Organic ligands. Medical search. Frequent questions

Complexes of this ligand also catalyze a wide array of reactions, including the arylation of ketones and esters, borylation of aryl chlorides, and the arylation of indoles. (wikipedia.org)
The reaction of the Schiff base ligand with Co(II) and Cu (II) salts in methanol affords the [CoL] and [ClCuHL] complexes. (scirp.org)
This research concerns a new generation of phosphorus ligands bearing short and branched perfluoroalkyl or perfluoropolyether substituents of the fluorine content and their coordination chemistry as an alternative ligands and metal complexes having a potential application in fluorous biphase system in all common organic solvents. (bl.uk)
The perfluoroalkylated phosphine, phosphinite, phosphonite ligands have been reacted with transition metal complexes to form complexes of the type cis and trans-[PtCl₂L₂], and [Cp*RhCl₂L]. (bl.uk)
The derivatised phosphonic acid ligands have been reacted with transition metal complexes as dianionic bidentate ligands to form coordination complexes of the type [Pt(O₃PR)(PPh₃)₂] and zirconium phosphonate Zr[O₃PC₆H₄-4-R]₂. (bl.uk)
A study into potential fluorous solubility of the synthesised ligands and their metal complexes was also undertaken. (bl.uk)
Herein, we report two nickel hydride complexes with one or two cationic ligands that enable the measurement of BDFE values in both aqueous and organic solvents using their reduction potential and pKa values. (chemrxiv.org)
The Ni(I/0) reduction potentials increase anodically as more charged groups are introduced into the ligand framework and are among the most positive values measured for Ni complexes. (chemrxiv.org)
Two new lanthanide complexes were synthesized in which the meta (Eu3+ or Gd3+) first coordination sphere is formed by three beta-diketonate ligands (bifa is the 4,4,4-trifluoro-l-phenyl-1,3-butanedionate ion) and two methanol (MeOH) molecules The complexes also comprise the bpeta (1,2-bis(4-pyridyl)ethane) ligand. (ua.pt)
The team found that the complexes are useful in catalysis-even with weakly binding substrates-due to the weakly binding HFB ligand. (chemistryviews.org)
We are interested in small-molecule activation using low-valent transition metal complexes as well as complexes featuring metal-ligand multiple bonds. (lu.se)

A study published in the journal Science China Chemistry found that PBA3[InCl6]·H2O exhibits a special "herringbone" stacking mode that enables abundant weak interactions between organic ligands and metal halide units. (phys.org)
In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. (phys.org)
Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry. (phys.org)
The chemistry of the precursor from which charge transport layers are formed can significantly affect the device performance of organic solar cells. (aip.org)
During recent years, the biotic ligand model (BLM) has been proposed as a tool to evaluate quantitatively the manner in which water chemistry affects the speciation and biological availability of metals in aquatic systems. (researchgate.net)
In organic chemistry , a functional group is a substituent or moiety in a molecule that causes the molecule's characteristic chemical reactions . (wikipedia.org)
Many hypervalent iodine compounds are used as versatile reagents in synthetic organic chemistry. (uwaterloo.ca)
As such, in addition to their applications in organic reactions, they are utilized in fields such as medicinal chemistry, biochemistry, and chemical biology. (uwaterloo.ca)
Overall our studies have shed light on the influence of ligand chemistry on crystal growth and stabilization of the nanocrystals, which opens the door to functionalizable perovskite nanocrsytals through surface ligand manipulation. (spm.com.cn)
The Journal of Organic Chemistry 2018 , 83 (3) , 1634-1642. (acs.org)
The Journal of Organic Chemistry 2014 , 79 (5) , 2203-2212. (acs.org)
Total Synthesis of Microtubule-Stabilizing Agent Ceratamine A. The Journal of Organic Chemistry 2013 , 78 (24) , 12814-12818. (acs.org)
Scientists from Zelinsky Institute of Organic Chemistry of Russian Academy of Sciences in Moscow imaged an organic chemical reaction with an electron microscope and recorded the transformation in real time. (phys.org)
The course integrates organic, physical, theoretical chemistry, and biochemistry to describe how a given drug molecule can interact with a disease-relevant target biomolecule, as well as how drug molecules can be chemically optimized with respect to pharmacokinetic and pharmacodynamics properties. (lu.se)

