• The Institute for Bioengineering of Catalonia (IBEC) is an institution engaged in basic and applied research in bioengineering and nanomedicine, with experts working on tissue regeneration, biomechanics, molecular dynamics, biomimetics, drug delivery, organs 'on-a-chip', cell migration, stem cells, artificial olfaction and microbial biotechnology. (wikipedia.org)
  • Autologous human adipose tissue-derived mesenchymal stem cells (MSCs) have the potential for clinical translation through their induction into osteoblasts for regeneration. (hindawi.com)
  • For autologous human adipose tissue-derived MSCs, enhanced differentiation into osteoblastic phenotype can be advantageous and may be used with matrix biomaterials for regeneration of the patient's own damaged bones due to fractures, osteoporosis, and deformities. (hindawi.com)
  • To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
  • Programs also support the development of novel cell-based therapies to bring the expertise of transfusion medicine and stem cell technology to the repair and regeneration of human tissues and organs. (hhs.gov)
  • What he didn't have was expertise in the biology of cell regeneration to optimize the printing process. (ncbiotech.org)
  • Increased oxygen levels stimulate capillary remodelling, regeneration of damaged tissues and organs, help prevent and fight infections, reduce inflammation and significantly speed up the healing process. (lentifurdo.hu)
  • This change in oxygen levels is the most powerful trigger for tissue regeneration and capillary regeneration. (lentifurdo.hu)
  • Stem cell therapies have the potential to transform medicine by allowing the regeneration of tissues or organs damaged by disease or trauma. (ca.gov)
  • Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
  • My lab focuses on understanding the role of the extracellular environment for endogenous and exogenous lung tissue regeneration in healthy and diseased lung. (lu.se)
  • We further aim to build new models of human lung tissue to reduce animal usage, better understand how regeneration processes are deranged in CLDs, and for use as drug discovery and therapeutic screening platforms. (lu.se)
  • My Ph.D. studies have focused on the regeneration of salivary gland, which is an organ that is responsible for the production of saliva in our mouths. (lu.se)
  • Then, to translate the knowledge from Paper I and III, a new model that could use human samples needed to be found, this is Paper II, in which we developed a bioengineered model for salivary gland disease that can be used to evaluate regeneration and test pharmaceutical trials (like EV therapy). (lu.se)
  • Transplantation of Organs and Tissues of Human Origin, adopted by the Council of Europe in 2002. (who.int)
  • Transplantation of organs and tissues is increasing ( Figure ). (cdc.gov)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • The scientific and technological research at the institute is grouped into three core application areas: Bioengineering for Regenerative Therapies, Bioengineering for Future Medicine and Bioengineering for Active Ageing. (wikipedia.org)
  • and biomaterials for regenerative therapies. (wikipedia.org)
  • TissueGene, Inc. is a biopharmaceutical company based in Rockville, Maryland , specializing in regenerative therapies for the treatment of various orthopedic diseases. (prnewswire.com)
  • What we do here will produce a durable and adaptable resource for the development and advancement of regenerative therapies for injured military personnel as well as civilian victims of trauma. (rutgers.edu)
  • This restores cells' ability to prevent or treat disease and heal or regenerate tissue. (streetinsider.com)
  • of Wisconsin and recognized nationally for their work with stem cells, which can help regenerate tissues and organs so they work better. (uwhealth.org)
  • and transplants to enable the body to repair, replace, restore and regenerate damaged tissues and organs. (rutgers.edu)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications for funding to perform research leading to the development of novel and supportive technologies for the improvement of cell replacement interventions using novel biomaterials and devices for type 1 diabetes (T1D) treatment. (nih.gov)
  • To support this, it is necessary to develop/optimize novel/smart/safe biomaterials, scaffolds, bio-matrices and bio-barriers that may protect grafted cells from immune rejection and simultaneously promote appropriate vascularization/innervation with an efficient exchange of nutrients to optimize cellular long-term survival and proper function. (nih.gov)
  • The Helmholtz Pioneer Campus at Helmholtz Munich plays a special role in all of this: A magnet that brings together the next generation of international talent from biomedicine with experts from engineering and computer science to produce biomaterials and artificial tissues, for example, thus synergistically linking the program's topics. (helmholtz.de)
