AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Lymphoid TissueLymphoma, B-Cell, Marginal ZonePalatine TonsilPeyer's PatchesLymph NodesSpleenChemokine CCL21B-LymphocytesChemokine CXCL13Tissue and Organ ProcurementOrgan TransplantationThymus GlandOrgan SpecificityImmunity, MucosalT-LymphocytesAppendixMesenteryLymphocytesMucous MembraneLymphotoxin-betaMice, Inbred C57BLReceptors, CXCR5Chemokine CCL19Dendritic CellsLymphotoxin beta ReceptorOrgan SizeMice, Inbred BALB CReceptors, CCR7CD4-Positive T-LymphocytesImmunohistochemistryLymphotoxin-alphaMultiple Organ FailureChoristomaIntestinal MucosaNasal MucosaOrgan of CortiGerminal CenterLymphomaAdenoidsDendritic Cells, FollicularChemokines, CCLymphocyte ActivationLymphoma, B-CellMucoproteinsImmunoglobulin APseudolymphomaIntestinesChromosomes, Human, Pair 18Cell MovementImmunophenotypingReceptors, ChemokineReceptors, Lymphocyte HomingImmunologic MemorySimian Acquired Immunodeficiency SyndromePlasma CellsStomach NeoplasmsT-Lymphocyte SubsetsTissue DistributionImmunoenzyme TechniquesMice, TransgenicAntibodies, MonoclonalHelicobacter pyloriFlow CytometryL-SelectinEndothelium, LymphaticThoracic DuctLungOrbital NeoplasmsMice, KnockoutImmunoglobulinsLymphocyte SubsetsHIV-1Helicobacter InfectionsCD8-Positive T-LymphocytesIntestine, SmallSimian immunodeficiency virusMolecular Sequence DataBursa of FabriciusAntigens, CDAntibody-Producing CellsLymphoma, Non-HodgkinGerm-Free LifeMacaca mulattaScrapieB-Lymphocyte SubsetsCell DifferentiationCells, CulturedHelicobacter heilmanniiTime FactorsPropylene GlycolsLymphocyte CountNuclear Receptor Subfamily 1, Group F, Member 3Antigens, CD3BronchiAntigensWasting Disease, ChronicDigestive SystemCD4-CD8 RatioGastric MucosaChromosomes, Human, Pair 11
Secondary lymphoid organsMucosa-associSpleenThymusLymphocytesLymphomaEctopic Lymphoid TissueMucosalMacrophagesHaematopoieticSmall intestinePrimary lymphoidLymph nodeStructuresBoneMalignantCellsSpecificityTransplantationDigestiveLiverEpithelialLymphatic organsGALTPeyer's PatchesSymptomsVesselsConnective tissue disordersSoft tissueBody'sBloodBODYTropismLung
Secondary lymphoid organs8
  • The lymphoid organs, based on their function, are classified into central (primary) and peripheral (secondary) lymphoid organs. (brainkart.com)
  • After acquiring immu-nological competency, the lymphocytes migrate to secondary lymphoid organs to induce appropriate immune response on exposure to antigens. (brainkart.com)
  • In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T cells in vivo. (nih.gov)
  • To compare the functions of primary and secondary lymphoid organs. (pearson.com)
  • They then migrate via the lymphatics to secondary lymphoid organs (spleen, lymph nodes, mucosa-associated lymphoid tissue of the digestive tract and lungs) where they present these antigens to T and B lymphocytes. (univ-mrs.fr)
  • This is the moment when the cells detect the microbes or danger, change their biological functions and begin their migration to secondary lymphoid organs. (univ-mrs.fr)
  • MHC proteins determine antigen recognition by lymphocytes and therefore their activation within secondary lymphoid organs. (univ-mrs.fr)
  • Here, we describe a novel CD3+ CD20+ double-positive (DP) lymphocyte subset, resident in secondary lymphoid organs of humans and rhesus macaques (RMs), that appear predominantly after membrane exchange between TFH and B cells. (bvsalud.org)
Mucosa-associ8
Spleen9
  • Spleen - A fist-sized organ located in the abdominal cavity. (malaghan.org.nz)
  • The second part consists of lymphoid organs and tissues including the bone marrow, lymph nodes, spleen, and thymus. (pearson.com)
  • Other important organs in this system include the bone marrow, spleen, thymus and gut-associated lymphoid tissue (GALT), which is the lymphatic tissue associated with the gastrointestinal (GI) tract. (petplace.com)
  • The lymphatic system is composed of a network of lymph vessels referred to as lymphatics, as well as certain organs and tissues, including the lymph nodes, bone marrow, spleen, thymus and GALT. (petplace.com)