Single crystal X-ray diffraction measurements reveal that each organic modifier makes use of only one of two available carboxylate oxygens to accomplish grafting. (northwestern.edu)
Characterization of the ligand was performed by FT-IR, 1 H NMR, 13 C NMR, UV-Vis, elemental analysis and single crystal X-ray diffraction. (scirp.org)

This work opens the door to the rational design and synthesis of porous organic phosphorine -based polymers with applications in gas separation and metal-based heterogeneous catalysis. (ornl.gov)
Dialkylbiaryl phosphine ligands are phosphine ligands that are used in homogeneous catalysis. (wikipedia.org)
Use of coordination compounds of some precious metal ions will be explained in relation to homogeneous catalysis for the production of useful organic and pharmaceutically important substances. (freevideolectures.com)
Highly fluorinated benzenes (HFB) are useful , but underused, solvents and ligands in organic synthesis and catalysis. (chemistryviews.org)

The work presented in this thesis is concerned with the design and synthesis of metal- organic frameworks (MOFs). (tcd.ie)
Urotropine is a cheap and promising ligand for the synthesis of metal-organic frameworks containing uncoordinated nitrogen atoms. (edu.sa)

In the three compounds, urotropine performs diff erent functions, acting as a monodentate ligand (compound 1), a bidentate ligand (compound 3), or a methylammonium counterion (compound 2). (edu.sa)
Combining the names of functional groups with the names of the parent alkanes generates what is termed a systematic nomenclature for naming organic compounds . (wikipedia.org)
Targeting EPPIN's essential residues for its biomolecular interactions may improve the rational design of EPPIN ligands as spermiostatic compounds. (bvsalud.org)
Hypervalent iodine reagents are capable of oxidizing trivalent phosphorus compounds into pentavalent, by transferring their heteroatom ligands onto phosphorus. (uwaterloo.ca)
Industrialization brought us boron-based glasses, polymer glasses and metallic glasses, but now an international team of researchers has developed a new family of glass based on metals and organic compounds that stacks up to the original silica in glass-forming ability. (sciencedaily.com)
The metal-organic glass the researchers produced substitutes zinc for silicon, but uses two similar but different organic compounds at the corners -- imidazolate and benzimidazolate. (sciencedaily.com)
Zinc-based organic glass is more difficult to produce than silica glass because the organic compounds imidazolate and benzimidazolate first need to be synthesized, mixed with hydrous zinc nitrate and a solvent. (sciencedaily.com)
Esters have been identified to act as a new and clean coupling partner for the carbon-carbon bond forming cross-coupling reaction to make useful compounds for pharmaceuticals, agrochemicals and organic materials. (phys.org)
Researchers have since found that vitamins are essential organic compounds that the human body cannot synthesize. (medscape.com)

Here we explore a related concept: tuning of support/catalyst interactions, and therefore, catalyst activity, via parallel installation of organic modifiers on the support itself. (northwestern.edu)
The predicted interactions were assessed by cis-inhibition assay using [ 3 H]1-methyl-4-phenylpyridinium ([ 3 H]MPP + ) as a model substrate, or by measuring the uptake of radiolabeled ligands in intact cells. (figshare.com)
Interactions of the male contraceptive target EPPIN with semenogelin-1 and small organic ligands. (bvsalud.org)
Physicochemical characterisation of macromolecule/ligand interactions and development of biosensory methods. (uni-marburg.de)