  • The institute also will dramatically accelerate the rate at which promising biomaterials as well as cell-based and combined regenerative medicine technologies will be converted into new therapies to restore lost tissue and lost function. (rutgers.edu)
  • Biomaterials will play a crucial role in developing new therapies for regenerating tissue and healing large wounds. (rutgers.edu)
  • Bone healing can be driven by biophysical stimulation using electricity for activating quiescent adult stem cells. (hindawi.com)
  • Hematopoietic stem cells from bone marrow are one of the few clinically approved stem cells which are proven to increase the survival rate for thousands of patients [ 4 ]. (hindawi.com)
  • Bone marrow-derived mesenchymal stem cells, or the blood stem cells that are nonhematopoietic, are currently being used in clinical trials and show promise in improving recovery based on early indicators [ 5 ]. (hindawi.com)
  • The development of new technologies such as this tissue engineering approach is very important since millions of people [ 9 ] suffer from bone injuries on a yearly basis. (hindawi.com)
  • For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
  • Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
  • Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)
  • Aplastic anemia (AA) is a hematopoietic stem cell disorder characterized by pancytopenia and hypocellular bone marrow. (haematologica.org)
  • For example, hematopoietic stem cell transplantation (HSCT), using bone marrow or cord blood as a source of HSCs, is an established curative treatment for a broad variety of genetic, blood, and immune disorders. (parentsguidecordblood.org)
  • These clusters included infection transmitted to recipients of vascularized organs or tissues such as bone, tendon, skin, or corneas. (cdc.gov)
  • Skin grafts Many different types of tissues can be transplanted, including skin, bone, cartilage, adrenal tissue, fetal thymus, corneas, and composite transplantation of tissues to restore the face or extremities. (msdmanuals.com)
  • Recipients of grafts containing immune cells (particularly bone marrow, intestine, and liver) are at risk of graft-vs-host disease, in which the donor immune cells attack recipient tissue. (msdmanuals.com)
  • Mesenchymal stem cells (MSCs) are multipotent stromal cells in connective tissues capable of differentiating into a variety of specialized and functional cells, including osteoblasts, chondroblasts, myocytes, and adipocytes. (hindawi.com)
  • At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
  • The goal of this work is to elucidate novel molecular mechanisms that can be therapeutically targeted to regulate cell migration in a tissue-specific fashion - to inhibit it in certain contexts (e.g., inflammatory diseases and cancer metastasis) and promote it in others (e.g., stem cell transplantation and cell-based therapies). (bu.edu)
  • One focus is on causal research, from the molecular level to organs and the behavior of affected individuals. (helmholtz.de)
  • Molecular biological methods, cell culture and tissue culture are treated to a less extent. (lu.se)
  • She is also director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering at the university. (routledge.com)
  • Experts in artificial intelligence, cell programming, structural biology/drug development and bioengineering come together there. (helmholtz.de)
  • Turn Bio is a pre-clinical-stage company focused on repairing tissue at the cellular level and developing transformative drug delivery systems. (streetinsider.com)
  • The company is completing pre-clinical research on tailored therapies targeting indications in dermatology and immunology, and developing therapies for ophthalmology, osteo-arthritis, and the muscular system. (streetinsider.com)
  • A series of scientific sessions and speakers highlighted key aspects of the latest scientific, clinical and technologic developments in cell therapy, involving a unique set of cell products with a special emphasis on converging concepts in these fields. (nih.gov)
  • CryoStor and HypoThermosol ® , our cell and tissue storage and shipping media, are now incorporated into more than 220 pre-clinical validations and clinical trials of cell-based therapies, targeting blood cancers, solid tumors, vision loss, heart disease, stroke, and movement disorders such as osteoarthritis. (prnewswire.com)
  • TissueGene has completed Phase 2 trials and has reached an agreement with the U.S. Food and Drug Administration regarding a Special Protocol Assessment (SPA) on the design, endpoints and statistical analysis plan for a Phase 3 clinical trial for Invossa, an allogeneic cell therapy for osteoarthritis of the knee. (prnewswire.com)
  • BioLife's enabling technology provides commercial companies and clinical researchers significant improvement in shelf life and post-preservation viability and function of cells, tissues, and organs. (prnewswire.com)
  • Numerical simulations based on these models are useful for both basic science and increasingly for clinical diagnostic and therapeutic applications such as targeting ablation therapy for atrial arrhythmias, defibrillator design and cardiac resynchronization therapy. (simula.no)