  • A tough capsule of fibrous tissue covers the spleen. (petplace.com)
  • stage IV--liver and/or spleen involvement or stage V--manifestations in the blood and involvement of bone marrow and/or other organ systems), as well as anatomical classification (multicentric, alimentary, cutaneous, mediastinal or extranodal). (vin.com)
  • A series of sublethal doses of radiation is directed at the patient's lymphoid tissue (spleen, thymus, and lymph nodes in the neck, chest, and abdomen), with bone marrow and other vital organs shielded from the exposure [ 387 ]. (nanomedicine.com)
  • Community participation and involvement was mobilized that integrated non-governmental organizations, Organs rich in lymphoid tissue such as the liver, spleen, thymus, religious and faith-based entities and school children. (who.int)
  • Here we show that caspase-1-induced pyroptosis, a highly inflammatory programmed cell death pathway, is the dominant mechanism responsible for the rapid depletion of CD4 T cells in gut-associated lymphatic tissue (GALT), spleen, and lymph nodes during acute simian immunodeficiency virus (SIV) infection in rhesus macaques. (bvsalud.org)
Thymus5
Lymphocytes5
  • These are the organs in which precursor lymphocytes proliferate, develop, and differ-entiate from lymphoid stem cells to become immunologically competent cells. (brainkart.com)
  • A network of channels all over the body that carries lymphocytes to the lymphoid organs and bloodstream. (uhhospitals.org)
  • Lymphoid organs and tissues are the sites where lymphocytes are produced, reside, and come in contact with pathogens. (pearson.com)
  • The five types of leukocytes from most to least common are neutrophils, lymphocytes, monocytes which turn into macrophages when they enter tissues, eosinophils and basophils. (pearson.com)
  • The lymphoid organs house phagocytic cells and lymphocytes, which play essential roles in body defense and resistance to disease. (nutters.com)
Lymphoma5
  • Lymphoma is a malign neoplasia resulting from the proliferation of cells from the lymphoid system, which has a varying potential for organic aggression. (scielo.br)
  • Lymphocytic leukemias, plasmocytomas, Hodgkin's lymphoma and non Hodgkin's lymphomas stem from this lymphoid lineage. (scielo.br)
  • Hodgkin lymphoma, also called Hodgkin's lymphoma and Hodgkin disease, is a cancer of the lymphoid system. (curesearch.org)
  • Malignant lymphoma can arise in any organ containing lymphoid tissue and is characterized by malignant proliferation of lymphoid cells. (slu.se)
  • While nodular lymphoid hyperplasia is not cancerous (benign), activated PI3K-delta syndrome increases the risk of developing forms of blood cancer called Hodgkin lymphoma and non-Hodgkin lymphoma. (medlineplus.gov)
Ectopic Lymphoid Tissue1
Mucosal3
  • Chin YH, Cai JP, Hieselaar T. Lymphocyte migration into mucosal lymphoid tissues: mechanism and modulation. (medscape.com)
  • The authors compare this with the development of lymphoid structures in mucosal tissues after birth and of tertiary lymphoid organs at sites of chronic inflammation. (nature.com)
  • We will also examine how other factors such as genes, microbes and other environmental toxins (including tobacco smoke) could influence the triggering of autoimmunity at mucosal sites and eventually systemic organ disease. (medscape.com)
Macrophages2
Haematopoietic1
  • WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. (crossref.org)
Small intestine4
Primary lymphoid1
  • Central or primary lymphoid organs are the major sites for lymphopoiesis. (brainkart.com)
Lymph node1
  • Extending from the collagenous capsule inward throughout the lymph node are connective tissue trabeculae that incompletely divide the space into compartments. (medscape.com)
Structures1
Bone9
  • Some lymphoid cells develop and mature within the bone mar-row and are referred to as B cells (B for bursa of Fabricius , or bone marrow). (brainkart.com)
