Oscillations calcium signaling. Medical search. Frequent questions

Ca2+ can act in signal transduction resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. (wikipedia.org)
Most of the other pathways in this list rely on metabolic reactions for their initiation and termination, calcium differs in an important way from these other pathways in that as an inorganic cation, calcium can be neither created nor destroyed. (hstalks.com)
Calcium moves across the plasma membrane through pathways such as the plasma membrane calcium ATPase (PMCA), or the sodium calcium exchanger, these are important in expelling calcium from the cell. (hstalks.com)
Calcium can enter through pathways such as store-operated, voltage-operated, or receptor-operated calcium channels. (hstalks.com)
The molecular components of key Ca2+ signalling pathways have been identified. (hstalks.com)
Consequently our understanding of Ca2+ signalling is now advancing rapidly through experimental approaches that involve the controlled expression, inhibition of expression and use of naturally occurring or engineered mutations of channels, pumps, effectors and other proteins related to Ca2+ signalling pathways. (hstalks.com)
Finally, these signaling pathways induce expression of the nuclear factor of activated T cells c1 (NFATc1), which is a key transcription factor for osteoclastogenesis. (molcells.org)
Synaptic activity triggers intracellular calcium (Ca+2) oscillations that locally modulate several signaling pathways. (uam.es)
Neuronal control of behavior arises from the activity of underlying neural circuits, which in turn are specified by the interaction of various signaling pathways. (jneurosci.org)
Signaling pathways, such as calcium signal transduction, are particularly prone to random fluctuations. (hu-berlin.de)
Finally, the influence of noise on the performance of signaling pathways is investigated. (hu-berlin.de)
Chow and his colleagues are interested in applying this biological nanomachine to studying G-protein coupled receptors, or GPCRs, which are involved with signaling pathways by which cells communicate and sense their environment. (upenn.edu)

Calcium signaling is the use of calcium ions (Ca2+) to communicate and drive intracellular processes often as a step in signal transduction. (wikipedia.org)
To put this signaling pathway into perspective, I really like this slide adapted from Sir Michael Berridge, which presents an inventory of the known intracellular signal transduction cascades. (hstalks.com)
Using the information-theoretic measure Transfer Entropy (Schreiber 2000) we studied the properties of this signal transduction under different conditions. (videolectures.net)
It is a modulator of the olfactory SIGNAL TRANSDUCTION PATHWAY. (lookformedical.com)
The latter indicated the presence of an intracellular urocortin-induced signal transduction pathway that is unique to keratinocytes. (biologists.com)

Hormones that act through the calcium-releasing messenger, inositol 1,4,5-trisphosphate (IP3), cause intracellular calcium oscillations. (nottingham.ac.uk)
iPSC-derived cardiomyocytes form a synchronously beating monolayer that can be used to reliably reproduce drug-associated, cardio-physiologic phenotypes using a fast, kinetic fluorescence assay that monitors changes in intracellular calcium oscillations. (moleculardevices.com)

Therefore, we coupled a simple Ca2+-dependent enzyme activation process to a model of calcium oscillations (Kummer 2000) and to experimentally measured calcium time series. (videolectures.net)
Simulated and experimentally measured calcium time series are stochastically coupled to an intracellular target enzyme activation process. (hu-berlin.de)

After stimulation, the calcium concentration in the cytosol of hepatocytes, for example, can display complex dynamic behavior including spiking and bursting oscillations. (videolectures.net)
Spontaneous fluctuations in hemodynamic signals in the absence of a task or overt stimulation are used to infer neural activity. (nature.com)
Although all Ca2+ mobilizing agonists in pancreatic acinar cells utilize the phosphoinositide-signaling (PI) pathway, stimulation by individual agents results in markedly different temporal and spatial patterns of Ca2+ signaling. (rochester.edu)
Stimulation of cells with physiological concentrations of calcium-mobilizing agonists often results in the generation of repetitive cytoplasmic Ca(2+) oscillations. (ox.ac.uk)
Here, we show that following stimulation of cysteinyl leukotriene type I receptors in rat basophilic leukemia (RBL)-1 cells, large amplitude Ca(2+) oscillations, CRAC channel activity, and downstream Ca(2+)-dependent nuclear factor of activated T cells (NFAT)-driven gene expression are all exclusively maintained by the endoplasmic reticulum Ca(2+) sensor stromal interaction molecule (STIM) 1. (ox.ac.uk)
However, stimulation of tyrosine kinase-coupled FCεRI receptors evoked Ca(2+) oscillations and NFAT-dependent gene expression through recruitment of both STIM2 and STIM1. (ox.ac.uk)
Furthermore, the islets of Gem-deficient mice exhibited decreased free calcium responses to glucose and the calcium oscillations seen upon glucose stimulation were smaller in amplitude and had a reduced frequency. (edu.au)
adrenoceptors are priorly stimulated, the time for APD oscillations to become apparent is remarkably reduced, with the oscillation time lapse being an exponential function of the pre-stimulation level. (unideb.hu)
In particular, during the first few minutes after stimulation, the probability distribution of calcium wave sizes is characterized by a power law, thus indicating critical behavior. (um.si)

