AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsNamed GroupsHealth Care
Reperfusion InjuryMyocardial Reperfusion InjuryIschemiaReperfusionMyocardial IschemiaMyocardial ReperfusionBrain IschemiaIschemic PreconditioningMyocardiumIschemic Preconditioning, MyocardialRats, Sprague-DawleyRats, WistarDisease Models, AnimalMyocardial InfarctionIschemic PostconditioningCardiotonic AgentsWarm IschemiaTime FactorsPeroxidaseCold IschemiaProtective AgentsMalondialdehydeIschemic Attack, TransientMyocytes, CardiacHeartMice, Inbred C57BLInfarction, Middle Cerebral ArteryOxidative StressApoptosisPerfusionNeuroprotective AgentsKidneyNecrosisCoronary CirculationMitochondria, HeartL-Lactate DehydrogenaseSpinal Cord IschemiaCreatine KinaseLiverRandom AllocationConstrictionHemodynamicsMyocardial ContractionCytoprotectionSuperoxide DismutaseMice, KnockoutNeutrophil InfiltrationReactive Oxygen SpeciesAntioxidantsDogsTioproninGerbillinaeMyocardial StunningNitric OxideModels, AnimalAspartate AminotransferasesOrgan PreservationOrgan Preservation SolutionsAcute Kidney InjuryOrgan TransplantationAlanine TransaminaseIntestinesMicrocirculationVentricular Function, LeftRabbitsHindlimbHydroxy AcidsDecanoic AcidsFree Radical ScavengersIn Situ Nick-End LabelingCerebral InfarctionBrainSignal TransductionCaspase 3Heme Oxygenase-1ImmunohistochemistryBlotting, WesternMesenteric Artery, SuperiorEnzyme InhibitorsCerebrovascular CirculationHeart Arrest, InducedCell DeathNeutrophilsCardioplegic SolutionsRats, Inbred LewAdenosineRNA, MessengerFree RadicalsLiver DiseasesLipid PeroxidationTissue and Organ ProcurementCells, CulturedVentricular PressureSwineCoronary VesselsOxygenTourniquetsBrain EdemaHeart Function TestsLiver Transplantation
Exposed to ischemia-reperfusion injuryRenalRatsDysfunctionHypoxiaLiverTherapeuticHepaticIschemicInflammationTissuesApoptosisVascularInducesInjuriesAnti-apoptoticAvailable for transplantationCellularStreptozotocinMechanismsCardiac arrestOutcomesKidneysInhibitionMyocardiumSerumExtracellularShockClinicallyAbdominalInadequateLungSubsequentTransplantReoxygenationNitric OxideEffectsReactiveResuscitationAcute kidneyDamageMetabolismKidney transplantationImmune responseMitigateHeartTransplantation procedures
Exposed to ischemia-reperfusion injury1
  • citation needed] While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (wikipedia.org)
Renal17
  • Renal ischemia/reperfusion injury (IRI) may influence distance organ such as lung. (phypha.ir)
  • The aim of this study was to determine gender differences in renal IR inducedlung injury in different reperfusion time. (phypha.ir)
  • Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
  • The renal MDA level of male increased during 3h reperfusion but not seen in females. (phypha.ir)
  • The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
  • Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
  • Nacetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat. (phypha.ir)
  • Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. (phypha.ir)
  • Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
  • Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
  • 15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
  • The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
  • Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
  • Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
  • Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
  • Paul Morrissey, MD is interested in outcomes after renal transplantation for organ donors and recipients. (lifespan.org)
  • This paradox, known as the pH paradox, is the driving mechanism behind reperfusion injury following cardiac, renal or cerebral ischemia . (tocris.com)
Rats6
  • Effect of acetylcholine and ischaemia/reperfusion injury on the heart of rats with STZ-induced experimental diabetes. (nel.edu)
  • Knezl V, Kysel'ová Z, Zúrová-Nedelcevová J, Navarová J, Tribulová N, Drímal J. Effect of acetylcholine and ischaemia/reperfusion injury on the heart of rats with STZ-induced experimental diabetes. (nel.edu)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and the possible mechanism. (iasp-pain.org)
  • ObjectiveThe aim of this study was to investigate (a) macrophage migration inhibitory factor (MIF) levels in polytrauma patients and rats after haemorrhagic shock (HS), (b) the potential of the MIF inhibitor ISO-1 to reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-term follow-up) HS rat models and (c) whether treatment with ISO-1 attenuates NF-kappa B and NLRP3 activation in HS. (unito.it)
