• During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
  • We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
  • Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
  • In oncology, immune cell types can be quickly identified alongside stromal and endothelial cells within the tumor. (techscience.com)
  • Endothelial cells line the entire circulatory system , from the heart to the smallest capillary . (wikidoc.org)
  • Both blood and lymphatic capillaries are composed of a single layer of endothelial cells. (wikidoc.org)
  • Endothelial cells also control the passage of materials - and the transit of white blood cells - into and out of the bloodstream. (wikidoc.org)
  • In some organs, there are highly differentiated endothelial cells to perform specialized 'filtering' functions. (wikidoc.org)
  • In particular, FUNGENES identified genes controlling the development of pluripotent embryonic stem (ES) cells into heart cells (cardiomyocytes), nerve cells (neurons), smooth muscle cells, vascular endothelial cells, fat cells (adipocytes), liver cells (hepatocytes) and insulin-producing cells of the pancreas. (europa.eu)
  • PD-L1 is expressed not only by all hematopoietic cells but also by many non-hematopoietic cell types such as endothelial cells and epithelial cells ( Sharpe and Pauken, 2018 ). (frontiersin.org)
  • Asmani, M.N., J. Ai, G. Amoabediny, A. Noroozi, M. Azami, S. Ebrahimi-Barough, M. Navaei-Nigjeh, A. Ai, M. Jafarabadi (2013) Three-dimensional culture of differentiated endometrial stromal cells to oligodendrocyte progenitor cells (OPCs) in fibrin hydrogel. (karger.com)
  • Bakshi, A., C.A. Keck, V.S. Koshkin, D.G. LeBold, R. Siman, E.Y. Snyder, T.K. McIntosh (2005) Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain. (karger.com)
  • Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
  • Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
  • Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
  • Broadly, tissue regeneration is achieved in two ways: by proliferation of common differentiated cells and/or by deployment of specialized stem/progenitor cells. (nih.gov)
  • The older prostate contains more luminal progenitor cells (brown). (ucla.edu)
  • The prostates of older mice contain more luminal progenitor cells - cells capable of generating new prostate tissue - than the prostates of younger mice, UCLA researchers have discovered. (ucla.edu)
  • Research had previously shown that the numbers of progenitor cells are also diminished in organs that shrink with age. (ucla.edu)
  • Like stem cells, progenitor cells can differentiate into new cells, but they are more constrained in what type of cells they can become. (ucla.edu)
  • For instance, prostate progenitor cells can only form prostate tissue. (ucla.edu)
  • Whether levels of stem cells or progenitor cells in the prostate changed with age was not previously known. (ucla.edu)
  • When the team looked more closely at the luminal cells, they discovered that older prostates contained more luminal progenitor cells. (ucla.edu)
  • One of the biggest questions we have now is what is causing this age-related increase in the number of luminal progenitor cells," Goldstein said. (ucla.edu)
  • Answering that question, he said, could help identify a way to curb the growth of luminal progenitor cells and, in turn, prevent or treat prostate cancer or benign prostatic hyperplasia. (ucla.edu)
  • In a series of genetic labelling experiments, Mass has shown that these cells are mainly yolk sac-derived progenitor cells that migrate to the developing organs, where they immediately differentiate and self-maintain for a lifetime. (uni-bonn.de)
  • Primordium cells, in contrast to stem cells, are already specified, have entered a period of maximal proliferation, but for a limited number of times, and can thus be considered the plant equivalent of progenitor cells in animal organs. (biomedcentral.com)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • Initially, all these cells are identical, but soon, they start to form the three germ layers, which represent the first stage of differentiation of the developing embryo. (mpg.de)
  • Therefore, researchers have begun exploring combined therapies with biomaterials that promote cell growth and differentiation while localizing cells in the injured area. (karger.com)
  • This article reviews recent advancements in biomaterial strategies for the differentiation of neural stem cells into oligodendrocytes, and presents new data indicating appropriate properties for oligodendrocyte precursor cell growth. (karger.com)
  • Aizawa, Y., N.D. Leipzig, T. Zahira, M.S. Shoichet (2008) The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels. (karger.com)
  • But we also have provided the first evidence that BMDCs can contribute simultaneously to different encephalic areas through different mechanisms of plasticity - cell fusion for Purkinje cells - among the largest and most elaborately dendritic neurons in the human brain - and differentiation for olfactory bulb interneurons. (eurekalert.org)
  • For this reason, our group has recently described and patented a method to obtain cardiac stem cells (CSCs) from small biopsies of myocardium and grow them through several generations in the laboratory without losing differentiation potential. (derstandard.at)
  • The FUNGENES project aimed to achieve a detailed basic understanding of stem cell self-renewal and differentiation. (europa.eu)
  • FUNGENES identified the gene subsets that are active in self-renewing cells, during the exit from pluripotency and at specific stages of mouse ES cell differentiation. (europa.eu)
  • Understanding the genetic pathways underlying differentiation of ES cells to somatic cells would contribute to future therapeutic strategies for degenerative diseases such as heart disease, diabetes and Parkinson's. (europa.eu)
  • Differentiation involves morphogenesis but also cell-appropriate organelle biogenesis programs. (biomedcentral.com)
  • Monocot leaves, where cell proliferation and differentiation are displayed along a linear developmental gradient, provide an ideally suited experimental system to study these processes. (biomedcentral.com)
  • Differentiation subsequently occurs in leaf primordia basipetally, resulting in a gradient of easily distinguishable cellular morphologies of distal differentiated cells towards the tip of the leaf, basal progenitor proliferating cells adjacent to the shoot apical meristem, and all possible intermediate stages in between. (biomedcentral.com)
  • To date, it has been assumed that the differentiation of stem cells depends on the environment they are embedded in. (neurosciencenews.com)
  • The current view proposes that stem cell differentiation is controlled by their local environment, the so-called niche. (neurosciencenews.com)
