• Osteoarthritis is the most common degenerative joint disease, causing pain and immobilization and creating a huge economic burden. (hindawi.com)
  • Osteoarthritis (OA) is a degenerative joint disease that should ideally be detected earlier on in the disease process when treatments will likely be more effective. (stanford.edu)
  • It can be damaged by trauma such as accidents, mechanical injury such as a fall, or from degenerative joint disease (osteoarthritis) occurring in older people. (prairie-ortho.com)
  • Osteoarthritis (OA) is the most common degenerative joint disease, of which the pathogenesis is inadequately understood. (nordicbioscience.com)
  • Osteoarthritis is a degenerative joint disease, in which the tissues in the joint break down over time. (nih.gov)
  • Our results should encourage clinicians and middle aged patients with degenerative meniscal tear and no definitive radiographic evidence of osteoarthritis to consider supervised exercise therapy as a treatment option. (bmj.com)
  • 4 In these patients, most meniscal tears are degenerative and might be regarded as the first sign of osteoarthritis. (bmj.com)
  • Osteoarthritis is a degenerative joint disease which commonly impacts the knees, hands, hips, neck and lower back. (williamhaseltine.com)
  • Although the retrieval of MSCs from normal tissues is very straightforward, yet it could be challenging in degenerative conditions that limit the expansion of stem cells such as osteoarthritis. (uitm.edu.my)
  • Conclusions: Activation of Wnt/β-catenin signalling by HOTAIR through WIF-1 repression in osteoarthritic chondrocytes increases catabolic gene expression and promotes cartilage degradation. (researchsquare.com)
  • The aim of the study was to develop and characterize a novel biomarker of chondrocytes hypertrophy and investigate how this marker was associated with cartilage degradation and inflammation in patients with various degrees of OA. (nordicbioscience.com)
  • Immuno-staining revealed that ColX was predominately located around the hypertrophic chondrocytes and the clustered chondrocytes indicating that C-Col10 measures may be linked to cartilage hypertrophic changes. (nordicbioscience.com)
  • RESULTS: TSG-6 is predominantly associated with chondrocytes in regions of cartilage damage where high TSG-6 expression aligns with low MMP13, the major collagenase implicated in OA progression. (ox.ac.uk)
  • Mesenchymal Stromal Cells (MSCs), which can differentiate into chondrocytes, are used to regenerate articular cartilage. (asiapharmaceutics.info)
  • The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block cartilage destruction in osteoarthritis. (nih.gov)
  • In conclusion, this study has demonstrated that SIN inhibits the IL-1 ß-induced inflammatory response and cartilage destruction by activating the Nrf2/HO-1 signaling pathway and inhibiting the NF-κB signaling pathway in mouse chondrocytes , suggesting a new use for SIN in the treatment of OA. (bvsalud.org)
  • Adipose-derived mesenchymal stromal cells (ASCs)-EVs were fluorescently labeled and tracked during their uptake into chondrocytes micromasses or cartilage explants, both derived from OA patients. (inrim.it)
  • 3,4 The swelling that generally occurs in early OA is the result of an increased production of proteoglycans which reflects the chondrocytes' (cartilage cells) efforts to repair articular cartilage damage. (health.mil)
  • Board B693 sition and organization of these components varies across both growth plate and Increased Cytoskeletal Stiffness of Schlemm's Canal Endothelial Cells in articular cartilage and in the vicinity of chondrocytes. (nih.gov)
  • During cartilage development, chondrocytes secrete the extracellular matrix (ECM) and embed within the same environment. (medicalxpress.com)
  • A major barrier to the development of disease-modifying interventions is the nature of knee OA progression, where initial articular cartilage damage triggers a vicious cycle of molecular events and tissue interactions in a downward spiral and rapidly progresses to diffuse knee OA. (nih.gov)
  • The developed technique was tested by microstructural analysis of articular cartilage and meniscus samples from osteoarthritic patients and osteoarthritis-free tissue donors. (oulu.fi)
  • These likely involve a multitude of complex and interrelated processes affecting the entire joint, including articular cartilage, subchondral bone, synovial tissue and the meniscus (4). (researchsquare.com)
