Organs tissues mammalian embryonic. Medical search. Frequent questions

In January 2017, scientists from Salk Institute for Biological Studies managed to create a pig embryo that had part of its DNA, critical for the growth of organs, edited out. (wikipedia.org)
Media solidified with agar are also used for organ culture and these media consist of 7 parts 1% agar in BSS, 3 parts chick embryo extract and 3 parts of horse serum. (wikipedia.org)
Embryo-like models with spatially organized morphogenesis and structure of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (that is, the embryonic disc, the bilaminar disc, the yolk sac, the chorionic sac and the surrounding trophoblast layer) remain lacking 1 , 2 . (nature.com)
Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs) 3 . (nature.com)
Within a short time, the cells of the three germ layers are transformed into an embryo containing most of its major internal and external organs. (mpg.de)
The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
Development of the heart and vascular system is often described together as the cardiovascular system, with the heart being the first functional organ that forms in the embryo. (edu.au)
Development begins very early in mesoderm both within (embryonic) and outside (extra embryonic, yolk sac and placental) the embryo. (edu.au)
In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. (techxplore.com)
The particular stem cells that will eventually make the future body, the embryonic stem cells (ESCs) cluster together inside the embryo towards one end: this stage of development is known as the blastocyst. (cam.ac.uk)
Both the embryonic and extra-embryonic cells start to talk to each other and become organised into a structure that looks like and behaves like an embryo," explains Professor Magdalena Zernicka-Goetz from the Department of Physiology, Development and Neuroscience, who led the research. (cam.ac.uk)
During the development of vertebrates, including humans, the fertilized egg develops into the embryo, and the cells in the embryo then proceed to differentiate to form somatic cells of different tissues and organs. (shawprize.org)
The fertilized egg is considered totipotent, as it can develop into a whole organism, while the cells in the embryo are pluripotent because they are capable of differentiating into somatic cells that make up all the organs. (shawprize.org)
In the developing mouse embryo, Rev3L transcript is found in all tissues. (pitt.edu)
Embryonic stem cell research garnered great controversy because it derives cells from human embryos through the process of disassembling the embryo. (firebaseapp.com)
Embryonic development refers to the process of growth and development of embryo. (brainyhomeworkhelp.com)
Stage of embryonic development is a phase within the period of embryonic development that is marked by distinct growth changes in the embryo. (brainyhomeworkhelp.com)
About 21 days after the implantation of the embryo onto the uterus, the endoderm, mesoderm and ectoderm grow further and differentiate to form neutral tube and notocord, among other vital organs of the body. (brainyhomeworkhelp.com)

Strategies for regenerative therapies in adult mammals, therefore, might be based on stimulating growth of adult stem cells or their surrogates in specific tissues rather than on introducing embryonic stem cells into adults. (iospress.com)

We think that it will be possible to mimic a lot of the developmental events occurring before 14 days using human embryonic and extra-embryonic stem cells using a similar approach to our technique using mouse stem cells," she says. (cam.ac.uk)

Much of this process relies on the morphogenesis of the extra-embryonic tissues and the effect this has on the organization of embryonic cells. (nature.com)
The interdisciplinary consortium "Supervised Morphogenesis in Gastruloids" (SUMO) received a total funding of 4.95 mio EURO (including UK replacement funding) to challenge the current limitations for realistic in vitro organ models by building on state-of-the-art gastruloid technology. (leibniz-fmp.de)
The Glypicans ( glypi ated proteogly can s) are a small multigene family of GPI-linked heparan sulfate (HS) proteoglycans that likely play a key role in embryonic morphogenesis (1, 2, 3, 4). (rndsystems.com)
Dynamic imaging of Drosophila embryonic tracheal morphogenesis demonstrates that SERCA's principal function is to govern cell migration. (caltech.edu)
Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
Serotonergic neurotransmission modulates cell proliferation in several tissues, but is involved mainly in the morphogenesis of the craniofacial region 8 . (bvsalud.org)

