• citation needed] The most common cause of polyuria in both adults and children is uncontrolled diabetes mellitus, which causes osmotic diuresis, when glucose levels are so high that glucose is excreted in the urine. (wikipedia.org)
  • Polyuria is caused by osmotic diuresis secondary to hyperglycemia. (medscape.com)
  • Answer: Kidney cannot reabsorb all of the glucose causing osmotic diuresis. (flashcardmachine.com)
  • Additionally, high amounts of solutes within the renal tubules cause a passive osmotic diuresis (solute diuresis) and thus an increase in urine volume. (msdmanuals.com)
  • Glucose-induced osmotic diuresis in diabetes mellitus is further increased with use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) that lower plasma glucose levels by inhibiting renal glucose reabsorption and increasing renal glucose excretion. (msdmanuals.com)
  • can have an osmotic diuresis. (msdmanuals.com)
  • Consequently, in bitches with pyometra, factors other than osmotic diuresis appear to be mainly responsible for the reduction in concentrating ability and polyuria. (biomedcentral.com)
  • The water is drawn out by osmotic diuresis secondary to excess glucose in the urine. (shrinksinsneakers.com)
  • Polyuria, defined as daily urine output in excess of 3.0 to 3.5 L/d, can occur due to solute or water diuresis. (medscape.com)
  • We describe a case of polyuria due to high solute ingestion and excessive water intake leading to a mixed picture of solute and water diuresis. (medscape.com)
  • [ 3 ] The differential diagnosis of polyuria includes central diabetes insipidus, congenital or acquired nephrogenic diabetes insipidus, psychogenic polydipsia, high protein or hyperglycemic osmotic diuresis, salt-wasting nephropathies, mixed polyuria due to excess solute and water intake, and postobstructive diuresis following recovery from urinary obstruction. (medscape.com)
  • [ 3-14 ] Osmotic diuresis, driven by high protein intake, is typically encountered in hospitalized patients fed with exogenous protein administered by the enteral or parenteral route. (medscape.com)
  • DKA patients are severely dehydrated due to osmotic diuresis from their hyperglycemic state. (iem-student.org)
  • When glucose passes through urine, it draws more water into urine due to a phenomenon called (osmotic diuresis). (doctor-explains.com)
  • As the osmotic diuresis continues, the intravascular volume is profoundly depleted, which further decreases renal perfusion and the ability of the kidneys to remove glucose from the blood. (ems1.com)
  • Sodium, potassium, phosphate and magnesium are typically lost during the osmotic diuresis leading to electrolyte imbalances. (ems1.com)
  • Polyuria can result in volume depletion, rapid fluctuations in serum sodium levels, and distension of the renal outflow tract due to high urinary output volume. (medscape.com)
  • In diabetes insipidus, there is a significant reduction in the synthesis, storage and release of vasopressin (ADH) or also due to the renal inability to respond to the action of available antidiuretic hormone (ADH), resulting in uncontrolled or lost polyuria in both cases. (sleeeeeep.com)
  • Severe nocturnal enuresis secondary to polyuria can be an indication of onset of diabetes in young children. (medscape.com)
  • Hyperosmolar Hyperglycemic tate (HSS)-Individuals present with severe dehydration due to excessive osmotic water loss secondary to high sugars. (busogatoday.com)
  • In this case, excessive thirst is considered secondary to polyuria, that is, it is the result of deterioration in the mechanism of fluid conservation in the body. (sleeeeeep.com)
  • According to NICE, desmopressin can be considered for nocturnal polyuria, which can be caused by diabetes mellitus, if other medical treatments have failed. (wikipedia.org)
  • In a healthy individual, thirst and AVP release are stimulated by an increase in body fluid osmolality above a certain osmotic threshold, which is approximately 280-290 mOsm/L and is considered to be similar if not identical for both thirst and AVP release. (medscape.com)
  • Copeptin - a marker indicating vasopressin activity - serum sodium and osmolality, plasma IL-8 and TNF-alpha were measured at baseline and directly after osmotic stimulus. (uni-wuerzburg.de)
  • The change in the serum osmotic pressure may cause potassium, sodium, chloride, phosphate, magnesium and bicarbonate to be depleted from the tissues, even though the serum electrolyte levels may appear to be normal or elevated. (ems1.com)
  • they are involved in maintaining the osmotic pressure, fluid balance and acid-base balance 9in our body just like sodium. (haseloto.com)
  • Solute-induced polyuria can be seen in hospitalized patients after a high solute load from exogenous protein administration or following relief of urinary obstruction. (medscape.com)
  • Restriction of the daily solute load and water intake resulted in complete resolution of polyuria. (medscape.com)
  • One study from 2008 lays out a hypothesis that hyperglycaemic and osmotic polyuria play roles ultimately in diabetic nephropathy. (wikipedia.org)
  • Taken together these data for the first time identify Aqp5 as a Dot1a potential transcriptional target and an Aqp2 binding partner and regulator and suggest that the upregulated Aqp5 may contribute to polyuria possibly by impairing Aqp2 membrane localization in mice and in patients with diabetic nephropathy. (bioskinrevive.com)
  • SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria. (genscript.com)
  • Animal and human in vitro studies have shown that inflammatory parameters, such as interle ukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), increase in parallel in the central nervous system and bronchial, corneal or intestinal epithelial cell lines in response to osmotic stimulus. (uni-wuerzburg.de)
  • Polyuria may also be due to various chemical substances, such as diuretics, caffeine, and ethanol. (wikipedia.org)
  • Reduced expression and/or apical localization of Aqp2 under pathological conditions (i.e. nephrosis hypokalemia and mutations) results in polyuria. (bioskinrevive.com)
  • Polyuria means excessive urinary output, i.e. urine volume >3 L/day. (rimikri.com)
  • The goal of treatment is to restore body water and osmotic homeostasis avoiding complications. (sleeeeeep.com)
  • Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and osmotic stimulation. (uni-wuerzburg.de)
  • This is accompanied by large fluid losses in the form of urine (polyuria). (sleeeeeep.com)
  • A 9-year-old boy (currently a 16-year-old boy) who came to our pediatric clinic with osmotic presentations. (biomedres.us)
  • We therefore investigated the influence of osmotic stimulus on circulatory markers of systemic inflammation in healthy volunteers. (uni-wuerzburg.de)
  • Compared to controls mice have polyuria without serious impairment in keeping regular electrolyte and acid-base stability [30]. (bioskinrevive.com)
  • To verify the polyuria phenotype we performed additional metabolic evaluation further. (bioskinrevive.com)
  • The diagnostic principles used in this teaching case illustrate the approach to the evaluation of polyuria in an outpatient setting. (medscape.com)
  • Polyuria (/ˌpɒliˈjʊəriə/) is excessive or an abnormally large production or passage of urine (greater than 2.5 L or 3 L over 24 hours in adults). (wikipedia.org)
  • In this study, osmotic stimulus does not increase circulating markers of systemic inflammation. (uni-wuerzburg.de)