Oscillation cell cycle progression. Medical search. Frequent questions

In metazoans, circadian oscillation is normally mediated with the transcriptionally well balanced feedback loop between your BMAL1-CLOCK proteins acetyl transferase [16] as well as the transcription regulators PER1-3, CRY2 and CRY1 [17]. (monossabios.com)
It has been demonstrated that ~30% of gene products present circadian oscillation only when the brain becomes epileptic. (databasefootball.com)

Cell-cycle events have been shown to be triggered by oscillations in the activity of cyclin dependent kinases (CDKs) when bound to cyclins. (duke.edu)
Cell cycle progression is governed by a complex network of cyclin-dependent kinases that define not only the phase of the cell cycle, but also the timing of transitions between phases 13 . (biorxiv.org)

Although spontaneous changes of [Ca 2+ ] i have been examined in immature cortical neurons, the calcium dynamics of cortical precursor cells have received less attention. (jneurosci.org)
Immunohistochemical staining confirmed that these events occurred primarily in precursor cells rather than in postmitotic neurons. (jneurosci.org)
Furthermore, the changes in the expression of clock genes can cause misaligned oscillations between hippocampal neurons and other oscillators. (databasefootball.com)

Paradoxically, progression deeper into cell cycle arrest was accompanied by increases in proliferative effectors such as CDKs and cyclins, which can drive cell cycle re-entry by overcoming p21 induction. (bvsalud.org)
Repetitive cell cycles, which are essential to the perpetuation of life, are orchestrated by an underlying biochemical reaction network centered around cyclin-dependent protein kinases (Cdks) and their regulatory subunits (cyclins). (ox.ac.uk)
The second model proposes that a transcription factor (TF) network oscillator controls the timing of cell-cycle events, via proper timing of gene expression, including cyclins. (duke.edu)
Cell cycle progression is faster in cells in which invadopodia are abolished (by Tks5 knockdown), evidenced by earlier induction of cyclins A and B. A close look at the regulators of G1 revealed that the overexpression of p27 kip1 , but not p21 cip1 , causes faster turnover of invadopodia and increased ECM degradation. (biorxiv.org)

Cyanobacteria use circadian clocks to regulate nitrogen-fixation, cell division, and other metabolic processes. (wikipedia.org)
In this dissertation, I explore the mechanisms that coordinate and regulate cell-cycle progression in the budding yeast, Saccharomyces cerevisiae. (duke.edu)
Our simulations show that, if HMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpressed, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. (biomedcentral.com)
The primary actions that regulate circadian rhythms, although mediated by nonhomologous proteins, are conserved in progression [16] highly. (monossabios.com)

The rhythmic expression of cyanobacterial genes is driven by oscillation in the phosphorylation state of the Kai oscillator and its interaction with various output mechanisms. (wikipedia.org)
APP23 TG mice without diurnal oscillation in genes exhibited hyperexcitability and reduced sleep. (news-medical.net)
A recent study demonstrated that some clock genes display dysregulated oscillations in their expression in the hippocampus of epileptic animals which can enhance the occurrence of seizures at precise time-points by affecting the 24-hour oscillations of molecules that play a role in excitatory or inhibitory neurotransmission. (databasefootball.com)

Most eukaryotic cells use the spindle assembly checkpoint (SAC) to ensure faithful chromosome segregation in each round of cell division by delaying mitotic progression until all chromosomes are properly attached to spindle microtubules at their kinetochores. (biologists.com)
However, in other large-celled organisms such as sea urchins and clams, treatment with microtubule depolymerizing drugs caused a delay in mitotic progression, suggesting that these embryos may be SAC competent. (biologists.com)
They monitored the mitotic marker phospho-histone H3 (pH3) over time to assess whether each species arrests in mitosis or continues to cycle through cell division, thus demonstrating whether embryos respond to or lack SAC signaling, respectively. (biologists.com)
Similar to the published data in Xenopus and zebrafish, the chordate tunicate P. mammillata showed pH3 oscillations and continued to cycle, while multiple species of sea urchin (echinoderms), the mussel M. galloprovincialis (a mollusk), and the jellyfish C. hemisphaerica (a cnidarian) delayed mitotic progression. (biologists.com)
Treatment with the Mps1 inhibitor reversine shortened the nocodazole-induced mitotic arrest and restored cell cycle timing, which confirms the SAC dependence of the mitotic arrest. (biologists.com)
Cdc14 release and ME is controlled by mitotic cyclin-Cdk oscillation, the FEAR network including a non-proteolytic function of separase (Esp1), and the Mitotic Exit Network (MEN) indirectly activated by spindle elongation through cohesin cleavage by the proteolytic function of Esp1. (rockefeller.edu)
Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. (rupress.org)
Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)

