (karger.com)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)

We demonstrated that AAV9 capsid modified with N -ethyl Maleimide (NEM) increased its tropism more towards murine bone marrow (osteoblast lineage ) while decreased transduction of liver tissue compared to the unmodified capsid. (nature.com)
Moreover, AAV9-NEM localized strongly in vivo to cells lining the calcified trabecular bone and transduced primary murine osteoblasts in culture, while WT AAV9 transduced undifferentiated bone marrow stromal cells as well as osteoblasts. (nature.com)

The cells found in bone are osteoblasts which build bone tissue, osteocytes which maintain bone, and osteoclats which break down (resorb) bone. (freezingblue.com)
Osteocytes ("mature bone cells") and osteoblasts ("immature bone cells") are the major cellular components of bone. (learninggnm.com)
Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. (lu.se)
The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. (lu.se)
The study uses IDG-SW3 cells as a model for the differentiation from osteoblasts to osteocytes. (lu.se)

Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. (nih.gov)
Trabecular bone scores (TBS) would further help estimate bone integrity if they are available. (medscape.com)
[ 10 ] The acute bone loss was estimated at 1.6% per month in the first 5 months, more in trabecular bone than in cortical bone. (medscape.com)
KO ) results in trabecular bone loss. (lu.se)
Most bones have a thick, well-organized outer shell (cortex) and a less dense mesh of bony struts in the center (trabecular bone) (see the image below). (medscape.com)
The only bones that lack a true cortex are the vertebrae, which are covered by a compact condensation of trabecular bone. (medscape.com)
Most commonly associated with joint surfaces, it usually comprises a thin, compact bone shell with a large amount of bony struts (trabecular bone) for support of the cortical shell. (medscape.com)

Sowers and colleagues have investigated potential associations between changes in bone resorption during the menopause transition and reproductive hormones, body mass index (BMI) and ethnicity [1]. (imsociety.org)
During the menopause transition, a decline in ovarian function beginning about 2 years before the FMP is followed by an increase in bone resorption and subsequently by bone loss. (imsociety.org)
The magnitude of the increase in bone resorption is inversely associated with BMI. (imsociety.org)
Ethnic differences in changes in bone resorption are attenuated, but not eliminated, by adjustment for BMI. (imsociety.org)
Ethnic differences in BMI, and corresponding ethnic differences in bone resorption, appear to account for much of the ethnic variation in perimenopausal bone loss. (imsociety.org)
Changes in bone resorption across the menopause transition: effects of reproductive hormones, body size, and ethnicity. (imsociety.org)
But this balance is occasionally disturbed: in osteoporosis, bone resorption takes over, so that fractures and deformities can occur. (medicalxpress.com)
Bone metastases, which occur in the course of many cancers, are also often caused by bone resorption processes. (medicalxpress.com)
However, the effect of SF in bone resorption has not been studies. (biomedcentral.com)

Recent studies have identified B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation. (nih.gov)

Over time, they form a fibrocartilaginous repair tissue in the defect and close the connection with the subchondral bone. (hindawi.com)
A focus is on the steps of mobilization of cells from the subchondral bone and repair tissue formation, including adherence of the bone marrow clot to the subchondral bone. (hindawi.com)
Reduced breakdown of bone tissue can contribute to the bone thickening characteristic of craniometaphyseal dysplasia. (medlineplus.gov)
The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. (sciencedaily.com)
But appearances are deceptive: in fact, bone tissue is in a constant state of remodeling. (medicalxpress.com)
Abnormal loss of bone tissue with tendency to fracture. (freezingblue.com)
maintains bone but does not produce new bone tissue. (freezingblue.com)
Connective tissue membrane covering a bone. (freezingblue.com)
What are the two types of osseous (bone) tissue and where is each type found? (freezingblue.com)
This expression across diverse tissue types indicates that its biologic functions may extend beyond bone metabolism. (biomedcentral.com)
She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
The bone tissue stores several minerals, specifically calcium and phosphorus that keep the bones strong. (learninggnm.com)
3D bioprinting is a promising technology which might allow fabrication of tissue constructs like skin and bone with limited equipment and materials which mostly could be produced locally. (selectbiosciences.com)
They usually develop from the cartilaginous rings (they help the trachea from collapsing during the absence of air and also protect it) and are composed of cancellous bone (it is the spongy interior layer of the bone that protects the bone marrow) capped by cartilage (type of dense connective tissue). (wearethecure.org)
[ 1 ] All bones are encased in a soft tissue envelope known as the periosteum, which is vital for perfusion and nutrient supply to the outer third of the bone (see the image below). (medscape.com)
[ 1 ] ) of bone is a nonheritable disease in which abnormal tissue develops in place of normal bone. (medscape.com)
Fibrous dysplasia lesions are characterized by woven ossified tissue and extensive marrow fibrosis. (medscape.com)
Cancellous bone maintenance is perturbed, and bone undergoing physiologic remodeling is replaced by an abnormal proliferation of fibrous tissue. (medscape.com)
Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)

Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)
Confluent C3H10T1/2 stem cells were treated for 6 days with 10-100 ?g/mL of RK in culture medium containing 10?nM all-trans-retinoic acid (ATRA) or 300?ng/mL recombinant human bone morphogenetic protein (rhBMP)-2 protein as an osteoblast-differentiating agent. (ironmagazine.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
In this work, for the first time, we adopt a multidisciplinary approach to characterize the morphological, biochemical, and molecular changes underlying the response of human bone marrow stromal cells to long-term simulated microgravity exposure during osteogenic differentiation. (lu.se)

To identify such substances, the researchers first had to find out which signaling pathways control osteoblast activity. (medicalxpress.com)
For a previously unpublished BMP6 study, GAGE predicted novel regulatory mechanisms for BMP6 induced osteoblast differentiation, including the canonical BMP-TGF beta signaling, JAK-STAT signaling, Wnt signaling, and estrogen signaling pathways-all of which are supported by the experimental literature. (biomedcentral.com)
We found novel proteins were dysregulated under simulated microgravity, including CSC1-like protein, involved in the mechanotransduction of pressure signals, and PTPN11, SLC44A1 and MME which are involved in osteoblast differentiation pathways and which may become the focus of future translational projects. (lu.se)
[ 10 ] Although the mutation is known, the actual pathways that lead to abnormal osteoblast differentiation and function remain to be fully elucidated. (medscape.com)

These improvements were associated with increases in growth velocity and reduced frequencies of bone fracture. (nih.gov)
Researchers also showed that OCR stem cells, when transplanted to a fracture site, contribute to bone repair. (sciencedaily.com)
If you make a fracture in the mouse, these cells will come alive again, generate both bone and cartilage in the mouse--and repair the fracture. (sciencedaily.com)
Regular weight-bearing and muscle-strengthening exercises are recommended to improve bone strength and reduce the risk of fracture. (medscape.com)
Skeletal phenotyping, such as measuring bone mineral density (BMD) and histomorphometry analysis with bone biopsy, has provided an explanation, in part, of the elevated fracture risk. (medscape.com)
As a consequence of this bone fragility, patients have an increased (~50%) risk of fracture. (medscape.com)
The most common surgical indications are fracture of a weightbearing bone and progressive disease. (medscape.com)
Nonunion and segmental bone loss after fracture, reconstructive surgery, or lesion excision can present complex orthopedic problems, and the multiple surgical procedures often needed are associated with patient morbidity and reduced quality of life. (who.int)

On days 7, 14 and 21 of osteogenic differentiation, the cultures were submitted to evaluations of MTT conversion in formazan, of alkaline phosphatase activity (AP), of collagen and mineralized matrix synthesis, evaluation of the number of cells per field and there was quantification of the gene transcripts for osterix, bone sialoprotein (BSP), osteonectin (ON) and osteocalcin (OC). (scielo.br)
The higher the concentration, the more alkaline phosphatase the cells manufacture, an indication that the cells were developing into osteoblasts, bone cells that build up the skeleton. (ironmagazine.com)
The more raspberry ketone there was present, the more alkaline phosphatase the cells manufactured - and the greater the bone cell development. (ironmagazine.com)