  • Articular or hyaline cartilage is the tissue lining the surface of the two bones in the knee joint. (prairie-ortho.com)
  • Healthy cartilage tissue (graft) is taken from the bone that bears less weight and is transferred to the place of the injured joint. (prairie-ortho.com)
  • A cartilage tissue (graft) is taken from a donor and transplanted to the site of the injury. (prairie-ortho.com)
  • Such hyperphysiological compression triggers a shift in cartilage homeostasis towards catabolism and inflammation, hypertrophy, and the acquisition of a gene expression profile akin to those seen in clinical osteoarthritic tissue. (nature.com)
  • A Norwegian-Swiss research team has succeeded in growing cartilage tissue cells using algae. (norwegianscitechnews.com)
  • Microscope images showing cartilage tissue cells growing in alginate. (norwegianscitechnews.com)
  • The image on the right shows sulphate combined with the alginate, which promotes the formation of cartilage tissue. (norwegianscitechnews.com)
  • Currently there are no medications or treatments available to cure a condition that causes cartilage tissue, which acts as a shock absorber in the joints, to wear away in response to the breakdown of its collagen fibres. (norwegianscitechnews.com)
  • The news that the research team has succeeded in growing cartilage tissue using macroalgae ( brown seaweeds ) as a raw material has thus attracted worldwide attention. (norwegianscitechnews.com)
  • They achieve this by combining sulphate, which is characteristic of the carbohydrates that occur in natural cartilage tissue. (norwegianscitechnews.com)
  • In simple terms, we can say that these new alginates imitate nature and act to provide the cells with a message to survive, divide, and generally behave as cartilage tissue cells should. (norwegianscitechnews.com)
  • This is turn has reduced the impact of so-called oxidative stress, which contributes towards accelerating the degradation of cartilage tissue. (norwegianscitechnews.com)
  • The next step is to test the new materials and the lab-manufactured cartilage tissue on mice. (norwegianscitechnews.com)
  • In addition, the improvements in tissue engineering technology such as the use of different types of the scaffold as well as blood product and growth factors with MSC have had a great impact in treating OA and regenerating cartilage. (asiapharmaceutics.info)
  • Cartilage, the tissue that covers the ends where two bones meet to form a joint. (nih.gov)
  • Cartilage is the tough but flexible tissue that covers the ends of your bones at a joint. (medlineplus.gov)
  • Joints such as those in the knees and hands rely on cartilage tissue to keep the bones from rubbing together. (nih.gov)
  • Glucosamine and chondroitin are structural components of cartilage, the tissue that cushions the joints. (nih.gov)
  • Cartilage is the connective tissue that cushions the ends of bones within the joints. (nih.gov)
  • The bovine nasal cartilage explant model and the destabilization of the medial meniscus (DMM) model of osteoarthritis in the mouse were used to assess chondroprotection at the tissue and whole-animal levels. (nih.gov)
  • Articular cartilage is an avascular tissue, and consequently oxygen supply is reduced. (indexindex.com)
  • In vitro, hypoxia promotes the expression of the chondrogenic phenotype and cartilage-specific matrix formation, indicating that oxygen tension is probably a key parameter in chondrocyte culture, and particularly in the context of tissue engineering and stem cells transplantation. (indexindex.com)
  • When the joints are injured, as with osteoarthritis, the tissue will attempt to heal the damage. (williamhaseltine.com)
  • This failed tissue regeneration is key to osteoarthritis. (williamhaseltine.com)
  • Cartilage injury is a common cause of joint dysfunction and existing joint prostheses cannot remodel with host joint tissue. (medicalxpress.com)
  • Cyclical loading leads to changes at the tissue and cellular levels in articular cartilage. (cdc.gov)
  • In articular cartilage, the cells were found to be larger and more elongated in osteoarthritic samples compared to healthy samples. (oulu.fi)
  • Initial osteoarthritic changes include proteoglycan loss, deterioration of the collagen network, and increased water content within the articular cartilage and menisci. (nih.gov)