  • Thus, stem cells receive and interpret specific factors present in their niche that guide their differentiation into specific and restricted cell types. (neurosciencenews.com)
  • Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons. (neurosciencenews.com)
  • Early stages of B-cell differentiation can be identified by the status of the immunoglobulin genes and by the cell surface markers CD34, CD19, and surface immunoglobulin (sIg). (medscape.com)
  • The protooncogene encoding for BTK has been cloned and its genomic organization determined, allowing an in-depth analysis of the role of BTK and other signaling molecules in B-cell differentiation. (medscape.com)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
  • During the process of harvesting embryotic stem cells, the embryo is destroyed. (healthline.com)
  • Chu-Wang, I.W., R.W. Oppenheim (1978) Cell death of motoneurons in the chick embryo spinal cord. (karger.com)
  • Soon after conception, the embryo differentiates into three layers of cells. (whattoexpect.com)
  • Subsequently, all cell nuclei were extracted and a molecular barcode specific to the respective embryo was introduced to the RNA molecules of each cell. (mpg.de)
  • Each cell could thus be assigned a specific transcriptome, which in turn could be assigned to an individual embryo. (mpg.de)
  • Within a short time, the cells of the three germ layers are transformed into an embryo containing most of its major internal and external organs. (mpg.de)
  • Totipotent cells have the capacity to differentiate to all cell types, including somatic cells, germ cells, and certain cells that exist outside the embryo and are important to fetal development that are termed extraembryonic cells. (citizendium.org)
  • Such tissue renewal may be accomplished via the use of adult stem cells, or embryonic stem cells, which may be derived from a human embryo in the blastocyst stage. (citizendium.org)
  • However, supporters of embryonic stem cell research frequently contend that even the comparison to abortion is inappropriate, since while a several month old fetus might have sufficient neurological development to be conscious in some meaningful sense, a human embryo in the blastocyst stage has so little development that one can safely conclude that it cannot exist as a conscious being. (citizendium.org)
  • Solely from stem cells, without egg, sperm or womb, synthetic mouse embryo models were created. (disabled-world.com)
  • The team set out to grow a synthetic embryo model solely from naïve mouse stem cells cultured for years in a petri dish, dispensing with the need for starting with a fertilized egg. (disabled-world.com)
  • The method opens new horizons for studying how stem cells form various organs in the developing embryo. (disabled-world.com)
  • It may one day make it possible to grow tissues and organs for transplantation using synthetic embryo models. (disabled-world.com)
  • But in a Weizmann Institute of Science study published today in Cell , researchers have grown synthetic embryo models of mice outside the womb by starting solely with stem cells cultured in a petri dish - that is, without using fertilized eggs. (disabled-world.com)
  • The embryo is the best organ-making machine and the best 3D bioprinter - we tried to emulate what it does," says Prof. Jacob Hanna of Weizmann's Molecular Genetics Department, who headed the research team. (disabled-world.com)
  • The course for organ health is set in the early embryo. (uni-bonn.de)
  • That's why Father Pacholczyk, director of education at the National Catholic Bioethics Center in Philadelphia, said that the efforts to help people understand the immorality of embryo reserch, including human cloning, must focus on humanizing the issue and appreciating our own embryonic origins, not just on the desired results of embryonic or other types of stem-cell research. (archstl.org)
  • There are a number of sources of stem cells, namely, adult cells generally extracted from bone marrow, cord cells, extracted during pregnancy and cryogenically stored, and embryonic cells, extracted from an embryo before the cells start to differentiate. (jonathanturley.org)
  • Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
  • To activate a cytotoxic or helper T cell to proliferate and differentiate into an effector cell , an antigen-presenting cell provides two kinds of signals. (nih.gov)
  • And the therapy based on transplantation of MSCs in some solid organs has been suggested in recent years. (nih.gov)
  • However, the rejection reaction often occurs in the transplantation of MSCs and could induce cell death. (nih.gov)
  • Cross-species transplantation was possible without the rejection of the human embryonic stem cells by the mice's immune systems because the mice were genetically modified to suppress certain immune responses that would have interfered with transplantation. (citizendium.org)
  • Until now, in most studies, the specialized cells were often either hard to produce or aberrant, and they tended to form a mishmash instead of well-structured tissue suitable for transplantation. (disabled-world.com)
  • Tampa, Fla. (Dec, 19 2011) - Bone marrow-derived stem cells (BMDCs) have been recognized as a source for transplantation because they can contribute to different cell populations in a variety of organs under both normal and pathological conditions. (eurekalert.org)
  • Their results are published in the current issue of Cell Transplantation (20:8) now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ . (eurekalert.org)
  • Six weeks after transplantation, however, more bone marrow-derived microglial cells were observed in the olfactory bulbs of the test animals where the degeneration of mitral cells was still in progress. (eurekalert.org)
  • This study shows a potential new contribution of bone marrow derived cells following transplantation into the brain, making these cells highly versatile, in their ability to both differentiate into and fuse with endogenous neurons" said Dr. Paul R. Sanberg , coeditor-in-chief of CELL TRANSPLANTATION and distinguished professor of Neuroscience at the Center of Excellence for Aging and Brain Repair, University of South Florida. (eurekalert.org)
  • The editorial offices for CELL TRANSPLANTATION are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. (eurekalert.org)
  • Lineage tracing revealed scant contribution of pre-existing mature epithelial cells in such repair, whereas orthotopic transplantation of LNEPs, isolated by a definitive surface profile identified through single-cell sequencing, directly demonstrated the proliferative capacity and multipotency of this population. (nih.gov)