Ca2+ is important for cellular signalling, for once it enters the cytosol of the cytoplasm it exerts allosteric regulatory effects on many enzymes and proteins. (wikipedia.org)
This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. (rochester.edu)
The oscillations were dependent upon the influx of extracellular calcium via mechanisms that were insensitive to inhibitors of L-type voltage operated calcium channels (nifedipine, verapamil, diltiazem), G-proteins (pertussis toxin) or the GABA (A) receptor (bicuculline). (edu.au)
Free Ca 2+ is then rapidly sequestered by the action of calcium pumps and exchangers and also with buffering by cytosolic calcium binding proteins. (jneurosci.org)
Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. (ox.ac.uk)
We conclude that different agonists activate different STIM proteins to sustain Ca(2+) signals and downstream responses. (ox.ac.uk)
signaling proteins , the PSD also contains scaffolding proteins . (arasysperfector.com)

However, studies on oligodendroglia Ca 2+ signal dynamics are still scarce, especially during myelin repair, and there are no software solutions to properly analyze the unique Ca 2+ signal characteristics in these cells. (biorxiv.org)
Understanding the dynamics of calcium signals is achieved. (brainmass.com)
The dynamics of calcium signals which are achieved are given. (brainmass.com)
The goal of the meeting was to bring together leading experts in the field of experimental and theoretical analysis of cellular calcium dynamics and to provide a stimulating exchange among scientists working on various aspects of the cellular calcium toolbox. (nottingham.ac.uk)
In human spermatozoa, calcium dynamics control most of fertilization events. (bvsalud.org)
To study spatiotemporal calcium dynamics within these syncytia, we make use of computational modeling and confocal high-speed functional multicellular imaging. (um.si)
After this period, the dynamics changes qualitatively such that the number of global intercellular calcium events increases to the point where the behavior becomes supercritical. (um.si)
Our results indicate that the loss of oscillatory changes, along with the rise in plasma glucose observed in diabetes, could be associated with a switch to supercritical calcium dynamics and loss of beta cell functionality. (um.si)
Dynamics of individual cells is simulated by a mathematical model for ▫$Ca^{2+}$▫ oscillations. (um.si)

The most common signaling pathway that increases cytoplasmic calcium concentration is the phospholipase C (PLC) pathway. (wikipedia.org)
Given that tremendous molecular diversity is expressed at all levels of this signaling pathway, our working hypothesis is that individual agonists do not couple to the signaling machinery in an identical fashion. (rochester.edu)
We are utilizing fluorescence imaging techniques including high-speed confocal microscopy to monitor [Ca2+]i while manipulating the signaling pathway with neutralizing antibodies and antisense technology. (rochester.edu)

Research in this laboratory focuses on gaining a better understanding of the mechanisms which underlie these signaling patterns with a primary goal of relating this knowledge to the physiology and pathophysiology of exocrine cells. (rochester.edu)
Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state. (edu.au)
The purpose of this work is to show the mechanisms of transitions between different dynamic modes of spontaneous astrocytic calcium activity. (sgu.ru)
The mechanisms of oscillatory mode development with the increase of the maximal calcium flux out of the SERCA pump in the presence of low and high level of extracellular calcium concentration were demonstrated. (sgu.ru)
Here we aimed to identify the mechanisms of progesterone-induced calcium signaling in human spermatozoa. (bvsalud.org)
What mechanisms regulate calcium channel trafficking and abundance at single release sites? (mit.edu)
Conversely, mechanisms for temperature compensation in neuropil regions are relatively unexplored, despite the importance of dendritic signal propagation and summation for AP initiation. (jneurosci.org)