Incorporation of a sulfonate group at the 4-position allows this ligand to be used for Sonogashira couplings in aqueous biphasic solvents. (wikipedia.org)
Oxygen-17 spin relaxation has been used extensively to magnet technology sets an upper limit of ;100 MHz for the study single-molecule rotation in bulk water (2,3) and in the 17O resonance frequency, so the picosecond-nanosecond hydration shells of small organic solutes (4,5) and proteins hydration layer dynamics cannot be resolved directly in the (1,6,7) in dilute aqueous solution. (lu.se)

Solution phase studies on purified nanocrystal samples by 1H NMR and IR spectroscopies have confirmed the presence of both carboxylate and alkylammonium ligands on surfaces, with the alkylammonium ligand being much more mobile and susceptible to detachment from the nanocrystal surfaces during polar solvent washes. (spm.com.cn)
A cross-coupling reaction is typically performed in an organic solvent and leads to the production of a large amount of solvent waste, which is often harmful to the environment. (phys.org)
In general, protein nanoparticles offer a number of advantages including biocompatibility and biodegradability.They can be prepared under mild conditions without the use of toxic chemicals or organic solvent s. (cdc.gov)

New data concerning the structure and photochemical reactivity of strong Fe(III) binding ligands (siderophores) produced by pelagic marine bacteria suggest that direct photolysis via ligand-to-metal charge transfer reactions may be an important mechanism for the production of reduced, biologically available iron (Fe[II]) in surface waters. (bioone.org)
Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. (phys.org)
These values have been studied primarily in organic solvents to predict or understand reactivity. (chemrxiv.org)

Dialkylbiaryl phosphine ligands were first described by Stephen L. Buchwald in 1998 for applications in palladium-catalyzed coupling reactions to form carbon-nitrogen and carbon-carbon bonds. (wikipedia.org)
Their enhanced catalytic activity over other ligands in palladium-catalyzed coupling reactions have been attributed to their electron-richness, steric bulk, and some special structural features. (wikipedia.org)
Extensive experimentation by the Buchwald group has shown that further minor changes to the structure of these ligands can dramatically alter their catalytic activity in cross coupling reactions with different substrates. (wikipedia.org)
DavePhos, the first reported dialkylbiaryl phosphine ligand, was initially used in Pd-catalyzed Suzuki-Miyaura cross-coupling reactions as well as Buchwald-Hartwig aminations. (wikipedia.org)
This ligand has been utilized in multiple reactions including the amination of a range of aryl halides and triflates as well as the arylation of thiophenes. (wikipedia.org)
Palladium/P,O-Ligand-Catalyzed Suzuki Cross-Coupling Reactions of Arylboronic Acids and Aryl Chlorides. (unboundmedicine.com)
The phenyl backbone-derived P,O-ligands 1 and 2 were investigated for their utility as ligands in palladium/ligand-catalyzed Suzuki reactions. (unboundmedicine.com)
The 2-(2'-dicyclohexylphosphinophenyl)-2-methyl-1,3-dioxolane (ligand 1) in combination with Pd(dba)(2) affords an efficient catalyst for general Suzuki reactions of a wide variety of arylboronic acids and aryl chlorides, bromides, and iodides to afford the desired biaryl products in high isolated yields. (unboundmedicine.com)
Thus, the higher efficiency of ligand 1 over ligand 2 in Pd/L-catalyzed Suzuki arylation of aryl chlorides can be ascribed to the ability of ligand 1 to generate and stabilize mono-phosphine P,O-chelating Pd/L intermediates, which appear to be most suitable for Suzuki arylation reactions involving certain substrates and conditions. (unboundmedicine.com)

Gerard Martin Tobin, 'Synthesis and structural characterisation of metal-organic frameworks composed of transition or lanthanide metal cations linded via tritopic ligands', [thesis], Trinity College (Dublin, Ireland). (tcd.ie)

Gharamaleki, J. , Akbari, F. , Karbalaei, A. , Ghiassi, K. and Olmstead, M. (2016) Synthesis, Characterization and Crystal Structure of a New Schiff Base Ligand from a Bis(Thiazoline) Template and Hydrolytic Cleavage of the Imine Bond Induced by a Co(II) Cation. (scirp.org)

