Organisms genome helminth. Medical search. Frequent questions

WormBase's partner site, WormBase ParaSite, is a portal for parasitic helminth genomes providing rapid access to the genome sequences, annotation and comparative genomics of around one hundred parasitic species. (sanger.ac.uk)

Also known as the hologenome theory of evolution, the idea is that the object of natural selection is not the individual organism, but the holobiont, i.e. the individual organism plus its associated microbial communities which include a mind numbingly complex web of bacteria, viruses, protozoa, helminths and fungi. (greenmedinfo.com)
The Pathogens link leads to organism-specific sequencing information for more than 100 bacteria, fungi, protozoa, helminths, vectors, and plasmids, as well as a variety of computational tools. (nih.gov)
Gastrointestinal (GI) infections can be caused by many types of microbes, including bacteria, viruses, protozoa, and helminths. (nih.gov)
Parasites refer to microscopic unicellular protozoa, multicellular helminths which may reach large dimensions, and arthropods which comprise diverse organisms. (medscape.com)

WHO fact sheet on soil-transmitted helminth infections caused by different species of parasitic worm. (nih.gov)
The Commission recommends research goals that are focused on identifying disease-causing microbes, understanding what distinguishes those organisms from the normal microflora of the human GI tract, and using that knowledge to develop safe, effective therapies to prevent and treat intestinal infections. (nih.gov)
Diseases caused by soil-transmitted helminths are among the most common infections in the world, affecting marginalized, low-income and resource-poor populations. (unifesp.br)
Also of great concern is the fact that polyparasitism is often present where most neglected tropical diseases occur, for instance, there is widespread overlap between HIV-AIDS and schistosomiasis, TB and intestinal helminth infections, and a high rate of hookworm and malaria coinfections. (medscape.com)
Julian Dommann, Master Student at Swiss TPH, was part of a study that found an association between gut-microbial community and drug efficacy against soil transmitted helminth infections. (swisstph.ch)
However, ivermectin is considered for its antiparasitic activity, and it is used during mass-drug administration (MDA) campaigns for the control of helminth infections. (swisstph.ch)
Helminth parasites represent a significant threat to the health of human and animal populations, and there is a growing need for tools to treat, diagnose, and prevent these infections. (biomedcentral.com)
How dysregulation of the immune system results in immunodeficiencies, autoimmunity, inflammation, allergy, chronic infections, and lymphoproliferative diseases and what strategies might be valuable for therapeutic or vaccine development related to these conditions as well as cancer are important topics of interest, as is the behavior of the meta-organism. (nih.gov)
Gastrointestinal (GI) helminth infections cause significant morbidity in both humans and animals worldwide. (biomedcentral.com)
We describe two cases of wound infections of koalas ( Phascolarctos cinereus ), one wild and one captive, in which Lonepinella -like organisms were involved. (bioone.org)

To identify interactions between parasite success and the microbiome, we quantified longitudinal associations between an intestinal helminth of zebrafish, Pseudocapillaria tomentosa , and the gut microbiome in 210 4-month-old 5D line zebrafish. (biomedcentral.com)

are important nematode parasites of foals and were historically model organisms in the field of cell biology, leading to many important discoveries. (bvsalud.org)
[ 202 ] Most of the diseases in this group are parasitic diseases, caused by a variety of protozoan and helminth parasites. (medscape.com)
In contrast to other parasites, such as A lumbricoides, no tissue migratory phase occurs with Trichuris organisms, confining infection to the GI tract. (medscape.com)
The course will emphasize the dynamic nature of the relationship between parasites and their hosts and seeks to present an overview of current basic and applied research on the organisms that live in the third great environment - namely the body of another individual. (aber.ac.uk)
The organization of parasite genomes and some of the unique mechanisms of mRNA editing found in parasites will also be covered. (aber.ac.uk)
The subject of our research however encompasses different kinds of worms, namely soil-transmitted helminths (STHs) - parasites. (swisstph.ch)
Human parasites are organisms that live on or in a person and derive nutrients from that person (its host). (msdmanuals.com)
En tant que parasites de l' homme et des animaux ils sont responsables des bilharzioses. (malaimare.ro)