  • Thus, this study aimed to establish human MSCs culture from osteoarthritic cartilage (OA hC-MSCs) by optimising the sample processing and culture techniques. (uitm.edu.my)
  • Various osteoarthritis-related modifications have been identified in both subchondral bone and calcified cartilage. (hindawi.com)
  • However, the osteoarthritis-derived alterations in subchondral bone and calcified cartilage (especially those concomitant with articular cartilage) and specifically the role of these changes in initiation and progression of osteoarthritis remain elusive. (hindawi.com)
  • Understanding the concomitant and independent alterations in articular cartilage, calcified cartilage, and subchondral bone, together with the crosstalk between these tissues in osteoarthritis, may be the key towards novel inhibitive or progress preventative treatments of osteoarthritis. (hindawi.com)
  • In this special issue, the fundamental modifications of subchondral bone in osteoarthritis will be discussed through original research articles and comprehensive review articles. (hindawi.com)
  • A demonstration of conceptual understanding of the crosstalk between subchondral bone and the articular cartilage, supported by a combination of analysis techniques, is especially welcomed. (hindawi.com)
  • Furthermore, in vivo and in vitro studies on subchondral bone-targeted drug treatments as well as mechanisms and crosstalk between subchondral bone and articular cartilage are encouraged. (hindawi.com)
  • Some molecules such as fibroblast growth factor (FGF) and exogenous cartilage matrixes that can be fixated over the perforated subchondral bone and act as scaffolds for released MSC and growth factors are in late stages of clinical development and show promise for knee OA. (nih.gov)
  • These cysts occur in the subchondral bone, the layer of bone just under the cartilage. (medicalnewstoday.com)
  • At least one study suggests that delivering localized ultrasonic therapy to cartilage and subchondral bone may help treat OA. (medicalnewstoday.com)
  • Silencing and over-expression of HOTAIR in SW1353 cells respectively reduced and increased the expression of genes associated with cartilage degradation in OA. (researchsquare.com)
  • 0.0001), which suggested that chondrocyte hypertrophy was associated with inflammation and cartilage degradation. (nordicbioscience.com)
  • The inhibitory activities of TSG-6 and its isolated Link module (Link_TSG6) on cytokine-induced degradation of OA cartilage explants were compared. (ox.ac.uk)
  • These results are consistent with the regular pattern of cartilage ingredient change in different degradation stage, while the tibial platform images created by microscopic spectral imaging technology is highly compliant with pathology description. (gpxygpfx.com)
  • However, when ROS production exceeds the antioxidant capacities of the cell, an "oxidative stress" occurs leading to structural and functional cartilage damages like cell death and matrix degradation. (indexindex.com)
  • It shows, that oxygen and ROS play a crucial role in the control of cartilage homeostasis and that at this time, the exact role of "oxidative stress" in cartilage degradation still remains questionable. (indexindex.com)
  • Most importantly, we have revealed for the first time that in OA, SIN inhibited the inflammatory response and ECM degradation by activating the Nrf2/HO-1 signaling pathways and inhibiting NF-κB activity in mouse - cartilage cells . (bvsalud.org)
  • This inflammation, plus the physical stress produced by normal movement, can destroy replacement cartilage quickly. (nih.gov)
  • A research team led by Dr. Farshid Guilak from Washington University in St. Louis has been testing whether cartilage cells could be engineered to protect themselves from inflammation. (nih.gov)
  • The team showed that, in response, TRPV4 activates specific genetic pathways in cartilage cells associated with inflammation and metabolism. (nih.gov)
  • SFN inhibits the expression of key metalloproteinases implicated in osteoarthritis, independently of Nrf2, and blocks inflammation at the level of NF-κB to protect against cartilage destruction in vitro and in vivo. (nih.gov)
  • Histologic changes associated with CPPD correspond to calcium deposits and to inflammation due to cartilage fragments. (medscape.com)
  • Used alone or with chondroitin sulfate, glucosamine salts alleviate pain and inflammation from osteoarthritis and reportedly have beneficial effects on degenerated joints. (nih.gov)
