Oscillation circadian rhythm. Medical search. Frequent questions

The research focused on fruit fly cryptochromes, key components of the circadian clocks of plants and animals, including humans. (news-medical.net)
Besides light exposure, external cues such as the time of food intake also influence circadian rhythms but exert their effects mostly through the peripheral biological clocks. (medicalnewstoday.com)
In mouse models, DIO and the absence of TRF (mice could eat as much as they wanted whenever they wanted) resulted in disruptions to gut microbiome rhythms and the signaling pathways that help modulate intestinal clocks. (genengnews.com)
Circadian rhythms, 24-hour internal clocks running in all cells, aid living organisms in acclimatizing their physiology and behavior to the day/night changes in light, temperature, accessibility of food, and other periodic ecological factors. (databasefootball.com)
The investigators are part of the UCSD Center for Circadian Biology, which is dedicated to the nascent and -often-overlooked field of chronobiology, the science of our inner biological clocks. (popsci.com)
Circadian clocks enable organisms to define subjective time, that is, to anticipate diurnal day and night cycles. (go.jp)
Our first study is dedicated to circadian clocks inducing daily biological rhythms. (springer.com)
Previous reports have suggested that protein kinases play important roles in the regulation of circadian clocks ( Reischl and Kramer, 2011 ). (elifesciences.org)
However, some recent studies imply that the present widely accepted molecular models of circadian clocks may not always be supported by the experimental evidence. (bioone.org)
Rapid Adjustment of Circadian Clocks to Simulated Travel to Time Zones across the Globe . (ucsd.edu)
Circadian clocks coordinate the organism to the alternating cycles of day and night. (uni-wuerzburg.de)
Circadian clocks help them achieve this by regulating the timekeeping mechanism in each organism and adjusting it to changes. (uni-wuerzburg.de)
Circadian clocks with a periodicity of about 24 hours enable animals to adapt to the day-and-night cycles. (uni-wuerzburg.de)
In their study, the scientists examined an old concept of chronobiology which says that circadian clocks must have certain properties, namely a 24-hour rhythm, the ability to synchronise to external stimuli, and another property which scientists call "self-sustaining" which means the ability to intrinsically maintain a rhythm in the long run. (uni-wuerzburg.de)

Many biological processes are under the control of an endogenous circadianclock, a prominent example within the plant kingdom being photosynthesis.Here we report a robust circadian rhythm of photosynthetic oxygen evolutionin the red marine macroalga Grateloupia turuturu. (awi.de)
Numerical simulations of the stochastic models show that robust circadian oscillations can already occur with a limited number of mRNA and protein molecules, in the range of a few tens and hundreds, respectively. (aip.org)

Circadian rhythm of photosynthesis and concurrent oscillations of transcript abundance of photosynthetic genes in the marine red alga Grateloupia turuturu. (awi.de)
Goulard, F. , Lüning, K. and Jacobsen, S. (2004): Circadian rhythm of photosynthesis and concurrent oscillations of transcript abundance of photosynthetic genes in the marine red alga Grateloupia turuturu. (awi.de)
Cells throughout the brain and periphery express core circadian clock genes that engage in feedback loops to insure temporal coordination. (umass.edu)
We use molecular genetics to achieve conditional deletion of critical circadian clock genes in specific neurons of female mice. (umass.edu)
Previous studies in zebrafish and rainbow trout have shown that circadian oscillation of clock genes represents one of the earliest detectable rhythms in the develo. (researchgate.net)
These rhythms are produced by "clock genes," which drive the 24-hour cyclical expression of up to 50% of the entire genome. (databasefootball.com)
A recent study demonstrated that some clock genes display dysregulated oscillations in their expression in the hippocampus of epileptic animals which can enhance the occurrence of seizures at precise time-points by affecting the 24-hour oscillations of molecules that play a role in excitatory or inhibitory neurotransmission. (databasefootball.com)
Furthermore, the changes in the expression of clock genes can cause misaligned oscillations between hippocampal neurons and other oscillators. (databasefootball.com)
The bacterial signature showed promise for finding and predicting T2D cases in a subset of 699 participants from the KORA cohort, while additional metagenomic sequence data for a subset of 50 study participants with or without T2D or pre-diabetes, each tested twice five years apart, provided a window into some of the gut microbe genes and pathways that are altered when metabolic disease-related microbe oscillations are upended. (genomeweb.com)
Output from the circadian clock is transduced through regulating transcription of downstream genes directly by the oscillator components. (go.jp)
These lines of evidence suggest that the transcriptional-translational feedback loop mediated by the clock genes, and the post-translational modification of their products, are indispensable to the circadian clock machinery. (elifesciences.org)
Additionally, high doses of melatonin were observed to result in resynchronization of oscillatory circadian rhythm genes (Per2 and Sirt1). (ugr.es)
A set of core genes constitutes this transcriptional pathway that forms the identity of the endogenous circadian pacemaker. (frontiersin.org)
The CLOCK/BMAL1 heterodimer activates the transcription of Per/Cry genes, and the production and resulting phosphorylation of PER/CRY inhibit the CLOCK/BMAL1 heterodimer, reducing the transcription of Per/Cry forming the negative feedback loop required to maintain circadian rhythmicity at a basic molecular level. (frontiersin.org)