The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
The protein p53 is one of the most important tumor suppressor proteins: its activation can lead to cell cycle arrest, DNA repair, or apoptosis. (biomedcentral.com)
Which signaling pathways are fundamental for describing HMGB1 signal transduction, and what mechanisms are responsible to explain recent results linking overexpression of HMGB1 with decrease of apoptosis (and increased cancer cell survival)? (biomedcentral.com)
This could be used to arrest cancer cells at a certain phase in the cell cycle, but also to induce premature cell death (apoptosis). (revoscience.com)
The protein professional duct of NGFRAP1 interacts with p75, Collectively they process caspase 2 and caspase three to energetic kinds, and promote apoptosis in selelck kinase inhibitor 293T cells, NGFRAP1 requires p75 to induce apoptosis. (inhibitorkits.com)

Double-strand break-induced (DSB) cells send signal that induces DSBs in neighbour cells, resulting in the interaction among cells sharing the same medium. (yasar.edu.tr)
4 So, to determine whether MAP4K4 inhibition might preserve calcium homeostasis, vCor.4U hiPSC-CMs were challenged with menadione (vitamin K3, which induces intracellular reactive oxygen species through quinone redox cycling 5 ) in the presence of a fluorescent intracellular calcium indicator (Figure 6). (domainex.co.uk)
In vivo , higher expression of FOXK1 promotes CRC cell invasion and metastasis, and induces EMT in CRC as well. (oncotarget.com)
Alltogether, it was concluded that the higher expression of FOXK1 could indicate a poor prognosis in CRC patients since that FOXK1 induces EMT and promotes CRC cell invasion in vitro and in vivo . (oncotarget.com)
Modulation of the NALP3 protein inflammasomes induces regulatory T cells to express cytotoxic T-lymphocyte antigen 4, IL-10, and transforming growth factor-beta (TGF-β). (medscape.com)

Most AD patients experience disturbed circadian rhythmicity, which is prominent through their altered sleep/wake cycles due to difficulties falling and staying asleep. (news-medical.net)
Also, new molecules can gain 24-hour oscillation, which may contribute to the rhythmicity of seizures. (databasefootball.com)

For example, the early embryonic cleavages of both Xenopus frogs and zebrafish do not have cell cycle checkpoints until the mid-blastula transition and zygotic genome activation. (biologists.com)
Further, I show that during a wild-type cell cycle, checkpoints are responsible for arresting the bulk of periodic transcription. (duke.edu)

The computer model simulates the rhythmic oscillation of the membrane potential during the transition between cell cycle phases and enables prediction of the changes in membrane potential that are caused by drug-induced switching on and off of selected ion channels. (revoscience.com)

Oscillations of Cdk1/CycB activity between low and high levels during the cycle trigger DNA replication and mitosis in the correct order. (ox.ac.uk)

Tumor cell invasion and metastasis require cancer cells to be both proliferative and invasive, i.e. migrate through the tissue and assemble invadopodia. (biorxiv.org)