  • As this is a risk factor for the development of osteoarthritis, quitting smoking and avoiding secondhand smoke may reduce the symptoms of SBCs and OA. (medicalnewstoday.com)
  • A team of researchers affiliated with several institutions in Alabama has linked 10 genetic loci to the development of osteoarthritis. (medicalxpress.com)
  • Osteoarthritis year in review 2021: epidemiology & therapy. (nih.gov)
  • Computational finite element (FE) models of the knee joint are able to offer a quantitative estimation about risks for the onset and development of knee osteoarthritis (OA) based on mechanical signals experienced by tissues. (springer.com)
  • However, not much is known about the very early events of osteoarthritis on the microstructural level, especially regarding the soft tissues of the joint. (oulu.fi)
  • Although less well studied as in other tissues, lncRNAs have been reported to play critical roles in the development of bone and cartilage, and diseases associated with these tissues (10). (researchsquare.com)
  • Osteoarthritis happens when the cartilage and other tissues within the joint break down or have a change in their structure. (nih.gov)
  • This cartilage is an avascular, unique matrix composed of chondrocyte cells, which can resist compression and redistribute loads but have poor self-regenerative capacity. (asiapharmaceutics.info)
  • A cartilage cell, called a chondrocyte, is stimulated with a very small glass pipette, about 1/5 the diameter of a human hair. (nih.gov)
  • 5 However, this process is accompanied by the presence of proinflammatory cytokines which result in the deterioration of chondrocyte metabolism and limit self-regeneration of cartilage. (health.mil)
  • Cartilage helps the bones move smoothly against each other and can withstand the weight of the body during activities such as running and jumping. (prairie-ortho.com)
  • Healthy cartilage helps you move by allowing your bones to glide over each other. (medlineplus.gov)
  • In osteoarthritis, the surface layer of cartilage between the bones of a joint wears down. (nih.gov)
  • OA causes the cartilage and bones within a joint to gradually break down. (medicalnewstoday.com)
  • Carticel should not be used in patients who have previously had cancer in the bones, cartilage, fat or muscle of the treated limb. (nih.gov)
  • Abstract In-situ analysis the chemical composition of tibial articular cartilage of female Hartley guinea pigs with Fourier transform infrared (FTIR) microspectroscopy was conducted. (gpxygpfx.com)
  • [ 8 ] It is possible to estimate normal cartilage volume to distinguish diseased knees from healthy ones. (medscape.com)
  • They had encountered his doctorate studies because they were working with a similar project for the international football federation FIFA, which is very interested in opportunities to repair cartilage in injured footballers' knees. (norwegianscitechnews.com)
  • The knees, hips, spine, and hands are the parts of the body most likely to be affected by osteoarthritis. (nih.gov)
  • Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways. (bvsalud.org)
  • The objective of this study was to describe the rate of change in knee cartilage volume over 4.5 years in subjects with symptomatic knee osteoarthritis (OA) and to determine factors associated with cartilage loss. (medscape.com)
  • Tibial cartilage declines at an average rate of 4% per year in subjects with symptomatic knee OA. (medscape.com)
  • [ 15 ] We have extended the observation of a cohort of community-dwelling subjects with predominantly mild symptomatic knee OA to determine the change in knee cartilage volume in subjects with knee OA over 4.5 years, [ 10 ] and factors that may affect this. (medscape.com)
  • Over the last decade, a variety of regenerative medicine approaches that either preserve articular cartilage in people who started with a focal cartilage injury and thus are at a higher risk of developing knee osteoarthritis (OA) or restore defective articular cartilage in patients with symptomatic knee OA have been investigated. (nih.gov)
  • Carticel is an autologous cellular product indicated for the repair of symptomatic cartilage defects of the femoral condyle (medial, lateral or trochlea), caused by acute or repetitive trauma, in patients who have had an inadequate response to a prior arthroscopic or other surgical repair procedure (e.g., debridement, microfracture, drilling/abrasion arthroplasty, or osteochondral allograft/autograft). (nih.gov)