To further assess whether this physiological rhythm was correlatedwith changes at the level of gene transcription in G. turuturu, abundance ofthe transcripts encoding the phycoerythrin a and b subunits and theribulose 1,5 bisphosphate carboxylase/oxygenase (Rubisco) subunits was analysed under light-dark cycles (LD) and constant illumination (LL).Abundance of both transcripts exhibited diurnal and circadian changes inG. (awi.de)
Circadian rhythms refer to changes in biological processes at the molecular, physiological, and behavioral levels that follow an approximately 24-hour cycle. (medicalnewstoday.com)
In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug metabolism, affecting our ability to formulate efficient pharmaceutical interventions or properly assess drug toxicity (i.e. (europa.eu)
Endogenous circadian rhythms regulate many aspects of an organism's physiological and morphological growth and development. (go.jp)
Sik3 -/- mice also exhibited other circadian abnormalities, including lengthening of the period, impaired entrainment to the light-dark cycle, phase variation in locomotor activities, and aberrant physiological rhythms. (elifesciences.org)
The physiological properties of most organisms, from cyanobacteria to human, display a circadian (Latin circa dies , or 'about a day') pattern of activity, which is regulated by an endogenous circadian clock. (bioone.org)
The circadian clock allows organisms to anticipate periodic changes in environmental circumstance and to change their physiological status accordingly. (bioone.org)
The circadian clock is a regulatory system, with a periodicity of approximately 24 h, which generates rhythmic changes in many physiological processes, including mitochondrial activity. (ugr.es)
Mammalian circadian rhythms can be observed from the genetic level to the tissue level, and even to the macroscopic level, affecting behavior, biochemical and physiological processes. (frontiersin.org)
Background The circadian clock influences a number of cardiovascular (patho)physiological processes including the incidence of acute myocardial infarction. (bmj.com)

Also, new molecules can gain 24-hour oscillation, which may contribute to the rhythmicity of seizures. (databasefootball.com)
W]e demonstrate that loss of circadian rhythmicity affects microbiome features related to the onset and progression of T2D and identified bacterial signatures for metabolic risk profiling in human populations," senior author Dirk Haller, a researcher affiliated with the Technical University of Munich, and his co-authors wrote. (genomeweb.com)
In the course of investigating metabolic defects in Sik3 -deficient mice ( Sik3 -/- ), we observed that circadian rhythmicity of the metabolisms was phase-delayed. (elifesciences.org)
Neurodegenerative disorders have been shown to exhibit substantial interconnectedness with circadian rhythmicity. (frontiersin.org)
The cellular stress and subsequent DNA damage signaling imposed by hyperactivity of these multiple molecular systems in addition to aberrant circadian rhythmicity lead to extensive protein aggregation such as α-synuclein pre-formed fibrils (α-Syn PFFs), suggesting a specific molecular pathway linking circadian rhythmicity, PARP1/E3 ligase activity, and Parkinson's disease. (frontiersin.org)