Unfortunately, the most surprising discovery about these bacteria is too recent to be included in this book, namely, that they can integrate nearly their entire genome into the chromosome of their host, a unique example of massive lateral gene transfer. (cdc.gov)
Entrez (keyword search tool), BLAST (sequence search tool), Genome Data Viewer, PGAP (bacteria genome annotation tools), RAPT (bacteria genome assembly and annotation pipeline), and more. (nih.gov)
Intestinal helminths are extremely prevalent among humans and animals, and live in intimate contact with the host gut microbiota and harbor bacteria within their own intestines. (antimicrobialresistance.eu)

To reveal impacts of sexual mode on genome content, we compared chromosome-scale assemblies of the outcrossing nematode Caenorhabditis nigoni to its self-fertile sibling species, C. briggsae C. nigoni 's genome resembles that of outcrossing relatives but encodes 31% more protein-coding genes than C. briggsae C. nigoni genes lacking C. briggsae orthologs were disproportionately small and male-biased in expression. (nih.gov)
The Model Organisms link yields resources categorized by organism: mouse, zebrafish, Caenorhabditis elegans , Schizosaccharomyces pombe , and Xenopus tropicalis . (nih.gov)
New strategy for antihelmintic discovery using the model organism caenorhabditis elegans. (unifesp.br)
The free-living nematode Caenorhabditis elegans is widely recognized as a model organism for investigating the biology of parasitic nematodes due to its easy laboratory culture, short generation time and fully sequenced genome. (unifesp.br)
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. (tamu.edu)

The Geshiyaro project is a 5-year intervention to assess the impact of community- and school-based water, sanitation, and hygiene (WaSH) interventions on reducing infection with soil-transmitted helminths (STH. (biomedcentral.com)

A major milestone of the BUG Consortium ( https://bugconsortium.wordpress.com/ ), a multidisciplinary group focused on building genomic resources to map genes driving anthelmintic resistance, these genome resources represent years of work by many people, including long-running collaborative efforts of the Parasite Genomics Group at the Wellcome Sanger Institute ( https://www.sanger.ac.uk/group/berriman-group/ ), the University of Glasgow, and the Moredun Research Institute. (springernature.com)
Model organism databases (MODs) host the genomic and functional information produced by organism-specific research projects and provide query and visualization tools to access these data. (biomedcentral.com)
WormBase 2016: expanding to enable helminth genomic research. (dagstuhl.de)

The densely packed website offers a wealth of scientific resources related to its research on human genetics, model organisms, pathogens, bioinformatics, sequencing, and proteomics. (nih.gov)
In order to obtain full protection against some pathogens, particularly non-invasive micro-organisms such as Vibrio cholerae, mucosal immunity may be particularly important. (bmj.com)
The recent improved understanding of bacterial virulence associated gene function offers the possibility of introducing multiple, defined, attenuating and stable mutations into the genome of bacterial pathogens. (bmj.com)

Phylogenetic analyses of ascaridoid nematodes based on the amino acid sequences of 12 protein-coding genes of mitochondrial genomes were performed using maximum likelihood and Bayesian inference. (bvsalud.org)
PacBio Genome Sequences of Escherichia coli Serotype O157:H7, Diffusely Adherent E. coli , and Salmonella enterica Strains, All Carrying Plasmids with an mcr-1 Resistance Gene. (cdc.gov)
Even as the explosion of available genome sequences and associated genome-scale data continues apace, the sustainability of professionally maintained biological databases is under threat due to policy changes by major funding agencies. (biomedcentral.com)
The nine studies cover catalytic schistosomiasis fever in transcripts from Schistosoma non- autonomous retro- transposons, mobile genetic elements of malaria vectors and other mosquitoes, retro- transposons in the genomes of the digenean parasitic trematodes Clonochis sinensis and Paragonimus westermani, endogenous retro- transposon sequences of the Schistosoma mansoni intermediate snail host Biomphalaria. (malaimare.ro)
We could functionally classify 776 (35%) sequences using the Gene Ontologies (GO) and established pathway associations to 696 (31%) sequences in Kyoto Encyclopedia of Genes and Genomes (KEGG). (biomedcentral.com)