The experiment used rat heart cells and produced functional heart tissue. (wikipedia.org)
In order to further test applications to humans as a cure, a way to transform human stem cells into heart tissue would have to be found. (wikipedia.org)
Cells Tissues Organs (2011) 193 (4): 239-252. (karger.com)
Here we extend those findings to humans using only genetically unmodified human naive embryonic stem cells (cultured in human enhanced naive stem cell medium conditions) 4 . (nature.com)
Development of new or improved laboratory/experimental techniques, instruments, or supporting software that measure the location and dynamics of molecules in situ, and organelles, cells, or tissues on the nanometer and micrometer length scales. (nih.gov)
Profoundly different patterns of potency and division are exhibited by mammalian embryonic and adult stem cells. (iospress.com)
The embryos of larger arthropods and deuterostomes with well-provisioned eggs or viviparity, on the other hand, exhibit regulative development, while their larval "set-aside" or adult stem cells function in the growth, maintenance, and regulation of organ size coupled to constrained proliferation and cell turnover. (iospress.com)
Mammalian embryonic stem cells would seem adapted to rapid proliferation, functioning in part to enclose yolk or to acquire access to maternal resources. (iospress.com)
The cellular products of embryonic stem cells routinely come under global influences and give rise to the cells of germ layers and organ rudiments. (iospress.com)
Mammalian adult stem cells resemble the blastomeres of planktonic and benthic organisms with small eggs and may have evolved in mature organisms as an adaptation to the growth and maintenance of tissues via proliferation and the regulation of organ size via cell loss (e.g., terminal differentiation). (iospress.com)
Cloning of human cells is a technology that holds the potential to cure many diseases and provide a source of exactly matched transplant tissues and organs. (news-medical.net)
One cloning technology that has been developed for mammalian and human cells is somatic cell nuclear transfer (SCNT). (news-medical.net)
SCNT is a method of cloning mammalian cells that can be used to create personalized embryonic stem cells from an adult animal or human. (news-medical.net)
Embryonic stem cells are immortal, and have the potential to develop into any type of adult cell, even after months growing in culture dishes. (news-medical.net)
By transferring adult cell DNA into an embryonic stem cell, it is possible to create a line of immortal embryonic cells that are able to develop into any type of adult cell, genetically identical to the donor. (news-medical.net)
In humans, a major roadblock in achieving successful SCNT leading to embryonic stem cells has been the fact that human SCNT embryos fail to progress beyond the eight-cell stage. (news-medical.net)
This was the first successful reprogramming of human somatic cells into embryonic stem cells using a cloning technique, SCNT. (news-medical.net)
Dermal fibroblasts were taken from a 35-year old male and a 75-year-old male and used to create embryonic stem cells. (news-medical.net)
The adult cell nuclei were transferred into metaphase-II stage human oocytes, producing a karyotypically normal diploid embryonic stem cell line from each of the adult male donor cells. (news-medical.net)
Although attempts have not yet been made to create a therapeutic transplant from embryonic stem cells, the methods have been developed to allow the creation of functional, mature cells using human cell cloning technology. (news-medical.net)
When a heart attack strikes, heart muscle cells die and scar tissue forms, paving the way for heart failure. (eurekalert.org)
Cardiovascular diseases are a major cause of death worldwide, in part because the cells in our most vital organ do not get renewed. (eurekalert.org)
Investigation of the regenerative process through live imaging and molecular studies revealed how this happens: The cardiomyocytes "dedifferentiate" - that is, they revert to an earlier form, something between an embryonic and an adult cell, which can then divide and differentiate into new heart cells. (eurekalert.org)
Cells known to express GPC-6 are adult ovary and embryonic vascular and visceral smooth muscle, plus mesenchyme (embryonic connective tissue) in multiple organs (1, 5, 6). (rndsystems.com)
Transcripts from the Drosophila KDEL receptor gene KdelR - formerly known as dmErd2 - are provided maternally and, at later stages, are at elevated levels in several embryonic cell types, including the salivary gland secretory cells, the fat body and the epidermis. (johnshopkins.edu)
In contrast, symmetric divisions in epithelia divide cellular components equally, and usually results in both daughter cells remaining in the tissue. (elifesciences.org)
In the future, embryonic stem cells may be able to restore sight to millions of people. (thefutureofthings.com)