In recent years, progress has been made toward understanding the role of biologically produced organic ligands in controlling the speciation and photochemical redox cycling of iron in ocean surface waters. (bioone.org)

The resulting complex [Fe(phtmeimb)2]+, where phtmeimb is [phenyl(tris(3-methylimidazol-1-ylidene))borate]-, exhibits strong, visible, room temperature photoluminescence with a 2.0 ns lifetime and 2% quantum yield via spin-allowed transition from a ligand-to-metal charge-transfer (2LMCT) state to the ground state (2GS). (lu.se)

The ΔT m positively correlated with ligand molecular weight/chemical complexity, which typically has high entropic costs, suggesting that large ΔT m reflect a larger displacement of bound water molecules. (figshare.com)
Small organic molecules targeting EPPIN's SEMG1-binding are under development as male contraceptives . (bvsalud.org)
The present method is demonstrated through the design of small organic molecules with the property requirements on HOMO-LUMO gap and internal energy. (springer.com)
For instance, the chemical space of small organic molecules is known to consist of more than \(10^{60}\) candidates. (springer.com)
These organic molecules randomly take the place of the oxygen atoms at the tetrahedron corners. (sciencedaily.com)
Biological pharmaceuticals are presented, discussed, and compared with small organic molecules from a drug perspective. (lu.se)

Before their development, use of first- or second-generation phosphine ligands for Pd-catalyzed C-N bond-forming cross-coupling (e.g., tris(o-tolyl)phosphine and BINAP, respectively) necessitated harsh conditions, and the scope of the transformation was severely limited. (wikipedia.org)
Dialkylbiaryl phosphine ligands are sometimes referred to as the "Buchwald ligands. (wikipedia.org)
Dialkylbiaryl phosphine ligands are air-stable solids. (wikipedia.org)
Br)}(2) with ligand 2 affords the bis-phosphine complex L(2)Pd(4-(t)()Bu-C(6)H(4))(Br) (13, L = 2). (unboundmedicine.com)

Moreover, organic material in decomposition, imbalance in N, S, and C cycles, excessive uptake of cations over anions and the uptake of nitrogen by leguminous crops all increase the concentration of H + and reduce soil pH (Figure 1 ). (frontiersin.org)
The decomposition of the organic matter, the imbalance of the N, S, and C cycles, the excess in the cation uptake on anions and the N fixation by the legumes influence the concentration of protons [H + ] in the soil solution. (frontiersin.org)
Laboratory batch sorption and column experiments were performed to investigate the role of organic ligands such as galacturonic, glucuronic and alginic acids (main constituents of bacterial exopolymeric substances (EPS)) on Cr(VI) uptake and transport in heterogeneous subsurface media. (comu.edu.tr)
On the other hand, organic ligands have no or little effect on Cr(VI) uptake under highly alkaline pH conditions since the catalytic Cr(VI) reduction decreases with increasing pH. (comu.edu.tr)

They were prepared from precursors with norbornadiene ligands by hydrogenation. (chemistryviews.org)

The zirconium phosphonates are immiscible in all the organic solvents. (bl.uk)

Insight into the Ligand-Mediated Synthesis of Colloidal CsPbBr3 Perovskite Nanocrystals: The Role of Organic Acid, Base, and Cesium Precursors. (spm.com.cn)

The ligands-assisted rational design of a Eu3+-containing organic-inorgnic hybrid (di-ureasil) displaying the highest emission quantum yield (0 60 +/- 0 06) reported so far is introduced. (ua.pt)