Although Orai1 and STIM1, have been linked by several studies, for a proposed model of store-operated calcium influx. (wikipedia.org)
For many years Cl- channels have been well studied in neurological systems, where these channels initiate action potentials at synapses, propagate signals along axons and dendrites, and trigger neurotransmitter release and Calcium influx. (brainmass.com)
read more keep the cytoplasmic calcium ([Ca2+]c) low and then allow selective increases in [Ca2+]c by stimulating either Ca2+ release from the cells' internal Ca2+ stores or the influx of Ca2+ from the extracellular environment. (hstalks.com)
How does calcium influx during an action potential initiate and regulate synaptic communication. (mit.edu)

Signaling occurs when the cell is stimulated to release Ca2+ ions from intracellular stores, and/or when Ca2+ enters the cell through plasma membrane ion channels. (wikipedia.org)
Calcium ions act as second messenger in many cell types. (videolectures.net)
Firstly, this natural calcite is not pure calcium carbonate but contains magnesium ions that substitute for calcium ions in the crystal lattice, as was quantified with the help of high-resolution X-ray powder diffraction performed at beamline ID22 [1]. (esrf.fr)
Notably, emergence of chaotic spontaneous calcium oscillations for specific level of calcium ions outside the cell was revealed. (sgu.ru)
In the jellyfish, in the presence of Calcium ions, Aequorin can to turn into an excited form that relaxes with the emission of blue light that in turn excites the GFP, which ultimately emits green light (Ref 6) , giving Aequorea victoria its colour that, hence, varies from blue to green (Fig from ref 5). (ibs.fr)
Calcium ions are an important second messenger in living cells. (um.si)

Intracellular Ca 2+ signals of oligodendroglia, the myelin-forming cells of the central nervous system, regulate vital cellular processes including myelination. (biorxiv.org)
Since a number of different effectors and cellular targets exist, it has been suggested, that specific information is encoded in the amplitude, frequency and waveform of the Ca-signal and decoded again, later on, by cellular targets. (videolectures.net)
A one-day workshop on the mathematical modelling of cellular calcium signals organised by Dr Stephen Coombes was held at the University of Nottingham on 28 April 2006. (nottingham.ac.uk)
His group uses molecular and cellular tools combined with network theory to explore the links between calcium signaling, cellular behavior and the early events leading to the destruction of normal heart rhythm (arrhythmia). (swansea.ac.uk)

Spontaneous hemodynamic signals reflect a combination of behavior, local neural activity, and putatively non-neural processes. (nature.com)
Sinitsina M. S., Gordleeva S. Y., Kazantsev V. B., Pankratova E. V. Calcium concentration in astrocytes: Emergence of complicated spontaneous oscillations and their cessation. (sgu.ru)
article{ IzvVUZ_AND-29-3-440, author = {Sinitsina, Maria Sergeevna and Gordleeva, Susanna Yurevna and Kazantsev, Viktor Borisovich and Pankratova, Evgenija Valerevna}, title = {Calcium concentration in astrocytes: Emergence of complicated spontaneous oscillations and their cessation}, year = {2021}, journal = {Izvestiya VUZ. (sgu.ru)
Spontaneous calcium oscillation acquired with FLIPR Calcium Assay Kit and the FLIPR system from iPSC cardiomyocytes or 3D cardiac spheroids can be paired with cytotoxicity and mitochondrial integrity data from the ImageXpress confocal system for comprehensive phenotypic analysis and bioactivity profiling of both pharmaceutical and environmental compounds. (moleculardevices.com)

Both oscillatory events, especially when cooccurring in the constellation of spindles nesting in the slow oscillation upstate, are considered to support memory formation and underlying synaptic plasticity. (uni-luebeck.de)
In conclusion, when spindles are nested in slow oscillation upstates, maximum Pyr activity appears to concur with strong perisomatic inhibition of Pyr cells via PV-Ins and low dendritic inhibition via SOM-Ins (i.e., conditions that might optimize synaptic plasticity within local cortical circuits). (uni-luebeck.de)