  • But we realized that cell transplantation may not always be suitable for catastrophic events, such as a heart attack in which there is major myocardial damage. (derstandard.at)
  • These new transplantation systems enhance the viability of cells and stimulate their outward migration so that they can populate and help regenerate injured tissues. (derstandard.at)
  • These preparatory interregional and interdisciplinary meetings focused on the following areas: cloning and human reproductive health, biologicals, organ transplantation, research, and medical genetics. (who.int)
  • Stem cells have been used to treat illness in limited ways for decades, including transplantation from bone marrow. (sciencedaily.com)
  • That previous work, in both heart and lung transplantation, relied on genotyping both the organ donor and the recipient in order to distinguish which cfDNA fragments were being shed from the donor organ, and which were naturally occurring from the recipient. (genomeweb.com)
  • Recently announced trials are now underway to study both safety and efficacy of autologous stem cell transplantation in MS patients because of promising early results from previous trials. (jonathanturley.org)
  • Their discovery opened the door for others to develop the first medical use of stem cells in bone marrow transplantation for leukemia. (jonathanturley.org)
  • Furthermore, the use of diphtheria toxin -- which is far more toxic to human cells than mouse cells -- to destroy the human neurons in the mice reversed the observed improvements in motor function. (citizendium.org)
  • This result suggests that the observed increase in motor function was indeed produced by neurons derived from the human embryonic stem cells. (citizendium.org)
  • Diminished myelin levels lead to further cell death in which unmyelinated neurons die. (karger.com)
  • She found that the mutated microglia cells no longer carried out their traditional tasks but instead attacked and eliminated neurons in their vicinity. (uni-bonn.de)
  • Neural stem cells are generally accepted to produce three different cell types: neurons, astrocytes and oligodendrocytes. (neurosciencenews.com)
  • Magenta: the hippocampal stem cells generate newborn neurons. (neurosciencenews.com)
  • Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligodendrocytes. (neurosciencenews.com)
  • Thus, the "gut" was formed by cells of all three germ leaves - endoderm (intestinal epithelium), mesoderm (smooth muscles and connective tissue) and ectoderm (intestinal neurons). (vechnayamolodost.ru)
  • for example, we study how immune system cells decide to mature or how skin cells can be directly reprogrammed into neurons or stem cells. (lu.se)
  • Eventually, the cells begin to differentiate, taking on a certain function in a part of the body. (healthline.com)
  • The combined actions of signal 1 and signal 2 stimulate the T cell to proliferate and begin to differentiate into an effector cell by a curiously indirect mechanism. (nih.gov)
  • Bone marrow mesenchymal stem cells (MSCs) have been identified to have the potential to differentiate into multiple types of cells. (nih.gov)
  • Stem cells are undifferentiated cells that have the potential to differentiate into many cell types. (neurosciencenews.com)
  • Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering and regenerative medicine. (frontiersin.org)
  • Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. (nature.com)
  • In particular, chimeric antigen receptor (CAR) - patient T cells genetically engineered to express antigen receptors targeting cancer cells - and organoid technologies (tiny, self-organized three-dimensional tissue cultures derived from stem cells) will continue to disrupt the cell and gene therapy and regenerative medicine fields, translating early successes with liquid cancers to solid tumors and beyond. (corning.com)
  • By contrast, here we define the regenerative role of previously uncharacterized, rare lineage-negative epithelial stem/progenitor (LNEP) cells present within normal distal lung. (nih.gov)
  • In adults, stem cells act as a repair system for the body, replenishing specialised cells, and maintaining the normal turnover of regenerative organs such as blood, skin or intestinal tissues. (derstandard.at)
  • Understanding what's causing the prostate to grow with age helps us to consider strategies to prevent the expansion of these cells and possibly reduce a person's risk for prostate growth or disease," said Andrew Goldstein, member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and a UCLA assistant professor of urology and of molecular, cell, and developmental biology. (ucla.edu)
  • From "adult stem cells" to "xenotransplantation," learn about common and specialized regenerative medicine terms. (mayo.edu)
  • A type of stem cell found in organs of the body that can be used for regenerative interventions. (mayo.edu)
  • Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
  • Each year, the Lund Stem Cell Center recognizes notable scientific achievements made by our members in the fields of stem cell biology and regenerative medicine through our Article of the Year Award. (lu.se)
  • This recognition highlights the outstanding contributions made by our members in advancing the fields of stem cell biology and regenerative medicine. (lu.se)
  • As a consequence, the reticuloendothelial and lymphoid organs in which these cells proliferate, differentiate, and are stored are poorly developed. (medscape.com)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • This will help prevent the immune system from rejecting an organ transplant. (healthline.com)
  • Cell Transplant. (eurekalert.org)
  • There are different types of leukemia that hematologists in cell transplant laboratories can differentiate/diagnose based on microscopic images. (hindawi.com)
  • SAN FRANCISCO (GenomeWeb) - Noninvasive shotgun sequencing can be used to detect organ transplant rejection without prior knowledge of the donor's genotype, according to researchers from Stanford University and Cornell University. (genomeweb.com)
  • Iwijn De Vlaminck, an assistant professor of biomedical engineering at Cornell and senior author of the study, said that previous work had identified that donor-derived cell-free DNA is a "good marker of transplant rejection" because increased levels of donor cfDNA indicates more damage to the graft and thus, rejection. (genomeweb.com)
  • It may be performed using cells from the patient's own body (autologous transplant) or cells from a donor (allogeneic transplant). (mayo.edu)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • The stages that an organism undergoes from single cell to adult are many, complicated, and in constant danger of failure. (encyclopedia.com)
  • Adult stem cells have a misleading name, because they are also found in infants and children. (healthline.com)