  • Cell based treatment is at the front of clinical examination for cardiovascular infection, upheld by more than 10 years of thorough pre-clinical investigation of cell science, mechanism(s) of activity, immunology, and phenotypic adequacy. (alliedacademies.org)
  • Critically, making an interpretation of cell treatment into standard clinical practice requires the capacity to direct a protected and strong item at the ideal measurements promptly. (alliedacademies.org)
  • Likewise, in another clinical preliminary where allogeneic mesenchyme antecedent cells (MPCs) were conveyed to patients with left ventricular help gadgets, contributor explicit HLA refinement created after randomization in two MPC and three control patients, which were all settled by 1 year. (alliedacademies.org)
  • Managed care professionals should have an understanding of the clinical trial data and place in therapy in lymphoma, myeloma, and acute lymphoblastic leukemia as well as guideline recommendations for adverse effect management associated with CAR T-cell therapies. (ajmc.com)
  • The projects have to be suitable to replace the previously practiced use of animals within the framework of training or studies in the fields of anatomy, physiology, biochemistry, cell biology, clinical skills, and surgery as well as pharmacology. (invitrojobs.com)
  • 8 - 10 While most studies have been performed with hATG, more recently, rabbit-derived ATG (rATG) has been introduced into clinical practice, particularly in organ transplantation. (haematologica.org)
  • Proactive therapy chosen on the basis of a careful clinical assessment follows the diagnosis. (medscape.com)
  • The clinical application of cell replacement therapy in the US is dependent on the FDA's approval, and the primary objective of the FDA is to protect patients from unsafe drugs and procedures. (ca.gov)
  • Despite progress in the field, clinical implementation is still delayed, mainly due to insurmountable rejection, but also due to critical functional differences between xenografts and human tissue. (msdmanuals.com)
  • IVDs for clinical decisions on diagnosis and treatment, as does screening of blood/blood products for transfusion and human organs/tissues for transplantation. (who.int)
  • This document provides information to WHO Member States, manufacturers submitting to the WHO Prequalification of Diagnostics Programme, regulators and other stakeholders on an internationally recognized risk-based approach to the regulatory assessment of IVDs to determine the level of scrutiny of the assessment of an IVD and to assure there quality, safety and performance in clinical use. (who.int)
  • Secreted EVs from stem cells have become a hot topic with high research and clinical interest since they avoid concerns about the risks associated with directly injecting stem cells into the human body. (lu.se)
  • Immunotherapy has become an important part of hematopoietic stem cell (HSC) transplantation and cancer therapy. (nih.gov)
  • Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. (bu.edu)
  • Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
  • Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)
  • Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
  • Inflammatory macrophages in the dog contain high amounts of intravesicular ferritin and are associated with pouches of connective tissue fibers. (cdc.gov)
  • But what I was studying was a basic biomechanical effect…it's the binding of the needle to the connective tissue. (medlineplus.gov)
  • And today, that's what I'm still doing in my lab at NIH-I'm studying how stretching connective tissue affects cells. (medlineplus.gov)
  • Health Canada proposes to make NAT a requirement instead of a recommendation for the detection of human immunodeficiency virus type 1 ( HIV -1) and Hepatitis C ( HCV ) for tissue donation from deceased donors, as well as for cord blood donation. (canada.ca)
  • however, transplant therapy is limited due to shortage of transplantable islets (from deceased donors), limited durability of transplanted cells (cells that stop working or growing after transplantation), and the need for long-term immunosuppression therapy to prevent immune-based rejection of the transplanted cells, similar to organ transplants. (jdrf.ca)
  • The confidentiality of all personal data must be ensured throughout the process of donation, and the screening of potential donors should be based on scientific evidence. (who.int)
  • Common methods and standards for evaluating potential donors of organs and tissues are needed to facilitate effective data collection for assessing the risk for infectious disease transmission. (cdc.gov)
  • Number of deceased and living organ donors and deceased tissue donors, United States, 1998-2012. (cdc.gov)
  • In an attempt to prevent donor-derived infections in transplantation, organ and tissue donors are evaluated to identify those that might be more likely to harbor transmissible pathogens. (cdc.gov)