We combined time-lapse microscopy, highly multiplexed single-cell imaging of 48 core cell cycle proteins, and manifold learning to render a visualization of the human cell cycle. (bvsalud.org)
Invadopodia are cancer cell protrusions rich in structural proteins (e.g. (biorxiv.org)
The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
If some important proteins are mutated or there are defects in the signaling mechanisms, normal cell growth regulation will break down, possibly leading to the occurrence of cancer in the future. (biomedcentral.com)
Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
SIRT1 substrates in the mammalian nucleus Potential SIRT1 substrates could be discovered by acquiring proteins that talk about the SIRT1 identification theme, bind overexpressed SIRT1 or display elevated degrees of acetylation in SIRT1-depleted cells. (monossabios.com)

Single-cell transcriptomic signatures and gene regulatory networks modulated by W1s in mammalian midline facial formation and clefts. (stowers.org)
Epithelial to mesenchymal transition during mammalian neural crest cell delamination. (stowers.org)
In mammalian species, every single cell has this clock machinery and acts as an independent oscillator that works in synchrony with other oscillating cells in a multi-oscillatory system. (databasefootball.com)

This data-driven approach revealed the comprehensive "structure" of the cell cycle: a continuum of molecular states that cells occupy as they transition from one cell division to the next, or as they enter or exit cell cycle arrest. (bvsalud.org)

Understanding the regulatory mechanisms that control cell-cycle events remains to be a fundamental question in cell biology. (duke.edu)
Immune/inflammatory-mediated mechanisms, which result in muscle cell death and/or mechanisms leading to fibrosis, may be important initiators of lesions in dystrophin-deficient muscle. (hindawi.com)
In this review, we summarize the evidence for neuronal excitability changes over the course of AD onset and progression and the molecular mechanisms underpinning these differences. (nature.com)
Despite decades of research into the genetic basis and pathological mechanisms of AD, there is no treatment available to halt or reverse its progression, leading to an urgency for the development of new treatment options. (nature.com)
These cancer cells cleverly recruit our intelligent mechanisms using them for their own growth and survival. (gracegawlermedia.com)
Even further intensive research must be con ducted to pinpoint the molecular mechanisms underlying PGAM1 siRNA mediated cell death. (inhibitorkits.com)

Deregulated cell cycle is a hallmark of cancer 12 . (biorxiv.org)
Calcium cycling, a hallmark of the cardiac phenotype, is susceptible to redox- and phosphorylation-dependent abnormalities. (domainex.co.uk)
Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. (biomedcentral.com)

We have also argued that bistability underlies irreversible transitions between low and high Cdk activity states and thereby ensures directionality of cell cycle progression. (ox.ac.uk)

In addition, the widely supported "circadian- infradian rule" stipulated that cellular functions could only be coupled to a circadian oscillator in cells dividing only as fast as once in a 24-hour period. (wikipedia.org)
This finding adds a new layer of regulation to the second model, providing a mechanism that coordinates cell-cycle events with a TF network oscillator. (duke.edu)
This autonomous Cdc14 release oscillator functions at constant cyclin-Cdk levels by titrated introduction of undegradable Clb2, and at cell-cycle-average Clb2 levels given a block of cell cycle progression by actin depolymerization. (rockefeller.edu)
Using genetic manipulations, we demonstrate that this oscillator can operate in free-running cell cycles even without undegradable Clb2. (rockefeller.edu)
Its mechanism and regulation of its frequency by Clb2-Cdk, suggest the hypothesis that intrinsically autonomous Cdc14 release cycles are locked at once per cell cycle through entrainment by the cyclin-Cdk oscillator. (rockefeller.edu)

CyclinE is a cell cycle regulatory protein which regulates the G1-S phase transition during cell proliferation. (biomedcentral.com)
Cell proliferation, migration and cell death are regulated by alterations of cytosolic Ca 2+ activity [ 20 - 23 ]. (biomedcentral.com)
indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)

TAC treatment of MCF-7 cells was followed by Rac1 activation, actin polymerization, transient increase of Orai1transcript levels and protein abundance, and transient increase of SOCE. (biomedcentral.com)
The present study explored, whether mAR activation is followed by alterations of Orai1 protein abundance and function in MCF-7 breast tumor cells and addressed the role of actin reorganization and actin signaling to this effect. (biomedcentral.com)