Since these characteristics resemble those of the mammalian circadian pacemaker, the ultradian Ca 2+ rhythms may be involved in the circadian rhythm or have a similar rhythm generation mechanism. (elsevierpure.com)

Another critical function that is regulated by the circadian pacemaker is the discharge of luteinizing hormone from the anterior pituitary that triggers ovulation. (umass.edu)
The master circadian clock, or the central pacemaker of circadian rhythms, is the suprachiasmatic nucleus located in the hypothalamic region of the brain. (databasefootball.com)
The internal system that maintains circadian rhythms can be formally represented by three different components: namely, an input pathway, the pacemaker itself, and an output pathway ( Dunlap, 1999 ). (bioone.org)
The SCN assumes the role as the central pacemaker, and through a series of genetic feedback loops and highly coordinated neuronal innervation, endogenous timekeeping activity arises, giving way to the production of circadian rhythm. (frontiersin.org)

Alzheimer's patients exhibit high degradation of the suprachiasmatic nucleus (SCN), the central endogenous circadian timekeeper, and Parkinson's patients have highly disrupted peripheral clock gene expression. (frontiersin.org)
Sleep and wakefulness are impacted by several external and internal factors, but none are more important than the endogenous circadian system. (cdc.gov)

We are working to determine the relative contributions of circadian function in vasopressin, VIP, kisspeptin and GnRH neurons in order to reveal the loci at which the clock controls ovulation. (umass.edu)
Chemogenetics allows us to silence neurons at specific loci and at particular times of day in order to determine when and where circadian signals control neuroendocrine function. (umass.edu)
Central control of circadian phase in arousal-promoting neurons. (umass.edu)
The neurons in this tiny region of the hypothalamus regularly receive photic and nonphotic inputs from the environment as well as different organs in the body to orchestrate the endogenous rhythms and synchronize them to environmental cues. (databasefootball.com)
Ex vivo suprachiasmatic nucleus slices from Sik3 -/- mice exhibited destabilized and desynchronized molecular rhythms among individual neurons. (elifesciences.org)
What is more, only 150 neurons form the basis of the fly's circadian clock whose functions are well-known for the most part. (uni-wuerzburg.de)

2018. Suprachiasmatic function in a circadian period mutant: Duper alters light- induced activation of vasoactive intestinal peptide cells and PERIOD1 immunostaining. (umass.edu)
The brain region called the suprachiasmatic nucleus (SCN) serves as the principal circadian clock that regulates these internal rhythms. (medicalnewstoday.com)
Circadian rhythms in mammals are governed by the master oscillator located in the hypothalamic suprachiasmatic nucleus (SCN). (elifesciences.org)
Mechanistically, the precision of the circadian clock is established by a transcriptional autoregualtory loop that exists centrally within the suprachiasmatic nucleus of the hypothalamus, and in peripheral tissues. (cdc.gov)