As the embryonic cells divide and the daughter cells differentiate, they become increasingly specific. (thefutureofthings.com)
The cells of the ICM are no longer omnipotent, because they no longer share the fate of the trophoblast, and they have committed themselves to an embryonic fate with the ability to become any cell in the body (but not the trophoblast). (thefutureofthings.com)
The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)
These adult stem cells are considered multipotent, having the ability to differentiate into different cell types, albeit with a more limited repertoire than embryonic stem cells. (thefutureofthings.com)
In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)
The rest of this article will deal with embryonic stem (ES) cells and the future they hold for modern medicine. (thefutureofthings.com)
To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
The physical substance of the human organism, composed of living cells and extracellular materials and organized into tissues, organs, and systems. (rincondelvago.com)
The lymphocyte pool is regional, being the antibody mediated immune system of the Bursa of Fabricius (B-lymphocytes, as opposed to the thymic derived T-cells) that form the largest immune organ extending the length of the intestines and the stomach. (pharmaceuticalintelligence.com)
Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
Veins are more abundant than arteries Arteries Arteries are tubular collections of cells that transport oxygenated blood and nutrients from the heart to the tissues of the body. (lecturio.com)
embryonic stem cells that are isolated from the inner cell mass of blastocysts, and adult stem cells that are found in adult tissues. (techxplore.com)
In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialized cells, but also maintain the normal turnover of regenerative organs, such as blood, skin or intestinal tissues. (techxplore.com)
Stem cells can now be grown and transformed into specialized cells with characteristics consistent with cells of various tissues such as muscles or nerves through cell culture. (techxplore.com)
Embryonic cell lines and autologous embryonic stem cells generated through therapeutic cloning have also been proposed as promising candidates for future therapies. (techxplore.com)
Once a mammalian egg has been fertilised by a sperm, it divides multiple times to generate a small, free-floating ball of stem cells. (cam.ac.uk)
The other two types of stem cell in the blastocyst are the extra-embryonic trophoblast stem cells (TSCs), which will form the placenta, and primitive endoderm stem cells that will form the so-called yolk sac, ensuring that the foetus's organs develop properly and providing essential nutrients. (cam.ac.uk)
Attempts were then made to show that mammalian cells - and human cells in particular - could also be reprogrammed back to a pluripotent state, because it is believed that such knowledge may advance our understanding of developmental mechanisms, and yield new approaches for disease treatment. (shawprize.org)
In 1995, they produced a pair of lambs called Megan and Morag from embryonic cells. (shawprize.org)
They performed nuclear transfer experiments in which nuclei from embryonic, foetal and adult cells of the sheep were transplanted into fertilized eggs derived from ewes. (shawprize.org)
L-type Ca 2+ channels (LTCCs) drive the bulk of voltage-gated Ca 2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. (jneurosci.org)
Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. (cshlpress.com)
Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. (cshlpress.com)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
In addition, elucidating how Rev3L is expressed and regulated in mammalian cells will indicate what role it may play in tissues of the adult organism and why it is essential for life. (pitt.edu)
Furthermore, using a REV3L lacZ expression mouse model, the expression of REV3L in mouse organs containing proliferative cells was characterized. (pitt.edu)
ALS (Lou Gehrig's Disease) Goal: Test that safety of delivering embryonic stem cells to the spinal cord. (firebaseapp.com)
Stem cell research is a broad field, dealing with embryonic and adult stem cells (e.g. mesenchymal and neural stem cells) or induced pluripotent cells. (firebaseapp.com)
Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancerstem cells, developmental studies, genomics and translational research. (firebaseapp.com)
This research is focused on the two mammalian stem cell types, namely, the embryonic stem cells and adult (non-embryonic) stems cells. (firebaseapp.com)
whereas, adult stem cells are isolated from adult tissues. (firebaseapp.com)
One the layers, the epiblast, is layer of cells, which are the precursors of all embryonic cells. (brainyhomeworkhelp.com)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
Recently, research has increased in the area of transplanting embryonic cells across species and growing kidneys and endocrine pancreas cells in situ. (medscape.com)