In the model organism we study, the social amoeba Dictyostelium discoideum , starvation-triggered cell-cell aggregation and developmental morphogenesis are orchestrated by periodic extracellular cAMP waves, which provide both gradients for chemotactic migration and signals for development. (jhmi.edu)
We reasoned that the mechanism decoding oscillatory stimuli might be traced to a receptor-mediated regulation of a gene that is required for developmental progression. (jhmi.edu)
Although both are required for developmental gene expression, receptor occupancy promotes nuclear exit of GtaC, which leads to a transient burst of transcription at each cAMP cycle. (jhmi.edu)
Modulation of intracellular free calcium concentration ([Ca 2+ ] i ) may be part of the signaling pathway by which both local environmental factors and cell autonomous developmental programs influence corticogenesis. (jneurosci.org)
Developmental Cell 2019, 48 , 1-18. (ncl.ac.uk)

Under gamma irradiation, p53 gene regulatory network is able to exhibit three different modes, namely low state, oscillations, and high state. (yasar.edu.tr)

Circadian rhythms - endogenous, entrainable oscillations in biological processes with periods that roughly correspond to the 24-hour day - were once believed to be an exclusive property of eukaryotic lifeforms. (wikipedia.org)
Biological oscillations are universally found in nature and are critical at many levels of cellular organization. (jhmi.edu)
We demonstrate that this biological circuit filters out high-frequency signals and counts those admitted, thereby enabling cells to modulate gene expression according to the dynamic pattern of the external stimuli. (jhmi.edu)
The seizures also modify the temporal oscillation of several biological processes, including body temperature, locomotor activity, sleep pattern, and secretion of hormones. (databasefootball.com)

Understanding the organization of the cell cycle has been a longstanding goal in cell biology. (bvsalud.org)
Nature Cell Biology 2007, 9 (10), 1192-1198. (ncl.ac.uk)
Journal of Cell Biology 2006, 174 (6), 791-801. (ncl.ac.uk)
Nature Cell Biology 2006, 8 (9), 1035-1037. (ncl.ac.uk)

However, the role of FOXK1 in the progression of colorectal cancer (CRC) remains unknown. (oncotarget.com)
Evaluation of RAS Mutational Status in Liquid Biopsy to Monitor Disease Progression in Metastatic Colorectal Cancer Patients. (unifi.it)
Transcriptomic data of bevacizumab-adapted colorectal adenocarcinoma cells HCT-116. (unifi.it)

We have combined the proteomic analysis of Xenopus laevis in vitro-assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. (rupress.org)

A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets. (duke.edu)

Although the death of heart muscle cells (cardiomyocytes) plays a causal role, and hence a cardio-protective drug would be a logical treatment, no existing therapeutics target the intracellular pathways responsible for cardiomyocyte death. (domainex.co.uk)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Additionally, experiments were conducted to test the self-sustainable oscillation of KaiC phosphorylation, which is important in the regulation of the kaiABC gene cluster. (wikipedia.org)
Currently, two models of cell-cycle regulation have been proposed. (duke.edu)
This result fits with the second model of cell-cycle regulation. (duke.edu)
Taken together, these data provide further insight into the regulation of the cell cycle. (duke.edu)
These results demonstrate distinct patterns of spontaneous [Ca 2+ ] i change in cortical precursor cells and raise the possibility that these dynamics may contribute to the regulation of neurogenesis. (jneurosci.org)
Signaling of tumor-cells may further involve up-regulation of pore forming Ca 2+ channel protein Orai1, which accomplishes store operated Ca 2+ entry (SOCE). (biomedcentral.com)

This concept incorporates autonomous cell cycle oscillators previously reported into a coherent cell cycle control by cyclin-Cdk oscillation, therefore, may have broad implications for the structure and evolution of eukaryotic cell cycle. (rockefeller.edu)

T-cells and macrophages are classically thought to be responsible for triggering and orchestrating the immune response, inducing target cell death, recognizing immune stimuli, and removing cellular debris. (hindawi.com)
Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)
Subsequent exposure and ingestion of silica by alveolar macrophages leads to cell necrosis, autophagy, and the release of nondegraded intracellular silica. (medscape.com)