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. (medicalxpress.com)
Compact bone makees up the main shaft of long bones and the outer layer of other bones spongy (cancellous) bone makes up the ends of the long bones and the center of other bones. (freezingblue.com)
The red bone marrow inside of bones produces most of the blood cells, including erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (platelets). (learninggnm.com)
Most bones of the limbs contain mainly yellow bone marrow composed for the most part of fat. (learninggnm.com)
They usually develop from bones like the pelvis, leg bone or arm bone. (wearethecure.org)
Bones vary widely in size, ranging from the tiny inner ear bones that are responsible for transmitting mechanical sound waves to the sensory organs to the large (nearly 2 ft long) femur bone that is strong enough to withstand 30 times one's body weight. (medscape.com)
INTRODUCTION: Periostin-Like-Factor (PLF) is expressed in developing bone and is up-regulated in adult bones that undergo remodeling due to fractures. (cdc.gov)
CONCLUSION: The expression of PLF in bones undergoing remodeling and reorganization suggests that PLF plays a significant role in maintenance of bone after repetitive loading or injury. (cdc.gov)
[ 12 ] This risk of fractures or bone deformity is higher in the long bones (eg, femur, tibia, and humerus), but all the bones can be affected. (medscape.com)

Thus, bone fragility, osteoporosis, and osteoporotic fractures are thought to be linked to mechanisms which promote BMAT accumulation. (wikipedia.org)
Here we describe the initial results of allogeneic bone marrow transplantation in three children with osteogenesis imperfecta, a genetic disorder in which osteoblasts produce defective type I collagen, leading to osteopenia, multiple fractures, severe bony deformities and considerably shortened stature. (nih.gov)
Further study could provide greater understanding of how to prevent and treat osteoporosis, osteoarthritis, or bone fractures. (sciencedaily.com)
Patients often suffer greatly from painful bone metastases and fractures frequently occur," says Sonja Loges from the DKFZ-Hector Cancer Institute at the University Medical Center Mannheim. (medicalxpress.com)

RK], which is one of the major aromatic compounds of red raspberry and exhibits anti-obesity action, could promote osteoblast differentiation in C3H10T1/2 stem cells. (ironmagazine.com)

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
Overall, our findings indicate that Fgfr3 + endosteal stem/stromal cells with OCT identities dictate active and aggressive osteogenesis, identifying these cells as an important regulator of long-term bone homeostasis. (nature.com)
A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. (sciencedaily.com)
Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body's ability to repair bone injury--a process that declines significantly in old age," says Timothy C. Wang, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine at CUMC, who initiated this research. (sciencedaily.com)
Previously, Dr. Wang found an analogous stem cell in the intestinal tract and observed that it was also abundant in the bone. (sciencedaily.com)
These stem cells, extracted from bone marrow, can develop into fat cells but also into bone cells in the body. (ironmagazine.com)
The Japanese hypothesised that raspberry ketone might inhibit the development of stem cells into fat cells but promote the development of the stem cells into bone cells. (ironmagazine.com)
In an experiment the Japanese researchers exposed the stem cells to rhBMP-2, a protein that induces stem cells to develop into bone cells. (ironmagazine.com)
This compound also stimulates the development of stem cells into bone cells. (ironmagazine.com)
Our results indicate that raspberry ketone has the ability to promote the differentiation of C3H10T1/2 stem cells into osteoblasts", the researchers wrote. (ironmagazine.com)
Raspberry ketone promotes the differentiation of C3H10T1/2 stem cells into osteoblasts. (ironmagazine.com)
Our results suggest that RK enhances the differentiation of C3H10T1/2 stem cells into osteoblasts, and it may promote bone formation by an action unrelated to adipocyte differentiation. (ironmagazine.com)
Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)

We established a protocol for rat mandible and long-bone marrow stromal cell (BMSC) isolation and culture. (bvsalud.org)

Thin membran that lines the marrow cavity of a bone. (freezingblue.com)
Osteonecrosis of the jaws (ONJ), a severe side effect of antiresorptive medications, is characterized by exposed, nonhealing bone in the oral cavity. (bvsalud.org)
[ 1 , 2 ] The remainder of the blood supply is through nutrient vessels that pierce the cortex and supply the marrow cavity and the inner two thirds of the cortical bone. (medscape.com)
PLF over expression by adenovirus in the bone marrow cavity of rats resulted in increased bone formation. (cdc.gov)

Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)