Such human fully integrated and complete SEMs recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos, including the epiblast, the hypoblast, the extra-embryonic mesoderm and the trophoblast layer surrounding the latter compartments. (nature.com)
They derived several human embryonic stem cell lines from these cloned embryos whose DNA was an exact match to the adult cell that donated the DNA. (news-medical.net)
In the Mus musculus (house mouse), gastrulation is like a continually changing process, three-dimensional puzzle that has specific characteristics when comparing it to non-mammals and other mammalian embryos. (brainyhomeworkhelp.com)
In another, published in Developmental Neuroscience last month, researchers with the University of Alberta observed the expression of six key receptors that endocannabinoids bind to - CB1 , CB2 , TRPV1 , TRPA1A , TRPA1B , and GPR55 - in developing zebrafish embryos across a timeline roughly equivalent to the first two to ten weeks of human embryonic development. (projectcbd.org)

Similarly, during Drosophila embryonic development, SERCA activity is required for the proper formation of both the central nervous system axon tracts and the network of tracheal tubules that deliver oxygen to tissues. (caltech.edu)
Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)

We portrayed the Notch system in embryonic stem cell (ESC)-derived embryoid bodies (EBs) differentiating under the standard protocols used to assess yolk sac (YS) hematopoiesis in vitro. (karger.com)
These include embryonic disc and bilaminar disc formation, epiblast lumenogenesis, polarized amniogenesis, anterior-posterior symmetry breaking, primordial germ-cell specification, polarized yolk sac with visceral and parietal endoderm formation, extra-embryonic mesoderm expansion that defines a chorionic cavity and a connecting stalk, and a trophoblast-surrounding compartment demonstrating syncytium and lacunae formation. (nature.com)

Since steady progress is being made in regenerative therapy of organs, including the salivary gland, the need for further development of cryopreservation technologies for organs will almost certainly increase in the future. (iiarjournals.org)

The process of formation of body organs from the germ layers is called neurulation (Campbell & Reece, 2005). (brainyhomeworkhelp.com)

The mesoderm also undergoes through a series of developments leading to the formation of vertebrae, muscles, and connective tissues. (brainyhomeworkhelp.com)

Supportive and Connective Tissues. (rincondelvago.com)

It is a development from tissue culture methods of research, as the use of the actual in vitro organ itself allows for more accurate modelling of the functions of an organ in various states and conditions. (wikipedia.org)
A key objective of organ culture is to maintain the architecture of the tissue and direct it towards normal development. (wikipedia.org)
Scientists from Seattle and Berlin have published an atlas on mouse embryonic development. (mpg.de)
Junyue Cao, Malte Spielmann and their colleagues describe, which cell types differentiate between days 9.5 and 13.5 of mouse embryonic development, and how they transform into organs. (mpg.de)
In addition, they described 56 developmental trajectories in organ development for different cell types. (mpg.de)
Organ development of mammals is an amazing process. (mpg.de)
All of this takes place in the first third of embryonic development. (mpg.de)
The matrix is essential for early embryonic development and it regulates nearly every facet of cell behaviour. (biologists.com)
A book on such a profoundly important topic requires a clear vision of the breadth of the ECM and its roles in development, cell and tissue function and disease. (biologists.com)
Mouse SMG rudiment development begins on embryonic day 12 (E12) when the epithelial tissue of the floor of the mouth sinks towards the direction of the neck. (iiarjournals.org)
Prof. Eldad Tzahor of the Institute's Biological Regulation Department thought that part of the answer to the regeneration puzzle might lie in his area of expertise: embryonic development, especially of the heart. (eurekalert.org)
Exposure windows were chosen based on the three stages of swim bladder development: budding (24-48 hpf), pre-inflation, i.e., the formation of the swim bladder tissue layers (48-72 hpf), and inflation phase (72-120 hpf). (bvsalud.org)
Gene transcript analysis showed that these TH level alterations disturb both Wnt and hedgehog signaling, known to be essential for swim bladder formation, eventually resulting in impaired development of the swim bladder tissue layers. (bvsalud.org)
The overall results indicate that exposure to terbutryn induces apoptosis and disrupts organ development. (bvsalud.org)
The HGF‑Met signaling pathway contributes in a paracrine manner to the development of epithelial organs, exerts regenerative effects on the epithelium, and promotes the regression of fibrosis in numerous organs. (spandidos-publications.com)
Mammalian chimeras are valuable for studying early embryonic development. (asu.edu)
JmjC proteins have been associated with many human diseases including various cancers, developmental and neurological disorders, however, the shared biology and possible common contribution to organismal development and tissue homeostasis of all JmjC proteins remains unclear. (sdbonline.org)
In mouse, gastrulation starts after a blastula implants into the uterine walls of the mother, and is immediately followed by development of different organ systems also knows as organogenesis. (brainyhomeworkhelp.com)
Stoned lobsters, zebrafish, CBD-averse caterpillars, and the role of cannabinoid-interacting receptors in early embryonic development. (projectcbd.org)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
Several drugs cross the placental barrier and some have teratogenic effects on the fetus, which may cause dysfunction and disorders during embryonic development, particularly during the first three months of intrauterine life 2 . (bvsalud.org)
People with ovotesticular disorder of sexual development are individuals who have both ovarian and testicular tissue. (medscape.com)
However, because of functioning normal ovarian tissue, most people experience breast development at puberty, and approximately two-thirds of those with a 46,XX peripheral karyotype menstruate. (medscape.com)