Calcium is required for muscle contractions and also for many cells (like neurons) to properly secrete signals and hormones. (brainmass.com)
During development dorsal epithelial cells receive signals from the notochord that causes them to differentiate into neural tissue to form the neural tube. (brainmass.com)
In some cells the Ca2+ signals are very brief, taking only milliseconds, whilst in other cells they can persist over several hours. (hstalks.com)
In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. (rochester.edu)
Exposure of cells to neurotransmitters and hormones results in a rapid elevation of intracellular calcium. (rochester.edu)
A further project relates to the organization and regulation of calcium release sites in exocrine cells. (rochester.edu)
By imaging the calcium responses generated in individual cells, we have demonstrated that during this plateau phase, spermatozoa exhibit a series of asynchronous secondary calcium oscillations. (edu.au)
However, treatment with an inhibitor of the GABA-associated chloride channel (picrotoxin) significantly suppressed the incidence of secondary calcium oscillations in pentoxifylline-treated cells, as did two inhibitors of T-type calcium channels (pimozide and amiloride). (edu.au)
The secondary calcium oscillations created via these channels do not induce acrosomal exocytosis per se but may prime the cells so that this event is rapidly triggered when the spermatozoa make contact with the zona pellucida. (edu.au)
Researchers at the University of Pennsylvania describe optogenetic control of calcium oscillations in HeLa cells via expression of the photosensitive G protein- coupled receptor melanopsin. (lumencor.com)
Almost all organisms have photoreceptors in their cells, even ones that live at the bottom of the ocean, and there are many ways we know photoreceptors signal in response to light," Chow says. (upenn.edu)
Here, using twophoton imaging in mice, we relate EEG-recorded slow oscillations and spindles to calcium signals recorded from the soma of cortical putative pyramidal-like (Pyr) cells and neighboring parvalbuminpositive interneurons (PV-Ins) or somatostatin-positive interneurons (SOM-Ins). (uni-luebeck.de)
Additional wide-field calcium imaging of Pyr cells confirmed the enhanced calcium activity and its widespread topography associated with spindles nested in slow oscillation upstates. (uni-luebeck.de)
The assays use iPSC-derived cardiomyocytes loaded with a calcium-sensitive dye and allow you to monitor the compound impact on oscillating calcium within the cells as they beat. (moleculardevices.com)
ScreenWorks® Peak Pro Software offers the ability to analyze multi-peak calcium oscillation responses of cells-in particular, cardiomyocyte beat rate as well as temporal characteristics of peaks including rise, decrease, and amplitude. (moleculardevices.com)
Aims and Hypothesis: Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. (edu.au)
Regulation of calcium handling in beta-cells remains incompletely understood. (edu.au)
Gem, a member of the RGK (Rad/Gem/Kir) family regulates calcium channel handling in other cell types, and Gem over-expression inhibits insulin release in insulin-secreting Min6 cells. (edu.au)
determine the levels of IP 3 required for calcium release in A7r5 cells (a rat smooth muscle cell from the thoracic aorta). (cellml.org)
Results: Our results show that there are large inter-individual differences in the time lapse for the development of LF oscillations in APD following sympathetic provocation, with some cells requiring just a few seconds and other cells needing more than 3 min. (unideb.hu)
Cells presenting short oscillation time lapses are commonly associated with large APD oscillation magnitudes, which facilitate the occurrence of pro-arrhythmic events under disease conditions involving calcium overload and reduced repolarization reserve. (unideb.hu)
A coordinated functioning of beta cells within pancreatic islets is mediated by oscillatory membrane depolarization and subsequent changes in cytoplasmic calcium concentration. (um.si)

As you can see, the calcium ion is highly represented, and in fact, this messenger is recycled for many different purposes to mediate the actions (for example) of G protein-coupled receptors, receptor tyrosine kinases, voltage-operated calcium channels, among others. (hstalks.com)
This distribution of receptors is the major factor in defining the spatial characteristics of the Ca2+ signal. (rochester.edu)
In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied. (rochester.edu)

Mechanical movement and calcium fluxes of the cardiac spheroid can be observed from the stacks of the time-lapse acquisition images. (moleculardevices.com)

Calcium is a ubiquitous second messenger with wide-ranging physiological roles. (wikipedia.org)
Furthermore, the assumptions that permit a whole cell ode model, namely uniformly distributed calcium and the law of large numbers, do not apply under many physiological conditions. (nottingham.ac.uk)

