RegenerationDifferentiationMesenchymalBMPsTarget genesRecombinantEmbryonicReceptorPhysiologicalPathwaysSox9Normal tissuesCartilageCellExtracellularTendonsJoint tissuesSomatic cellsCandidate genesConnective tissue dUndetectableSelf-renewalTranscriptionalResorptionArticularDefectsEncodesSecretoryMutationsOncogenesCongenitalPhenotypicVitroMiceActivates transcriptionApoptosisInhibitsCollagen fibrilsDevelopmentalScaffoldsHomologyRolesDevelopmentFibrosisManifest2022TumorSkeletalCellsAlterationsPancreasTranscriptionRegenerativeAdultMolecularCharacteristicKinaseMammary glandTendon
Regeneration16
- Its wide-ranging biological effects may include the reversal of senescence in clinical applications, as well as the ability to reverse age-related pathological changes and regulate organ regeneration after injury. (wikipedia.org)
- Although different stem cells, morphogens and scaffolds can be combined to simulate natural odontogenic regeneration, it is crucial to determine which options most closely replicate the characteristics of human dental tissues. (scielo.br)
- Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)
- Regeneration of large bone defects is a common clinical problem. (dovepress.com)
- Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
- Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
- She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
- So, the research on renal tissue repair and regeneration has ignited a new field of study that focuses on various regenerative options. (biomedcentral.com)
- Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
- Bone Selleckchem SU5402 regeneration in the alveolar process and dental implant are widely used and there are a lot of different products. (chk-signal.com)
- It's conclude that calcium sulfate can be used in bone reparation of minor defects and the biological membrane can be used in guide bone regeneration with success. (chk-signal.com)
- The expression of Prx1 has been used as a marker to define the skeletal stem cells (SSCs) populations found within the bone marrow and periosteum that contribute to bone regeneration. (researchgate.net)
- The aim of this study was to compare the potential of human BMSC cultured as 2D monolayers or 3D spheroids encapsulated in constructs of 3D-printed poly-L-lactide-co-trimethylene carbonate scaffolds and modified human platelet lysate hydrogels (PLATMC-HPLG) for bone regeneration. (biomedcentral.com)
- Bone regeneration was assessed via in vivo computed tomography (CT), ex vivo micro-CT and histology. (biomedcentral.com)
- The endothelial to mesenchymal transition (EndMT) is a newly recognized, fundamental biological process involved in development and tissue regeneration, as well as pathological processes such as the complications of diabetes, fibrosis and pulmonary arterial hypertension. (bmbreports.org)
- However, no satisfactory solution has yet been found for regeneration of big, and so-called critical, bone losses. (mdpi.com)
Differentiation25
- Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is encoded by the growth differentiation factor 11 gene. (wikipedia.org)
- An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
- Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
- The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
- Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)
- To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)
- The results showed that MSC did not alter their osteogenic differentiation capacity, surface marker profile, and the expression profiles of MSC during expansion. (biomedcentral.com)
- Microarray analysis of MSC during osteogenic differentiation identified three candidate genes for further examination and functional analysis: ID4, CRYAB, and SORT1. (biomedcentral.com)
- Finally we analyzed the gene expression profiles of MSC during osteogenic differentiation. (biomedcentral.com)
- In the early stage of adipocyte differentiation, ERK1/2 promotes adipocyte differentiation by promoting the expression of C/EBPα and PPARγ. (cusabio.com)
- Inhibition of the p38 MARK pathway down-regulates the activity of protein kinase C ( PKC ), which plays an important role in osteogenic differentiation of cells. (cusabio.com)
- Among them, Runx2 is a key target gene affecting osteogenic activity, and Cbfa1 regulates the differentiation of MSCs into osteoblasts at the transcriptional level. (cusabio.com)
- The p38 signaling pathway regulates the differentiation direction of stem cells, which may be related to the regulation of the stability of p53 protein [3] [4] . (cusabio.com)
- WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
- During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