  • For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
  • Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
  • Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
  • To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)
  • Adult stem cells don't present any ethical problems. (healthline.com)
  • The term stem cell is also used in reference to any adult cells that are capable of assisting in the restoration of adult tissue via self-renewal. (citizendium.org)
  • Adult stem cells hold great promise in mitigating much of the ethical debate over embryonic stem cell use. (citizendium.org)
  • This means that CSCs represent a logical source for cardiac regeneration therapy because, unlike other adult stem cells, they are intrinsically programmed to generate cardiac tissue in the lab and thus increase cardiac tissue viability in humans. (derstandard.at)
  • The liver is one of the few organs in the body where differentiated adult stem cells can divide to regenerate after an injury. (childrenshospital.org)
  • The Church also supports research and therapies using adult stem cells, which are cells that come from any person who has been born - including umbilical cord blood, bone marrow, skin and other organs. (archstl.org)
  • Dozens of adult stem cell treatments are moving through clinical trials and showing early success, raising hopes that some could reach the market within five years. (ibtimes.com)
  • The cells used are derived from adult tissue such as fat, or bone marrow, thereby circumventing the ethical concerns raised by the use of cells derived from embryos. (ibtimes.com)
  • Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell-intrinsic mechanism. (neurosciencenews.com)
  • These are neural stem cells in the adult mouse hippocampus. (neurosciencenews.com)
  • Abstract for "Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB" by Chiara Rolando, Andrea Erni, Alice Grison, Robert Beattie, Anna Engler, Paul J. Gokhale, Marta Milo, Thomas Wegleiter, Sebastian Jessberger, and Verdon Taylor in Cell Stem Cell . (neurosciencenews.com)
  • As to source and method of acquiring stem cells, harvesting autologous adult cells entails the least risk and controversy. (jonathanturley.org)
  • After the adult AMSCs were identified by flow cytometry, the 3rd passage cells were selected for the follow-up experiments. (bvsalud.org)
  • Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
  • This allows us to generate the first biologically-informed gene expression map of this leaf, with the entire developmental gradient from meristematic to fully differentiated cells captured. (biomedcentral.com)
  • Human air-liquid-interface (ALI) organotypic airway tissue models derived from primary tracheobronchial epithelial cells have in vivo-like structure and functions when they are fully differentiated. (cdc.gov)
  • The most infamous study of embryonic stem cells asserted that cloned human embryos had been created via somatic cell nuclear transfer, and stem cells had been generated from these embryos. (citizendium.org)
  • Before the announcement in February 1997 of the cloning of a sheep by somatic cell nuclear transfer, existing legislation in a number of countries already precluded human cloning for reproductive purposes, sometimes implicitly. (who.int)
  • It became a hot topic in 1996 when Dolly the sheep was cloned via a process called somatic cell nuclear transfer. (archstl.org)
  • Cells Tissues Organs (2001) 169 (4): 347-354. (karger.com)
  • Cells Tissues Organs (2016) 202 (1-2): 85-101. (karger.com)
  • Then you will learn about the body as a whole and how to differentiate cells, tissues, organs, systems, and cavities. (ed2go.com)
  • The signaling events initiated by the binding of peptide-MHC complexes to T cell receptors (signal 1). (nih.gov)
  • Its T-cell receptors (TCR) differentiate themselves from other lymphocyte types. (differencebetween.net)
  • They not only help activate B cells to secrete antibodies and macrophages to destroy ingested microbes, but they also help activate cytotoxic T cells to kill infected target cells. (nih.gov)
  • These immune cells are referred to as tissue-resident macrophages and belong to our innate immune system. (uni-bonn.de)
  • Elvira Mass's research also has implications for medicine, because organ-specific defects might be associated with malfunctioning tissue-resident macrophages originally derived from the yolk sac. (uni-bonn.de)
  • In the future, Mass will investigate which environmental factors change the epigenetic imprinting of the yolk sac-derived tissue-resident macrophages and how these changes affect the health of organs. (uni-bonn.de)
  • In contrast, PD-L2 expression is more restricted and can be induced on hematopoietic cells such as DCs, B cells, and monocytes/macrophages. (frontiersin.org)
  • The unknown antigen triggers a cell-mediated immune response that is characterized by the accumulation of T cells and macrophages, release of cytokines and chemokines, and organization of responding cells into granulomas. (msdmanuals.com)
  • In vitro, ivacaftor does not alter LPS-induced CD80 and tumor necrosis factor alpha mRNA increases in BV2 microglial cells, while augmenting mRNA levels of these markers in mouse macrophages and differentiated human THP-1-derived macrophages. (lu.se)
  • Organoids are generated using tissue-specific stem cells, which are typically undifferentiated epithelial cells. (corning.com)
  • Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells - overview and perspectives. (cdc.gov)
  • They arise from the genital tubercle that forms anterior to the cloacal folds (proliferating mesenchymal cells around the cloacal membrane). (wikipedia.org)
  • Activated cells proliferate and migrate widely to occupy heavily injured areas depleted of mature lineages, at which point they differentiate towards mature epithelium. (nih.gov)
  • Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
  • Current models in the lung posit that epithelial repair can be attributed to cells expressing mature lineage markers. (nih.gov)
  • The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
  • The lung is an organ that is directly exposed to the external environment. (cdc.gov)
  • Pulmonary symptoms range from none to cough, exertional dyspnea and, rarely, lung or other organ failure. (msdmanuals.com)
  • Retrieved August 18, 2016 from https://neurosciencenews.com/neural-stem-cells-genetics-4869/[/cbtab][cbtab title="Chicago"]University of Basel. (neurosciencenews.com)
  • https://neurosciencenews.com/neural-stem-cells-genetics-4869/ (accessed August 18, 2016). (neurosciencenews.com)
  • Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
  • Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