New research from a multidisciplinary team helps to illuminate the mechanisms behind circadian rhythms, offering new hope for dealing with jet lag, insomnia and other sleep disorders. (news-medical.net)
The research, 'Cryptochrome-Timeless Structure Reveals Circadian Clock Timing Mechanisms' published April 26 in Nature . (news-medical.net)
Biologists have come to believe that the negative effects happen because toiling through the wee hours screws with our circadian rhythms, mysterious internal timing mechanisms that can be modulated by external cues like light and temperature. (popsci.com)
The authors noted that it may be important to take circadian gut microbe oscillations into account "to better understand the underlying mechanisms of disease-associated microbiome alterations and to validate risk profiles in prospective cohorts. (genomeweb.com)
However, the molecular mechanisms underlying the determination or stabilization of the circadian period and phase remain to be investigated in mammals. (elifesciences.org)
The goal is to provide a broad introduction to the phenomena, mechanisms, and pathologies of circadian rhythms and sleep.While a good part of the readings and lectures will focus on experimental results addressing these phenomena the mechanisms underlying them, the goal for students is to identify the implications of this research for cognition. (ucsd.edu)
Mechanisms of Circadian Systems in Animals and Their Clinical Relevance (pp. 1-12). (ucsd.edu)
Shift workers, who experience irregular exposure to the light-dark cycle, have chronically disrupted circadian rhythms and increased risk of developing cardiovascular disease, but the mechanisms are unknown. (uky.edu)
Although numerous studies exist analyzing the mechanisms of neurodegeneration and circadian rhythm function independently, molecular mechanisms establishing specific links between the two must be explored further. (frontiersin.org)
Thus, in this review, we explore the possible intersecting molecular mechanisms between circadian rhythm and neurodegeneration, with a particular focus on Parkinson's disease. (frontiersin.org)
To garner a more comprehensive understanding of the effects of circadian rhythms on health and neurodegeneration, the underlying fundamental molecular mechanisms and interrelated processes must be explored ( Cox and Takahashi, 2019 ). (frontiersin.org)

TRF partially restores diurnal rhythms of the ileal microbiome and transcriptome, increases GLP-1 release, and alters the ileal bile acid pool and farnesoid X receptor (FXR) signaling, which could explain how TRF exerts its metabolic benefits. (nih.gov)
The biological oscillations like the diurnal rhythms. (scipinion.com)
These same birds will likely have diurnal rhythms in eating behaviour and digestion, body temperature, immunity response and hormone release among others. (ciencia-e-vinho.com)

Circadian rhythm Circadian oscillator Neural oscillation Mackey, M.C. (wikipedia.org)
The circadian clock is an autonomous oscillator responsible for regulating physiology and behavior, thereby conferring adaptive advantage to living organisms by allowing them to anticipate regular changes in their environment. (jneurosci.org)
This is might because of the circadian oscillator that affects the circadian rhythm. (scipinion.com)

The circadian clock is an evolutionarily, highly conserved feature of most organisms. (researchgate.net)
Using innovative cryo-electron microscopy techniques, the researchers have identified the structure of the circadian rhythm photosensor and its target in fruit flies (Drosophila melanogaster), one of the major organisms used to study circadian rhythms. (news-medical.net)
The rhythms of activity in all biological organisms, both plants and animals, are closely linked to the gravitational tides created by the orbital mechanics of the Sun-Earth-Moon system. (eurekalert.org)
These oscillations continue to exist, and may modulate the behavior of living organisms," Gallep said. (eurekalert.org)
Living systems on earth are governed by many natural laws, but circadian rhythms play one of the most important roles in sustaining organisms, acting as the biological timekeepers that perpetuate life from mere seconds to the full Gregorian year. (frontiersin.org)
These oscillations, which are autonomously maintained, explain how living organisms adapt their biological rhythm so that it is synchronized with the Earth's revolutions. (sciencedaily.com)
In fact, the first hypotheses about the existence of a circadian clock in living organisms came with the observation of leaf and flower movements in plants. (sciencedaily.com)
Chronobiology refers to the periodic rhythms of organisms in response to solar or lunar cycles. (ciencia-e-vinho.com)
Cycling rhythms in biological organisms can occur with change in seasons (such as flower development or hibernation), to lunar-monthly (marine animal breeding), to changes that cycle approximately every 24 hours (the sleep-wake cycle in many animals), to cycles that last less than 24 hours (REM periods during sleep). (ciencia-e-vinho.com)

Targeted disruption of the gene encoding D4Rs reduces the amplitude of the contrast sensitivity rhythm by reducing daytime sensitivity and abolishes the rhythmic expression of Npas2 and Adcy1 mRNA in the ganglion cell layer (GCL) of the retina. (jneurosci.org)
Luc oscillations that significantly decrease from 1 to 4-5 months, whereas the endogenous period and rhythmic power increase slightly until 2 to 3 months and then do not change until 8 months. (molvis.org)
Taken together, loss of diurnal oscillation in gut microbiota composition and associated rhythmic functions may contribute to the development of metabolic disorders," the authors concluded, though they cautioned that "[w]hether disease-associated arrhythmic taxa and their functionality are causally linked to the metabolic phenotype of T2D remains to be studied. (genomeweb.com)
Gap junctions may be necessary in order to generate rhythmic oscillations. (elsevierpure.com)