Experimental schematic (A) and two examples of different responses to nocodazole treatment, where the tunicate P. mammillata continues to cycle through cell divisions (B) and the sea star H. attenuata arrests in mitosis (C). From Figure 1. (biologists.com)
When cells pass from S to G 2 , the nuclei migrate toward the VZ surface where mitosis occurs. (jneurosci.org)
After mitosis, daughter cells can either remain proliferative and re-enter the cell cycle or become terminally postmitotic and migrate out of the VZ ( McConnell, 1995 ). (jneurosci.org)

One could freeze cancer cells while they are growing or induce them to commit suicide. (revoscience.com)
In a recent study, activation of mAR by dehydrotestosterone (DHT) in prostate cancer cells was reported to induce rapid Ca 2+ influx via Orai that was important for rapid androgen effects [ 31 ]. (biomedcentral.com)
Indeed, the principal adipocytes isolated from obese mice could induce antigen-specific Compact disc4+ T cell activation (58). (exposed-skin-care.net)

However, under these microenvironmental conditions, only 15% of tumor cells assemble invadopodia at any given time, while the rest are non-motile. (biorxiv.org)
Membrane androgen receptors (mAR) are functionally expressed in a variety of tumor-cells including the breast tumor-cell line MCF-7. (biomedcentral.com)

However, compared to excitable cells, the potential changes occur very slowly and over the entire cell cycle, i.e. over hours and days, and serve as a signal for the transition between the individual cell cycle phases, explains Baumgartner. (revoscience.com)

To this end, MCF-7 cells were exposed to TAC and Orai1 protein abundance at the cell surface was determined by confocal microscopy and flow cytometry as well as intracellular Ca 2+ release and SOCE were quantified utilizing Fura-2 fluorescence. (biomedcentral.com)
In a first step, confocal microscopy was employed to visualize the effect of TAC on the Orai1 protein abundance at the MCF-7 cell membrane surface. (biomedcentral.com)
As illustrated in Fig. 1 , mAR activation was followed by a rapid increase of Orai1 protein abundance at the surface of MCF-7 cells. (biomedcentral.com)
BNIP3 promotes autophagy in response to hypoxia, along with the WDR45L related protein, WIPI 49, co localizes with the autophagic marker LC3 following amino acid depletion in autophagosomes, It is not identified if BNIP3 or putative WDR45L related autophagy success in cell survival or death. (inhibitorkits.com)

This approach will enable the comparison of alternative cell cycles during development, in response to environmental perturbation and in disease. (bvsalud.org)
A recent Cell Metabolism study explores the therapeutic potential of circadian-modulating interventions to treat Alzheimer's disease (AD). (news-medical.net)
Several studies have shown that circadian alterations in AD manifest earlier in the disease progression, which may aggravate its pathology. (news-medical.net)
For example, a mouse model of Huntington's disease has demonstrated the significance of time-restricted feeding (TRF) in improving motor performance, sleep/wake cycles, and inflammation. (news-medical.net)
Progressive weakness of the arms and legs, along with kyphoscoliosis, continues through late disease progression. (hindawi.com)
Observations of activated immune cell infiltrates in dystrophic muscle suggest that the immune/inflammatory response may play a role in exacerbating the disease [ 8 - 12 ]. (hindawi.com)
Immunosuppressive therapy, such as treatment with glucocorticoids, improves muscle strength and prolongs ambulation in DMD patients but does not prevent disease progression [ 3 , 12 ]. (hindawi.com)
Patients with SPMS present with features of progressive neurologic disability, with or without clinically overt relapses, and insidious disease progression. (medscape.com)
Identifying early changes in the disease course may provide new therapeutic targets to halt or reverse disease progression. (nature.com)
The mechanism and function of heterochromatin disruption in FSHD muscular dystrophy is another area of research, in which we perform single cell/nucleus analyses to isolate and characterize a small number of disease-driving cells and are developing 3D and tissue on a chip to measure intrinsic defects of FSHD and CRISPR-engineered mutant myocytes. (uci.edu)
Cell Death and Disease. (nebraska.edu)