  • After multivariate adjustment, annual medial tibial cartilage loss was predicted by lesser severity of baseline knee pain but was independent of age, body mass index and structural factors. (medscape.com)
  • The only significant factor affecting the loss of medial tibial cartilage was baseline knee pain, possibly through altered joint loading. (medscape.com)
  • All patients had some degree of disc disease accompanying medial or tricompartmental osteoarthritis. (researchgate.net)
  • Applying intensity and size thresholds on the difference maps created from longitudinal acquisitions, the cluster analysis method is able to identify focal cartilage lesions and evaluate potential differences that are important and different from those observed within healthy individuals. (stanford.edu)
  • Deep learning applications for OA research, including analysis of both radiographs for automatic detection of OA severity, and MR images for detection of cartilage/meniscus lesions and cartilage segmentation for automatic T 2 quantification will be described. (nih.gov)
  • It was demonstrated that cartilage and meniscal T2 relaxation time values were significantly increased in subjects with compared to those without radiographic OA and focal knee lesions, respectively. (nih.gov)
  • Validation of the Knee Injury and Osteoarthritis Outcome Score subscales for patients with articular cartilage lesions of the knee. (rush.edu)
  • Engelhart L, Nelson L, Lewis S, Mordin M, Demuro-Mercon C, Uddin S, McLeod L, Cole B, Farr J. Validation of the Knee Injury and Osteoarthritis Outcome Score subscales for patients with articular cartilage lesions of the knee. (rush.edu)
  • [ 1 , 2 ] Our understanding of joint cartilage development and the pathophysiology of OA has previously been limited by the lack of a non-invasive method for assessing joint cartilage in vivo . (medscape.com)
  • Traditionally osteoarthritis has been thought to be a disease of articular cartilage, but it is currently accepted to be a disease of the whole joint. (hindawi.com)
  • Osteoarthritis is a common joint disorder that leads to disability. (oulu.fi)
  • To determine whether the presence of definite osteophytes (in the absence of joint space narrowing [JSN]) on radiographs is associated with (subregional) increases in cartilage thickness in a within-person, between-knee cross-sectional comparison of participants in the Osteoarthritis Initiative. (nih.gov)
  • Cartilage loss was assessed by two observers who scored the change in joint space width between two radiographs. (bmj.com)
  • Patients with articular cartilage damage experience symptoms such as joint pain, swelling, stiffness, and a decrease in range of motion of the knee. (prairie-ortho.com)
  • People with osteoarthritis usually have joint pain and, after rest or inactivity, stiffness for a short period of time. (nih.gov)
  • Bits of bone or cartilage can also break off and float inside the joint space. (nih.gov)
  • Genetic defect in joint cartilage. (nih.gov)
  • Race and sex differences in willingness to undergo total joint replacement: the Johnston County Osteoarthritis Project. (cdc.gov)
  • Joint-specific hand symptoms and self-reported and performance-based functional status in African-Americans and Caucasians: the Johnston County Osteoarthritis Project. (cdc.gov)
  • The symptoms of osteoarthritis can include joint pain, stiffness, and swelling. (nih.gov)
  • Our study reveals a positive' time-dependent' structural effect of the combination of PRP and HA obtained with Cellular Matrix on the proteoglycan content of the knee joint cartilage. (houstonsportsdoctor.com)
  • This pilot study demonstrates for the first time the modulatory effect on the structure of the knee joint cartilage of a combination of platelet-rich plasma and hyaluronic acid prepared with a specially dedicated medical device (Cellular Matrix) during the course treatment. (houstonsportsdoctor.com)
  • Objective: To determine the effect of Alphacalcidol supplementation on pain based on WOMAC pain index and joint cartilage condition based on cartilage oligomeric matrix protein (COMP) serum markers in knee osteoarthritis (OA) elderly patients. (ui.ac.id)
  • Osteoarthritis is a joint condition which plagues more than 32.5 million people in the United States-around 1 in every 7 American adults. (williamhaseltine.com)