Animal care practices in experiments on biological rhythms and sleep. (umass.edu)
Journal of Biological Rhythms , 30, 557-562. (ucsd.edu)
Journal of Biological Rhythms , 27, 339-352. (ucsd.edu)
are the most widespread biological rhythms generated autonomously at the molecular level. (aip.org)

Circadian rhythms are approximately 24-hour oscillations of nearly every biological process in the body. (uky.edu)

We have found that disruption of the circadian clock in any of several cell types in identified hypothalamic circuits alters timing of the LH surge. (umass.edu)
Our studies investigated the effects of light-induced circadian disruption on atherosclerosis in ApolipoproteinE -deficient ( ApoE -/- ) mice. (uky.edu)
We found that male ApoE -/- mice housed in constant light for 12 weeks, which results in severe disruption of circadian rhythms or arrhythmicity, developed significantly more atherosclerosis compared to mice in control light-dark conditions, and this increase was attributed to increased atherogenic VLDL/LDL cholesterol fractions. (uky.edu)
Next, we mimicked circadian disruption experienced by shift workers by housing ApoE -/- mice in chronic jet lag conditions where the light-dark cycle was advanced by 6-hours every week for 12 weeks. (uky.edu)
Together, these data show that light-induced circadian disruption increases atherosclerosis, in part via exacerbated dyslipidemia. (uky.edu)
However it is based on a theory that light at night (LAN) would disrupt circadian rhythms and that this disruption might increase cancer risk. (who.int)

Deterministic models account for the occurrence of autonomous circadian oscillations, for their entrainment by light-dark cycles, and for their phase shifting by light pulses. (aip.org)
Besides an increase in the number of molecules, entrainment by light-dark cycles, and cooperativity in repression enhance robustness, whereas the proximity of a bifurcation point leads to less robust oscillations. (aip.org)

It appears that the mutation affects both cell autonomous circadian oscillators and the brain's master paemaker. (umass.edu)
Recent findings concerning biochemical properties of central oscillators in Arabidopsis thaliana have advanced our understanding of circadian clock function. (go.jp)

Hence, we have identified a circadian clock mechanism in a subset of RGCs that modulates an important aspect of retinal physiology and visual processing. (jneurosci.org)
The core molecular mechanism responsible for circadian oscillations relies on the negative regulation exerted by a protein on the expression of its own gene. (aip.org)

Although time-restricted feeding (TRF) maintains circadian synchrony and protects against DIO, its impact on the dynamics of the cecal gut microbiome is modest. (nih.gov)

The core circadian molecular machinery gives rise to endogenous timekeeping activity. (frontiersin.org)

KaiC ATPase activity constitutes the most fundamental reaction underlying circadian periodicity in cyanobacteria. (asmblog.org)
The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 drives oscillations in global mRNA transcript abundances with 24 h periodicity under continuous light conditions. (harvard.edu)

Compositional oscillations of the gut microbiome are essential for normal peripheral circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). (nih.gov)
We demonstrate the effect of diet and feeding rhythms on the ileal microbiome composition and transcriptome in mice. (nih.gov)
The dynamic rhythms of ileal microbiome composition and transcriptome are dampened in DIO. (nih.gov)
Finally, we provide a web resource for exploration of ileal microbiome and transcriptome circadian data. (nih.gov)
And what we've learned is that cyclical changes in the gut microbiome are quite important for health since they help with the circadian clock, and with that the regulation and control of glucose, cholesterol and fatty acids-and overall metabolic health. (genengnews.com)
These findings underscore the influence of diet and time restricted feeding patterns in maintaining a healthy gut microbiome, which in turn modulates circadian rhythms that govern metabolic health," said Zarrinpar. (genengnews.com)
Digging into these diurnal gut microbiome dynamics, they noted that individuals that had T2D or were obese appeared to lose gut oscillations that involved changes in microbiome levels of dozens of gut bugs. (genomeweb.com)
The authors noted that while both obesity and T2D coincided with altered gut microbiome oscillations during the span of a day, there were differences in the operational taxa units involved, hinting that weight "contributes to T2D risk stratification independent of disrupted circadian rhythms in the microbiome. (genomeweb.com)