WormBase is the model organism database of C. elegans and other nematodes. (sanger.ac.uk)
WormBase is a comprehensively curated database of the genetics, genomics and biology C. elegans that also contains curated genomes for a key parasitic nematodes. (sanger.ac.uk)
Of the 2258 representative ESTs, 1159 (51.3%) had homologues in the free-living nematode C. elegans , 1174 (51.9%) in parasitic nematodes, 827 (36.6%) in organisms other than nematodes, and 863 (38%) had no significant match to any sequence in the current databases. (biomedcentral.com)

The structural proteins are encoded at the 3' region of the genome and are expressed from a set of subgenomic mRNAs. (wikipedia.org)
citation needed] Many proteins have been identified on the genomes of Nidovirales, but their function has not yet been determined. (wikipedia.org)
For instance, recent research shows that our body draws from over 90 different bacterial strains in our gut to digest the gluten proteins in wheat that our own genome does not readily enable us to break down with any efficiency. (greenmedinfo.com)
Heat shock proteins (HSPs) are evolutionarily conserved proteins, produced by cells in response to hostile environmental conditions, that are vital to organism homeostasis. (biomedcentral.com)
The first gene encodes four proteins necessary for genome replication (Rep78, Rep68, Rep52, and Rep40), and the second expresses three structural proteins (VP1-3) that assemble to form the viral capsid. (justia.com)

The related resource WormBase ParaSite, is a portal for the draft genomes of parasitic helminths. (sanger.ac.uk)
While safe and effective drugs can treat helminth infection, the rapid rise of anthelmintic drug resistance [ 6 ] necessitates development of new strategies for parasite control. (biomedcentral.com)

Here we report a method to edit the C. elegans genome using the clustered, regularly interspersed, short palindromic repeats (CRISPR) RNA-guided Cas9 nuclease and homologous recombination. (tamu.edu)
Together our results outline a flexible methodology to produce essentially any desired modification in the C. elegans genome quickly and at low cost. (tamu.edu)

The microbiome, however, is part of the new definition of the human body as a meta-organism, consisting of trillions of other microbial organisms and viruses without which we would never have survived. (greenmedinfo.com)

The institute has been a leading contributor to the Human Genome Project and now focuses much of its work on studying human DNA sequence variations and how these correlate with genetic diseases. (nih.gov)
The goal of the HEP is to locate, identify, and catalog methylation variable positions within the human genome. (nih.gov)
The partners have conducted a pilot study of the methylation patterns within the major histocompatibility complex, a region of chromosome 6 that is associated with more diseases than any other region of the human genome. (nih.gov)

The study of how animals function with emphasis on the integration of physiological processes at the cellular, organ, and whole organism levels in ecological and evolutionary contexts. (princeton.edu)

That part of the genome that corresponds to the complete complement of EXONS of an organism or cell. (bvsalud.org)

WormBase: a modern Model Organism Information Resource. (dagstuhl.de)
WormBase 2012: more genomes, more data, new website. (dagstuhl.de)

By resolving the chromosomes of the gastrointestinal parasitic nematode, Haemonchus contortus, we have provided unique insights into the chromosomal evolution and genome-wide diversity of this globally important pathogen. (springernature.com)
Note that T trichiura is usually found in association with other helminths that flourish under similar conditions, a common pathogen being A lumbricoides. (medscape.com)

Genome-based prediction of bacterial antibiotic resistance. (cdc.gov)