  • In this study, researchers grafted bone marrow cells into mutant mice suffering from the degeneration of specific neuronal populations at different ages, then compared them to similarly transplanted healthy controls. (eurekalert.org)
  • Several technologies have been described over the past 10 years to create functional heart tissue by using stem cells that have been isolated from other tissues such as bone marrow, skeletal muscle, and umbilical cord blood. (derstandard.at)
  • It has three major types, namely: Natural Killer (NK) cells, T-cells (Thymus cells) and B-cells (Bone cells). (differencebetween.net)
  • In mammals, immature B-cells are formed in the bone marrow, where its name is derived from. (differencebetween.net)
  • The red bone marrow's stem cells, called hemocytoblasts, give rise to almost all white blood cells. (differencebetween.net)
  • Most organs in the body - including the kidneys, liver and spleen - lose mass as people age, and bone and muscle mass tend to decrease over time. (ucla.edu)
  • This abnormal phenomenon is caused by excessive proliferation and immature growth of blood cells, which can damage red blood cells, bone marrow, and the defense system. (hindawi.com)
  • Until a few years ago, it was believed that this task is performed by immune cells originating from the bone marrow. (uni-bonn.de)
  • We're actually developing products now," said Timothy Mayleben, chief executive of Aastrom, which is using cells derived from a patient's own bone marrow to develop treatments for cardiovascular disease. (ibtimes.com)
  • A medical procedure in which healthy bone marrow stem cells are injected into the body to replace damaged or diseased bone marrow. (mayo.edu)
  • Various stem cell therapies are already practiced, a popular one being bone marrow transplants that are used to treat leukemia. (jonathanturley.org)
  • The Laboratory of Bone Organ Modeling and Regeneration received the 2023 Article of the Year Award for their research generating human mini-bones in a laboratory setting which mimics the properties of real human bone. (lu.se)
  • This means they can potentially produce new cells for any organ or tissue. (healthline.com)
  • MSCs can promote host tissue repair through several different mechanisms including donor cell engraftment, release of cell signaling factors, and the transfer of healthy organelles to the host. (frontiersin.org)
  • This recognition comes as ultra-deep sequencing technologies coupled with error-reducing sequencing techniques have enabled the detection of mutant cells occupying less than one percent of an examined tissue sample ( Martincorena, 2019 ). (techscience.com)
  • The use of the pluripotent and/or self-renewing qualities of stem cells is believed to have therapeutic benefits for the regeneration of tissue in humans. (citizendium.org)
  • Our findings indicate that distinct stem/progenitor cell pools repopulate injured tissue depending on the extent of the injury, and the outcomes of regeneration or fibrosis may depend in part on the dynamics of LNEP Notch signalling. (nih.gov)
  • After injecting these cells into the hearts of animals with damaged myocardial tissue, my colleagues and I have observed an improvement in physiological functions. (derstandard.at)
  • So we decided to use these stem cells in association with an artificial, netlike matrix to support formation of functional tissue-like structures that can be used in a new therapeutic approach to repair the heart. (derstandard.at)
  • Using a hybrid therapy that incorporates tissue engineering, we seeded a biodegradable mesh with cardiac stem cells. (derstandard.at)
  • The mesh acted as a scaffold on which the stems cells were grown into morphologically recognizable cardiac tissue. (derstandard.at)
  • We then joined the cardiac tissue built from the mesh scaffold onto the diseased structure of the heart to stimulate the regeneration of the optimal cell types for that particular portion of the heart. (derstandard.at)
  • We thought it was a real possibility that older cells would have a reduced capacity to generate prostate tissue when we took them out of the prostate," said Goldstein, who is also a member of the UCLA Jonsson Comprehensive Cancer Center . (ucla.edu)
  • So it was a surprising and important finding that there's really no difference between old cells and young cells in their ability to form prostate tissue. (ucla.edu)
  • The higher concentration of luminal progenitors, coupled with their maintained ability to form new tissue, helps explain why the prostate grows with age and why the risk of prostate cancer and benign prostatic hyperplasia increase: Both are associated with the growth of cells. (ucla.edu)
  • The results show that the enzyme aminopeptidase in the stem cell niche -- in this case, the area where stem cells are found in the testicular tissue in fruit flies -- plays a role in both of these functions. (sciencedaily.com)
  • That's because there's a delicate balance to be struck in managing the proliferation of undifferentiated stem cells in tissue, Chen said. (sciencedaily.com)
  • This is because stem cells have the ability to grow into any kind of cell and, if transplanted into the body, will relocate to the damaged tissue, replacing it. (jonathanturley.org)
  • Till and McCulloch documented the way in which embryonic stem cells differentiate themselves to become mature cell tissue. (jonathanturley.org)
  • Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • Our results suggest that ivacaftor promotes contrasting effects depending on target tissue post-MI, which may be largely dependent on its effects on different myeloid cell types. (lu.se)
  • We detect alterations of protein properties in numerous cellular pathways and components including ribosome biogenesis and demonstrate that modulation of ribosome maturation through SBDS protein can be helpful for manipulating cell stemness in vitro. (nature.com)
  • This leads to substrate accumulation in the lysosomes, cellular dysfunction and organ damage. (bioworld.com)
  • He explains that scientists already know how to restore mature cells to "stemness" - pioneers of this cellular reprogramming had won a Nobel Prize in 2012. (disabled-world.com)
  • His group has developed cellular barcoding methodologies that allow for a unique genetic label to be embedded in the cells' DNA. (childrenshospital.org)
  • Taking advantage of the developmental gradient in the bread wheat leaf, we provide a simultaneous quantitative analysis for the development of mesophyll cells and of chloroplasts as a cellular compartment. (biomedcentral.com)
  • Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
  • In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Helper T cells are arguably the most important cells in adaptive immunity, as they are required for almost all adaptive immune responses. (nih.gov)