With suitable delays between the events of gene expression and repression, an oscillation in protein levels is established. (news-medical.net)
Blue light, Crane said, changes the chemistry and structure of cryptochrome's flavin cofactor, which allows the protein to bind the TIM protein and inhibit TIM's ability to repress gene expression and thereby reset the oscillation. (news-medical.net)
Our study demonstrates a circadian rhythm of contrast sensitivity that peaks during the daytime, and that its regulation involves interactions of D4Rs, the clock gene Npas2 , and the clock-controlled gene adenylyl cyclase 1 ( Adcy1 ) in a subset of retinal ganglion cells (RGCs). (jneurosci.org)
Studies on the developmental onset of the teleost circadian clock have been carried out in zebrafish and, recently, in rainbow trout and Senegalese sole, where rhythms of clock gene expression entrained by light-dark (LD) cycles have been reported from the first days post fertilization. (researchgate.net)
It allows direct monitoring of molecular rhythms of the protein PER2 as a real-time reporter of circadian gene dynamics. (molvis.org)
It has been demonstrated that ~30% of gene products present circadian oscillation only when the brain becomes epileptic. (databasefootball.com)
However, the direct links between circadian clock gene expression, mitochondrial activity, and the antiproliferative effects of melatonin in cancers, including head and neck squamous cell carcinoma (HNSCC), remain largely unknown. (ugr.es)
Another parameter that appears to be crucial for the coherence of circadian rhythms is the binding/unbinding rate of the inhibitory protein to the promoter of the clock gene. (aip.org)

Findings suggest that eating late at night may disrupt this rhythm in adipocytes resulting in lower energy expenditure and weight gain. (medicalnewstoday.com)
We review the fundamental relationships between the circadian timing system and biologic processes, considering how common practices, such as shift work and variations in sleep timing on work /school versus work /school-free days (ie, social jetlag), disrupt circadian alignment and predispose individuals to cardiovascular, metabolic, and pulmonary disease. (cdc.gov)
This innovative metric provides a new tool for investigating shift and personal factors that most strongly disrupt circadian rhythms and thereby, perhaps, risk of two of the most common cancers in people, breast and prostate. (who.int)

The very first item in this blog was about the circadian rhythm in cyanobacteria ( It Don't Mean a Thing If It Ain't Got That Swing ). (asmblog.org)

CK1, however, is also found in every other organism with eukaryotic (nonbacterial) cells, including single-celled green algae in which it has been implicated in circadian rhythms. (medicalxpress.com)
Circadian rhythms gives an organism the competitive advantage of 'anticipating' change in its environment so that it can respond appropriately. (ciencia-e-vinho.com)

These participate in transcriptional/translational feedback loops and many homologous clock-components in the fruit fly Drosophila are also expressed in mammalian clock tissues with circadian rhythms. (bioone.org)
This and much other circadian behaviour are under transcriptional and translational regulation with underlying multiple interlocked feedback loops. (ciencia-e-vinho.com)

The SCN receives light cues from the eyes and synchronizes the internal rhythms with daily light-dark cycles. (medicalnewstoday.com)
The circadian system coordinates these rhythms of physiology and behavior with environmental cycles such as the light-dark cycle. (uky.edu)
The periodic oscillations exhibit two daily cycles and are modulated monthly and annually by the motions of these two celestial bodies. (eurekalert.org)

Partch noted that it is important to understand how these clock proteins regulate our circadian rhythms, because those rhythms affect not only the sleep cycle but almost every aspect of our physiology. (medicalxpress.com)