This includes gene, protein and metabolic networks, cellular architecture and intracellular dynamics, cell communication and motility, cell division and differentiation, tissue formation and organogenesis, tissue and organ functions, changes in population characteristics as a consequence of interaction of organisms with their physical environment, with individuals of their own species, and with organisms of other species. (nih.gov)
They are well-known as structural elements of the ECM but over the past 10 years or so peer-reviewed papers have revealed their importance in cell growth and differentiation, particularly in the embryonic nervous system. (iduron.co.uk)

Gastruloids are multi-tissue embryonic organoids that can recapitulate mammalian developmental processes, including early organogenesis, in a dish. (leibniz-fmp.de)
Organogenesis is characterized by the formation of vital organs such as brain and spinal cord, coelom, muscle tissues, notochord and neural tube (Ibim, 2010). (brainyhomeworkhelp.com)

ECMs range from pericellular matrices, such as basement membranes, to the grander structures of connective tissue that give organs their shape, and the tendons, cartilage and bones that bestow humans and animals with their form. (biologists.com)
Müllerian duct structures typically develop on the gonad side(s) not containing testicular tissue. (medscape.com)
Wolffian duct structures tend to be observed on the gonad side(s) containing functioning testicular tissue. (medscape.com)

Though smaller and less complex than that of humans, the rat brain is extremely useful as a subject of study because most regions of the brain are essentially the same among mammalian species. (microscopyu.com)
The tiny fish develops rapidly, reproduces abundantly, and is hardy and easy to care for, but also shares important organs, tissues, and genetics with humans. (projectcbd.org)

In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. (frontiersin.org)
In this review, we summarize the history of interspecies chimerism in various animal models to find hints for BC application and describe the challenges and prospects of utilizing BC for human organ generation. (frontiersin.org)
Typical of mammalian structure, the human body shows such characteristics as hair, mammary glands, and highly developed sense organs. (rincondelvago.com)
Among the mammals, only human beings have a predominantly two-legged (bipedal) posture, a fact that has greatly modified the general mammalian body plan. (rincondelvago.com)
This plot shows the dynamic methylation landscape of the human genome, where the x axis (left) corresponds to the maximal observed methylation change across 24 human cell and tissue types, y is the median total methylation and z is the density of CpG dinucleotides. (mpg.de)
Stem cell laws and policy in the United States - Wikipedia National Academies Guidelines for Human Embryonic Stem Cell Research. (firebaseapp.com)
Xenotransplantation involves the transplantation of nonhuman tissues or organs into human recipients. (medscape.com)
The concept was pioneered a century ago, when transplanting human organs was considered ethically controversial. (medscape.com)
In light of the lack of supply of human organs for transplantation, several alternatives have been investigated and debated. (medscape.com)
9,10] Organs from pigs have been the focus of much of the research in xenotransplantation, in part because of the public acceptance of killing pigs and the physiologic similarities between pigs and human and nonhuman primates. (medscape.com)
Additionally, organs from animal sources could be transplanted into patients currently excluded from the human organ transplantation list. (medscape.com)
Finally, most patients perceive xenotransplantation as an acceptable bridge to transplantation of human organs in life-threatening situations. (medscape.com)