Specifically, we use various DNA damaging methods, including laser microirradiation to study nucleus-wide epigenetic responses to complex DNA damage through PARP signaling and metabolic alteration. (uci.edu)
Ca2+ signals can be complex with some involving periodic oscillations of varying frequencies or responses that are restricted to specific regions of the cell. (hstalks.com)
Progesterone, present in the female reproductive system, can trigger several types of calcium responses, such as low-frequency oscillations. (bvsalud.org)
Two computational models were developed to describe the spermatozoa calcium responses: a homogeneous one based on a system of ordinary differential equations and a three-dimensional one with added space dimensions and diffusion for the cytosolic species. (bvsalud.org)
In response to progesterone, three types of calcium responses were observed in human spermatozoa: a single transient rise of calcium concentration in cytosol, a steady elevation, or low-frequency oscillations. (bvsalud.org)
The homogenous model provided qualitative description of the oscillatory and the single spike responses, while the three-dimensional model captured the calcium peak shape and the frequency of calcium oscillations. (bvsalud.org)

However, an interesting corollary of these plasma membrane fluxes is that they can potentially lead to significant alterations in local calcium concentration at the extracellular face of the cell. (hstalks.com)
By combining results from the literature, mathematical modelling and bio-inspired experimental results on synthetic calcite (characterised at beamline ID22), the brittle star's calcite was revealed to form via the crystallisation of Mg-rich amorphous calcium carbonate with a concentration of Mg that is in an instability region. (esrf.fr)
The Ca 2+ signal is characterized by a rapid increase in the concentration of free cytosolic calcium ([Ca 2+ ] i ) attributable to the opening of calcium channels located in the plasma membrane and in the membranes of intracellular calcium stores. (jneurosci.org)
It was shown that emergence of oscillations occurs via supercritical Andronov–Hopf bifurcation, and the properties of the oscillatory mode with further increase of the maximal calcium flux out of the SERCA pump are highly dependent on the value of extracellular calcium concentration. (sgu.ru)
Recent experimental studies have shown that IP3 levels oscillate together with the calcium concentration. (nottingham.ac.uk)

Specific signals can trigger a sudden increase in the cytoplasmic Ca2+ levels to 500-1,000 nM by opening channels in the ER or the plasma membrane. (wikipedia.org)
Ca2+ signals are attenuated by sequestration of Ca2+ into intracellular organelles that function as Ca2+ stores or by the expulsion of Ca2+ back across the plasma membrane. (hstalks.com)
We hypothesise that the sub-population of spermatozoa exhibiting secondary calcium oscillations are characterised by a hyperpolarized plasma membrane that sets T-type channels in a closed but activation-competent state. (edu.au)

Welcome to this lecture on extracellular calcium signaling. (hstalks.com)
They transfer extracellular signals (e.g. from hormones) to targets within the cell, like Ca2+-dependent enzymes or transcription factors. (videolectures.net)

5,6 The method to record and analyze calcium oscillations using time-lapse imaging and the ImageXpress® Micro High-Content Imaging System in iPSC-derived cardiomyocytes has been previously described. (moleculardevices.com)
In this talk, I will describe my attempt to develop and analyze mathematical models of the events underlying stochastic calcium oscillations, including a model for spark generation, a model for the spark to wave transition leading to a model of stochastic whole cell calcium release. (nottingham.ac.uk)

Filmstrips of time-lapse images of spheroid and 2D iPSC derived cardiomyocytes stained with the Calcium 6 dye. (moleculardevices.com)

However, sperm functions are known to be highly regulated by phosphorylation signaling. (bvsalud.org)
The major mechanism underlying the delay in APD oscillations appearance is related to the slow IKs phosphorylation kinetics, with its relevance being modulated by the IKs conductance of each individual cell. (unideb.hu)
Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation. (arasysperfector.com)

Ca spikes and oscillations have three advantages over a graded amplitude regulation of Ca++. (brainmass.com)

Short time lapses in the development of APD oscillations are associated with large oscillatory magnitudes and pro-arrhythmic risk under disease conditions. (unideb.hu)

6 The cardiomyocytes were then stained with the EarlyTox ™ Cardiotoxicity Kit or Calcium 6 dye, both of which measure changes in cytoplasmic calcium levels, a kinetic indicator of the cardiomyocyte contraction. (moleculardevices.com)

The application of molecular biology to Ca2+ signalling research has also opened new avenues of investigation. (hstalks.com)