  • The soft, spongy tissue found in bone cavities. (uhhospitals.org)
  • Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
  • The bone marrow consists of connective tissue, the cells of which form a delicate meshwork within the marrow cavity. (petplace.com)
  • WHO Classification of Tumours of Soft Tissue and Bone. (crossref.org)
  • This type of cancer begins in either the bone or in the body's soft tissues. (wearethecure.org)
  • Sometimes further classification is made between bone sarcoma and soft tissue sarcoma. (wearethecure.org)
  • These agents also damage all tissues (e.g., gut epithelium, bone marrow) where rapid cell division is occurring, creating other undesirable side effects, thus often may not be suitable for use in medical nanorobotics. (nanomedicine.com)
  • In due course, the stem cells in the bone marrow reconstitute the peripheral lymphoid system but the newly formed T cells seem to accept the graft as self [ 403 ]. (nanomedicine.com)
Malignant3
  • Malignant tumors can invade surrounding tissue and spread to distant organs. (merckvetmanual.com)
  • Generally, sarcomas are malignant tumors that affect the "connective tissues" in the body. (wearethecure.org)
  • Malignant tumour cells are able to invade nearby tissues and spread to other parts of the body. (nutters.com)
Cells26
  • These organs have the ability to produce pro-genitor cells of the lymphocytic lineage. (brainkart.com)
  • It reaches its maximal size at puberty and then atrophies, with a significant decrease in both cortical and medullary cells and an increase in the total fat content of the organ. (brainkart.com)
  • The development of the GALT has also been described in several marsupial species, including tammar wallabies, stripe-faced dunnarts (Sminthopsis macroura), and red-tailed phascogales The Peyer's patch is an aggregate of lymphoid cells projected to the lumen of the gut which acts as a very important site for the initiation of the immune response. (wikipedia.org)
  • The immune system is made up of different organs, cells, and proteins that work together. (uhhospitals.org)
  • A veterinarian can perform a fine needle aspiration of cells or a biopsy (which removes a small amount of tissue from a tumor) for evaluation. (merckvetmanual.com)
  • If malignancy is suspected, tissue surrounding the tumor will also be removed to increase the chance that none of the tumor cells are left behind. (merckvetmanual.com)
  • Micro-aspiration of gut bacteria or movement of sensitized immune cells through lymph or bloodstream can also influence immune response of other organs. (frontiersin.org)
  • Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. (epa.gov)
  • Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. (epa.gov)
  • In this topic, we will review the cells, tissues, and organs that make up the immune system. (pearson.com)
  • Some cells migrate to tissues to take up residence whereas others circulate through the blood and lymphatic system, entering tissues when needed. (pearson.com)
  • Within the spaces of this tissue, the immature and adult stages of different blood cells exist. (petplace.com)
  • These organs produce, store and carry white blood cells to fight infection and disease. (curesearch.org)
  • Lymph nodes are small tissues located throughout the body that store white blood cells to help filter out germs. (curesearch.org)
  • In the blood, mucous membranes and lymphoid organs, dendritic cells provide a dual role as sentinels, but also as conductors of the immune orchestra. (univ-mrs.fr)
  • and (iii) the dramatic reductions to lymphocyte numbers and function 1-2 h after exercise reflects a transient and time-dependent redistribution of immune cells to peripheral tissues, resulting in a heightened state of immune surveillance and immune regulation, as opposed to immune suppression. (frontiersin.org)
  • Here, we characterized the whole-genome distribution of methyl-CpG and 5-hydroxymethylcytosine (5hmC) in mouse innate lymphoid cell 3 (ILC3), ILC2 and natural killer (NK) cells. (stanford.edu)