It increases in states of low bone density -osteoporosis, anorexia nervosa/ caloric restriction, skeletal unweighting such as that which occurs in space travel, and anti-diabetes therapies. (wikipedia.org)
Thus, it is thought that BMAT results from preferential MSC differentiation into the adipocyte, rather than osteoblast, lineage in the setting of osteoporosis. (wikipedia.org)
BMAT is thought to result from preferential MSC differentiation into an adipocyte, rather than osteoblast lineage in osteoporosis based on the inverse relationship between bone and BMAT in bone-fragile osteoporotic states. (wikipedia.org)
Our approach could provide a promising platform for expanding clinical AAV development to treat bone pathologies such as cancer and osteoporosis. (nature.com)
[ 1 ] The pretransplant bone evaluation should include a careful history, with particular attention to risk factors for osteoporosis. (medscape.com)
The findings contribute to a better understanding of the mechanisms of bone mass regulation and can help develop efficient therapeutic strategies for osteoporosis treatment. (lu.se)
Osteonecrosis of the jaws (ONJ) is a rare but severe complication of antiresorptive medications, such as bisphosphonates, used in the treatment of bone malignancy or osteoporosis. (bvsalud.org)

This aging-related biasing of MSC away from osteoblast lineage may represent higher basal PPARγ expression or decreased Wnt10b. (wikipedia.org)
In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. (thermofisher.com)

Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. (hindawi.com)
Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
This underscores the need to assess molecular targets that can be exploited in prevention or clinical management of lung cancer metastases to bone. (hindawi.com)
We believe that these molecular targets could guide in determining timing of therapeutic interventions that offer the best opportunity to prevent and/or halt extent of bone metastases. (hindawi.com)
Thus, in this report, we will assess the data on lung cancer bone metastases with the intention of evaluating key molecular targets that could be applied in optimizing lung cancer treatment strategies. (hindawi.com)
An agent that inhibits the activity of this enzyme reduced cancer-related bone loss and the number of bone metastases in multiple myeloma and in lung and breast cancer models in mice. (medicalxpress.com)
The RANKL inhibitor denosumab acts to reduce skeletal-related events in patients with bone metastases. (biomedcentral.com)

Applications Tested: The TEK4 antibody has been tested by blocking of staining with fluorochrome conjugated TEK4 on mouse bone marrow cells. (thermofisher.com)

PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. (imsociety.org)

It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)

bottom, longitudinal view of cancellous bone) ( b ). (medicalxpress.com)
Trabecular and cancellous bone. (medscape.com)

The effects of exposure of rat calvarial osteoblasts to a pulsed 50 Hz magnetic field on cell proliferation and differentiation as well as and the role of primary cilia in this context should be investigated. (emf-portal.org)

Therefore, understanding the mechanisms behind ectopic bone formation in response to TBI is likely to have a significant impact on identification of novel therapeutic targets for HO treatment. (mdpi.com)
Pharmaceutical inhibition of osteoclast differentiation is a current therapeutic approach for the treatment of bone loss-related diseases. (biomedcentral.com)

This gene provides instructions for making a protein called connexin 43, which is involved in the development of many tissues in the body, including bone. (medlineplus.gov)
The protein may be involved in bone remodeling. (medlineplus.gov)
j Analysis of MERTK protein in osteoblast cultures from Mertk flox/flox mice treated with recombinant CRE recombinase. (medicalxpress.com)
OBJECTIVE: To assess the efficacy of osteogenic protein-1 (OP-1) for long bone nonunion. (who.int)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (msdmanuals.com)

Hematopoietic cells (also known as blood cells) reside in the bone marrow along with BMAds. (wikipedia.org)

However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)

Moreover, the BMA clot provides a three-dimensional environment, possibly further supporting chondrogenesis and protecting the subchondral bone from structural alterations. (hindawi.com)
Finally, it is possible that it protects the subchondral bone plate and the subarticular spongiosa from structural alterations of its microarchitecture. (hindawi.com)
The subchondral bone is not true cortical bone, in that it lacks some of the organization of cortical bone. (medscape.com)

However, current evidence suggests the use β-TCP can in fact delay bone healing and mechanisms for this observation are yet to be comprehensively investigated. (frontiersin.org)
By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
Further investigations of the mechanisms leading to the effect of raspberry ketone on osteoblast differentiation are required. (ironmagazine.com)

Prophylaxis against bone loss should be given to all transplant recipients, regardless of baseline skeletal reserve. (medscape.com)