Such rhythms are found on a broader spectrum of biological processes from body temperature and hormone secretion to cognition and memory. (databasefootball.com)
They orchestrate our daily peak rhythms for things like cognition, fat synthesis, and even hair growth. (popsci.com)
This course focuses on two fundamental biological phenomena that have significant, but underappreciated, implications for cognition--circadian rhythms and sleep. (ucsd.edu)

Our results indicate that the contrast sensitivity rhythm is modulated by D4Rs via a signaling pathway that involves NPAS2-mediated circadian regulation of Adcy1 . (jneurosci.org)

Thus, other regions of the gut, particularly the ileum, the nexus for incretin and bile acid signaling, may play an important role in entraining peripheral circadian rhythms. (nih.gov)
The authors hypothesized that other regions of the gut, with a focus on the ileum, may play an important role in entraining peripheral circadian rhythms. (genengnews.com)

These daily oscillations are synchronized to the environment by external cues such as light and temperature, resulting in enhanced fitness and growth vigor in plants. (go.jp)
These rhythms persist for some time despite the absence of environmental cues such as changes in light or temperature, but they are able to adjust (entrain) to these stimuli. (ciencia-e-vinho.com)
However, after some time the rhythm is lost, illustrating the importance of environmental cues in maintaining the rhythm. (ciencia-e-vinho.com)

This group now reports that one of these proteins, the KaiC ATPase, is the timekeeper that is responsible for the characteristic oscillation. (asmblog.org)
This finding represents the first description of a simple biochemical reaction acting as a circadian timekeeper. (asmblog.org)

Shift work: health, performance and safety problems, traditional countermeasures, and innovative management strategies to reduce circadian misalignment. (ucsd.edu)
This desynchronization is also understood as circadian misalignment, a behavioral pattern in which sleep and activity occur during conflicting circadian phases (eg, sleeping during the day, eating and activity during the night). (cdc.gov)
Circadian misalignment can also be observed naturally in individuals experiencing irregular sleep either resulting from endogenous factors, such as sleep disorders, or from exogenous factors, such as work and social schedules. (cdc.gov)

This research not only deepens our understanding of circadian rhythm regulation but also opens up new possibilities for developing therapies targeting related processes. (news-medical.net)
Consistent with this, time-restricted feeding aims to align food intake with circadian rhythms observed in metabolic processes to optimize metabolic health. (medicalnewstoday.com)
The seizures also modify the temporal oscillation of several biological processes, including body temperature, locomotor activity, sleep pattern, and secretion of hormones. (databasefootball.com)
The essential role of the output pathway in the circadian system is to make different elementary steps responsible for daily cellular processes exert maximum effects at specific times of the day. (go.jp)
In the laboratory, the circadian clock is measured via oscillations in these physiologic processes (ie, core body temperature, cortisol, or melatonin concentrations). (cdc.gov)

Surprisingly, the resynchronizing effect of melatonin on Per2 and Sirt1 did not produce alterations in the oscillation of mitochondrial respiratory activity. (ugr.es)

At the Department of Neurobiology and Genetics, it's all about the circadian clock of Drosophila , also known as the common fruit fly. (uni-wuerzburg.de)

Collectively, SIK3 plays key roles in circadian rhythms by facilitating phosphorylation-dependent PER2 destabilization, either directly or indirectly. (elifesciences.org)

We celebrated the amazing finding by a group from Nagoya University that the 24-hour circadian clock of Synechococcus elegans can be reconstituted in vitro with just three purified proteins in the presence of ATP. (asmblog.org)

Here, we describe the development of a novel platform that captures the synchronization of circadian rhythms in self-assembled human micro-livers by microfluidic oscillations of temperature and hormones. (europa.eu)

Moreover, Adcy1 transcript rhythms were abolished in the GCL of Npas2 −/− mice. (jneurosci.org)