A two‐step topotactic pathway for the preparation of phosphabenzene ‐based porous organic polymers (POPs) under metal‐free conditions was achieved without the use of unstable phosphorus‐based monomers. (ornl.gov)
Two bis(acetylide)-functionalized platinum(II) polymers containing ferrocenyl pendant ligands, trans-[{-Pt(PBu n 3 ) 2 -C≡CRC≡C-} n P1 (R = 9-ferrocenylmethylene-2,7-diethynylfluorene) and P2 (R = ferrocenylmethylene-2,5-diethynylbenzene), were prepared in good yields and were characterized by NMR spectroscopy and GPC. (elsevierpure.com)
abstract = "Two bis(acetylide)-functionalized platinum(II) polymers containing ferrocenyl pendant ligands, trans-[{-Pt(PBun3)2-C≡CRC≡C-}n P1 (R = 9-ferrocenylmethylene-2,7-diethynylfluorene) and P2 (R = ferrocenylmethylene-2,5-diethynylbenzene), were prepared in good yields and were characterized by NMR spectroscopy and GPC. (elsevierpure.com)

In contrast, the structurally related ligand 2-(2'-dicyclohexylphosphinophenyl)-1,3-dioxolane (ligand 2) was found to be less efficient under similar conditions. (unboundmedicine.com)
Relying on quantitative bioactivity models we designed and synthesized structurally novel, selective, nanomolar, and ligand-efficient 5-HT2B modulators with sustained cell-based effects. (duke.edu)

In these membranes, inorganic nanoparticles are coated with a shell of organic ligands that interlock as spacers and provide tensile strength. (nature.com)
Figure 4: Coarse-grained molecular dynamics simulations showing asymmetry in ligand distribution for single nanoparticles and their self-assembled array residing at the air/water interface. (nature.com)
Moreover, due to their defined primary structure, protein-based nanoparticles offer various possibilities for surface modifications including covalent attachment of drugs and targeting ligands. (cdc.gov)

These polymeric ligand exchange columns utilize a range of counter ions to deliver selectivity required for the analysis of carbohydrates, organic acids, and sugar alcohols. (thermofisher.com)
HyperREZ XP Carbohydrate columns are based on a monodisperse resin with 4 or 8% divinylbenzene content, and provide an ideal medium for the analysis of carbohydrates and organic acids. (thermofisher.com)
We have additionally demonstrated that employing a more soluble cesium acetate precursor in place of the universally used Cs2CO3 results in enhanced processability without sacrificing optical properties, thus offering a more versatile recipe for perovskite nanocrystal synthesis that allows the use of organic acids and amines bearing chains shorter than eight carbon atoms. (spm.com.cn)
The chief functions of albumin are to transport a wide variety of ligands, to maintain plasma oncotic pressure, and to serve as a source for endogenous amino acids. (medscape.com)

The reaction of bis-[2-amino-4-pheny1-5-thiazolyl] disulfide with 5-nitro-salicylaldehyde in absolute ethanol resulted in the formation of a new Schiff base ligand H 2 L (1). (scirp.org)
The reaction of ligand 1 with Pd(dba)(2) affords the complex LPd(dba) (14, L = 1). (unboundmedicine.com)

Ligands with similar affinity showed markedly different ΔT m , indicating different enthalpic and entropic contributions for similar binding affinities. (figshare.com)
Triazoloquinazolinediones as novel high affinity ligands for the benzodiazepine site of GABA(A) receptors. (lu.se)

Here we design a suite of ligand-stabilized metal oxide clusters and find that these modulate carbon dioxide reduction pathways on a copper catalyst, enabling thereby a record activity for methane electroproduction. (nature.com)

Even though this approach is conceptually applicable to non-volatile and high molecular weight organics as well, it is more challenging to predict the other PBPK model parameters required for modelling the kinetics of these chemicals (particularly tissue diffusion coefficients, association constants for binding and oral absorption rates). (cdc.gov)

We report an investigation of the "missing-linker phenomenon" in the Zr-based metal-organic framework UiO-66 using atomistic force field and quantum chemical methods. (elsevierpure.com)
Methods: Molecular modelling and in silico docking of different ligands revealed two distinct binding sites at OCT2 outer part of the cleft. (figshare.com)