  • They are activated on the surface of antigen -presenting cells, which mature during the innate immune responses triggered by an infection. (nih.gov)
  • The innate responses also dictate what kind of effector cell a helper T cell will develop into and thereby determine the nature of the adaptive immune response elicited. (nih.gov)
  • We also consider how innate immune responses determine the nature of adaptive responses by stimulating helper T cells to differentiate into either T H 1 or T H 2 effector cells. (nih.gov)
  • Lymphocytes are a type of white blood cells in the immune system. (differencebetween.net)
  • NK cells are a type of cytotoxic (cell toxic) lymphocyte that represent a major component of the inherent immune system. (differencebetween.net)
  • The thymus, a specialized organ of the immune system, is primarily responsible for the T cell's maturation. (differencebetween.net)
  • In her research, she showed that specialized immune cells from the yolk sac accompany organ development and contribute to maintaining their health throughout life. (uni-bonn.de)
  • For Elvira Mass, impaired function of these immune cells might cause many diseases. (uni-bonn.de)
  • Elvira Mass's research has provided a completely new perspective on the role of cells of the innate immune system regulating embryonic development of tissues and organs," says Prof. Dr. Dr. h.c. (uni-bonn.de)
  • and since they are the patient's own, autologous cells are better than both cord and embryonic sources as they perfectly match the patient's own DNA, meaning that they will never be rejected by the patient's immune system. (jonathanturley.org)
  • CD4 cells are a type of white blood cells that play an important role in maintaining a healthy immune system to help fight infection. (who.int)
  • The regrowth of myelinating oligodendrocytes from neural stem cells through a biomaterials approach may prove to be a beneficial strategy following the onset of demyelination. (karger.com)
  • Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
  • Using our integrative proteomics approach and the web-based tool, we uncover a molecular basis for the uncoupling of robust transcription from parsimonious translation in stem cells and propose a method for maintaining pluripotency in vitro. (nature.com)
  • Now a group of Japanese scientists from the Nara Medical University have managed to grow a complex and functional "organ" like a gut from iPSCs in vitro. (vechnayamolodost.ru)
  • It lacks the necessary throughput and resolution to provide a global overview of the dynamic molecular processes that take place in the different and rapidly growing populations and subpopulations of cells during organogenesis. (mpg.de)
  • They have discovered novel genes that control blood forming stem cells and uncovered new cell populations that produce platelets. (childrenshospital.org)
  • Such systems biology models can, for example, describe how whole populations interact with their environment, how individual cells choose to differentiate into different cell types, or how multicellular systems form patterns and grow new organs in two or three dimensions. (lu.se)
  • But when it comes to studying diverse populations of cells, this approach can fall short and an extra dimension is needed. (lu.se)
  • Stem cell therapies already exist in medical practice. (derstandard.at)
  • The Catholic Church has always held that stem-cell research and therapies are morally acceptable, as long as they don't involve the creation and destruction of human embryos. (archstl.org)
  • The case sent a chill through the scientific community when it came to light 15 years ago and typifies some of the hurdles researchers have faced while trying to bring stem cell therapies to the market. (ibtimes.com)
  • In their study the researchers examined about two million cells, with the RNA of each cell labeled individually with a specially developed method termed sci-RNA-seq. (mpg.de)
  • Together with researchers from Berlin, the American team used this method to study the activity of all cells from mouse embryos at the age of 9.5 to 13.5 days. (mpg.de)
  • Researchers have recently described new lines of stem cells derived from amniotic fluid [9] . (citizendium.org)
  • Today, the regrowth of Prometheus' liver has become a symbol to medical researchers for the possible renewal of damaged human organs through the use of human stem cells. (derstandard.at)
  • But medical researchers hope to be able to use technologies derived from stem cell research to treat a much wider variety of diseases. (derstandard.at)
  • The researchers then isolated luminal cells - one subset of prostate cells - from the mice and grew them to form prostate organoids, or smaller, simplified versions of the prostates. (ucla.edu)
  • Medical researchers and scientists believe that stem cell therapy will, in the near future, advance medicine dramatically and change the course of disease treatment. (jonathanturley.org)
  • Research into stem cells grew out of the findings of two Canadian researchers, Dr's James Till and Ernest McCulloch at the University of Toronto in 1961. (jonathanturley.org)
  • In today's world of science, single-cell sequencing technologies allow researchers to examine the genetic details of individual cells, creating a treasure trove of data. (lu.se)
  • Embryonic stem cells come from human embryos that are three to five days old. (healthline.com)
  • We analyzed the morphological features of dying cells in the developing axial structures of 5 human embryos between 5 and 8 weeks of postovulatory age. (karger.com)
  • According to our findings, apoptosis seems to be the most frequently observed type of PCD, but it is not the exclusive type of morphological cell death during the development of axial structures in human embryos. (karger.com)
  • Overview of Single Cell Combinatorial Indexing for labeling the transcriptome of single cells The cells of mouse embryos at day 9.5 to 13.5 were isolated and distributed into different wells of a microtiter plate. (mpg.de)
  • The use of embryonic stem cells has been a source of considerable controversy due to its sacrifice of human embryos in the blastocyst stage, which some people view as the destruction of human life . (citizendium.org)
  • Human embryos fertilized in the ordinary manner and harvested in the blastocyst stage have been used as an extensive source of stem cells for research purposes, and have been shown to possess therapeutic value in laboratory animals. (citizendium.org)
  • Ethical objections to the use of human embryonic stem cells revolve around the destruction of human embryos in the blastocyst stage to obtain the stem cells. (citizendium.org)