While the emergence of resistance by human-infective helminths is less well established, resistance is clearly established in helminths of veterinary importance throughout the world, such that in some regions, treatment options are running out. (springernature.com)

Member viruses have a viral envelope and a positive-sense, single-stranded RNA genome which is capped and polyadenylated. (wikipedia.org)
citation needed] Nidoviruses as a group have the largest RNA genomes of viruses. (wikipedia.org)
Molecular biology of viruses which use a single stranded negative sense RNA molecule as genome. (warwick.ac.uk)
It is not part of the International Committee on Taxonomy of Viruses classification of viruses (ie, it is not a species, genus, or family), which is based on the nature and structure of the viral genome. (msdmanuals.com)

report the chromosome-scale genome assembly and transcriptome sequence data of Haemonchus contortus, a key parasitic nematode model. (springernature.com)
We have recently completed the chromosome-scale genome assembly of H. contortus , now published in Communications Biology. (springernature.com)

A collective genome representative of the many organisms, primarily microorganisms, existing in a community. (nih.gov)
1. Microorganisms are best defined as organisms that A. can only be found growing in laboratories. (intertekglobal.eu)

The genetics of living things tells us all living organisms will suffer mutations in their genetics. (biotech2k.com)
Topics include functions of cell components, how organisms obtain and process energy, genetics and inheritance, and evolution. (neiu.edu)

The pan-genome of gut microbes encompasses 150-fold more genes compared to their human host, resulting in outstanding genetic diversity and therefore considerable possibilities of interaction - also with orally administered drugs. (swisstph.ch)

Potential costs and benefits of antibiotic resistance in commensal organisms. (antimicrobialresistance.eu)

Recent linkage analyses of a genome-wide scan revealed that two quantitative trait loci on chromosomes 9 and 18 may be responsible for the susceptibility to trichuriasis in some genetically predisposed individuals. (medscape.com)
A "reverse vaccinology" strategy using in silico analyses based on the genome sequence information of the organism represents a novel approach to identifying vaccinogens. (medscape.com)
The characterization of the D. viviparus transcriptome also provides a foundation for whole genome sequence analysis and future comparative transcriptomic analyses. (biomedcentral.com)

The nature of parasitism will be discussed using examples from the major protozoan, helminth and arthropod groups. (aber.ac.uk)

Prevalence of helminth infection was higher in the schools where hygiene conditions (ie, tapwater, handwashing soap) were lacking. (medscape.com)

One study in Nigeria was undertaken to determine helminth infection status and hygienic conditions in primary schools. (medscape.com)

in arthropods or helminths and manipulate their hosts and progeny. (cdc.gov)

They shared 44 % sequence identity with each other and 14.8-44.8 % with orthologues/homologues from other organisms. (biomedcentral.com)

Motivated by the utility of the draft genome and transcriptome published in 2013 for investigating H. contortus biology (see Laing et al , https://doi.org/10.1186/gb-2013-14-8-r88 ), we quickly realised that a highly-contiguous genome assembly was necessary to understand precisely how drug selection shapes genetic variation throughout the genome. (springernature.com)

Nidoviruses have a viral envelope and a positive-sense, single-stranded RNA genome which is capped and polyadenylated. (wikipedia.org)

Helminth GSTs play pertinent roles during sequestration of harmful xenobiotics since most helminths lack the cytochrome P-450 detoxifying enzyme. (biomedcentral.com)

Research on the nature and function of the human microflora could suggest strategies to manipulate these beneficial microbes to combat pathogenic organisms. (nih.gov)