To overcome this significant crisis, researchers are investigating various approaches involving direct xenotransplantation, organoids, decellularization, and recellularization, and more recently, organ bioengineering using blastocyst complementation (BC). (frontiersin.org)

Skeletal tissues are generally placed directly on the grid but softer tissues like glands or skin are first placed on rafts, which are then kept on the grids. (wikipedia.org)
The diaphragm divides the chest cavity from the abdominal cavity in mammals through a partition of skeletal muscle and connective tissue. (microscopyu.com)

ECM receptors thus convert both chemical and physical extracellular inputs to determine cell survival, proliferation, migration and tissue-specific gene expression. (biologists.com)

Materials and Methods: Embryonic day 13 SMG rudiments were cryopreserved with or without a cryoprotectant. (iiarjournals.org)
Conclusion: Cryopreservation might be a useful technology for preserving tissues from small organs, such as fetal SMG rudiments. (iiarjournals.org)
BrM is studied in SMG rudiments on filters floating in serum-free medium in ex vivo organ culture systems ( 7 - 10 ). (iiarjournals.org)

However, it remains unknown how the timing of branch formation is encoded and whether this branching clock function is unique for different tissue types or is conserved across species and lineages that undergo iterative branching. (caltech.edu)

Embryonic organ culture is an easier alternative to normal organ culture derived from adult animals. (wikipedia.org)

Methylation of mammalian DNA and histone residues are known to regulate transcription, and the discovery of demethylases that remove methylation in DNA and histones provide a basis for the understanding of dynamic regulation of mammalian gene expression. (cmbn.no)
not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)

While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
8 Important Pros and Cons of Embryonic Stem Cell Research List of Cons of Embryonic Stem Cell Research. (firebaseapp.com)

Organ culture technology has contributed to advances in embryology, inflammation, cancer, and stem cell biology research. (wikipedia.org)
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic polypeptide, distantly related to transforming growth factor-beta (TGF-beta), originally isolated by virtue of its ability to induce dopamine uptake and cell survival in cultures of embryonic ventral midbrain dopaminergic neurons, and more recently shown to be a potent neurotrophic factor for motorneurons. (rupress.org)
Despite all the available protocols for successful cryopreservation of different cell types, cryopreservation of organs and tissues is still considered difficult. (iiarjournals.org)
The cloning method is based on the fact that cytoplasmic factors in mature, metaphase II oocytes are able to reset the identity of a transplanted adult cell nucleus to an embryonic state. (news-medical.net)
Core components of the secretory pathway have largely been identified and studied in single cell systems such as the budding yeast S. cerevisiae or in mammalian tissue culture. (johnshopkins.edu)
On the other hand, morphogens and cell-cell interactions are critical to form a complex, specialized organ such as the mammalian lung. (caltech.edu)
Loss of REV3L causes embryonic lethality in mice and leads to progressive chromosomal instability in Rev3L disrupted cell lines. (pitt.edu)

Investigations of the function of the sarcoplasmic-endoplasmic reticulum calcium ATP-ase (SERCA) reveal that protein kinase C (PKC)-modulated SERCA activity controls branch formation across tissues and species. (caltech.edu)
Diamino benzidine was the has been reported in mammalian species such as tigers substrate developed as a chromogen. (cdc.gov)
Though there are some differences in the function of the colon in different species, the organ primarily acts as a temporary repository for waste products and as a site of water absorption. (microscopyu.com)
Prolonged exposure to high concentrations of ZDTPs, calcium alkyl phenates, and magnesium, sodium, and calcium sulphonates had significant effects on the reproductive organs of male rabbits (testicular atrophy and reduction or absence of spermatozoa) which appeared to be species specific. (cdc.gov)

We report here on the mRNA expression, biological activities and initial receptor binding characterization of GDNF and a shorter spliced variant termed GDNF beta in different organs and peripheral neurons of the developing rat. (rupress.org)

