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  • Differentiation
  • NR2E3 (PNR/RNR) is a retina-specific orphan nuclear receptor believed to play a role in photoreceptor development, differentiation, and survival. (arvojournals.org)
  • The impairment in Th17 differentiation by treatment with CRAC channel blocker was recapitulated in Orai1-deficient T cells, which could be rescued by exogenous expression of retinoic-acid-receptor-related orphan receptors or a constitutive active mutant of NFAT. (jimmunol.org)
  • The orphan nuclear receptor ERR beta is expressed in undifferentiated trophoblast stem cell lines and extraembryonic ectoderm, and genetic ablation of ERR beta results in abnormal trophoblast proliferation and precocious differentiation toward the giant cell lineage. (diethylstilbestrol.co.uk)
  • constitutive
  • HNF4 was originally classified as an orphan receptor that exhibits constitutive transactivation activity apparently by being continuously bound to a variety of fatty acids. (wikipedia.org)
  • binds
  • As secretin binds to these receptors, it stimulates adenylate cyclase activity and converts ATP to cyclic AMP. (wikipedia.org)
  • A conserved C-terminal domain containing secondary IGF binding residues, a cysteine rich region (6 cysteine residues), an 18 residue basic motif that binds heparin, the acid labile subunit (ALS), and a nuclear localization sequence. (wikipedia.org)