Here, we focus on model organism databases to demonstrate the myriad ways in which biological databases not only act as repositories but actively facilitate advances in research. (biomedcentral.com)
We present data that show that reducing financial support to model organism databases could prove to be not just scientifically, but also economically, unsound. (biomedcentral.com)
By gathering and interconnecting diverse types of information from many sources, MODs enhance the communication of knowledge gained via model organism-based research to the broader community. (biomedcentral.com)
The quantity of literature produced using a species is one metric for the "success" of a model organism research community. (biomedcentral.com)
9 ] assessed publication trends and showed that a "model organism" designation did not necessarily correlate to an increase in the number of publications. (biomedcentral.com)
The ability to precisely modify genomes is critical to fully realize the utility of model organisms. (tamu.edu)
This technology is an important addition to the array of genetic techniques already available in this experimentally tractable model organism. (tamu.edu)
The species Pristionchus fissidentatus is a free-living nematode, of interest as a comparator to a model organism Pristionchus pacificus . (wormbase.org)
Alliance of Genome Resources Portal: unified model organism research platform. (dagstuhl.de)

Schistosomiasis fever report here analysis of the megabase nuclear genome of the blood fluke. (malaimare.ro)

A cyst is an environmentally hardy form, designed to protect the genetic material when conditions are harsh and unfavorable for the growth of the organism. (encyclopedia.com)

Evaluation of Whole-Genome Sequencing for Identification and Typing of Vibrio cholerae. (cdc.gov)

Wolbachia organisms became noteworthy in tropical medicine when they were found in nematode worms, specifically those causing filariasis. (cdc.gov)
Helminths, more commonly called parasitic worms, represent an incredibly diverse group of organisms that exploit a variety of life-history strategies for their survival and persistence. (springernature.com)
The methodologies currently used to identify new compounds are based on the subjective evaluation of the motile worms, or involve transgenic organisms. (unifesp.br)
Just like the worms in my front yard, helminths are a frequent encounter. (swisstph.ch)

Developing new, more efficient diagnostic methods to identify specific organisms is critical for rapid treatment and for understanding the epidemiology of infectious disease outbreaks. (nih.gov)

4 Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA 95616, USA. (nih.gov)

This book covers all aspects of Wolbachia organisms from basic science and history to medicine and veterinary science. (cdc.gov)

An agent causing disease or illness to its host, such as an organism or infectious particle capable of producing a disease in another organism. (nih.gov)
In the absence of a helper it establishes a latent state in which its genome is maintained episomally or integrated into the host chromosome. (justia.com)
Cancer la san ppt parasitic helminths have a highly developed system to enhance host transmission, detoxifiere botosani que faire contre le papillomavirus humain. (mediafilmcenter.ro)
It requires a host for the completion of its life cycle, and its survival comes at the expense of the host organism. (encyclopedia.com)

The generation of modern live oral vaccines involves the construction of genetically defined attenuated micro-organisms capable of inducing immunity in a non-harmful way. (bmj.com)

treating filariasis patients with antimicrobial drugs results in elimination of Wolbachia organisms and the microfilaremia. (cdc.gov)
Transmission Surveillance for Antimicrobial-Resistant Organisms in the Health System. (cdc.gov)

Anatomy10

Organisms60

Diseases33

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes82

Disciplines and Occupations7

Technology, Industry, Agriculture2

Information Science13

Health Care5

Geographicals2

Hundred parasitic1

Protozoa4

Infections10

Intestinal helminth1

Parasites8

Bacteria3

Caenorhabditis5

Soil-transmitted1

Genomic3

Pathogens3

Sequences5

Nematodes3

Proteins5

ParaSite2

Elegans2

Meta-organism1

Human genome3

Whole organism1

Exons1

WormBase2

Pathogen2

Bacterial1

Emergence of resistance1

Viruses4

Chromosome-scale2

Microorganisms2

Genetics2

Genes1

Antibiotic resistance1

Analyses3

Protozoan1

Prevalence1

Infection1

Arthropods1

Sequence1

Transcriptome1

Single-stranded1

Pertinent1

Microbes1

Model9

Schistosomiasis1

Genetic1

Vibrio1

Worms4

Rapid1

Biology1

Veterinary1

Host4

Immunity1

Antimicrobial2