Thanks to this study, we have learned how the plant circadian clock affects the plant growth, which is an important process at the agronomic level," adds Guiomar Martín, the first author of the work, who is currently at the Gulbenkian Institute of Science (Portugal). (sciencedaily.com)

In addition, different parameters may affect the retinal circadian bioluminescence signal and its dynamic in in vitro assays. (molvis.org)
In cultured cells, Sik3 -knockdown resulted in abnormal bioluminescence rhythms. (elifesciences.org)

This theoretical study would establish a framework for future research on feedback between starch metabolism and circadian clock as well as plant productivity. (frontiersin.org)
This novel platform provides the first device that recapitulates circadian rhythms and can accurately predict the metabolism, clearance and toxicity of pharmaceuticals. (europa.eu)
Through manipulation of the circadian oscillation with bicarbonate, and shutting down the glucose metabolism of cancer cells with fasting, we can kick cancer cells down the block. (drsircus.com)
In the podcast we cover how to test food sensitivities with a metronome, ph balance and its effect on the body, circadian rhythm , metabolism, the state of being a night owl vs. a morning lark, and the acid/alkaline tendencies of certain supplements. (selfhack.com)
The daily tracking of the sun by leaves of the mimosa plant (first described in 1729 by French astronomer Jean Jacques d'Ortous de Mairan), the opening and closing of tulip petals, the tracking of the sun by the sunflower, and carbohydrate metabolism are good examples of this type of rhythm. (ciencia-e-vinho.com)

In fact, every animal and plant on the planet- even certain bacteria-has evolved with these cellular oscillations. (popsci.com)
Plant circadian rhythms. (scipinion.com)
For instance, the opening and closing of a flower is circadian, not just diurnal, if it continues after the plant is placed in continuous darkness. (ciencia-e-vinho.com)
Growth of plant organs can also follow circadian rhythms. (ciencia-e-vinho.com)

She explains that several high-latitude species that live in the far north or south are known to no longer adapt their activities to a 24-hour rhythm but have adopted an arrhythmic behaviour instead. (uni-wuerzburg.de)

Within our second study, we present a meta-model of an entire circadian clockwork able to adapt its oscillation to an external stimulus in terms of a frequency control system acting in a phase-locked loop. (springer.com)
The constant change between light and dark, day and night is the rhythm to which all living beings must adapt if they want to survive and reproduce. (uni-wuerzburg.de)

Dissociated cultures of rat hypothalamic cells showed spontaneous oscillations in intracellular Ca 2+ with periods of 5-8 s (ultradian rhythm). (elsevierpure.com)
Time of STEMI onset was divided into four 6-hour periods in phase with circadian rhythms. (bmj.com)

Circadian "rhythms" are the physiologic outputs of the circadian clock, such as the circadian-based variations in hormone secretion, enzyme activity, and organ function, among others. (cdc.gov)

The interaction between the proteins is then modulated and the ability of light to reset the oscillation is changed, thus altering the circadian clock and extending the period of the fly's dormancy, which helps it survive the winter. (news-medical.net)

Anatomy20

Organisms17

Diseases7

Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology13

Phenomena and Processes52

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care4

Clocks14

Robust circadian2

Genes14

Physiological10

Rhythmicity5

Mammalian circadian1

Pacemaker4

Endogenous circadian2

Neurons6

Suprachiasmatic4

Mechanisms11

Diurnal rhythms3

Oscillator3

Organisms9

Rhythmic4

Biological rhythms4

Approximately 24-hour1

Disruption6

Entrainment2

Oscillators2

Mechanism2

Maintains circadian1

Core circadian1

Periodicity2

Microbiome8

Gene8

Disrupt3

Cyanobacteria1

Organism2

Transcriptional2

Cycles3

Regulate1

Cognition3

Signaling pathway1

Peripheral2

Cues3

Timekeeper2

Misalignment3

Processes5

Melatonin1

Drosophila1

PER21

Synechococcus1

Microfluidic1

Transcript1

Affects1

Bioluminescence2

Metabolism5

Plant4

Behaviour1

Adapt2

Periods2

Hormone secretion1

Fly's1