Heart tissue does not regenerate if damaged, so producing replacement patches is of great interest. (wikipedia.org)
New research at the Weizmann Institute of Science provides insight into the question of why the mammalian heart fails to regenerate, on one hand, and demonstrated, in adult mice, the possibility of turning back this fate. (eurekalert.org)
However, not all tissues possess the ability to regenerate. (thefutureofthings.com)

Alexis Carrel is known as the founding father of experimental organ transplantation because of his pioneering work with vascular techniques. (medscape.com)

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. (rupress.org)
Overall, GDNF mRNA expression was significantly higher in peripheral organs than in neuronal tissues. (rupress.org)

Denervation of embryonic mouse lung explants reveals that lung branching requires nerves. (caltech.edu)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)

Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)

To provide a detailed description of the embryonic developmental toxicity of terbutryn, zebrafish (Danio rerio) were exposed to 2, 4, and 6 mg/L of terbutryn and the morphological changes, pathological abnormalities, and developmental endpoints were assessed relative to that of a solvent control. (bvsalud.org)
7 Today, zebrafish are the most commonly used non-mammalian animal model in toxicology, pharmacology, and behavioral neuroscience research 8,9 - including both psychedelic 10,11 and cannabinoid science. (projectcbd.org)

But there are also drawbacks and limitations to mammalian research that have led scientists in various fields to continue exploring other animal models. (projectcbd.org)

GDNF also promoted survival of about half of the neurons in embryonic chick nodose ganglion and a small subpopulation of embryonic sensory neurons in chick dorsal root and rat trigeminal ganglia. (rupress.org)

Organ culture is the cultivation of either whole organs or parts of organs in vitro. (wikipedia.org)

The reproductive systems of mammalian males contain a component called the epididymis. (microscopyu.com)

The 5-HT neurotransmitter regulates important pathways of mammalian metabolism and is synthesized from the phenylalanine, tyrosine and tryptophan amino acids 5 . (bvsalud.org)

For this, individual genes are switched off systematically and their effects on the on the developing organs or whole organisms are examined. (mpg.de)

A variety of adult organs (e.g. the liver) have been cultured using special media with special apparatus (Towell's II culture chamber). (wikipedia.org)
The virus isolated from The paraffin-embedded tissues, including brain, lung, the pigeon and the cat showed the same cluster as the kidney, heart, spleen, pancreas, liver, and intestine tissue, viruses obtained during the outbreak in Thailand. (cdc.gov)

Xenografts have been proposed as appropriate for infants who are physically too small to accommodate organs retrieved from adult or pediatric donors. (medscape.com)

The scope of the systems covered ranges from cellular to tissue, organ, systems studies, and up to populational dynamics. (nih.gov)
Depending on the patient's medical condition, a refractory disease patient also requires an on-time selective option, such as less invasive cellular therapy options or curative organ transplantation that can function immediately after transplantation. (frontiersin.org)
In this regard, whole organ generation via the BC approach holds great promise with a ready resource (livestock) for cellular therapies and as a radical treatment option for most terminal diseases. (frontiersin.org)

Finally, REV3L expression in mice is highest in testis, cardiac tissue and the smooth musculature of lung and intestines and low in lymphoid tissues. (pitt.edu)

A diagnosis of OT-DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. (medscape.com)

Anatomy56

Organisms35

Diseases4

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes76

Disciplines and Occupations1

Information Science4

Named Groups1

Health Care2

Embryo18

Introducing embryonic stem1

Extra-embryonic stem1

Morphogenesis6

Cells65

Embryos4

Drosophila2

Yolk sac2

Including the salivary gland1

Germ layers1

Mesoderm1

Connective Tissues1

Development23

Differentiation2

Organogenesis2

Structures3

Humans2

Human12

Organoids1

Skeletal2

Extracellular1

Rudiments3

Lineages1

Derived from adult1

Regulation2

Stem-cell res2

Cell7

Species4

Different organs1

Regenerate3

Vascular1

Peripheral2

Explants2

Additionally1

Zebrafish2

Scientists1

Sensory1

Vitro1

Reproductive1

Pathways1

Organisms1

Liver2

Pediatric1

Cellular3

Lung1

Characteristics1