Introduction Growing evidence in the literature supports the accuracy of sentinel lymph node (SLN) biopsy in early-stage cervical cancer. (bmj.com)
Lymphadenectomy2
Methods After IRB approval, consecutive patients who underwent surgery for International Federation of Gynecology and Obstetrics stage IA1 with lymph-vascular space involvement to IB1 between November 2017 and July 2019 and had SLN biopsy and pelvic lymphadenectomy were included. (bmj.com)
Results Eighteen patients underwent SLN assessment with OSNA and systematic pelvic lymphadenectomy in the study period. (bmj.com)
Breast cancer1
The MIRROR trial is the most representative of these, comparing early breast cancer untreated patients with ITC or micrometastases in the SN against a control group of similar patients but in whom cancer has not spread to nearby lymph nodes (N0). (medscape.com)
Patients3
The aim of this study was to evaluate the rate of low-volume metastasis in SLNs detected by OSNA in patients with early-stage cervical cancer. (bmj.com)
OSNA detected micro-metastasis in 6/18 (33.3%) patients. (bmj.com)
Moreover, since most cohort studies include patients diagnosed before 2002, the TNM version used then did not differentiate between micrometastases and ITC, so reliable conclusions could not be drawn. (medscape.com)
Found1
Studies with ALND prior to the application of the SN found that the presence of micrometastases implied a lower OS and DFI. (medscape.com)
Negative3
Secondary aims were to define the sensitivity and the negative predictive value of SLN biopsy assessed with OSNA. (bmj.com)
The sensitivity and negative predictive value of SLN in detecting lymph node metastasis with OSNA calculated per pelvic sidewall were 85.7% and 96.1%, respectively. (bmj.com)
The rationale of the assay is that if the SN is negative, the rest of the nodes in the ALND specimen will also be negative. (medscape.com)