• We have investigated the induction of DNA-adducts in relation to mutagenesis in bladder and various non-target organs of transgenic Big Blue® mice treated weekly (i.p.) with a representative aromatic-amine compound, 4-aminobiphenyl (4-ABP), for six weeks, followed by a six-week recovery period. (aacrjournals.org)
  • In confirmation, we show a predominant and sustained mutagenic effect of 4-ABP in bladder, and much weaker but significant mutagenicity of 4-ABP in the kidney and liver of carcinogen-treated mice, as reflected by the elevation of background cII mutant frequency in the respective organs. (aacrjournals.org)
  • Organ specific drug targeting was explored in mice as a possible alternative to surgery to treat prostate diseases. (pnas.org)
  • Systemic treatment of mice with a chimeric peptide consisting of the SMSIARL homing peptide, linked to a proapoptotic peptide that disrupts mitochondrial membranes, caused tissue destruction in the prostate, but not in other organs. (pnas.org)
  • While these cross-reactive T cells did not cause pathology in immunocompetent mice, adoptive transfer into immunodeficient mice resulted in organ-specific inflammation of the small intestine but not the colon, despite comparable migration in both tissues, and elevated expression of murine heat shock protein 60 (mu HSP60) * in the colon ( 2 ). (rupress.org)
  • Systemic vasculitis in MRL/lpr mice is genetically controlled with cumulative effects of multiple gene loci, each of which has tissue specificity. (wiley.com)
  • Although alopecia areata (AA) is one of the most frequent organ-specific autoimmune diseases, the association of AA with other autoimmune diseases and the genetic basis of the association remain to be analyzed. (thyroidmanager.org)
  • It is proposed that lymphocyte surface receptors specific for organ-restricted endothelial cell determinants mediate the antigen-independent organ specificity of lymphocyte migration. (nih.gov)
  • THE vast majority of tissues and organs of the adult plant are formed postembryonically. (genetics.org)
  • This process of decellularizing tissues and organs is still being developed, but the exact process of taking a tissue from a donor and removing all the cellular components is considered to be the decellularization process. (wikipedia.org)
  • We demonstrate an organ-specificity of 4-ABP in inducing repair-resistant DNA-adducts in bladder, kidney and liver of carcinogen-treated animals, which accords with the bioactivation pathway of this chemical in the respective organs. (aacrjournals.org)
  • Although single organ specific toxicity assays have already been commercialised, it is not yet possible to assess toxicity in the three main organs (brain, heart and liver) in the same animal. (nc3rs.org.uk)
  • ZeGlobalTox have created a new genetically modified line of zebrafish to drive the expression of unique fluorescent proteins in the three main organs (brain, heart and liver) enabling assessment of acute multi-organ toxicity and teratogenicity in the same animal. (nc3rs.org.uk)
  • CAR-T cell therapy has shown promising results for the treatment of relapsed or refractory Multiple Myeloma,however, a subset of patients relapse due to the loss of target in tumor cells.Dual Specificity CD38 and BCMA CAR-T cells can recognize and kill the malignant cells through recognition of CD38 or BCMA. (clinicaltrials.gov)
  • 1.For patients with detectable disease, measure anti-tumor response due to dual specificity CD38 and BCMA CAR-T cell infusions. (clinicaltrials.gov)
  • 1- Organ specific and tumor specific (specificity). (slideserve.com)
  • Fingerprint Dive into the research topics of 'Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. (elsevier.com)
  • Additionally, DPL can be used in nonemergency circumstances as a means of detecting solid-organ injury or HVI requiring laparotomy. (medscape.com)
  • Evidence is presented that the organ specificity of lymphocyte migration is determined by selective interaction of lymphocytes with specialized endothelial cells. (nih.gov)
  • Systemic lupus erythematosus (SLE) is an autoimmune multi-organ disease, characterized by episodes of disease flares and remissions over time, which may restrain affected patients' ability to perform daily activities. (biomedcentral.com)
  • The presence of activity limitation, as detected by the HAQ instrument, was significantly associated with quality of life (EuroQol-5D) and accrual of organ damage using the Systemic Lupus International Collaborative Clinics/ACR damage index. (biomedcentral.com)
  • To evaluate the duration of in vivo persistence of adoptively transferred T cells, and the phenotype of persisting T cells.Real Time polymerase chain receptor (RT-PCR) and Flow cytometry(FCM) analysis of PB,BM and lymph node will be used to detect and quantify survival of universal dual specificity CD38 and BCMA CAR-T cells over time. (clinicaltrials.gov)
  • Organ specificity was examined for each transcript using a gene expression atlas. (lww.com)
  • 2007). At four days post fertilisation (dpf) the vital organs of zebrafish are already fully functional and any drug-induced effect can be easily detected and evaluated. (nc3rs.org.uk)
  • Understanding the specificity and functional significance of GPCR heterodimerization is of tremendous clinical importance since GPCRs are the molecular targets for numerous therapeutic drugs. (aspetjournals.org)
  • This review will focus on the current state of research on GPCR heterodimerization, with an emphasis on the specificity of these interactions and their functional significance. (aspetjournals.org)