- In some cases, "master" genes have been described which control differentiation versus self-renewal. (justia.com)
- Prior studies of acute phosphate restriction during the endochondral phase of fracture healing showed delayed chondrocyte differentiation was mechanistically linked to decreased bone morphogenetic protein signaling. (researchgate.net)
- Iroquois transcription factor gene IRX3 is highly expressed in 20â€"30\% of acute myeloid leukemia (AML) and contributes to the pathognomonic differentiation block. (diagenode.com)
- Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). (biomedcentral.com)
- PLATMC-HPLG constructs with 2D or 3D BMSC were assessed for osteogenic differentiation based on gene expression and in vitro mineralization. (biomedcentral.com)
- Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
- Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
- Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. (uchicago.edu)
- Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. (uchicago.edu)
- Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. (uchicago.edu)
Mesenchymal8
- Modifications of gene manifestation in the embryonic thymi of MafB-deficient mice included the decreased manifestation of Wnt3 and BMP4 in mesenchymal cells and of CCL21 and CCL25 in epithelial cells. (academiaperuanadepsicologia.org)
- Several investigators possess reported that neural crestCderived mesenchymal cells critically regulate the development and advancement of thymic epithelial cells26 by secreting substances, including Wnts, bone tissue morphogenetic protein (BMPs), and fibroblast development elements (FGFs).27C30 However, the transcriptional mechanisms that govern these epithelial-mesenchymal interactions as of this lymphocyte accumulation stage possess continued to be elusive. (academiaperuanadepsicologia.org)
- By testing for genes that are indicated in E11.5 3PPs, we've identified how the transcription factor MafB is strongly expressed in thymic mesenchymal cells instead of thymic epithelial cells or thymocytes. (academiaperuanadepsicologia.org)
- The E11.5 3PP of MafB-deficient mice exhibits decreased expression of several mesenchymal molecules, including BMP4 and Wnt3, and many epithelial molecules, including CCL25 and CCL21, recommending that MafB indicated in thymic mesenchymal cells regulates embryonic thymus advancement in the lymphocyte accumulation stage critically. (academiaperuanadepsicologia.org)
- PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)
- Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
- Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
- Because hydrostatic pressure can be a major factor in chondroinduction of mesenchymal stem cells, it was proposed to investigate the importance of the cytoskeleton in transduction of hydrostatic pressure by C3H10T1/2 murine fibroblasts, a model of primary bone marrow mesenchymal stem cells. (openorthopaedicsjournal.com)
BMPs5
- Mutations in the protein hemojuvelin are the most common cause of juvenile hemochromatosis, and recent research has demonstrated a key role for hemojuvelin in regulating hepcidin expression in the liver, primarily through incompletely defined interactions with bone morphogenetic proteins (BMPs), growth factors with multiple effects on growth, development, and tissue repair. (ohsu.edu)
- Research in this paper demonstrates direct actions of hemojuvelin on several classes of BMPs, and shows that soluble naturally occurring forms of hemojuvelin can inhibit binding of BMP2 and BMP6 to their cell-surface receptors, thus antagonizing BMP-mediated signaling pathways and blocking BMP-stimulated gene expression in liver cells. (ohsu.edu)
- Besides showing that in different cellular contexts hemojuvelin exerts differential effects on BMP actions, key findings of the paper include the demonstration that soluble hemojuvelin is a novel BMP binding protein, as it interacts with different classes of BMPs, suggesting potential therapeutic uses in other cell and tissue types. (ohsu.edu)
- We discovered hemojuvelin as a novel gene expressed in muscle cells as part of another research project, teamed up with Ujwal Shinde because of his expertise in protein analysis and function, and followed up other observations to study the biochemistry of hemojuvelin's actions on BMPs. (ohsu.edu)
- Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)
Target genes4
- The weighted correlation network analysis (WGCNA) for potential target genes of 3 good prognosis-related DEmiRNAs (miR-135b-5p, miR-9-3p, miR-135b-3p) identified 4 hub genes with highly positive correlation with TNBC subtype: FOXC1, BCL11A, FAM171A1 and RGMA. (nature.com)
- Importantly, the regulatory functions of 4 DEmiRNAs and 3 verified target genes on cell proliferation and migration were explored in TNBC cell lines. (nature.com)
- Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
- We found that 4HPR impairs DU145 and PC3 prostate cancer cells migration and invasion by down-regulating FAK and AKT activation and by enhancing β-catenin degradation, causing the downregulation of target genes like cyclin D1, survivin and VEGF. (biomedcentral.com)
Recombinant3
- Recombinant human bone morphogenetic protein 2 (rh. (researchgate.net)
- Recombinant human bone morphogenetic protein 2 (rhBMP2) is a. (researchgate.net)
- The expression of Recombinant adenovirus IkappaBalphaM in human hepatocarcinoma HepG2 and it's inhibitive effect to the activity of NF-kappaB]. (uchicago.edu)
Embryonic4
- Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
- Prx1 expression also connotes calvaria and appendicular tissues during embryonic develop. (researchgate.net)
- Totipotent stem cells contain all the constituents necessary to produce a living being, given that these cells can supply all embryonic and extraembryonic tissues required for proper growth (Can/Hematol 2008). (papersowl.com)
- The methodology included inducing differentiated somatic cells with the primary genes responsible for embryonic stem cell potency. (papersowl.com)
Receptor5
- Human apelin was identified and isolated in 1998 as an endogenous ligand of the G-protein-coupled receptor APJ and was named the APJ endogenous ligand. (encyclopedia.pub)
- Six compounds (cyclamic acid, perfluoroalkylic carboxylic acids, perfluorosulfonic acid, alpha-linolenic acid, adenosine receptor antagonist (CGS 15943), and Prodigiosin) present in M. bealei serum may exhibit therapeutic effects against alcoholic HCC by downregulating CDK1 and TOP2A expression levels in vitro. (bvsalud.org)
- The main process of this pathway: the growth factor activates the receptor by binding to the tyrosine kinase receptor, and the activated tyrosine kinase receptor activates the Ras protein, then the Ras protein phosphorylates the Raf, and the activated Raf phosphorylates the downstream MEK. (cusabio.com)
- Mutations in bone morphogenetic protein receptor 2 ( BMPR2 ) are the cause of most heritable cases but the vast majority of other cases are genetically undefined. (biomedcentral.com)
- For example, bone morphogenetic protein receptor type 2 ( BMPR2 ) mutations are observed in 60-80% of familial (FPAH) cases, but data from population registries indicate that penetrance of the disease phenotype ranges from 14 to 42% [ 6 ]. (biomedcentral.com)
Physiological2
- Being a dynamic and steady variable, expression modifications using the developmental and physiological states. (plasignaling.com)
- because the only way to decipher what is going on is to work backwards, from morphogenetic/physiological events to the underlying genes involved. (scienceblogs.com)
Pathways5
- Coinciding with this, metazoans evolved complex plasma membrane machines containing adhesome proteins that link the ECM to the cytoskeleton and intracellular signalling pathways. (biologists.com)
- The matrix enables a first-pass checkpoint for growth and developmental signals, it is the vehicle for morphogenetic gradients in development, and it is the spatial rheostat for intracellular signalling pathways. (biologists.com)
- WNT signals are context-dependently transduced to both pathways based on the expression profile of WNT, SFRP, WIF, DKK, Frizzled receptors, coreceptors, and the activity of intracellular WNT signaling regulators. (aacrjournals.org)
- These alterations can take the form of epigenetic modifications, point mutations, translocations, amplifications or deletions and modify gene functions in ways that deregulate cellular signalling pathways leading to the cancer phenotype. (bmj.com)
- Here we show that the Bone Morphogenetic Protein (BMP) and Wnt signaling pathways share Apcdd1 as a common inhibitor and that Apcdd1 is a taxon-restricted gene with novel domains and signaling functions. (xenbase.org)
Sox93
- Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. (uchicago.edu)
- Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair. (uchicago.edu)
- Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells. (uchicago.edu)
Normal tissues2
- Hamartomas are malformations of mucosa, consisting of disorganized normal tissues. (czytelniamedyczna.pl)
- The term of hamartoma corresponds to a non-neoplastic tumour, consisting of disorganized normal tissues and characteristic of the site of manifestation of the tumour. (czytelniamedyczna.pl)
Cartilage3
- ECMs range from pericellular matrices, such as basement membranes, to the grander structures of connective tissue that give organs their shape, and the tendons, cartilage and bones that bestow humans and animals with their form. (biologists.com)