  • Although regulatory requirements and risk-benefit considerations for evaluating organ and tissue donors differ, the fundamental process for donor screening and testing, and the challenges faced in prospectively assessing the risk for donor-derived infection, are similar for organ and tissue donors. (cdc.gov)
  • and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • Its eTurna™ Delivery Platform uses unique formulations to precisely deliver cargo to specific organs, tissues, and cell types. (streetinsider.com)
  • Glandular therapy involves supplementing with extracts produced from specific organs or glands of animals in supplement form. (agentnateur.com)
  • Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)
  • Although both types of ATG share similar mechanisms of action, rATG may be more potent than hATG at an equivalent concentration based on its capacity to produce more profound and prolonged lym-phocytopenia. (haematologica.org)
  • This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
  • You will be introduced to the mechanisms used to produce different cell and tissue types and ensure these cells develop in the correct position and identity. (manchester.ac.uk)
  • To provide a general introduction to the mechanisms used in both plants and animals to produce and position, during embryonic development, the many different cell types required to create a functional adult organism. (manchester.ac.uk)
  • To understand the basic mechanisms used to produce different cell types and to arrange cells in three dimensions during development. (manchester.ac.uk)
  • In addition the general mechanisms by which cells adopt different fates will be described. (manchester.ac.uk)
  • I describe the mechanisms by which different wavelengths of light impact the cells, tissues and organs of the human body, and how specifically timed light exposure of specific wavelengths can be used to improve sleep, enhance alertness, modulate hormone levels, and improve mood. (lifeboat.com)
  • Throughout the episode, I describe the mechanisms of light-based therapies and actionable tools that people can use positively impact mental and physical health. (lifeboat.com)
  • The group aims to understand the mechanisms of morphogenesis and cell differentiation within an embryo. (royalsociety.org)
  • New and innovative forms of therapies, based on stem cells and tissue engineered medical products offer the hope of developing customizable implantable artificial tissue to overcome shortages of transplant organs and revolutionize injury and disease treatment. (euramet.org)
  • This will help prevent the immune system from rejecting an organ transplant. (healthline.com)
  • Such infections must be distinguished from other transplant-associated infections, including nosocomial infections and infections derived from tissue contamination during handling or processing. (cdc.gov)
  • This meeting report summarizes a workshop sponsored by the National Heart, Lung and Blood Institute (NHLBI) and Production Assistance for Cellular Therapies (PACT), held on 23-24 April 2009 at the National Institutes of Health (NIH, USA). (nih.gov)
  • Mathematical models describing cellular membranes form the basis of whole tissue models to describe the electrical activity of entire organs, such as the heart. (simula.no)
  • The process for administering CAR T-cell therapy is complex, with multiple steps including CAR T-cell manufacturing, lymphodepleting chemotherapy, cellular therapy infusion, and management of short-term and long-term toxicities. (ajmc.com)
  • 2,3 Cellular therapy centers, manufacturers, payers, and policy makers will need to work together to address barriers to care as new CAR T-cell products with improved efficacy and tolerability are approved for use in more diverse malignancies. (ajmc.com)
  • Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
  • Despite the high potential and over 200 years of experience with cell therapies, the number of available cellular treatments and their beneficial impact on patients are limited. (parentsguidecordblood.org)
  • The challenges of developing a robust manufacturing process and the complex logistics for storage and distribution of cellular therapies play a significant role in delaying cell therapy progress. (parentsguidecordblood.org)
  • Therefore, the development of preservation methods that allow long-term storage of viable cells at ambient temperatures has become an important goal for scientists working in the field of cellular therapies. (parentsguidecordblood.org)
  • Three types of cystinosis have been described based on the age at diagnosis and magnitude of cellular cystine deposition: infantile onset, adolescent onset, and adult onset. (medscape.com)
  • The thymus is a powerhouse for your immune system and is the gland responsible for immunological development during childhood, particularly of T-cells involved in fighting infections and cancer cells. (agentnateur.com)
  • The Rutgers approach is based on using experimental screening assays in combination with computational modeling. (rutgers.edu)