  • A type of undifferentiated stem cell found in embryos. (mayo.edu)
  • Malignant white blood cells, or lymphoblast, in the blood reach other organs, such as the spleen, brain, liver, and kidneys, and then metastasize to important tissues of the body [ 1 - 3 ]. (hindawi.com)
  • The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
  • Thus, we know that the simple cells of an egg are preformed in the sense that they contain a preformed instruction set for development which is encoded in their genes. (encyclopedia.com)
  • In order to realize this, different genes have to be activated in each cell at different times. (mpg.de)
  • For this, individual genes are switched off systematically and their effects on the on the developing organs or whole organisms are examined. (mpg.de)
  • In order to find out which genes of a cell were active at a certain point of development, the scientists examined the transcriptome. (mpg.de)
  • Genes required for B cell development. (medscape.com)
  • The models are mainly based on the interaction between different genes and proteins, for example in stem cells. (lu.se)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • For instance, tumor organoids in a dish can be generated from cells collected during a biopsy by mixing them with a semisolid matrix and then exposing the mixture to media containing growth factors. (corning.com)
  • Nevertheless, the cells that remain can eventually regrow a tumor, and when they do, the tumor is usually resistant to further hormone therapy. (mskcc.org)
  • Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion of tumor cells from antitumor immunity. (frontiersin.org)
  • Because they can develop from their original state into specialized or differentiated cells, stem cells have long held out the promise of being used to replace damaged organs and muscle. (sciencedaily.com)
  • Building off previous methods that have demonstrated that shotgun sequencing of cell-free DNA shed in the bloodstream from the donor organ can identify rejection, the team demonstrated that the donor does not first have to be genotyped, which they said would make it more useful in a clinical setting. (genomeweb.com)
  • Stem cells have also been found in amniotic fluid. (healthline.com)
  • However, more research is needed to help understand the potential uses of amniotic fluid stem cells. (healthline.com)
  • A type of cell derived from amniotic fluid, which is the liquid that surrounds a developing fetus in the amniotic sac. (mayo.edu)
  • The mesoderm, or middle layer, will develop into your baby's bones - as well as his heart muscles, kidneys and sex organs. (whattoexpect.com)
  • Understanding transitions from one cell type or state to another is in the focus of modern molecular biology. (nature.com)
  • Single cell analysis is a promising alternative for such analyses,' explains Malte Spielmann, group leader at the Max Planck Institute for Molecular Genetics in Berlin. (mpg.de)
  • Molecular Biology of the CELL, 4th edition, Alberts et al. (wikidoc.org)
  • This barcode can be read by another technique called single cell RNAseq, which gives molecular information of each cells - the cell biography. (childrenshospital.org)
  • Canavanine-glycine-bromthymol blue agar was used to differentiate between C. gattii and C. neoformans ( 5 ). (cdc.gov)
  • Junyue Cao, Malte Spielmann and their colleagues describe, which cell types differentiate between days 9.5 and 13.5 of mouse embryonic development, and how they transform into organs. (mpg.de)
  • In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after the fertilization of the female egg cell by the male sperm cell. (disabled-world.com)
  • Through medical research, stem cells can now be grown and transformed into a variety of specialised cells with characteristics consistent with tissues such as muscles or nerves. (derstandard.at)
  • Stem cells are "non-specialized" cells that have the potential to form into other types of specific cells, such as blood, muscles or nerves. (jonathanturley.org)
  • Bible, E., D.Y. Chau, M.R. Alexander, J. Price, K.M. Shakesheff, M. Modo (2009) The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles. (karger.com)
  • Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
  • Scientists are hoping that the cells can be made from someone's own skin to treat a disease. (healthline.com)
  • Scientists from the Lexington, Mass.-based company have designed a strategy based on glucagon-like peptide-1 (GLP-1) to transform pancreatic cells and reverse the disease. (bioworld.com)
  • In total, the scientists were able to identify 38 different main cell types and over 500 subtypes. (mpg.de)
  • It also could inform scientists better about why other organs lose mass with age. (ucla.edu)
  • Studying the Hippo pathway can help scientists develop treatments which encourage a liver to heal itself, allow scientists to grow liver cells in the lab (a therapeutic approach not yet available) or study the development of liver cancer. (childrenshospital.org)
  • The scientists found that an enzyme in the spot where stem cells are found can help nurture a greater abundance of these cells by sustaining them in their original state, and by promoting other cells to lose their specialized traits and transform into stem cells. (sciencedaily.com)
  • The brain is a complex organ that contains the most differentiated and inaccessible cells in human biology. (bioworld.com)
  • Bioinformatic analysis of differential biology within the population of cells studied relies on inferences and grouping of cells due to the spotty nature of data within individual cell scRNA-seq gene counts. (techscience.com)
  • Given that aneuploidy is (a) known to contribute to cell biology and (b) is present at some detectable level in many cell types, it is valuable for single-cell sequencing studies to include aneuploidy information in their analyses. (techscience.com)
  • In a research paper to be published in the journal Cell Reports on Oct. 13, Xin Chen, an associate professor of biology in the university's Krieger School of Arts and Sciences, and six co-authors report on how stem cells are affected by their immediate surroundings. (sciencedaily.com)
  • The expression of B7 proteins on an antigen-presenting cell is induced by pathogens during the innate response to an infection. (nih.gov)
  • Effector T cells act back to promote the expression of B7 proteins on antigen-presenting cells, creating a positive feedback loop that amplifies the T cell response. (nih.gov)
  • A) A mature antigen-presenting cell can deliver both signal 1 and 2 and thereby activate the T cell. (nih.gov)
  • It makes antibodies and antigens and performs the role of antigen-presenting cells (APCs) and turns into memory B-cells after activation by antigen interaction . (differencebetween.net)