- Signaling mechanisms involved in the regulation of ePPi formation are poorly understood, but adenylyl cyclase activation decreases and protein kinase C activation increases the accumulation of ePPi in media surrounding cartilage or chondrocyte cultures [ 7 ]. (biomedcentral.com)
- However, the current view holds that osteoarthritis involves not only the articular cartilage but the entire joint organ, including the subchondral bone and synovium. (medscape.com)
Cell31
- It has been reported that GDF11 is down-regulated in pancreatic cancer tissue, compared with surrounding tissue, and pancreatic cell lines exhibit a low expression of the growth factor (65). (wikipedia.org)
- An incredibly current finding may perhaps even cast doubt over the utility of MSCs themselves, Medici and colleagues reported that endothelial cells taken care of with either bone morphogenetic protein four or transforming development factor b2 reverted to a multipotent cell with some traits of MSCs, and can be vary entiated into several endodermal cell styles. (plasignaling.com)
- The basic conclusion is that MSCs or their closely relevant cousins can reside in or pass via most tissues, and that this kind of cells may be isolated and/or selelck kinase inhibitor cultured by standard methods this kind of as fluorescence activated cell sorting or plastic adherence, and will be shown to possess multipotency. (plasignaling.com)
- Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
- To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
- To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
- The results indicated that the BMP-2-producing cell sheet group was more efficient than other groups in promoting bone formation in the defect area. (dovepress.com)
- Recently, stem cell- and gene-based therapy has been applied in BTE and achieved some good clinical results. (dovepress.com)
- Cell type and tissue specific alterations in fine GAG structure, which are strictly predetermined [ 8 - 10 ], allow these molecules to modulate with high specificity different cellular processes [ 7 ]. (hindawi.com)
- PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)
- The gene is located on chromosome 12q23 [ 26 ] and regulates transforming growth factor (TGF)-beta 1 activity as well as the cell cycle [ 27 ] . (encyclopedia.pub)
- In vitro experiments confirmed that M. bealei significantly suppressed cell proliferation and migration of HepG2 cells, while downregulating TOP2A and CDK1 expression. (bvsalud.org)
- ECM receptors thus convert both chemical and physical extracellular inputs to determine cell survival, proliferation, migration and tissue-specific gene expression. (biologists.com)
- A book on such a profoundly important topic requires a clear vision of the breadth of the ECM and its roles in development, cell and tissue function and disease. (biologists.com)
- mutations high frequency of IDH1/2 mutations in oligodendrogliomas, astrocytomas and in alteRations in the RB1 pathway in The TET2 gene encodes the -KG- secondary glioblastomas derived thereof low-gRade diffuse gliomas lacking dependent enzyme that catalyses suggests that these tumours share a common genetic alteRations the conversion of 5-methylcytosine to common progenitor cell population. (who.int)
- Conversely, the expression of constitutively active AKT (myr-AKT) overcame the effects of 4HPR and β-catenin-silencing on cell migration. (biomedcentral.com)
- In addition, we found that BMP-2, a 4HPR target with antiangiogenic activity, decreased prostate cancer cell proliferation, migration and invasion by down-regulating the pathway described involving AKT phosphorylation, β-catenin stability and cyclin D1 expression. (biomedcentral.com)
- As a consequence, 4HPR led to the regulation of genes controlling cell proliferation, angiogenesis and metastasis. (biomedcentral.com)
- WNT signals are transduced to the canonical pathway for cell fate determination, and to the noncanonical pathway for control of cell movement and tissue polarity. (aacrjournals.org)
- Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
- Currently, there is no consensus whether there is a single or multiple postnatal stem cell population(s) that contribute to skeletal homeostasis and postnatal bone formation. (researchgate.net)
- Each cell carries this complex collection of regulated genes independently and identically, but the boolean logic circuits produce different outputs varying with the inputs from the environment and the diverging histories of each cell. (scienceblogs.com)