  • Rats were subjected to Pringle maneuver (total hepatic ischemia) for 20 min with (HxIR) or without (IR) 70% hepatectomy. (bepress.com)
Dysfunction9
  • Pulmonary injury leading to early allograft dysfunction is caused by ischemia-reperfusion injury (IR) and originates from multiple pathogenic events, including endothelial damage, neutrophil extravasation into tissue, and peroxidation of cell membrane lipids, followed by pulmonary cell alterations and edema. (nih.gov)
  • Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10-12 week old) and aged (16-18 month old) mice against polymicrobial infection, organ dysfunction, and death. (nature.com)
  • This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
  • When there is increased demand in the setting of inflammation, ischemia-reperfusion injury, and organ dysfunction, endogenous arginine production falls short, and external supplementation may be necessary. (nih.gov)
  • They include ischemia and reperfusion injury, systemic inflammation, and vascular dysfunction. (medscape.com)
  • Upon blood reperfusion, circulation of disabling substances causes organ dysfunction. (screen.co.jp)
  • ConclusionOur results point to a role of MIF in the pathophysiology of trauma-induced organ injury and dysfunction and indicate that MIF inhibitors may be used as a potential therapeutic approach for MODS after trauma and/or haemorrhage. (unito.it)
  • We are now further exploring these observations, testing the basic hypotheses that ERK1/2 and ERK5 regulate TLR-dependent and TLR-independent activation of endothelial inflammatory pathways and contribute to endothelial dysfunction in septic shock and organ failure. (ucsf.edu)
  • Shock Shock is a state of organ hypoperfusion with resultant cellular dysfunction and death. (msdmanuals.com)
Hypoxia5
  • Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. (wikipedia.org)
  • The pathophysiological nature of MIRI is the short-term disturbance of myocardial energy and metabolism caused by reflow after ischemia and hypoxia in the coronary artery and the dynamic changes in apoptosis and the prosurvival signaling pathways in response to related injury factors. (hindawi.com)
  • The primary ischemia/hypoxia injury and secondary reperfusion injury are mainly caused by oxidative stress, which caused by hypoxia, such as free radical generation, energy metabolism disorder, intracellular calcium overload, excitatory amino acid release and inflammatory reaction. (iasp-pain.org)
  • Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). (elifesciences.org)
  • Hypoxia associated with OSA leads to hypoxia-reoxygenation with ischemia- reperfusion injury . (medscape.com)
Liver21
  • Liver ischemia/reperfusion (IR) often affects distant organs, such as small intestine, kidney, and lung. (rjme.ro)
  • In conclusion, it was observed that liver IR caused changes in distant organs, especially in the small intestine, lung, and kidneys. (rjme.ro)
  • The malfunction of an organ system can be corrected with transplantation of an organ (eg, kidney, liver, heart, lung, or pancreas) from a donor. (medscape.com)
  • The heart, kidneys, and liver are highly vascular organs and transplantation leads to a vigorous cell-mediated response in the host. (medscape.com)
  • Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (wikipedia.org)
  • I am currently investigating the mechanism of post-translational modifications in immune response during liver ischemia-reperfusion injury. (stanford.edu)
  • Revive's cannabinoid pharmaceutical portfolio focuses on rare inflammatory diseases and the company was granted FDA orphan drug status designation for the use of Cannabidiol (CBD) to treat autoimmune hepatitis (liver disease) and to treat ischemia and reperfusion injury from organ transplantation. (biospace.com)
  • Specifically, the researchers from Dresden, München, Regensburg and Essen aim to identify and validate common ferroptotic signatures and molecular mechanisms in organs mostly affected by IRI such as brain, liver, lung and kidney. (tu-dresden.de)
  • The liver is one of the only organs in the body that is able to replace damaged tissue with new cells rather than scar tissue. (jonbarron.org)
  • Ischemia/reperfusion (I/R) is a predominant cause of hepatic injury, which is of clinical significance following liver surgery, hemorrhagic shock and liver transplantation ( 1 ). (spandidos-publications.com)