  • If this cartilage wears away, the joint becomes inflamed and painful. (williamhaseltine.com)
  • In osteoarthritis, usually the cartilage thins in response to aging or joint injury (Figure 1). (williamhaseltine.com)
  • Figure 1: Comparison of a healthy joint and a joint with osteoarthritis. (williamhaseltine.com)
  • Methods: Human osteoarthritis knee cartilage samples were obtained (2-4 g) from 8 patients with a mean age of 62.75 years old during the joint replacement surgery. (uitm.edu.my)
  • Osteoarthritis (OA) is the most com-mon adult joint disease and accounts for significant morbidity burdens among U.S. civilian and military populations. (health.mil)
  • Engaging in high-impact activities can contribute to injury and damage to the joint and cartilage over time, possibly leading to SBCs. (medicalnewstoday.com)
  • Osteoarthritis, a disease that causes severe joint pain, affects more than 20 million people in the United States. (medicalxpress.com)
  • People suffering with osteoarthritis currently have only two treatment options: pain management and joint surgery. (medicalxpress.com)
  • Cyclical articular joint loading leads to cartilage thinning and osteopontin production in a novel in vivo rabbit model of repetitive finger flexion. (cdc.gov)
  • An in vivo rabbit model of repetitive joint flexion and loading was used to characterize the morphological effects of cyclical loading on articular cartilage. (cdc.gov)
  • 5% of patients), derived from the STAR study include arthrofibrosis/joint adhesions, graft overgrowth, chondromalacia or chondrosis, cartilage injury, graft complication, meniscal lesion and graft delamination. (nih.gov)
  • OBJECTIVE: To investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA. (ox.ac.uk)
  • The proposed technique was shown to enable the 3D visualization and analysis of articular cartilage and meniscus microstructures with the same level of detail as conventional 2D histology. (oulu.fi)
  • The new technique also enabled microstructural analysis of articular cartilage and meniscus in 3D. (oulu.fi)
  • The role of ANKH in pathologic mineralization of cartilage. (medscape.com)
  • These changes are suggestive of tidemark advancement and may indicate a reactivation of cartilage mineralization steps analogous to endochondral ossification. (cdc.gov)
  • Osteoarthritis results from breakdown of cartilage. (medlineplus.gov)
  • Compared with cytokines alone, SFN (10 μM) abrogated cytokine-induced destruction of bovine nasal cartilage at both the proteoglycan and collagen breakdown levels. (nih.gov)
  • Pain and other symptoms of osteoarthritis may lead you to feel tired, have problems sleeping, and feel depressed. (nih.gov)
  • Injured, inflamed, or damaged cartilage can cause symptoms such as pain and limited movement. (medlineplus.gov)
  • Main outcome measures Intention to treat analysis of between group difference in change in knee injury and osteoarthritis outcome score (KOOS 4 ), defined a priori as the mean score for four of five KOOS subscale scores (pain, other symptoms, function in sport and recreation, and knee related quality of life) from baseline to two year follow-up and change in thigh muscle strength from baseline to three months. (bmj.com)
  • Osteoarthritis (OA) is a leading cause of chronic disability worldwide, affecting over 50% of patients above 55-80 years of age (1). (researchsquare.com)
  • It is a surgical procedure performed to replace the worn out cartilage and is usually performed to treat patients with small areas of cartilage damage usually caused by sports or traumatic injuries. (prairie-ortho.com)
  • DESIGN: Knee articular cartilages from OA patients were analyzed for TSG-6 protein and mRNA expression using immunohistochemistry and RNAscope, respectively. (ox.ac.uk)
  • Osteoarthritis (OA) has a high burden and impact on society as it affects the quality of life of both young and older patients. (asiapharmaceutics.info)
  • To analyze the potential modulatory effect of Cellular Matrix, a new medical device de-signed for the one-step preparation of platelet-rich plasma in presence of hyaluronic acid, on the structure of articular cartilage in patients suffering from knee osteoarthritis using high-field Magnetic Resonance Imaging measurements of longitudinal relaxation time after gadolinium injection. (houstonsportsdoctor.com)
  • at the Wake Forest Institute of Regenerative Medicine examined cartilage deterioration in patients with osteoarthritis. (williamhaseltine.com)