However, the measured fluorescence signal is distorted by light scattering and tissue autofluorescence, potentially compromising complete tumor excision. (lumencor.com)
Fluorescence is an essentially background-free signal, to the point that single fluorescent molecules can be observed. (ibs.fr)

Other biochemical roles of calcium include regulating enzyme activity, permeability of ion channels, activity of ion pumps, and components of the cytoskeleton. (wikipedia.org)
Explain how a drug that interferes with the functioning of voltage-gated calcium channels could decrease the transmission of painful signals . (brainmass.com)
The functional properties and localization of the channels as well as the pumps, exchangers, and buffers are thought to play a crucial role in generating a range of calcium signals that vary from a brief local increase to repetitive calcium spikes and waves spreading over a larger region. (jneurosci.org)
Although there is consensus that calcium (Ca) puffs and sparks arise from the cooperative action of multiple intracellular Ca channels, the precise relationship between single-channel kinetics and the collective phenomena of stochastic Ca excitability and oscillations is not well understood. (nottingham.ac.uk)
Although oscillations arise from regenerative Ca(2+) release, they are sustained by store-operated Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels. (ox.ac.uk)
As in various central neurons the ImAHP has been shown to be regulated by voltage-gated calcium channels (VGCCs) and as the activity of the voltage-gated calcium channels has been in turn shown to be modulated by G-protein coupled signaling of GluK1 KARs, we went on to investigate whether a direct link between GluK1 KARs and VGCCs could be detected in the CA3 stratum radiatum interneurons of neonatal hippocampus. (helsinki.fi)

As G-protein mediated signaling has been shown to induce alterations in the voltage-dependence of the VGCC-mediated currents, we similarly investigated the effects of GluK1 inhibition on the current-voltage relationship of Ca2+ currents in CA3 interneurons during the first postnatal week as well as during the second postnatal week, since GluK1 subunit is known to undergo developmental changes in its expression during this time. (helsinki.fi)
Although in our experiments the GluK1-KAR inhibition seemed to induce no statistically significant changes in the Ca2+ current amplitudes or in the voltage-dependence of VGCC-mediated currents in the CA3 interneurons, further, more specific studies should be encouraged to investigate the phenomenon in specific interneuron subtypes and in distinct calcium channel families. (helsinki.fi)

The coupled IP3 and calcium oscillations have a greatly expanded frequency range compared to calcium fluctuations obtained with clamped IP3. (nottingham.ac.uk)

While the mechanical contractions can be recorded in transmitted light, it has also been shown that disturbance in calcium oscillation patterns, observed using Ca 2+ -sensitive fluorescent dyes, can be utilized to measure effects on cardiomyocyte beat rate and pattern. (moleculardevices.com)
It is designed to give an insight into the broad range of pathologies that involve a disturbance of Ca2+ signalling. (hstalks.com)

b) XRF tomography reconstruction slice across a lens (pixel size is 150 nm, red areas correspond to higher Ca content), and c) corresponding intensity line plot taken from the lens surface towards the centre of the bulk (marked by a yellow arrow), which shows the measured oscillations of the calcium signal and theoretical schematic oscillations of the magnesium content. (esrf.fr)
Calcium signals in form of waves serve as a means of intercellular communication and thus represent a vibrant subject for experimental and theoretical investigations. (um.si)

Research shows that calcium signals play a serious role in the control of neuronal (nerve) functions and plasticity (the ability of the brain to change formations during interconnections between neurons). (brainmass.com)
Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons. (rochester.edu)

Sirotin, Y. B. & Das, A. Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity. (nature.com)

Taken together, these findings provide the first evidence of ST5 involvement in positive regulation of osteoclastogenesis via Src/Syk/calcium signaling. (molcells.org)
Conclusions: These results suggest that Gem plays an important role in normal beta-cell function by regulation of calcium signalling. (edu.au)

The system can also monitor changes in intracellular Ca2+ flux (calcium oscillations) associated with cardiomyocyte contractions using the EarlyTox Cardiotoxicity Kit . (moleculardevices.com)

Additionally, in silico analysis suggested that the spatial distribution of calcium signaling enzymes governs the appearance of calcium oscillations in progesterone-activated human spermatozoa. (bvsalud.org)

Recently, a minimal mathematical model has been employed to describe the oscillations in Bacillus subtilis biofilms. (nature.com)
Experimental data were used to construct a mathematical model of the IP 3 -dependent calcium changes (see the figure below). (cellml.org)