  • The latter is done by microscopically evaluating the edge of the resected tissue (the "margins") to see whether tumor cells are present. (msdvetmanual.com)
  • Our bodies are made up of millions of cells, grouped together to form tissues and organs such as muscles and bones, the lungs and the liver. (nutters.com)
  • Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
  • The fungal metabolite cyclosporin A (cyclosporine) [ 384 , 385 ] has a greater specificity for lymphoid T cells than other cells. (nanomedicine.com)
  • The cellular or innate immune system was first described by the pathologist Elie Metchnikoff who recognized the existence of cells in the blood and tissues whose role was to identify, capture, and destroy invading pathogens. (aacrjournals.org)
  • Aggregates of immune cells formed near the sites of chronically inflamed, infected, or tumorous tissues. (bvsalud.org)
  • Upregulation of interferon-gamma inducible factor 16, a host DNA sensor that triggers pyroptosis, was also observed in tissue-resident CD4 T cells and correlated with viral loads and CD4 T cell loss. (bvsalud.org)
  • The white blood cells can also build up to form solid masses (nodular lymphoid hyperplasia), usually in the moist lining of the airways or intestines. (medlineplus.gov)
  • Overactive PI3K-delta signaling can also stimulate the abnormal proliferation of white blood cells, leading to lymphadenopathy and nodular lymphoid hyperplasia in some affected individuals. (medlineplus.gov)
Specificity1
  • The tissues that have evolved to a high degree of specificity of function are termed lymphoid organs . (brainkart.com)
Transplantation2
Digestive1
  • In the same way, the immune system tissues are strategically distributed throughout the body, particularly at those points where pathogens can most easily gain entry to the body such as the respiratory and digestive tract mucosae. (pearson.com)
Liver2
  • Dysbiosis within this homeostasis in the gut microbiota is associated with a multitude of health conditions affecting not only gut, but also distal organs like mouth, lung, brain, liver, vagina, etc. (frontiersin.org)
  • The lymphatic system is unique, in that it is a 1-way system that returns lymph fluid via vessels to the cardiovascular system for eventual elimination of toxic byproducts by end organs, such as the kidney, liver, colon, skin, and lungs. (medscape.com)
Epithelial1
  • Hereâ s What You Need To Know: The 4 basic body tissue types (epithelial, connective, muscle, and nervous tissues) and their functions. (pearson.com)
Lymphatic organs1
  • Although certain body organs (lymphatic organs and blood vessels) are intimately involved with the immune response, the immune system is a functional system rather than an organ system in an anatomical sense. (nutters.com)
GALT2
  • The GALT is made up of lymph tissue scattered throughout the GI tract including the tonsils and intestines. (petplace.com)
  • These data support a model in which caspase-1-mediated pyroptosis is the principal mechanism that results in CD4 T cell loss in the GALT and lymphoid organs and release of proinflammatory cytokines. (bvsalud.org)
Peyer's Patches1
  • Lymphoid organs include the gut-associated lymphoid tis-sues-tonsils, Peyer's patches, and appendix-as well as aggre-gates of lymphoid tissue in the submucosal spaces of the respiratory and genitourinary tracts. (brainkart.com)
Symptoms3
  • When symptoms of MALTomas are present, they are nonspecific and are related to the organs involved. (medscape.com)
  • They can also cause lesser degrees of limitations in two or more organs or body systems, and when associated with symptoms or signs, such as severe fatigue, fever, malaise, diffuse musculoskeletal pain, or involuntary weight loss, can also result in extreme limitation. (ssa.gov)
  • Observation is recommended for patients with advanced disease until they develop systemic symptoms or disease that threatens organ function. (medscape.com)
Vessels4