  • Participants Over 5500 solid organ transplant recipients have been enrolled in all six Swiss transplant centres by end of 2019, around three-quarter of them for kidney and liver transplants. (bmj.com)
  • Liver diseases are known to affect the function of remote organs. (bepress.com)
  • it is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. (uthscsa.edu)
  • The spleen is the organ damaged most commonly, followed by the liver and a hollow viscus (typically the small intestine). (msdmanuals.com)
  • The liver is the second most commonly transplanted major organ, after the kidney. (medscape.com)
  • The need for liver transplants currently far eclipses the supply of available donor organs. (medscape.com)
  • According to 2014 statistics from the United Network for Organ Sharing (UNOS), the waiting list now has approximately 15,500 patients awaiting a liver transplant. (medscape.com)
  • 1] Despite considerable efforts to increase the supply of available organs from deceased donors, the total number of liver transplants has remained fairly constant at 6200-6400 liver transplants per year over the last 10 years. (medscape.com)
  • As most commonly performed, split-liver transplantation (SLT) involves the division of donor liver from a deceased adult between a pediatric recipient and an adult recipient to maximize the benefit of each available donor organ. (medscape.com)
  • In 1984, Bismuth and Houssin reported successful transplantation of a reduced-size liver in which only a portion of the donor organ was used and the remaining liver discarded. (medscape.com)
  • Split-liver transplantation takes advantage of the knowledge gained in reduced-liver transplantation to increase the organ supply by using the right lobe or trisegmental graft that remains after the left lateral segment or left lobe is removed for a pediatric recipient. (medscape.com)
Therapeutic4
  • This coupled comorbidity of pathological ischemia and therapeutic reinjury of infarcted myocardium, namely, myocardial ischemia-reperfusion injury (MIRI), is particularly refractory to treatment [ 4 , 5 ]. (hindawi.com)
  • February 6, 2012 (Boston, Massachusetts) - Therapeutic hypothermia can help preserve the brain during cardiac arrest, so maybe it could protect organs throughout the body in other conditions that threaten their blood supply--such as cardiogenic shock. (medscape.com)
  • November 29 - Scientists have designed targeted nanoparticles to aid the therapeutic delivery of drugs directly to organs. (tts.org)
  • The goals are to further delineate the downstream pathways leading to coagulopathy and organ failure, and identify potential therapeutic targets to mitigate these deleterious outcomes without negatively impacting bacterial clearance. (ucsf.edu)
Hepatic4
  • Specifically, she is interested in the GLP- 1 receptor and its role in hepatic steatosis, apoptosis and autophagy in the setting of ischemia reperfusion injury. (choa.org)
  • However, the effect of GP on ischemia/reperfusion (I/R)-induced hepatic injury has, to the best of our knowledge, not previously been investigated. (spandidos-publications.com)
  • In addition, certain pro-inflammatory chemokines and cytokines are key during the initial period of reperfusion, whereas the late period of hepatic injury is neutrophil-mediated ( 3 ). (spandidos-publications.com)
  • The aim of the present study was to investigate the effects of Pringle maneuver, which results in hepatic ischemia-reperfusion (IR) injury, and partial hepatectomy (Hx) on the pharmacokinetics and brain distribution of sodium fluorescein (FL), which is a widely used marker of blood-brain barrier (BBB) permeability. (bepress.com)
Ischemic8
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
  • The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
  • Our current projects are focused on: 1) Rescue and Role of Complex I in Myocardial Ischemic Injury 2) Subcellular Regulation of Autophagy 3) Mitochondria and Stem Cells in Anthracycline-Induced Heart Failure 4) Development of Small-Molecular Cardioprotective Agents for Treatment of Reperfusion Injury and 5) Microbial Basis of Cardiovascular Disease. (pewtrusts.org)
  • When after an ischemic event reperfusion is induced, which happens for instance during organ transplantation or resuscitation after cardiac arrest, this reperfusion can paradoxically cause additional damage to the affected tissue. (tu-dresden.de)