  • Our proposed method of on-chip clearing for live imaging of 3D cell cultures provides an alternative for dynamic monitoring of deep tissue on a microfluidic device and has the potential to be used in 3D culture-based assays for high-throughput applications. (bvsalud.org)
  • 1997. In vitro genotoxic effects of hard metal particles assessed by alkaline single cell gel and elution assays. (cdc.gov)
  • Although cryopreservation retains viability of frozen cells, it requires specialized equipment to maintain ultralow temperatures. (parentsguidecordblood.org)
  • Several scientific reports in the literature have demonstrated feasibility of cell dehydration, however, data thus far has shown low cell viability and poor method reproducibility. (parentsguidecordblood.org)
  • As a result, the cell viability significantly decreased as the concentration of PS-NPs increased, while TEER levels decreased and permeability increased. (bvsalud.org)
  • The on-chip tissue clearing increased the imaging performance of live 3D spheroids with no influence on cell viability or spheroid proliferation and demonstrated robust compatibility with several commonly used cell probes. (bvsalud.org)
  • The company's proprietary mRNA-based ERA™ technology restores optimal gene expression by combatting the effects of aging in the epigenome. (streetinsider.com)
  • Another 10 employees at the company's subsidiary in Shoham, Israel, are refining the bioprinter so it can consistently manufacture tissues and organs to scale. (ncbiotech.org)
  • A critical roadblock to successful cell replacement therapies, no matter what the disease or injury, is the fact that the immune system's main function is to prevent the introduction of foreign substances into our bodies. (ca.gov)
  • Dr. Elliott J. Hagedorn is a cell and developmental biologist with expertise in hematopoiesis, stem cell biology and vascular heterogeneity. (bu.edu)
  • Funding encompasses a broad spectrum of hematologic inquiry, ranging from stem cell biology to medical management of blood diseases and to assuring the adequacy and safety of the nation's blood supply. (hhs.gov)
  • 4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
  • Discover how biology-based science can be applied for medical use through our wide-ranging course. (manchester.ac.uk)
  • The role that developmental biology plays in medicine in stem cell therapy, tissue engineering and regenerative medicine will also be considered. (manchester.ac.uk)
  • The unit will have a series of five scenario-based PBL exercises that simulate developmental biology experiments and cover important concepts from the course. (manchester.ac.uk)
  • Philippa Francis-West is a Professor in Developmental and Cell Biology at the Centre for Craniofacial and Regenerative Biology, King's College London. (royalsociety.org)
  • The biology of cryopreserving cells is complex. (parentsguidecordblood.org)
  • Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. (routledge.com)
  • Precise Bio has developed a laser-based biological "printer" that can fabricate tissues and organs from living cells in three dimensions, just as they are structured in the body. (ncbiotech.org)
  • Ten employees focus on the biological challenges of tissue and organ fabrication. (ncbiotech.org)
  • 1 Cell therapy is a key part of regenerative medicine that provides solutions to many conditions that otherwise cannot be addressed by medical devices, pharmaceuticals, and biological drugs. (parentsguidecordblood.org)
  • Three-dimensional (3D) cell cultures provide an important model for various biological studies by bridging the gap between two-dimensional (2D) cell cultures and animal tissues. (bvsalud.org)
  • AcouSort - a biotech company providing solutions for automated sample preparations involving biological cells or other organelles, using the technology of acoustophoresis. (lu.se)
  • It involves using animal tissues and cells to enhance physiological function and support natural healing. (agentnateur.com)
  • Glucose measurements are used in the diagnosis and treatment of pancreatic islet cell carcinoma and of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia. (cdc.gov)
  • Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. (nih.gov)
  • These include 'adult' differentiated cells of the body (known as somatic cells, e.g. skin cells) and stem cells from a range of sources - embryonic, foetal, cord blood, and mature tissues. (eurostemcell.org)
  • European cell therapy firms are split almost equally between therapies based on stem cells and therapies based on somatic cells. (eurostemcell.org)
  • IPI-504 preferentially targets and accumulates in tumor tissues, sparing healthy tissues. (salesandmarketingnetwork.com)
  • However, such payloads can be harmful if released outside the tumor in healthy tissues where the bacteria also engraft in smaller numbers. (nature.com)
  • Those lines that form around 50-something women's mouths reflect the decline of the function of their reproductive organs. (skininc.com)
  • Mirvetuximab soravtansine-gynx injection is used to treat certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. (medlineplus.gov)