- For instance, there is no code anywhere in the genome that commands the forelimbs to make five and only five digits: instead, a cascade of genes and cell movements produce a patterned tissue that in us contains sufficient mass and is of a size to generate five nuclei of condensing tissue that produce fingers. (scienceblogs.com)
- In order to understand what a particular gene does, you have to understand what all the other genes do, as well as all the details of signaling and cell interactions that are going on, oh, and also, it's entire developmental history, since epigenetic interactions can shape the future behavior of a cell lineage. (scienceblogs.com)
- While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
- Regardless of monolayer or spheroid cell culture, PLATMC-HPLG constructs represent promising scaffolds for bone tissue engineering applications. (biomedcentral.com)
- Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model. (uchicago.edu)
- The ank gene product is one of several cell membrane proteins, including ectonucleoside triphosphate pyrophosphohydrolase enzymes and alkaline phosphatase, that regulate extracellular inorganic pyrophosphate levels and thereby regulate mineralization. (biomedcentral.com)
- A cell membrane protein, ANK, affects ePPi concentrations and the balance of mineralization in articular tissues. (biomedcentral.com)
- Maternal expression at 8 cell stage (A, B) is localized in the animal pole and is frequently unevenly distributed. (xenbase.org)
- Until recently, it was believed that they were tissue-specific…however, this concept has been challenged… (multipotent cells) can differentiate in vitro and in vivo into various cell types not only from the tissue of origin" (Can/Hematol 2008). (papersowl.com)
Extracellular5
- The mechanisms leading to IF/TA in the transplanted kidney include inflammation, activation of renal fibroblasts, and deposition of extracellular matrix proteins. (biomedcentral.com)
- 8 nm).Ppy NPs effectively augment the conductivity, surface roughness, andthickness of BC composites despite reducing scaffolds' transparency.BC-Ppy composites were flexible (up to 10 mM Ppy), maintained theirintricate 3D extracellular matrix-like mesh structure in all Ppy concentrationstested, and displayed electrical conductivities in the range of nativecardiac tissue. (ibecbarcelona.eu)
- BTE aims to combine the cellular ( osteogenic cells), extracellular ( osteoconductive scaffolds) and/or molecular elements ( osteoinductive growth factors) required for bone healing [ 2 ]. (biomedcentral.com)
- The responsible nonsense mutation affects the protein product of ank, resulting in diminished production of extracellular inorganic pyrophosphate, an important inhibitor of nucleation and of the growth of apatite crystals. (biomedcentral.com)
- A landmark investigation into the genetic basis of murine progressive ankylosis has clarified the physiologic role of extracellular inorganic pyrophosphate (ePPi) in suppressing pathologic deposition of basic calcium phosphate (BCP) (an inclusive term for hydroxyapatite, octacalcium phosphate, and tricalcium phosphate) in articular tissue [ 1 ]. (biomedcentral.com)
Tendons4
- The difference is that ligaments connect bone to bone, while tendons connect muscle to bone. (handwiki.org)
- [4] Normal healthy tendons are anchored to bone by Sharpey's fibres. (handwiki.org)
- The collagen in tendons are held together with proteoglycan (a compound consisting of a protein bonded to glycosaminoglycan groups, present especially in connective tissue) components including decorin and, in compressed regions of tendon, aggrecan , which are capable of binding to the collagen fibrils at specific locations. (handwiki.org)
- Characterization of adenovirus-mediated gene transfer in rabbit flexor tendons. (uchicago.edu)
Joint tissues1
- Arthropathy is due to iron accumulation in joint tissues. (medscape.com)
Somatic cells1
- In contrast, adult stem cells can only give rise to differentiated somatic cells of the particular tissue from which these cells originated (Can/Hematol 2008). (papersowl.com)
Candidate genes3
- The candidate genes exhibit expression patterns in lung and heart similar to that of known PAH risk genes, and most variants occur in conserved protein domains. (biomedcentral.com)
- At least eight novel pediatric candidate genes carrying de novo variants have plausible roles in lung/heart development. (biomedcentral.com)
- Rare variant analysis of a large international consortium identified two new candidate genes- FBLN2 and PDGFD . (biomedcentral.com)
Connective tissue d2
- PAH can be associated with other diseases (APAH: connective tissue diseases, congenital heart disease, and others) but often the etiology is idiopathic (IPAH). (biomedcentral.com)
- Prior to joining Surrey, her research centred around pulmonary hypertension and connective tissue diseases. (surrey.ac.uk)
