As a result, most chemists in academia and industry now make use of boronic acids in synthetic chemistry, be it for Suzuki-Miyaura cross-coupling or other reactions. (weltbild.de)
In this research, we explored the rhodium(III)-catalyzed cross-coupling reactions of organoboronic acids and hydroxylamines derivatives. (edu.hk)
Furthermore, catalytic cycloaddition reactions of benzohydroxamic acids / semicarbazones with diazo compounds / alkynes were also accomplished. (edu.hk)
Likewise, N,N-dialkylhydroxylamines and benzohydroxamic acids are effective substrates for the C-N coupling reactions with the corresponding tertiary amines and amides being formed in 47 - 97% yields. (edu.hk)
Inspired by our previous finding on the rhodium(III)-catalyzed arene C-H coupling reactions with diazomalonates, we envisioned that a transformation involving formal [4 + 1] cycloaddition of diazo compounds with O-acetyl benzohydroxamic acids should give oxisoindoles as products via reductive elimination of the σ-allylrhodacycle. (edu.hk)
Diazo compounds having esters, phenylsulfone, cyano and phosphonate groups are good coupling partners, and their reactions with benzohydroxamic acids gave the corresponding oxisoindoles in up to 90% yields. (edu.hk)
Esters2
An alternative to esters in this method is the use of diboronic acid or tetrahydroxydiboron ([B(OH2)]2). (wikipedia.org)
Boronic esters are esters formed between a boronic acid and an alcohol. (wikipedia.org)
Arylboronic acids1
The arylation of N-alkylhydroxylamines with arylboronic acids was first examined by treating O-benzoyl-N-isopropylhydroxylamine with 6-methoxy-2-naphthaleneboronic acid and [Cp*Rh(OAc)₂] (Cp* = pentamethylcyclopentadiene, OAc = acetate) (0.25 mol%) in MeOH at room temperature for 2 h, and the desired amine 7a was obtained in 90% yield. (edu.hk)
Derivatives4
Furthermore, boronic acid derivatives constitute a class of inhibitors for human acyl-protein thioesterase 1 and 2, which are cancer drug targets within the Ras cycle. (wikipedia.org)
However, a significant fraction of commonly used boronic acids and their derivatives were recently found to gives a positive Ames test and act as chemical mutagens. (wikipedia.org)
The past two decades have witnessed phenomenal advances in the synthetic, biological, and medicinal applications of organoboronic acid derivatives. (weltbild.de)
The renowned boron chemist Prof. Dennis Hall is joined by a select group of expert authors to cover all modern aspects of boronic acid derivatives in one comprehensive handbook. (weltbild.de)
Moiety1
5- and 6-Alkynoylsilanes are converted to α -alkylidenecycloalkanones by treatment with [RhCl(CO) 2 ] 2 in the presence of acetic acid via transmetallation between the acylsilane moiety and a rhodium(I) complex. (go.jp)
Compounds1
A palladium-catalyzed oxidative cross-coupling of vinyl boronic acids and cyclic α-diazocarbonyl compounds has been reported. (unboundmedicine.com)
Phenylboronic acid2
For example, phenylboronic acid is produced from phenylmagnesium bromide and trimethyl borate followed by hydrolysis PhMgBr + B(OMe)3 → PhB(OMe)2 + MeOMgBr PhB(OMe)2 + 2 H2O → PhB(OH)2 + 2 MeOH Another method is reaction of an arylsilane (RSiR3) with boron tribromide (BBr3) in a transmetallation to RBBr2 followed by acidic hydrolysis. (wikipedia.org)
Phenylboronic acid can be selfcondensed to the cyclic trimer called triphenyl anhydride or triphenylboroxin. (wikipedia.org)
Substrates1
In particular, a large number of novel synthetic processes have signifi cantly expanded the breadth of usefulness of boronic acids as a class of substrates. (weltbild.de)
Boronates1
Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. (illinois.edu)
Synthesis1
Combined with an improved one-step synthesis of triol arylborates from boronic acid, this remarkably efficient new tool provided a variety of 4′-arylated phenylalanines and tyrosines in good yields at low catalyst loading with a wide functional group tolerance. (mdpi.com)
Synthetic1
Several synthetic routes are now in common use, and many air-stable boronic acids are commercially available. (wikipedia.org)
Deprotonation1
To ascertain that the reaction should go through chelation-assisted C-H/N-H deprotonation of O-acetyl benzohydroxamic acid, we reacted 3a (0.12 mmol) with [Cp*Rh(OAc)₂] (0.1 mmol) in THF at 60 °C for 2 h under a N₂ atmosphere. (edu.hk)
Preparation1
In 1860, Edward Frankland was the first to report the preparation and isolation of a boronic acid. (wikipedia.org)
Products1
The X-ray crystallographic analysis of the products indicates that the cis-addition of the acids to the Si-Si bond is preferable. (go.jp)
Form2
The pKa of a boronic acid is ~9, but they can form tetrahedral boronate complexes with pKa ~7. (wikipedia.org)
This compound then oxidized in air to form ethylboronic acid. (wikipedia.org)
Methods2
Boronic acids can be obtained via several methods. (wikipedia.org)
The detection of formic acid vapor in the usage environment is extremely important for human health and safety. (bvsalud.org)
Compared to conventional film sensors for the detection of formic acid molecules, aerogel sensors exhibit an 8-fold lower limit of detection, 15-fold better sensitivity at low concentrations, 34-fold faster response time, and higher stability. (bvsalud.org)