  • Remote ischemic preconditioning (RIPC) protects organs from ischemia-reperfusion injury. (bvsalud.org)
Inflammation3
  • An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
  • An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
  • However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
Tissues3
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • Transplantation is the act of transferring cells, tissues, or organs from one site to another, typically between different individuals. (medscape.com)
  • If biological tissues are exposed to body temperature without blood flow (warm ischemia), cellular homeostasis is not maintained due to the lack of oxygen and nutrients, and so disabling substances are released outside the cell. (screen.co.jp)
Apoptosis3
  • Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
  • 11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
  • We use a range of approaches including cell biology, organ physiology, biochemistry and molecular biology to understand the intracellular processes that determine whether the cardiac cells will survive and repair, or undergo programmed cell death through apoptosis or necrosis. (pewtrusts.org)
Vascular5
  • The influence of low dose streptozotocin diabetes on intestinal and vascular injury induced by mesenteric ischaemia/reperfusio. (nel.edu)
  • The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)
  • The Hellman Group studies TLR-dependent pathways expressed by macrophages as well as non-conventional inflammatory cells, including endothelial cells, in Inflammatory Critical Illness, focusing on their roles in coagulopathy, vascular permeability, neutrophil trafficking to organs, and organ injury and failure. (ucsf.edu)
  • 4. The effects of TLR2 activation on the vascular endothelium, including on endothelial inflammatory responses, leucocyte trafficking, coagulation pathways and permeability: Endothelial cell (EC) activation, coagulopathy, and vascular leak contribute to sepsis-induced organ failure. (ucsf.edu)
  • Hemorrhage due to low-grade solid organ injury, minor vascular laceration, or hollow viscus laceration is often low-volume, with minimal physiologic consequences. (msdmanuals.com)
Induces1
Injuries5
  • Polytrauma can be defined as a combination of multiple, simultaneous injuries to more than one body part or organ system. (medsci.org)
  • Injuries secondary to ischemia and cold preservation are mitigated. (sages.org)
  • Such ischemia-reperfusion injuries (IRI) are a serious complication, responsible for a variety of clinically important conditions including stroke and acute kidney injury. (tu-dresden.de)
  • 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
  • Penetrating injuries may or may not penetrate the peritoneum and, even if they do, they may not cause organ injury. (msdmanuals.com)
Anti-apoptotic1
  • Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. (researchgate.net)
Available for transplantation2
  • This new technique, ex vivo normothermic machine perfusion (NMP) could increase the number of viable organs available for transplantation. (tts.org)
  • Although this technique was successful in increasing the number of pediatric transplants, it did not increase the total number of organs available for transplantation. (medscape.com)
Cellular5
  • citation needed] Systemic effects of IR injury During periods of ischemia, cellular break down products accumulate in the local tissue. (wikipedia.org)
  • Once reperfusion occurs, these cellular products are returned to the systemic circulation, and are exposed to other organs. (wikipedia.org)
  • Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. (elifesciences.org)
  • By understanding the links between Ca2+, electrical excitability and energy production, we hope to understand the cellular basis of cardiac arrhythmias, ischemia-reperfusion injury, and sudden death. (hopkinsmedicine.org)
  • Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. (springeropen.com)
Streptozotocin2
  • Ischaemia/reperfusion-induced organ injury in low dose streptozotocin diabetes. (nel.edu)
  • To create an experimental model of associated comorbidities, for healing and regeneration studies, protocols for induction of nephropathy by ischemia and reperfusion (I/R) and induction of DM by injection of streptozotocin (STZ) were associated. (scielo.br)
Mechanisms5
  • These mechanisms are also involved in the rejection of transplanted organs, which are recognized as foreign by the recipient's immune system. (medscape.com)
