Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Organic Cation/Ergothioneine Transporter (OCTN1) in Tissue homogenates, cell lysates and other biological fluids. (therabio.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Organic Cation/Ergothioneine Transporter (OCTN1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (therabio.org)
Description: A sandwich ELISA kit for detection of Organic Cation/Ergothioneine Transporter from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
These include extensive research revealing the relationship between blood ET levels and health and disease, cellular and tissue protective mechanisms, potential therapeutic applications of ET, transporter expression and tissue distribution, biosynthetic mechanisms, and more. (biosynsis.com)
However, the OCTN1 gene knockout model (lacking tissue ET) has not shown any substantial dominant phenotype or deficiency syndrome. (biosynsis.com)
Using normalized consensus RNA expression data from three datasets (genotype tissue expression project, human protein map dataset, and FANTOM5 project), RNA expression of slc22a4 (encoding OCTN1) was obtained in humans. (biosynsis.com)
Perland and Fredriksson, 2017 ) or the pharmaceutical drug substrates of these transporters, and one clue to this may be to understand their differential tissue distribution. (biorxiv.org)
Uptake2
Discovered more than a century ago, interest in this low molecular weight thiol/ketone has reignited, partly due to its unique chemical properties (such as its unusual stability), as well as the recognition of a transporter, the organic cation transporter novel type 1 (OCTN1), responsible for the uptake and accumulation of ET in human tissues in our diet, as well as selective distribution into tissues due to differences in transporter expression. (biosynsis.com)
mainly involved in uptake, and ABC transporters (ABCs), mainly involved in efflux (e.g. (biorxiv.org)
Compound1
This compound belongs to the class of organic compounds known as monoalkylamines. (drugbank.com)
Human2
Recently, the use of naturally expressed and overexpressed OCTN1 in human cells has once again confirmed the selective preference of ET as the substrate for OCTN1, supporting the proposal to rename OCTN1 as the ergothione transporter (ET). (biosynsis.com)
We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
Cell2
Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
By contrast, the Gini coefficients for ABC transporters tend to be larger in cell lines than in tissues, implying that some kind of a selection process has taken place. (biorxiv.org)
Expression2
The expression of OCTN1 is also present in the proximal renal tubules of rats, which is important for the renal absorption of ET. (biosynsis.com)
The accumulation ability of ET in the body and its selective distribution in tissues (through differential expression of transporters) indicate that ET plays an important physiological role. (biosynsis.com)
Carnitine transporter2
Correction to: Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men. (nih.gov)
The present study was conducted to expand knowledge on a third means of uptake, namely the expression of drug transporters in the rat nasal epithelium. (nih.gov)
16. Drug transporters of platinum-based anticancer agents and their clinical significance. (nih.gov)
OCTN23
10. Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons. (nih.gov)
Die entsprechenden Gene kodieren für die organischen Kationentransporter OCTN1 (SLC22A4) und OCTN2 (SLC22A5), welche in vielen Geweben exprimiert werden. (uni-greifswald.de)
OCTN1 und OCTN2 wurden sowohl im gesunden als auch im erkrankten Parodontium detektiert, vor allem im Epithel und Gefäßendothel. (uni-greifswald.de)
Polymorphisms1
Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease. (cdc.gov)
Multidrug2
and multidrug resistance (MRP)1 and MRP4] in nasal respiratory mucosa, olfactory mucosa, and olfactory bulb to the level of expression of these transporters in the liver and kidney. (nih.gov)
3. Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). (nih.gov)
Kidney1
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. (nih.gov)
Putative2
9. Impaired cisplatin influx in an A2780 mutant cell line: evidence for a putative, cis-configuration-specific, platinum influx transporter. (nih.gov)
The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. (nih.gov)
Resistance2
7. Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin, carboplatin, and oxaliplatin in ovarian cancer cells. (nih.gov)
In addition, excellent piezoresistive performance, including superior discernibility for different amplitudes of compressive strain (up to 80%), rapid response time (150 ms), and high sensitivity (gauge factor of 1.44), was demonstrated for such foams, together with prominent durability (39,000 compression cycles at 60% strain in air) and excellent stability of resistance response in water and organic solvents (5000 compression cycles at 30% strain in water and ethanol). (bvsalud.org)
Human6
1. Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2). (nih.gov)
11. Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. (nih.gov)
14. Interaction of Cisplatin with the human organic cation transporter 2. (nih.gov)
Description: A sandwich quantitative ELISA assay kit for detection of Human ATP Binding Cassette Transporter C9 (ABCC9) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human ATP Binding Cassette Transporter C9 (ABCC9) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
Description: A sandwich ELISA kit for detection of ATP Binding Cassette Transporter C9 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
Role1
Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide: role of canalicular multispecific organic anion transporter and P-glycoprotein. (kanazawa-u.ac.jp)