  • Small organs shaped like beans, which are located all over the body and connect via the lymphatic vessels. (uhhospitals.org)
  • Lymph nodes - Small organs shaped like beans, which are located throughout the body and connect via the lymphatic vessels. (malaghan.org.nz)
  • It is a dark red organ that is supplied with numerous blood vessels. (petplace.com)
  • The lymphatic system actually consists of two semi-independent parts: (1) a meandering network of lymphatic vessels and (2) various lymphoid tissues and organs scattered throughout the body. (nutters.com)
Connective tissue disorders1
  • They are sometimes referred to as rheumatic diseases, connective tissue disorders, or collagen vascular disorders. (ssa.gov)
Soft tissue5
  • It may involve the soft tissue, lacrimal gland, periosteum, or bones of the orbital wall. (koreamed.org)
  • Hemangiosarcoma is a relatively deadly cancer most often classified separately from other soft tissue sarcomas because of its more aggressive behavior. (wearethecure.org)
  • The most commonly recommended treatment for soft tissue sarcomas is surgical excision with wide margins. (wearethecure.org)
  • The predicted outcome or life expectancy for dogs with soft tissue sarcomas is highly variable. (wearethecure.org)
  • There may be a positive outcome for many soft tissue sarcomas if the mass can be removed with wide surgical margins. (wearethecure.org)
Body's2
  • Immune system disorders may result in recurrent and unusual infections, or inflammation and dysfunction of the body's own tissues. (ssa.gov)
  • 2. Autoimmune disorders (14.00D) . Autoimmune disorders are caused by dysfunctional immune responses directed against the body's own tissues, resulting in chronic, multisystem impairments that differ in clinical manifestations, course, and outcome. (ssa.gov)
Blood5
  • Lymph is collected from the fluid of various tissues and eventually is returned to the blood circulatory system. (petplace.com)
  • The lymphatic system provides another route by which fluid can flow from distant tissues back into the blood stream, one that is separate from capillaries and veins. (petplace.com)
  • It also carries proteins and other substances away from tissues that cannot be removed or transported directly into the blood system. (petplace.com)
  • lymphoid system returns the same amount of interstitial sluid to the blood stream. (freezingblue.com)
  • The immune privilege of tissues is ascribed not only to the physiological blood-tissue barrier, but the local expression of Fas ligand (FasL). (medsci.org)
BODY6
  • Immune system disorders can cause a deficit in a single organ or body system that results in extreme (that is, very serious) loss of function. (ssa.gov)
  • It is important to understand the influence of gut microbiota and metabolites produced by them on the functioning of various organs within the body (Figure 1 ). (frontiersin.org)
  • A condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. (hivedmonton.com)
  • There are several parts of the human body that make up your immune system, but together they are known as the lymphoid organs and tissues. (heinens.com)
  • As the largest avascular organ in the human body, the intervertebral disc is isolated from the host immune system [ 8 ]. (medsci.org)
  • Some people with activated PI3K-delta syndrome develop autoimmunity, which occurs when the body attacks its own tissues and organs by mistake. (medlineplus.gov)
Tropism1
  • We hypothesized that blocking access to distinct lymphoid priming sites may alter the specific organ tropism and prevent aGVHD development. (nih.gov)
Lung2
  • The metabolites produced by them not only modulate gastro-intestinal immunity, but also impact distal organs like lung and brain. (frontiersin.org)
  • Apart from intestinal disorders (diabetes, obesity, colon cancer, inflammatory bowel disease, etc.), changes in dietary patterns and their effects on gut microbiota are implicated in disorders of other organs like lung (asthma, COPD, etc. (frontiersin.org)