  • Knowledge of these mechanisms is also critical in developing strategies to minimize rejection and in developing new drugs and treatments that blunt the effects of the immune system on transplanted organs, thereby ensuring longer survival of these organs. (medscape.com)
  • While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and have inadequately understood mechanisms. (hindawi.com)
  • However, while myocardial reperfusion is well established, the process itself can trigger myocardial reperfusion injury by causing further cardiomyocyte death through multiple pathophysiological mechanisms [ 3 - 5 ]. (hindawi.com)
  • Conceptual diagram of the development and unknown mechanisms of myocardial ischemia-reperfusion injury. (hindawi.com)
Cardiac arrest1
Outcomes1
  • The Food and Drug Administration (FDA) is announcing a public workshop to discuss the effects of ischemia/ reperfusion injury ( IRI ) on outcomes in kidney transplantation. (myast.org)
Kidneys3
  • Coincident with Rhode Island Hospital's experience in altruistic kidney donation and a large experience in utilizing kidneys from donors after cardiac death (DCD), he has written and lectured about safely expanding organ donation and transplantation. (lifespan.org)
  • SCREEN will place the medical device on the market and continue research and development, aiming to expand the intended for use to organs other than kidneys. (screen.co.jp)
  • This product has been notified to the authority as a medical device, and SCREEN will manufacture and market the product, and is planning to conduct research and development aiming to expand the product's application to organs other than kidneys. (screen.co.jp)
Inhibition1
  • In support of the integral involvement of NHE activity during organ ischemia, NHE1 inhibition has been shown to exert a protective effect during cardiac ischemia . (tocris.com)
Myocardium1
  • CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (medscape.com)
Serum1
  • A significant increment was seen in female serum level of nitrite compared with males after 3h reperfusion. (phypha.ir)
Extracellular2
Shock3
  • Cooling the whole body should have effects on multiple pathways and multiple organs that might be affected by the shock state. (medscape.com)
  • Cardiogenic shock in the MI setting was usually fatal until the advent of acute reperfusion therapy with balloon angioplasty, but even today with modern PCI and intra-aortic balloon pumping, mortality is about 50%, note the viewpoint's authors, led by Dr Brian M Stegman (Duke University Medical Center, Durham, NC). (medscape.com)
  • Cooling the whole body should have effects on multiple pathways and multiple organs that might be affected by the shock state and help temporize things until you can stabilize the patient, warm them back up, and avoid that period of injury. (medscape.com)
Clinically1
  • The ischemia-reperfusion injury associated with surgical tourniquets is typically not clinically apparent when used for less than two hours. (wikipedia.org)
Abdominal1
  • Penetrating trauma to the chest below the fourth intercostal space (or nipple line) should also be evaluated as a potential abdominal wound because of the location of abdominal organs within the chest during the respiratory cycle. (msdmanuals.com)
Inadequate1
  • Ischemia": an inadequate blood supply to an organ or part of the body. (wikipedia.org)
Lung2
Subsequent1
  • Persons with SCD produce abnormal hemoglobin that causes erythrocytes to become rigid and deform under low oxygen conditions, leading to ischemia-reperfusion injury in the microvasculature with subsequent organ damage and pain. (cdc.gov)
Transplant3
  • My current research focus is biomarker discovery of graft rejection in solid organ transplant patients and studying natural killer cells in viral infection using omics methods including Mass Cytometry and Next Generation Sequencing. (stanford.edu)
  • Additionally, Dr. Gupta is interested in the area of adolescent post-transplant care and transition and solid organ donations. (choa.org)
  • To connect the artery, vein, or the ureter of a donor organ to the recipient side in transplant surgery. (screen.co.jp)
Reoxygenation1
  • The resuscitation after an HS causes a reperfusion or reoxygenation insult [ 2 - 4 ], gut injury, and multiple organ dysfunctions [ 5 , 6 ]. (medsci.org)
Nitric Oxide1