  • We apply our method to study differences between human pluripotent stem cells and several cell types including their parental cell line and differentiated progeny. (nature.com)
  • Green: the stem cells and their progeny express protein. (neurosciencenews.com)
  • It thoroughly investigated the unique ability of mouse embryonic stem cells to develop into cells of any organ ("pluripotency"), created new tools for functional genomic studies and thus provided key knowledge to understanding the commitment of cells to differentiate into cells of a particular germ layer. (europa.eu)
  • Its major objective was to produce a gene expression atlas covering the development of ES cells into all three germ layers (ecto-, meso-, and endoderm) and into somatic cells. (europa.eu)
  • Stemcells.RuThe ability of induced pluripotent stem cells (iPSCs) to differentiate into cells of all three germ leaves is well documented. (vechnayamolodost.ru)
  • In contrast, access to models derived from mouse embryonic cells, which grow in lab incubators by the millions, is virtually unlimited. (disabled-world.com)
  • Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
  • Immunologically, characteristic markers of interstitial cells were identified, which formed a dense network in the inner wall. (vechnayamolodost.ru)
  • Embryonic stem cells are known as pluripotent stem cells. (healthline.com)
  • These new types of cells are called induced pluripotent stem cells (iPSCs). (healthline.com)
  • To get a new insight into pluripotency, we employed a plurifaceted experimental design combining expression proteomics with the proteome-wide integral solubility alteration (PISA) assay 7 to compare pluripotent cells with their isogenic progenies and parental cells as well as with allogeneic cells. (nature.com)
  • The term stem cell is generally used to describe cells that are totipotent , pluripotent , or multipotent . (citizendium.org)
  • Pluripotent cells may differentiate to cells of most types, and multipotent cells are capable only of differentiating to certain types within a group of cells that perform similar functions. (citizendium.org)
  • This complex process occurs in several steps and controls the development of pluripotent cells into highly specialised cells of an organism. (europa.eu)
  • Use of this type of stem cell has significantly decreased in recent years due to the discovery of induced pluripotent stem cells. (mayo.edu)
  • Generation of functional gut-like organ from mouse induced pluripotent stem cells. (vechnayamolodost.ru)
  • A decade later, cloning came to the forefront in Missouri with the narrow passage of Amendment 2, a ballot initiative in 2006 that constitutionally protects embryonic stem-cell research and human cloning. (archstl.org)
  • Among this years winners are studies that represent some of the ways in which we perceive and engage with stem cell research are being reshaped. (lu.se)
  • Summary: A new study reports hippocampal neural stem cells regulate their own cell fate via the protein Drosha. (neurosciencenews.com)
  • A research group at the University of Basel now describes for the first time a mechanism by which hippocampal neural stem cells regulate their own cell fate via the protein Drosha. (neurosciencenews.com)
  • The most common method for investigating embryonic developmental disorders is to concentrate on a single organ system in the mouse and conduct gene knockout studies. (mpg.de)
  • One biologically relevant variable is readily inferred from scRNA-seq gene count tables regardless of individual gene representation within single cells: aneuploidy. (techscience.com)
  • According to the random number table (the same grouping method below), the cells were divided into ANXA1-overexpressing group transfected with plasmid containing RNA sequences of ANXA1 gene and no-load control group transfected with the corresponding no-load plasmid. (bvsalud.org)
  • The other cells were divided into ANXA1-knockdown group transfected with plasmid containing small interfering RNA sequences of ANXA1 gene and no-load control group transfected with the corresponding no-load plasmid. (bvsalud.org)
  • Until recently, it was impossible to look deep into development and record this lineage tree information at a single cell resolution. (childrenshospital.org)
  • Maternal and fetal tissues were cultured for fungi, and diagnosis was based on Gram stain (budding yeast-like cells), India ink stain (positive for encapsulated cells), hydrolysis of urea (positive), and final confirmation by using API 20C Aux V3.0 (bioMérieux, Marcy l'Etoile, France). (cdc.gov)
  • But the benefits using these types of stem cells have ranged from marginal, to transient, to nil. (derstandard.at)
  • Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
  • Most cells in the body are differentiated cells. (healthline.com)
  • Other cells in the body can only replicate a limited number of times before they begin to break down. (healthline.com)
  • These cells can give rise to virtually any other type of cell in the body. (healthline.com)
  • These stem cells come from developed organs and tissues in the body. (healthline.com)
  • They can differentiate into all types of specialized cells in the body. (healthline.com)
  • But going in the opposite direction, causing stem cells to differentiate into specialized body cells, not to mention form entire organs, has proved much more problematic. (disabled-world.com)
  • The liver is an organ essential to digestion, energy metabolism and filtration of poisons from the body. (childrenshospital.org)
  • The human body is derived from a single cell. (childrenshospital.org)
  • The cells morph and form body parts. (ibtimes.com)
  • Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)
  • A nerve fiber that transmits signals away from the neuronal cell body and to the next nerve synapse. (mayo.edu)
  • They are unlike "differentiated" cells which have already become whatever organ or structure they are in the body. (jonathanturley.org)
  • Stem cells are present throughout our body, but more abundant in a fetus. (jonathanturley.org)
  • In theory and in fact, lifeless cells anywhere in the body, no matter what the cause of the disease or injury, can be replaced with vigorous new cells because of the remarkable plasticity of stem cells. (jonathanturley.org)
  • This innovative study by first-author Dr. Ani Grigoryan involved engineering mesenchymal stem cells and guiding them through a process mimicking how bones develop naturally in the human body. (lu.se)
  • For organs to stay healthy and functional, they must be constantly surveilled for abnormalities. (uni-bonn.de)
  • All these diseases are characterised by the irreversible loss of functional cells. (europa.eu)