Cavities up to 4 nm have been introduced into a hierarchically-assembled metal-organic framework by adopting an angular, semi-flexible tetratopic ligand. (rsc.org)
MOFs are a class of hybrid inorganic-organic material composed of metal-ions or clusters of metal-ions linked via organic linkers into high dimensional frameworks. (tcd.ie)
Previous work has shown that introduction of hexafluoroacetylacetone (Facac) units as nonstructural ligands for the zirconia-like nodes of the eight-connected metal-organic framework (MOF), NU-1000, greatly alters the selectivity of node-supported oxy-nickel clusters for ethylene dimerization vs oligomerization. (northwestern.edu)
The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. (phys.org)
The nature of metal-ligand bonding can range from covalent to ionic. (phys.org)
Furthermore, the metal-ligand bond order can range from one to three. (phys.org)
Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. (phys.org)
Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). (phys.org)
SCOR Working Group 139: Organic Ligands- A Key Control on Trace Metal " by Kristen N. Buck, Maeve Lohan et al. (usf.edu)
These results are expected to be of relevance to a wide range of metal-organic frameworks. (elsevierpure.com)
Silica glass had the best glass-forming ability of all glasses until the researchers synthesized zinc-based ZIF-62 metal-organic glass, the researchers reported today (Mar. 9) online in Science Advances . (sciencedaily.com)
They noticed that the more benzimidazolate incorporated into the metal/organic framework, the better the glass-forming ability. (sciencedaily.com)
ZIF-62 has the best glass-forming ability of 50 existing glasses and while standard silica glass is brittle, the metal-organic glass is far more pliable, which may also add to its glass-forming ability. (sciencedaily.com)

In this work, we design and synthesize a suite of ligand-stabilized cobalt oxide (CoO) nanoclusters. (nature.com)

The complex with two cationic ligands, 2-Ni(II)-H, displays exceptional stability in water with no evidence of decomposition at pH 1 for at least 2 weeks. (chemrxiv.org)

Electro-optical properties of polymer-based materials for organic photovoltaics (OPVs) and related organic electronic applications are predicted using first principles calculations. (lu.se)

Functional groups binding to a central atom in a coordination complex are called ligands . (wikipedia.org)

Functional group interconversion can be used in retrosynthetic analysis to plan organic synthesis . (wikipedia.org)

However, hydrolytic cleavage of Schiff base ligands readily occurs due to the reversible nature of the synthetic procedure. (scirp.org)
The team also demonstrated that the HFB ligands can be readily substituted by other weakly binding ligands such as isobutene, opening up new opportunities in synthesis. (chemistryviews.org)

We suggest, however, that regardless of mechanism for communication with active-sites of MOF-supported catalysts, intentional elaboration of nodes via grafted, nonstructural organic species could prove to be a valuable general strategy for fine-tuning supported-catalyst activity and/or selectivity. (northwestern.edu)

Numerous crystallographic studies have indicated that it behaves as a hemilabile ligand and is believed to play a role in stabilizing the highly reactive, formally 12-electron L-Pd0 intermediate during the catalytic cycle. (wikipedia.org)

Here, we show by X-ray scattering that nanoparticle membranes formed at air/water interfaces exhibit a small but significant ∼ 6 Å difference in average ligand-shell thickness between their two sides. (nature.com)
Crude membranes from HEK293 cells harboring human OCT2 (OCT2-HEK293) were solubilized in n-Dodecyl-β-D-Maltopyranoside (DDM), incubated with the ligand, heated over a temperature gradient, and then pelleted to remove heat-induced aggregates. (figshare.com)

We report a multi-objective de novo design study driven by synthetic tractability and aimed at the prioritization of computer-generated 5-HT2B receptor ligands with accurately predicted target-binding affinities. (duke.edu)

Scholars@Duke publication: Multidimensional de novo design reveals 5-HT2B receptor-selective ligands. (duke.edu)

Introduction: The human organic cation transporter 2 (OCT2) is involved in the transport of endogenous quaternary amines and positively charged drugs across the basolateral membrane of proximal tubular cells. (figshare.com)

Anatomy1

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