  • To gain a comparative insight into the similarities and differences into how organs are built and how plants respond to stress, the transcriptomes of Arabidopsis and rice were compared at the level of gene orthology and functional categorisation. (pubmedcentralcanada.ca)
  • However, reinnervation of distal organs and functional recovery are often deficient because random regeneration of axons results in aberrant target reinnervation [ 1 ]. (hindawi.com)
  • Thus, specificity of reinnervation is a key issue to improve functional recovery after peripheral nerve injuries. (hindawi.com)
  • Scientists can use the acquired ECM scaffold to reproduce a functional organ by introducing progenitor cells, or adult stem cells (ASCs), and allowing them to differentiate within the scaffold to develop into the desired tissue. (wikipedia.org)
  • The steps to go from a decellularized ECM scaffold to a functional organ is under the umbrella of recellularization. (wikipedia.org)
  • DPL was found to have a sensitivity of 100% but a specificity of only 43% for bowel injuries. (medscape.com)
  • The objective of our study was to prospectively compare the diagnostic value of sonography, contrast-enhanced sonography, and CT for the detection of solid organ injuries in blunt abdominal trauma patients,' said Massimo Valentino, MD, lead author of the study. (medindia.net)
  • But after some cases, they changed their attitude completely and now they greatly appreciate this tool, and they often ask me to carry out contrast enhanced ultrasound to rule out possible injuries to the solid organs of the abdomen, especially the spleen. (medindia.net)
  • We propose a model of how the tissue and organ specificity of trichome induction is regulated in normal development. (biologists.org)
  • To investigate whether tissue-restricted pathology is influenced by organ-specific processing of MHC class I ligands, we analyzed the subunit composition of 20S proteasomes from various organs and compared their ability to generate peptides and T cell epitopes which are involved in the induction of organ-specific pathology of the small intestine. (rupress.org)
  • As far as introducing the different liquidized chemicals and enzymes to an organ or tissue, perfusion and immersion decellularization techniques have been used. (wikipedia.org)
  • Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelia. (nih.gov)
  • Although other proteases with selective cleavage specificity might also contribute to the MHC class I peptide pool, this seems to apply only for a limited subset of peptides and cannot substitute for proteasome function ( 7 ). (rupress.org)
  • Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors. (aspetjournals.org)
  • End-organ damage contributes to the clinical picture of individuals with T2D and is demonstrated when observing the high prevalence of co-morbidities in this patient cohort. (bioportfolio.com)
  • Retinitis is the most common clinical manifestation of CMV end-organ disease in HIV-infected patients. (nih.gov)
  • Our experiments demonstrate that 20S proteasomes of different organs display a characteristic composition of α and β chain subunits and produce distinct peptide fragments with respect to both quality and quantity. (rupress.org)
  • The proposed framework as well as the curated scRNA-seq datasets are made available via an online platform, FUMA, to facilitate rapid evaluation of cell type specificity by other researchers. (nature.com)
  • As a result, approaches to induce tolerance to transplanted organs and/or minimize immunosuppression are a major priority. (omicsonline.org)
  • Cytomegalovirus (CMV) is a double-stranded DNA virus in the herpes virus family that can cause disseminated or localized end-organ disease in HIV-infected patients with advanced immunosuppression. (nih.gov)
  • Further, we demonstrate that the organ-specific potential to produce defined T cell epitopes reflects quantities that are relevant for cytotoxic T lymphocyte recognition. (rupress.org)
  • Such markers can be identified by specific monoclonal antibodies and are numbered CD1, CD2, CD3, etc. (for c luster d esignation, according to how their specificity characteristics group together when analyzed by computer). (thefreedictionary.com)
  • Spectra were compared among agents grouped according to target-organ specificity. (epa.gov)
  • After peripheral nerve injury, transected axons can regenerate and reinnervate target organs. (hindawi.com)
  • In fact, some authors argue that the key point for preferential attraction of axons to their adequate targets is the expression of trophic factors by their own target organ and the distal stump [ 2 , 3 ]. (hindawi.com)
  • During synapse formation, CAMs are critically involved in determining synapse specificity by mediating the initial target recognition between pre- and post-synaptic neurons. (iit.it)
  • Evolution has endowed plants with a flexible developmental program that enables them to elaborate new vegetative organs and attune reproduction to prevailing environmental conditions. (plantphysiol.org)
  • In addition, clv1 mutants enhance many of the Bam − organ phenotypes, indicating that, contrary to current understanding, CLV1 function is not specific to the meristem. (genetics.org)
  • Such profiles can be aligned with genome-wide association studies (GWASs) to implicate cell type specificity of the traits. (nature.com)
  • First, we investigate how a class of synaptic cell adhesion molecules (CAMs), the integrins, contribute to synaptic specificity and to coordinating pre- and postsynaptic activity under physiological and pathological conditions. (iit.it)