Undetectable2
- All of those other genes were and were undetectable in a number of organs of E11.5 mice, and was undetectable in a number of organs of 8-week-old mice (Shape 2), recommending that and display higher tissue expression specificity compared to the other 4 genes. (academiaperuanadepsicologia.org)
- Processes involved in later stage disease, like development of androgen independence as a consequence of androgen depletion therapy, neoangiogenesis and homing of metastatic cells in lymphatic or bone tissues are generally undetectable at early stages. (biomedcentral.com)
Self-renewal1
- Quiescent normal adult stem cells serve as a source of self-renewal in the maintenance of multiple adult epithelial tissues. (biomedcentral.com)
Transcriptional2
- Furthermore, it's recognized that a genes transcriptional response supplies significant clues to its perform. (plasignaling.com)
- In addition, transforming growth factor and bone morphogenetic protein BMP-2 induce Runx2 /Cbfa1 transcriptional expression via the p38 MAPK pathway. (cusabio.com)
Resorption1
- 1 The obstacles of current bone substitutes include the limited amounts of donor bone, the bone resorption of autografts, the risk of disease transmission and graft rejection of allografts, and the shortage of osteoinductive property for synthetic grafts. (dovepress.com)
Articular1
- The recently published ank gene story establishes the direct tie between low ePPi levels and excess BCP mineralization of articular structures in another animal model. (biomedcentral.com)
Defects5
- Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
- Over 200 genes have been associated with odontogenesis 1-2 and dental defects 1,3 . (bvsalud.org)
- reparation associated to bone substitute with calcium sulfate and a biological membrane in created defects in rabbit tibiae. (chk-signal.com)
- 3D printing offers the possibility to produce customized scaffolds for complex bone defects. (biomedcentral.com)
- Bone tissue engineering (BTE) strategies are increasingly being used to overcome the limitations of autogenous bone grafts and existing bone-substitute materials to reconstruct such defects [ 1 ]. (biomedcentral.com)
Encodes2
- The apelin gene located at chromosome Xq25-26.1, encodes a 77 amino acid preproprotein [ 1 ] [ 2 ] . (encyclopedia.pub)
- First, Flevaris and colleagues showed that a familial mutation in that gene, which encodes the protein plasminogen activator inhibitor-1 (PAI-1), leads to spontaneous cardiac fibrosis in otherwise healthy individuals in an Old Order Amish community. (northwestern.edu)
Secretory1
- Myoepithelial cells are seen in many secretory organs including salivary glands, where they are usually encountered in the acini and intercalated ducts (see the image below). (medscape.com)
Mutations1
- The following are hamartomatous diseases: juvenile polyposis syndrome (JPS), Peutz-Jeghers syndrome (PJS), Hereditary Mixed Polyposis Syndrome (HMPS) and the syndrome of hamartomatous tumours linked to the PTEN gene mutations (PTEN hamartoma tumour syndrome - PHTS). (czytelniamedyczna.pl)
Oncogenes2
Congenital1
- CPPD crystal deposits and elevated ePPi levels are particularly prominent in adult hypophosphatasia, congenital deficiency of tissue-nonspecific alkaline phosphatase. (biomedcentral.com)
Phenotypic1
- In hypophosphatasia, the predominant phenotypic disease expressions are rickets and osteomalacia. (biomedcentral.com)
Vitro1
- The authentic characteristic of MSCs their capacity to form fibroblastic colonies in vitro from BM or other tis sues plated onto tissue culture plastic has been extensively exploited, and there's a huge literature on their several phenotypical qualities. (plasignaling.com)
Mice2
- The findings in the human population confirmed previous observations in mice lacking the gene for PAI-1. (northwestern.edu)
- In the present study, transcriptomic analysis of fracture callus gene expression in three strains of mice was used to identify differe. (researchgate.net)
Activates transcription1
- The MAPK signaling pathway activates transcription factors and regulates gene expression through a cascade reaction (MAPKKK-MAPKK-MAPK). (cusabio.com)
Apoptosis1
- Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Inhibits2
- This month's featured paper was published in the August 6, 2010 edition of the Journal of Biological Chemistry, and is entitled " Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression . (ohsu.edu)
- APCDD1 inhibits BMP signaling in cells and tissues. (xenbase.org)
Collagen fibrils2
- Human decorin is a small leucine-rich proteoglycan of 90-140 kDa that is associated with collagen fibrils in all connective tissue. (encyclopedia.pub)