Schematic diagram for the generation of Ca2+ oscillation graphs for spheroid and 2D cardiomyocytes. (moleculardevices.com)

Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. (swansea.ac.uk)

Inositol-1,4,5-triphosphate (IP 3 )-mediated calcium release from the endoplasmic reticulum is an important intracellular signalling mechanism in many cell types. (cellml.org)

This imaging method satisfied the need for low phototoxicity, and almost provided the speed required, but suffered from the dramatic loss in signal intensity with increased imaging depth into the embryos. (zeiss.com)
The ZEISS Lattice Lightsheet 7 microscope enabled imaging of the entire depth of the embryos with little to no phototoxicity, at the required speed to prevent any motion artefacts, and with minimal loss of signal intensity. (zeiss.com)

Using a combination of fluorescent calcium imaging and electrophysiology, we observed that postsynaptic potentials and antidromic action potentials propagated less far within the dendritic neuropil as the system warmed. (jneurosci.org)

However, this increase is very dependent on the current dynamical mode of the system, such as spiking, bursting or irregular oscillations. (hu-berlin.de)
In fact, these data show that oscillations are initially very irregular with large average interspike interval and large variance, eventually settling into a regular oscillation as the bifurcation parameter (in this case [IP3]) is increased. (nottingham.ac.uk)

However the signals that initiate and regulate the homeostatic repair response following barrier disruption are still not well understood. (brainmass.com)

It is possible to identify toxicity in these compounds using both measurement of calcium flux, and high content imaging. (moleculardevices.com)
Calcium flux was measured in isolated islets. (edu.au)

These models generally show that the onset of oscillations is via a subcritical Hopf bifurcation. (nottingham.ac.uk)

In today's talk, I'm going to discuss the emerging idea that these calcium fluctuations outside the cell may serve as signals in their own right. (hstalks.com)

So it's powerful signaling actions can only be controlled by moving the calcium ion about in different locations inside and outside the cell, or by temporarily buffering it. (hstalks.com)
Calcium (Ca2+) plays a major role in controlling cell function. (hstalks.com)
Cell calcium. (rochester.edu)
Calcium oscillations are an important means of signalling in many cell types. (nottingham.ac.uk)
The calcium response to IP 3 release and its subsequent degradation were modelled using Vitual Cell software. (cellml.org)

a) Typical nano-holotomography reconstructed dorsal arm plate part, showing oscillations in mass-density (pixel size 35 nm). (esrf.fr)

abstract = "Progesterone has an extragenomic action on human spermatozoa characterised by the rapid induction of a calcium transient followed by a plateau phase during which [Ca2+], remains significantly above baseline. (edu.au)
abstract = "Slow oscillations and sleep spindles are hallmarks of the EEG during slow-wave sleep (SWS). (uni-luebeck.de)

Correction to: Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease. (medscape.com)

All of this transport activity is, of course, exceedingly important in shaping the intracellular calcium signal. (hstalks.com)
Hemodynamic signals during periods of rest were weakly correlated with neural activity. (nature.com)
Pyr calcium activity was increased more than threefold when spindles co-occurred with slow oscillation upstates compared with slow oscillations or spindles occurring in isolation. (uni-luebeck.de)
Independent of whether or not a spindlewas nested in the slow oscillation upstate, the slow oscillation downstate was preceded by enhanced calcium signal in SOM-Ins that vanished during the upstate, whereas spindles were associated with strongly increased PV-In calcium activity. (uni-luebeck.de)
In the neonatal hippocampus the GluK1 subunit containing KARs take part in regulating the activity of the CA3 interneurons and hence the maintenance of early synchronous network oscillations, which are thought to be vital for developing connections. (helsinki.fi)
AS is much more prolonged, in line with experimentally reported evidences, thus being this component the one driving the slow development of APD oscillations following enhanced sympathetic activity. (unideb.hu)

The physical and chemical laws of calcium waves and oscillations can be expressed in terms of differential equations describing reaction kinetics, fluxes through membranes, and diffusion. (cellml.org)

The result of these is a description of the onset of calcium oscillations that shows improved agreement with experimental observations. (nottingham.ac.uk)

What is the role of calcium++ in the human body and what are spikes and oscillations? (brainmass.com)

Anatomy42

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Psychiatry and Psychology3

Phenomena and Processes60

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Intracellular calcium oscillations2

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