We previously demonstrated that invasive cells oscillate between two distinct states, termed the Invadopodia state and the Migration state 10 . (biorxiv.org)

By measuring global gene expression dynamics in cells with persistent CDK activity, I show that periodic transcription continues. (duke.edu)
Hence the cells are able to count the number of repeated stimuli, they experience and modulate gene expression accordingly. (jhmi.edu)

From a system theory perspective, p53 network dynamics is interesting since it can exhibit three dynamical modes of p53, namely low-level equilibrium, oscillation, and high-level equilibrium. (yasar.edu.tr)
In recent years, cell cycle regulators have been shown to exhibit roles in both tumor suppression and tumor promotion, particularly cyclin-dependent kinase inhibitors (CKI) p27 kip1 and p21 cip1 14 . (biorxiv.org)
It is known from experimental studies that non-excitable cells also exhibit characteristic fluctuations of potential at the cell membrane. (revoscience.com)
Similar to CD4+ T cells, CD8+ T cells exhibit effector memory or effector phenotypes expressing elevated levels of IFN- in obese adipose tissue (31, 44). (exposed-skin-care.net)

Metastasis is a complex, multi-step process that is initiated when cancer cells in the primary tumor acquire invasive properties, including motility and the ability to breakdown the extracellular matrix (ECM) 1 , and is responsible for the majority of cancer-related mortalities 2 . (biorxiv.org)

Discrete, stochastic simulations show that p53 and MDM2 oscillations continue even after 10 hours, as observed by experiments. (biomedcentral.com)

Moreover, the elevated expression of FOXK1 was showed to be correlated with tumor progression and was a significant predictor of overall survival in CRC patients. (oncotarget.com)
Once told there would likely be a measured benefit from attending a support group - the press broadcast the news and the patients came on board en masse! (gracegawlermedia.com)

However, several studies have shown that some cell-cycle events, such as periodic transcription, can continue in the absence of CDK activity. (duke.edu)
The Invadopodia state is characterized by cell stasis and the presence of invadopodia, whereas the Migration state is defined by cell translocation and the absence of invadopodia. (biorxiv.org)

Cell-autonomous clocks are present in various regions of the brain, particularly in the frontal cortex and hippocampus. (news-medical.net)

Using an intact cortical mantle and confocal laser microscopy, we examined the spatiotemporal patterns of spontaneous [Ca 2+ ] i fluctuations in neocortical ventricular zone (VZ) cells in situ . (jneurosci.org)

That inflammatory response, in turn, exacerbates alcohol-induced organ damage, creating a vicious cycle and leading to additional deleterious effects of alcohol both locally and systemically. (nih.gov)
This vicious cycle self-perpetuates, causing progressive alveolar inflammation and fibrosis. (medscape.com)

Caption: The image shows the tracks from confocal microscopy images of four cells expressing GFP-GtaC (frames at 3.5-min intervals were processed and overlaid). (jhmi.edu)

Cellular morphology, time-lapse imaging, and nuclear staining demonstrated that this activity occurred in mitotically active cells. (jneurosci.org)

Circadian rhythms, 24-hour internal clocks running in all cells, aid living organisms in acclimatizing their physiology and behavior to the day/night changes in light, temperature, accessibility of food, and other periodic ecological factors. (databasefootball.com)

During this time, precursor cells undergo interkinetic nuclear migration ( Seymour and Berry, 1975 ) in which cells in the DNA synthetic S phase have their nuclei in the upper third of the VZ. (jneurosci.org)
studies indicated that RANTES is Purpureaside C an adipokine that can be produced by adipocytes and takes on an important part in T cell migration, suggesting a potential part of the RANTES/CCR5 axis in adipose T cell build up in obesity (24). (exposed-skin-care.net)

Both intrinsic and extrinsic signals are likely to influence the proliferative potential and eventual fates of precursor cells within the VZ. (jneurosci.org)