Several studies demonstrated exercise reduction of BMAT which occurs along with an increase in bone quantity. (wikipedia.org)
A notable exception occurs in the setting of caloric restriction: exercise suppression of BMAT does not yield an increase in bone formation and even appears to cause bone loss. (wikipedia.org)

In this study, we examined the potential of SF extract (SFE) to inhibit receptor activator of NF-κB ligand (RANKL) -induced osteoclast differentiation in cultured mouse-derived bone marrow macrophages (BMMs). (biomedcentral.com)

Therefore, Fgfr3 + endosteal SSCs are abundant in young bone marrow and provide a robust source of osteoblasts, contributing to both normal and aberrant osteogenesis. (nature.com)
In this study, we report a novel population of SSCs with osteoblast-chondrocyte transitional (OCT) identities in the bone marrow endosteal space, which highly expresses Fgfr3 and contributes to both normal and aberrant osteogenesis. (nature.com)

Hence, they are of high interest for supporting bone regeneration and wound healing. (degruyter.com)

Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis. (haematologica.org)
Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)
However, modern myelofibrosis prognostication systems utilized in risk-adapted treatment approaches do not include bone marrow fibrosis as a prognostic variable. (haematologica.org)
The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)
Here we review the pathogenesis, biological consequences, and prognostic impact of bone marrow fibrosis. (haematologica.org)
Bone marrow fibrosis (BMF) is characterized by the increased deposition of reticulin fibers and in some cases collagen fibers. (haematologica.org)
European consensus on the grading of bone marrow fibrosis. (haematologica.org)
Conditions associated with bone marrow fibrosis. (haematologica.org)

Cells thta break down bone. (freezingblue.com)

Here, we hypothesized that rat mandible vs. long-bone marrow-derived cells possess different osteogenic potential. (bvsalud.org)

All patients had increases in total body bone mineral content ranging from 21 to 29 grams (median, 28), compared with predicted values of 0 to 4 grams (median, 0) for healthy children with similar changes in weight. (nih.gov)
Such enhanced techniques of marrow stimulation have been shown to improve articular cartilage repair in both animal models and patients. (hindawi.com)
The bone is one of the frequent metastatic sites for lung cancer occurring in a large number of patients. (hindawi.com)
Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
Bone mineral density measurements by dual-energy X-ray absorptiometry (DEXA) of axial and appendicular bone should be performed on all patients prior to transplantation. (medscape.com)

What are the three types of cells found in bone and what is the role of each? (freezingblue.com)

Large segmental bone loss and bone resection due to trauma and/or the presence of tumors and cysts often results in a delay in healing or non-union. (frontiersin.org)

Involved bone cells are immature. (medscape.com)

Antiresorptive therapies like risedronate or zoledronate also decrease BMAT while increasing bone density, supporting an inverse relationship between bone quantity and BMAT. (wikipedia.org)
Reduction in bone density to below average levels. (freezingblue.com)

Bone homeostasis is maintained by the interplay between the receptor activator of nuclear factor kappa-B (RANK), its soluble activation ligand (RANKL), and OPG. (biomedcentral.com)

Anatomy50

Organisms14

Diseases37

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes46

Disciplines and Occupations1

Technology, Industry, Agriculture4

Information Science2

Named Groups1

Health Care3

Adipocytes8

Mesenchymal13

Chondrocytes6

Adipose7

Mineralization5

MSCs7

Osteoclasts10

Microenvironment7

Murine2

Osteocytes5

Trabecular bone7

Resorption9

Suppressing osteoblast differentiation1

Tissue19

Human bone7

Pathways4

Fracture8

Alkaline phosphatase3

Bones9

Fractures4

Promote osteoblast1

Stem15

Stromal cell1

Cavity4

Vitro2

Osteoporosis7

Lineage2

Metastases9

Mouse bone marro1

Progenitors1

Adult1

Cancellous bone2

Calvarial1

Therapeutic2

Protein5

Hematopoietic cells1

Vivo1

Subchondral bone3

Mechanisms3

Skeletal1

Increase in bone2

Osteoclast1

Endosteal2

Regeneration1

Fibrosis9

Break down bone1

Osteogenic potential1

Patients5

Found in bone1

Segmental bone loss1

Immature1

Density2

RANKL1