  • In spite of widespread use, data supporting specific practice paradigms for whole blood and component therapy transfusion are lacking, the notable exception being in the primary treatment of hemorrhagic shock. (medscape.com)
  • Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)
  • Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
  • Active hemorrhage resulting in shock is one of the few evidence-based established indications for transfusion. (medscape.com)
  • It is also necessary to investigate methods to use different cell sources including human progenitor cells and induced pluripotent stem cells as a valid option for cell replacement therapy. (nih.gov)
  • Embryonic stem cells are known as pluripotent stem cells. (healthline.com)
  • Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
  • These new types of cells are called induced pluripotent stem cells (iPSCs). (healthline.com)
  • Human embryonic stem cells (hESC), and other related pluripotent stem cells, have great potential as starting material for the manufacture of curative cell therapies. (ca.gov)
  • This proposal focuses on the role of the immune system in transplantation of derivatives of human pluripotent stem cells (hPSCs). (ca.gov)
  • There are two types of stem cell manufacturing: embryonic stem cell production, derived from early-stage embryos, and induced pluripotent stem cell (iPSC) production, which reprograms adult cells to an embryonic-like state. (imarcgroup.com)
  • Embryonic stem cells come from human embryos that are three to five days old. (healthline.com)
  • Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
  • To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)
  • However, in recent years, there has been controversy surrounding the way human embryonic stem cells are obtained. (healthline.com)
  • cells that behave very like embryonic stem cells and can differentiate into all the different types of cells in the body. (eurostemcell.org)
  • Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
  • The drug is based on protein A1M, an endogenous substance that captures and neutralises toxic substances in the body. (lu.se)
  • This Draft 2 nd Edition has been revised to reflect imminent updates to the Canadian Standards Association ( CSA ) standards, to improve the clarity in certain areas of the document, and to introduce new nucleic acid testing ( NAT ) requirements for certain tissues and cord blood. (canada.ca)
  • Mandatory and recommended tests are described in the CTO Guidance document, and Health Canada has taken this opportunity to propose new transmissible disease testing requirements that would be considered mandatory for tissue donation and cord blood donation. (canada.ca)
  • After the 2 nd Edition CTO Guidance document is revised and published, CTO establishments will have a reasonable period of time to implement newly introduced testing requirements (i.e., 6 months to introduce HIV -1 and HCV NAT for tissues and cord blood). (canada.ca)
  • Cord blood stem cells are harvested from the umbilical cord after childbirth. (healthline.com)
  • The challenge for existing stem cell-based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo , because stem cells are rather sensitive to even minute changes in their environment. (routledge.com)
  • Transcription factor induction of vascular blood stem cell niches in vivo. (bu.edu)
  • Third, IL-2 therapies aiming at expanding immunosuppressive regulatory T cells in vivo . (frontiersin.org)
  • 6 In addition, rATG may selectively promote the expansion of regulatory T cells, 11 possibly inducing in vivo immune tolerance through this mechanism. (haematologica.org)
  • Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
  • Experimental pharmacological methods are introduced, including operation techniques and in vitro experiments with excised tissues or organs. (lu.se)
  • In recent decades, in addition to monolayer-cultured cells, three-dimensional tumor spheroids have been developed as a potentially powerful tool for the evaluation of anticancer drugs. (bvsalud.org)
  • This CTO Guidance document provides clarification and interpretation of the regulatory requirements contained in the Safety of Human Cells, Tissues and Organs for Transplantation Regulations ( CTO Regulations). (canada.ca)
  • We look forward to progress by Kolon and other customers in gaining regulatory approvals to commence commercial manufacturing of these life-changing and life-saving cell therapies. (prnewswire.com)
  • In addition, suppressor immune cells such as FOXP3 + regulatory T cells (Tregs) exert dominant immune suppression to control autoreactive T and B cells. (frontiersin.org)
  • Consequently, the demand for stem cell-based treatments is soaring as patients seek alternatives to traditional approaches. (imarcgroup.com)
  • Additionally, if signs of cancer are still present after the completion of an initial treatment cycle, additional "boost" treatments might be recommended to destroy any remaining cancer cells. (moffitt.org)
  • For more information about total skin electron therapy or any of our other innovative radiation treatments, call 1-888-663-3488 or submit a new patient registration form online. (moffitt.org)