SIRT1 deacetylates PER2 also, improving its degradation and creating a poor feedback loop impacting the oscillation [18,19]. (monossabios.com)

The computer model, developed under the lead management of researchers at TU Graz, simulates the cyclical changes in the membrane potential of a cancer cell using the example of human lung adenocarcinoma and opens up completely new avenues in cancer research. (revoscience.com)
The international research team led by Baumgartner focused on the specific electrophysiological properties of non-excitable cancer cells for the first time. (revoscience.com)
Pathological changes in cell membrane voltage, particularly during the cell cycle, are fundamental to cancer development and progression. (revoscience.com)
For their digital cancer cell model, the team chose the example of the human lung adenocarcinoma cell line A549. (revoscience.com)
So, we get information about the effects of targeted interventions on the cancer cell," Baumgartner adds. (revoscience.com)
He and his team see the first digital cancer cell model as the beginning of more comprehensive research. (revoscience.com)
The present study explored the effect of membrane androgen receptor (mAR) activation on Ca 2+ signaling in MCF-7 breast cancer cells. (biomedcentral.com)
Options, Choices and Treatments for Cancer Recovery: De mystifying the oscillating the immune cycle. (gracegawlermedia.com)
When cancer cells challenge us - they are also smart. (gracegawlermedia.com)

Studies in C. elegans have also suggested that the larger cell size at earlier embryonic divisions causes the SAC signaling cascade to be too dilute to mount a meaningful response. (biologists.com)
As cells decrease in size, a sufficient kinetochore-to-cell volume ratio threshold is reached, allowing for stronger signaling responses. (biologists.com)
Given the variability of SAC signaling between organisms and cell size, the authors used a multi-species comparative analysis to determine if the SAC activity and response correlated with any particular cellular characteristic or evolutionary group. (biologists.com)
In order to determine which species activated SAC signaling for cell division, the authors treated two-celled embryos with nocodazole to completely depolymerize microtubules. (biologists.com)

Thomas C, Wetherall B, Levasseur MD, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes . (ncl.ac.uk)
Taken together, one important mechanism for obese adipose CD4+ T cell activation may be mediated through MHCII expressed on ATMs and adipocytes. (exposed-skin-care.net)
The mechanism for CD8+ T cell activation in adipose tissue is not fully understood. (exposed-skin-care.net)

Learning perturbation-inducible cell states from observability analysis of transcriptome dynamics. (duke.edu)

In addition to a role in adaptive immunity, memory CD8+ T cells are involved in innate immunity, being able to become activated and to proliferate under cytokine stimulation (107, 108). (exposed-skin-care.net)

Complimentary to this, fibroblasts exposed to fluid shear stress structurally rearranged pre-coated surface FN, but unstimulated and stretched cells did not. (nature.com)

Anatomy22

Organisms11

Diseases6

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes87

Disciplines and Occupations1

Information Science4

Health Care2

Circadian oscillation2

Cyclin depende2

Neurons3

Cyclins4

Regulate4

Genes3

Mitotic8

Apoptosis5

Induces5

Rhythmicity2

Checkpoints2

Rhythmic1

Cdk11

Invasion and metastasis1

Proteins6

Mammalian3

Arrest1

Mechanisms6

Hallmark3

Directionality1

Oscillator5

Proliferation4

Actin2

Developmental5

Regulatory1

Biological4

Biology4

Colorectal3

Chromosomes1

Yeast1

Pathways2

Regulation6

Oscillators1

Macrophages3

Mitosis3

Induce3

Tumor cells2

Transition1

Protein4

Disease11

Distinct1

Gene expression2

Exhibit4

Extracellular1

Discrete1

Patients2

Absence2

Autonomous1

Cortical1

Vicious cycle2

Confocal microscopy1

Time-lapse1

Physiology and behavior1

Migration2

Proliferative1

Degradation1

Cancer9

Signaling4

Mechanism3

Dynamics1

Cytokine stimulation1

Fibroblasts1