  • first collected synovial fluid from osteoarthritis patients, and then separated the cells from the fluid. (williamhaseltine.com)
  • 2006 . Activity limitations in the lower extremities in patients with osteoarthritis: the modifying effects of illness perceptions and mental health. (nih.gov)
  • Samples were collected from patients, with coxarthrosis (osteoarthritis) or fragility fracture (osteoporosis). (scirp.org)
  • To identify vitamin D regimens to correct vitamin D deficiency and prevent related musculoskeletal events, a European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group reviewed and analyzed meta-analyses of randomized controlled trials on the effects of vitamin D supplementation on fracture risk, falls or osteoarthritis. (springer.com)
  • Human trabecular bone from two disease groups, osteoporosis and osteoarthritis was analyzed. (scirp.org)
  • The purpose of this work was to review the current literature on cartilage and meniscal T2 relaxation time. (nih.gov)
  • Elevated cartilage and meniscal T2 relaxation times were found in subjects with vs without knee pain. (nih.gov)
  • The results suggest that a template- or population-based approach, which is much faster than fully subject-specific, could be applied as a clinical prediction tool for osteoarthritis. (springer.com)
  • Even with optimal clinical, radiographic, and histologic data, there is often no clear distinction between benign and low-grade malignant cartilage tumors. (medscape.com)
  • Here, we show, using a newly developed microphysiological cartilage-on-a-chip model that enables the application of strain-controlled compression to three-dimensional articular cartilage microtissue, that a 30% confined compression recapitulates the mechanical factors involved in OA pathogenesis and is sufficient to induce OA traits. (nature.com)
  • The molecular information obtained from the study is important for understanding the pathogenesis of cartilage diseases. (gpxygpfx.com)
  • Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population. (nih.gov)
  • [ 5 , 7 ] It correlates inversely with radiographic grade of disease, such that subjects with knee OA have less knee cartilage than normal healthy subjects. (medscape.com)
  • Once knee OA is established, knee cartilage tends to be lost more rapidly than in healthy adults. (medscape.com)
  • Complicating this is the recognised high variability of cartilage loss both between individuals who are healthy or who have OA [ 10 , 12 ] and between those with progressive and non-progressive OA. (medscape.com)
  • Cluster analysis, our proposed tool for identifying quantitative changes occurring across the cartilage plate that is not synonymous with changes expected within a normal population, may help tease out significant differences in healthy vs. at-risk populations. (stanford.edu)
  • 3D Visualization of Quantitative T2 Relaxation Times in the Femoral Condylar Cartilage in Healthy and ACL-injured Individuals . (stanford.edu)
  • Damaged cartilage needs to be replaced with healthy cartilage and the procedure is known as cartilage replacement. (prairie-ortho.com)
  • In this method, a piece of healthy cartilage from another site is removed using the arthroscopic technique and is cultured in a laboratory. (prairie-ortho.com)
  • No significant difference was detected between healthy cartilage types and correlations with previous studies of matrix composition and glaucomatous cells using sharp tips (7.4051.33 vs. 7.9950.97 kPa). (nih.gov)
  • cartilage matrix are the collagen mesh and the highly charged proteoglycan aggrecan entangled in and swelling the mesh. (nih.gov)
  • This may enable the prediction of cartilage change in an individual. (medscape.com)
  • The advancements of artificial intelligence (AI) for osteoarthritis (OA) applications have been rapid in recent years, particularly innovations of deep learning for image classification, lesion detection, cartilage segmentation, and prediction modeling of future knee OA development. (nih.gov)
  • In in vivo experiments, SIN treatment helped to improve the cartilage destruction in OA model mice . (bvsalud.org)
  • The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: A potential disease-modifying OA drug. (ox.ac.uk)
  • In addition, regression to the mean will induce a spurious negative correlation between initial cartilage volume and change in cartilage volume. (medscape.com)