- Each fascicle is bound by an endotendineum, which is a delicate loose connective tissue containing thin collagen fibrils [1] [2] and elastic fibers. (handwiki.org)
Developmental1
- The mammary gland is an ideal tissue in which to study a range of developmental processes, as discussed below. (biologists.com)
Scaffolds2
- 7 However, the scaffolds still face the problem of biocompatibility, mechanical properties, and bioresorbability, which are not adaptable to the properties of natural bone. (dovepress.com)
- Our results highlight the remarkablepotential use of BC-Ppy scaffolds as a cardiac patch in tissue regenerativetherapies. (ibecbarcelona.eu)
Homology2
- Xhibit excellent protein homology. (angiotensinreceptor.com)
- These main PG groups are further classified into families according to their gene homology, core protein properties, size, and modular composition. (hindawi.com)
Roles1
- This enormous parts-list of around 300 matrix proteins, newly christened the 'matrisome', highlights the diverse and extraordinary roles of the matrix in metazoan biology. (biologists.com)
Development8
- Gene deletion and over-expression studies indicate that GDF11 primarily regulates the embryological development of the skeletal system. (wikipedia.org)
- It may also help regulate development of the central nervous system, blood vessels, the kidney and other tissues. (wikipedia.org)
- During mouse development, GDF11 expression begins in the tail bud and caudal neural plate region. (wikipedia.org)
- The development of neoplasms is not restricted to the alimentary tract, but they can also be manifested in other organs. (czytelniamedyczna.pl)
- Odontogenesis is the result of a manifestation of an polygenic system, in which the development genes manifest themselves in a sequential, cyclic pattern 1-2 . (bvsalud.org)
- Many molecules and some gene cascades have been identified in the initial phases of tooth development: bud, cap, bell, and to a lesser degree, root formation 4-10 . (bvsalud.org)
- While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
- Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development. (uchicago.edu)
Fibrosis2
- Importantly, the scientists found that a protein called bone morphogenetic protein 7 (BMP7) can prevent the generation of fibrotic signals by cardiomyocytes and may be able to serve as a future therapy for cardiac fibrosis. (northwestern.edu)
- Tissue fibrosis is the leading cause of organ failure, but persists as one of the most pressing global health problems due to lack of effective pharmacotherapies. (northwestern.edu)
Manifest1
- The correct diagnosis of the disease using molecular methods allows to implement early treatment and therefore more effectively since it is followed by a strict monitoring of organs that manifest a predisposition to neoplastic transformation. (czytelniamedyczna.pl)
20221
- On June 19, 2022, the New York Times published an article about GDF11 and Elevian titled "Can a 'Magic' Protein Slow the Aging Process? (wikipedia.org)
Tumor2
- Tumor microenvironments often have low oxygen levels and increased inflammation, which could be the cause higher GDF11 expression in colon cancer patients. (wikipedia.org)
- The elaboration of ePPi by chondrocytes is a bioregulable process, enhanced by transforming growth factor β, ascorbate, retinoic acid, bone morphogenetic protein, transglutaminase, and thyroid hormones and diminished by parathyroid-hormone-related peptide isoforms, insulin-like growth factor-1, tumor necrosis factor α, and interleukin 1. (biomedcentral.com)
Skeletal2
- Myokines are small proteins (5-20 kDa) and proteoglycan peptides that are produced and secreted by skeletal muscle cells in response to muscle contractions. (encyclopedia.pub)
- It is involved in various metabolic processes, such as acting on white adipose tissue to upregulate brown adipose tissue-specific genes, enhancing PGC-1α expression to increase lipid oxidation, suppressing inflammation in skeletal muscles, inhibiting cardiometabolic risk factors, and suppressing endoplasmic reticulum stress in hepatoblastoma cells. (encyclopedia.pub)
Cells14
- Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells. (scielo.br)
- Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow. (scielo.br)
- Thus, these cells are becom ing almost ubiquitous residents in many tissues and organs. (plasignaling.com)
- The degree to which such cells or genuine MSCs may be utilized in tissue restore, gene or cancer therapy may have a bearing on lots of clinical outcomes. (plasignaling.com)
- We also identified the gene that serves as the master regulator of the synthesis and release of pro-fibrotic signals from heart muscle cells across different species. (northwestern.edu)