  • Cell therapies are treatments that use human cells, including stem cells, with the aim of restoring, maintaining, or improving the functioning of human tissues or organs. (eurostemcell.org)
  • If you can't get a clear diagnosis and are stuck in a vicious cycle of medical treatments without much improvement, IPEC Therapy offers assessment and interventions that promote and accelerate natural healing with swift results. (myholistictherapy.org)
  • Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
  • Peripheral tolerance occurs in the secondary lymphoid organs (e.g. spleen, lymph nodes, and mucosal/gut associated lymphoid tissues) and peripheral tissues. (frontiersin.org)
  • ATG can exert various effects on the immune system, including T-cell depletion in the blood and peripheral tissues, down-modulation of adhesion molecules and chemokine receptors, 7 and possibly a direct effect on hematopoietic stem cells. (haematologica.org)
  • 2004. Corrosion of tungsten coils after peripheral vascular embolization therapy: Influence on outcome and tungsten load. (cdc.gov)
  • These are at all stages of development from early preclinical research, as with a neural stem cell therapy being developed for Parkinson's Disease by Axontherapix S.L of Spain, through to products that are available to treat patients now such as Chondroselect ® , a cell therapy for repairing damaged tissue in knee joints produced by Belgian cell therapy firm TiGenix. (eurostemcell.org)
  • Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. (routledge.com)
  • Sebastiano and his team have used Turn Bio's ERA™ technology to reprogram several cell types, including skin and immune cells. (streetinsider.com)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
  • Among the cell types being investigated for therapy, immune cells have excelled in the treatment of hematologic malignancies. (nature.com)
  • However, ionizing radiation carries the risk of damage to host immune cells and engineered microbial cells 31 . (nature.com)
  • Existing lung-on-a-chip models also lack interactions among immune cells, which are crucial in monitoring complex responses. (bvsalud.org)
  • In the study, we built the lung-on-a-chip to accurately recapitulate the structural features and key functions of the alveolar-blood barrier while integrating multiple immune cells. (bvsalud.org)
  • This limits widespread use of cell therapies, complicates distribution, and increases cost. (parentsguidecordblood.org)
  • The stored cystine is poorly soluble and crystallizes within the lysosomes of many cell types, leading to widespread tissue and organ damage. (medscape.com)
  • Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anemia, chronic renal disease, and hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin). (cdc.gov)
  • To avoid damaging healthy organs, it is crucial that the therapeutic activity of microbes be targeted to tumors. (nature.com)
  • It is hypothesized that application of electric current will enhance their osteogenic differentiation, and addition of conductive carbon nanotubes (CNTs) to the cell substrate will provide increased efficiency in current transmission. (hindawi.com)
  • A possible differentiation enhancer is the application of an external stimulus to stem cells in the form of electricity [ 10 - 12 ]. (hindawi.com)
  • The current research focus is on the Dchs1-Fat4-PCP-Hippo signaling pathway and the role of mechanics during cell differentiation. (royalsociety.org)
  • Biotech products include protein drugs made by genetically-engineered cell cultures, monoclonal antibodies (laboratory-made copies of a single human antibody, often for use in cancer treatment ) and, most recently, human cell-based therapies. (eurostemcell.org)
  • Numerical simulation techniques coupled to parameter estimation methods aim at predicting and optimizing therapies efficacy. (ens-lyon.fr)
  • However, anti-TNF-α therapies have limitations, including known adverse safety risk, loss of therapeutic efficacy due to drug resistance, and lack of efficacy in numerous autoimmune diseases, including multiple sclerosis. (frontiersin.org)
  • 13 Only limited efficacy data are available for rATG used as initial therapy in severe AA. (haematologica.org)
  • Lung transplantation is the only option at end-stage disease and is further complicated by shortage in organs available for transplantation and low efficacy. (lu.se)
  • Chimeric antigen receptor (CAR) T-cell therapy is designed to enhance the body's immune system to effectively kill malignant cells. (ajmc.com)
  • The diagram Facial Reflex Zones (to the right) shows how the body's internal organs correspond to specific zones on the face. (skininc.com)
  • It increases the body's own antioxidant function, and the circulating stem cell numbers. (lentifurdo.hu)
  • Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
  • Adult stem cells have a misleading name, because they are also found in infants and children. (healthline.com)
  • Adult stem cells don't present any ethical problems. (healthline.com)
