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  • promotes
  • Bozozok itself acts as a transcriptional repressor, and promotes organizer formation by directly inhibiting expression of the bmp2b (swirl) gene and by negatively regulating Wnt signaling by an unknown mechanism. (zfin.org)
  • incomplete
  • An NTD originates from and is characterized by incomplete closure of the neural tube, which is an organizer and precursor of the central nervous system. (asu.edu)
  • mice
  • Mario R. Capecchi, Sir Martin J. Evans, Oliver Smithies, 'for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells. (livescience.com)
  • Because the mutant mice die at birth, cortical organization was assessed at embryonic ages. (biologists.org)
  • region
  • We find that removal of the morphological shield does not remove all goosecoid- and floating head-expressing cells, suggesting that the morphological shield does not comprise the entire organizer region. (zfin.org)
  • The earliest detectable defect occurs in the future forbrain region at embryonic day 9.5. (sdbonline.org)
  • cells
  • Secreted factors emanating from the organizer and from its derivatives lay down the identity of neighbouring cells and coordinate embryogenesis. (uni-goettingen.de)
  • effect
  • The experiments which finally led to the discovery of the phenomena which are now designated as "organizer-effect" were prompted by a question which actually goes back to the beginnings of developmental mechanics, indeed to the beginnings of the history of evolution in general. (nobelprize.org)
  • source
  • The cortical hem, a source of Wingless-related (WNT) and bone morphogenetic protein (BMP) signaling in the dorsomedial telencephalon, is the embryonic organizer for the hippocampus. (biologists.org)
  • A similar shift occurs when fibroblast growth factor (FGF) 8 is increased at the rostral telencephalic organizer, yet the FGF8 source was unchanged in hem-ablated brains. (biologists.org)
  • birth
  • My laboratory is interested in the problem of birth defects that occur when embryonic patterning fails to occur properly. (yale.edu)
  • identity
  • Somehow during the metamorphosis from sphere to salamander (or sparrow, or sperm whale), an embryonic cell must learn its adult identity. (nautil.us)