- One great advantage of MSC is that these cells may be directly obtained from individual patients, thereby eliminating the complications associated with immune rejection of allogenic tissue and infectious diseases. (biomedcentral.com)
- A tendon is made of dense regular connective tissue , whose main cellular components are special fibroblasts called tendon cells (tenocytes). (handwiki.org)
- PC cells usually remain confined in the organ, while a small proportion of carcinomas acquire the ability to metastasize and approximately 80% of patients who have died of advanced hormone refractory PC have clinical evidence of bone metastasis. (biomedcentral.com)
- The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
- GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
- Glucose transporter-1 (GLUT-1) is one of the major isoforms of the family of glucose transporter proteins that facilitates the import of glucose in human cells to fuel anaerobic metabolism. (chk-signal.com)
- A known population of cells that express Prx1 contributes to postnatal bone formation. (researchgate.net)
- In addition, mTEC screen thymocytes for their expression of high affinity αβ-TCRs, with negative selection limiting the release of these reactive T-cells into the peripheral pool ( 4 ). (frontiersin.org)
- RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells. (uchicago.edu)
Alterations1
- These genetic alterations result in either activation or inactivation of specific gene functions that contribute to the process of carcinogenesis. (bmj.com)
Pancreas1
- In hereditary hemochromatosis excessive iron accumulates in key organs such as the heart, liver, and pancreas, leading to tissue dysfunction and damage. (ohsu.edu)
Transcription3
- Taken together, these findings demonstrate that BPA increases StAR protein levels through an unknown mechanism independent of StAR gene transcription, translation, and protein half-life. (bvsalud.org)
- MEK can phosphorylate and activate ERK, which is transferred into the nucleus and regulates gene expression by activating other kinases or transcription factors. (cusabio.com)
- Evidence has emerged that environmentally-induced epigenetic changes can have long-lasting effects on gene transcription across generations. (diagenode.com)
Regenerative2
- The low endogenous regenerative capacity of the heart,added tothe prevalence of cardiovascular diseases, triggered the advent ofcardiac tissue engineering in the last decades. (ibecbarcelona.eu)
- Kidneys are an overly sensitive organ with restricted regenerative efficiency with respect to other vital organs. (biomedcentral.com)
Adult1
- We previously showed that prenatal BPA exposure resulted in elevated plasma corticosterone levels concomitant with increased adrenal levels of steroidogenic acute regulatory protein (StAR), the rate-limiting step in steroidogenesis, in adult female mouse offspring. (bvsalud.org)
Molecular3
- BAIBA (C 4 H 9 NO 2 ) is a small, non-protein myokine with a molecular weight of 103.6 Da that was first discovered in human urine in 1951 [ 11 ] . (encyclopedia.pub)
- However, the molecular mechanisms underlying the BPA-induced StAR protein expression in the adrenal gland remain unknown. (bvsalud.org)
- Since the transcriptome is a representation of the phenome, we hypothesized that both sex and sex specific temporal, transcriptomic differences in bone tissues over an 18‐month period would be informative to the underlying molecular proce. (researchgate.net)
Characteristic1
- It is associated with characteristic radiologic findings, that is, squared-off bone ends and hooklike osteophytes in the metacarpophalangeal (MCP) joints, particularly in the second and third MCP joints. (medscape.com)
Kinase2
- MAPK is a mitogen-activated protein kinase, a class of protein kinases with dual phosphorylation of serine and tyrosine in the cytosol. (cusabio.com)
- The c-Jun N-terminal kinase (JNK), also known as stress-activated protein kinase (SAPK), is another subclass of MAPK in mammals. (cusabio.com)
Mammary gland3
- The mammary gland is an exocrine organ and a supplementary reproductive structure providing the premise nutritional source for postpartum life [ 1 ]. (biomedcentral.com)
- The mammary gland is composed of numerous elongated ductal branches embedding in a background of fatty tissues. (biomedcentral.com)
- The primary function of the mammary gland is to provide nutrition for the young in the form of milk protein and fat. (biologists.com)
Tendon2
- A tendon or sinew is a tough band of dense fibrous connective tissue that connects muscle to bone . (handwiki.org)
- The space between the fascia and the tendon tissue is filled with the paratenon, a fatty areolar tissue. (handwiki.org)