  • Adult 'differentiated' cells are easier to obtain than stem cells and the know-how to grow and manipulate them is well established, but they are mainly used in indications with relatively limited patient populations such as wound healing and repairing damaged joints and ligaments. (eurostemcell.org)
  • Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
  • The protein protects tissue from inflammation when cells rupture. (lu.se)
  • For example, red blood cells are specifically designed to carry oxygen through the blood. (healthline.com)
  • When a stem cell divides, it can either remain a stem cell or turn into a differentiated cell, such as a muscle cell or a red blood cell. (healthline.com)
  • They make new red blood cells, white blood cells, and other types of blood cells. (healthline.com)
  • These cells have been successfully used to treat children with blood cancers, such as leukemia, and certain genetic blood disorders. (healthline.com)
  • The procedure proves unfeasible for blood transfusions, but paves the way for successful organ transplantation, for which Carrel receives the Nobel Prize in 1912. (aabb.org)
  • Research in the Hagedorn Lab utilizes a combination of genetics, genomics and advanced live cell imaging in zebrafish to understand how blood and cancer cells migrate into and out of distinct tissues and organs. (bu.edu)
  • An embolus may block blood flow to an organ or body part, causing pain and damage to the organ or body part that lies beyond the point at which the blood flow is obstructed. (hopkinsmedicine.org)
  • As the Facial Reflex Zones diagram reveals, the face's problem areas usually mirror imbalances in the internal organs, blood, qi (vital energy) and fluids. (skininc.com)
  • Methods that balance and heal the nervous system, help de-stress organs, tonify qi and blood, and promote emotional balance will improve the appearance and attractiveness of a person's face. (skininc.com)
  • Oxygen is delivered by red blood cells, normally at atmospheric pressure. (lentifurdo.hu)
  • This allows oxygen to reach tissues with reduced blood supply or damaged tissues. (lentifurdo.hu)
  • This powerful test can detect blocks in the energy field of your cells and organs long before it can be detected in medical testing (blood test, urine etc. (myholistictherapy.org)
  • Additionally, PS-NPs could induce oxidative stress and inflammatory responses at the organ level, and crossed the alveolar-blood barrier to enter the bloodstream. (bvsalud.org)
  • Anemia describes a diminished circulating red cell mass, expressed as grams of hemoglobin per 100 cc of whole blood. (medscape.com)
  • A1M is mainly produced in the liver, where it is secreted into the blood and quickly transported to all tissue before it is finally broken down in the kidneys. (lu.se)
  • Sickle cell disease (SCD) is a group of inherited red blood cell disorders. (cdc.gov)
  • Red blood cells contain hemoglobin, a protein that carries oxygen. (cdc.gov)
  • Healthy red blood cells are round, and they move through small blood vessels to carry oxygen to all parts of the body. (cdc.gov)
  • In someone who has SCD, the hemoglobin is abnormal, which causes the red blood cells to become hard and sticky and look like a C-shaped farm tool called a "sickle. (cdc.gov)
  • The sickle cells die early, which causes a constant shortage of red blood cells. (cdc.gov)
  • Infectious disease transmission through organ and tissue transplantation has been associated with severe complications in recipients. (cdc.gov)
  • A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
  • Stem cells have the potential to revolutionize contemporary medicine and therapy methods. (hindawi.com)
  • The project established measurement methods for generating and interpreting 3D functional maps of surfaces and cell cultures. (euramet.org)
  • This is an exciting project that harnesses the most cutting-edge methods to develop a safe and effective cell therapy solution that may lead to a cure for T1D. (jdrf.ca)
  • Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes. (wjgnet.com)
  • The methods for diagnosing cardiac sarcoma vary, to some degree, based on the symptoms present. (hopkinsmedicine.org)
  • Gentle methods include botanical and mineral applications, massage/acupressure, and low-intensity microcurrent and light therapies. (skininc.com)
  • Some of these methods deliberately injure the sensitive tissues of the face, thereby triggering granulation of new cells in response to the minor wounds created. (skininc.com)
  • Additionally, we describe a method of image-based analysis using artificial intelligence-based analysis software that can scan the whole plate and obtain data on three-dimensional spheroids. (bvsalud.org)
  • According to Kolon, Invossa is the world's first cell-mediated gene therapy for osteoarthritis, a degenerative joint disease affecting more than 150 million people. (prnewswire.com)
  • Kolon Life Science has been developing innovative cell and gene therapies including Invossa, the world's first cell-mediated gene therapy for osteoarthritis, since its founding in 2000. (prnewswire.com)