  • Serial perioperative blood samples were collected for quantification of amino acids, arginase, nitric oxide metabolites, and markers of organ function (lactate, Pao 2 /Fio 2 ratio, and creatinine clearance). (nih.gov)
Effects3
  • Protection of the heart against injury from acute ischemia remains challenging for emergency physicians and cardiologists because there are no therapies proven to directly protect the heart against the deleterious effects of ischemia in humans. (mcw.edu)
  • Rhizoma Dioscoreae polysaccharides (RDPS) are the primary active ingredient of RD. Modern medical research confirmed RDPS has multiple pharmacological effects, including neuroprotection, immunoregulation, antioxidant effect in many organs. (iasp-pain.org)
  • Research in our lab has incorporated mitochondrial energetics, Ca2+ dynamics, and electrophysiology to provide tools for studying how defective function of one component of the cell can lead to catastrophic effects on whole cell and whole organ function. (hopkinsmedicine.org)
Reactive2
  • Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
Resuscitation1
  • A resuscitation from an HS regards as a reperfusion insult which may induce neurological injury in patients with an UCCAO disease. (medsci.org)
Acute kidney1
Damage8
  • Sterile inflammatory insults, such as ischemia-reperfusion (I/R) injury, result from pathogenic factors, including damage-associated molecular pattern signaling, activation of innate immunity, and upregulation of proinflammatory cytokines. (usuhs.edu)
  • CaMKIV knockout mice experience significantly worse organ damage after I/R and are deficient in hepatocyte autophagic signaling. (usuhs.edu)
  • Restoration of autophagic signaling with rapamycin reduces organ damage in CaMKIV knockout mice to wild-type levels. (usuhs.edu)
  • In conclusion, the protective autophagic signaling pathway serves to reduce organ damage following I/R and is regulated by activation of CaMKIV signaling in hepatocytes. (usuhs.edu)
  • Proinflammatory cytokines (TNF-α, MIP-1, i-NOS) were decreased significantly and restoration of tissue damage was observed in all organs. (nature.com)
  • Sickle cell disease (SCD) disproportionately affects Black or African American persons in the United States and can cause multisystem organ damage and reduced lifespan. (cdc.gov)
  • The most relevant goal, they write, would be to "improve cardiac function and hemodynamics and reduce end-organ damage from prolonged hypoperfusion. (medscape.com)
  • These cells are particularly vulnerable to ischemia-reperfusion injury and damage from antidonor antibodies. (tts.org)
Metabolism1
  • Dr. Maria Fedorova, leader of the research group "Lipid Metabolism: Analysis and Integration" at the Center of Membrane Biochemistry and Lipid Research (ZML) at the Faculty of Medicine of TUD, is the project coordinator of the FERROPath consortium ( Ferroptosis as a common underlying pathomechanism in tissue ischemia/reperfusion injury ) that will be funded by the Bundesministerium für Bildung und Forschung (BMBF) from July 2022 for 3 years. (tu-dresden.de)
Kidney transplantation1
  • Made of a special gel material, this thermal isolation bag is an instrument shaped like a drawstring pouch bag and wraps an organ to be transplanted during kidney transplantation to properly hold it, blocking contact heat and physical stimuli from the surgeons or patient. (screen.co.jp)
Immune response1
  • The degree of immune response to a graft depends partly on the degree of genetic disparity between the grafted organ and the host. (medscape.com)
Mitigate1
  • To mitigate obligate reperfusion injury in VCA, we evaluate the efficacy of a novel normothermic hyperbaric oxygen warm ex-vivo perfusion strategy using hyperoxygenated University of Wisconsin (UW) solution in a porcine VCA model. (sages.org)
Heart3
  • These findings could help develop new treatments for diseases caused by a limited blood supply to human organs, such as a stroke or heart attack. (elifesciences.org)
  • Our research is focused on developing ways to protect the heart after ischemia and reperfusion. (pewtrusts.org)
  • We use the heart as our primary model organ but conduct many studies in cell lines or primary cell culture, using fluorescence microscopy to monitor intracellular processes in real-time in living cells. (pewtrusts.org)
Transplantation procedures1
  • The clinical trial is expected to confirm that OrganPocket provides greater reliability in organ protection during transplantation procedures. (screen.co.jp)